LOCUS       NM_029572               5267 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus endoplasmic reticulum protein 44 (Erp44), transcript
            variant 1, mRNA.
ACCESSION   NM_029572
VERSION     NM_029572.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5267)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 5267)
  AUTHORS   Xie,H., Wang,Y.H., Liu,X., Gao,J., Yang,C., Huang,T., Zhang,L.,
            Luo,X., Gao,Z., Wang,T., Yan,T., Liu,Y., Yang,P., Yu,Q., Liu,S.,
            Wang,Y., Xiong,F., Zhang,S., Zhou,Q. and Wang,C.Y.
  TITLE     SUMOylation of ERp44 enhances Ero1alpha ER retention contributing
            to the pathogenesis of obesity and insulin resistance
  JOURNAL   Metabolism 139, 155351 (2023)
   PUBMED   36427672
REFERENCE   3  (bases 1 to 5267)
  AUTHORS   Bi,Y., Yang,Z., Jin,M., Zhai,K., Wang,J., Mao,Y., Liu,Y., Ding,M.,
            Wang,H., Wang,F., Cai,H. and Ji,G.
  TITLE     ERp44 is required for endocardial cushion development by regulating
            VEGFA secretion in myocardium
  JOURNAL   Cell Prolif 55 (3), e13179 (2022)
   PUBMED   35088919
  REMARK    GeneRIF: ERp44 is required for endocardial cushion development by
            regulating VEGFA secretion in myocardium.
REFERENCE   4  (bases 1 to 5267)
  AUTHORS   Nyirimigabo,E., Jin,M., Yang,Z., Wang,J., Zhai,K., Mao,Y., Wang,H.
            and Ji,G.
  TITLE     The role of ERp44 in glucose and lipid metabolism
  JOURNAL   Arch Biochem Biophys 671, 175-184 (2019)
   PUBMED   31283909
  REMARK    GeneRIF: ERp44(-/-) newborns had lower blood glucose compared to
            wild-type
REFERENCE   5  (bases 1 to 5267)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5267)
  AUTHORS   Hedlund,E., Karsten,S.L., Kudo,L., Geschwind,D.H. and
            Carpenter,E.M.
  TITLE     Identification of a Hoxd10-regulated transcriptional network and
            combinatorial interactions with Hoxa10 during spinal cord
            development
  JOURNAL   J Neurosci Res 75 (3), 307-319 (2004)
   PUBMED   14743444
REFERENCE   7  (bases 1 to 5267)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   8  (bases 1 to 5267)
  AUTHORS   Turano,C., Coppari,S., Altieri,F. and Ferraro,A.
  TITLE     Proteins of the PDI family: unpredicted non-ER locations and
            functions
  JOURNAL   J Cell Physiol 193 (2), 154-163 (2002)
   PUBMED   12384992
  REMARK    Review article
REFERENCE   9  (bases 1 to 5267)
  AUTHORS   Anelli,T., Alessio,M., Mezghrani,A., Simmen,T., Talamo,F., Bachi,A.
            and Sitia,R.
  TITLE     ERp44, a novel endoplasmic reticulum folding assistant of the
            thioredoxin family
  JOURNAL   EMBO J 21 (4), 835-844 (2002)
   PUBMED   11847130
REFERENCE   10 (bases 1 to 5267)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK151497.1, AK141377.1, AK003217.1, AA434854.1, AL844861.3,
            AA000229.1 and BP759191.1.
            
            On Sep 13, 2017 this sequence version replaced NM_029572.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK172973.1, SRR9219381.145675.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-43                AK151497.1         2-44
            44-320              AK141377.1         2-278
            321-1611            AK003217.1         290-1580
            1612-1944           AK141377.1         1570-1902
            1945-2055           AK141377.1         1904-2014
            2056-2346           AA434854.1         239-529
            2347-2639           AK141377.1         2306-2598
            2640-4575           AL844861.3         6888-8823           c
            4576-4751           AA000229.1         1-176
            4752-5267           BP759191.1         45-560              c
FEATURES             Location/Qualifiers
     source          1..5267
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 26.09 cM"
     gene            1..5267
                     /gene="Erp44"
                     /gene_synonym="1110001E24Rik; Txndc4"
                     /note="endoplasmic reticulum protein 44"
                     /db_xref="GeneID:76299"
                     /db_xref="MGI:MGI:1923549"
     exon            1..206
                     /gene="Erp44"
                     /gene_synonym="1110001E24Rik; Txndc4"
                     /inference="alignment:Splign:2.1.0"
     CDS             150..1370
                     /gene="Erp44"
                     /gene_synonym="1110001E24Rik; Txndc4"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; thioredoxin domain containing 4 (endoplasmic
                     reticulum); endoplasmic reticulum resident protein 44kDa;
                     endoplasmic reticulum resident protein ERp44; thioredoxin
                     domain-containing protein 4; ER protein 44"
                     /codon_start=1
                     /product="endoplasmic reticulum resident protein 44
                     isoform 1 precursor"
                     /protein_id="NP_083848.1"
                     /db_xref="CCDS:CCDS18165.1"
                     /db_xref="GeneID:76299"
                     /db_xref="MGI:MGI:1923549"
                     /translation="MNPAVFLSLADLRCSLLLLVTSIFTPITAEIASLDSENIDEILN
                     NADVALVNFYADWCRFSQMLHPIFEEASDVIKEEYPDKNQVVFARVDCDQHSDIAQRY
                     RISKYPTLKLFRNGMMMKREYRGQRSVKALADYIRQQKSNPVHEIQSLDEVTNLDRSK
                     RNIIGYFEQKDSENYRVFERVASILHDDCAFLSAFGDLSKPERYNGDNVIYKPPGRSA
                     PDMVYLGSMTNFDVTYNWIQDKCVPLVREITFENGEELTEEGLPFLILFHMKDDTESL
                     EIFQNEVARQLISEKGTINFLHADCDKFRHPLLHIQKTPADCPVIAIDSFRHMYVFGD
                     FKDVLIPGKLKQFVFDLHSGKLHREFHHGPDPTDTAPGEQDQDVASSPPESSFQKLAP
                     SEYRYTLLRDRDEL"
     exon            207..279
                     /gene="Erp44"
                     /gene_synonym="1110001E24Rik; Txndc4"
                     /inference="alignment:Splign:2.1.0"
     exon            280..319
                     /gene="Erp44"
                     /gene_synonym="1110001E24Rik; Txndc4"
                     /inference="alignment:Splign:2.1.0"
     exon            320..435
                     /gene="Erp44"
                     /gene_synonym="1110001E24Rik; Txndc4"
                     /inference="alignment:Splign:2.1.0"
     exon            436..620
                     /gene="Erp44"
                     /gene_synonym="1110001E24Rik; Txndc4"
                     /inference="alignment:Splign:2.1.0"
     exon            621..736
                     /gene="Erp44"
                     /gene_synonym="1110001E24Rik; Txndc4"
                     /inference="alignment:Splign:2.1.0"
     exon            737..794
                     /gene="Erp44"
                     /gene_synonym="1110001E24Rik; Txndc4"
                     /inference="alignment:Splign:2.1.0"
     exon            795..911
                     /gene="Erp44"
                     /gene_synonym="1110001E24Rik; Txndc4"
                     /inference="alignment:Splign:2.1.0"
     exon            912..1023
                     /gene="Erp44"
                     /gene_synonym="1110001E24Rik; Txndc4"
                     /inference="alignment:Splign:2.1.0"
     exon            1024..1165
                     /gene="Erp44"
                     /gene_synonym="1110001E24Rik; Txndc4"
                     /inference="alignment:Splign:2.1.0"
     exon            1166..1268
                     /gene="Erp44"
                     /gene_synonym="1110001E24Rik; Txndc4"
                     /inference="alignment:Splign:2.1.0"
     exon            1269..5267
                     /gene="Erp44"
                     /gene_synonym="1110001E24Rik; Txndc4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1470..1475
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Erp44"
                     /gene_synonym="1110001E24Rik; Txndc4"
                     /note="hexamer: AATAAA"
     polyA_site      1499
                     /gene="Erp44"
                     /gene_synonym="1110001E24Rik; Txndc4"
                     /note="major polyA site"
     regulatory      1583..1588
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Erp44"
                     /gene_synonym="1110001E24Rik; Txndc4"
                     /note="hexamer: AATAAA"
     polyA_site      1614
                     /gene="Erp44"
                     /gene_synonym="1110001E24Rik; Txndc4"
     regulatory      1837..1842
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Erp44"
                     /gene_synonym="1110001E24Rik; Txndc4"
                     /note="hexamer: AATAAA"
     polyA_site      1859
                     /gene="Erp44"
                     /gene_synonym="1110001E24Rik; Txndc4"
     regulatory      2622..2627
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Erp44"
                     /gene_synonym="1110001E24Rik; Txndc4"
                     /note="hexamer: AATAAA"
     regulatory      2627..2632
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Erp44"
                     /gene_synonym="1110001E24Rik; Txndc4"
                     /note="hexamer: AATGAA"
     polyA_site      2645
                     /gene="Erp44"
                     /gene_synonym="1110001E24Rik; Txndc4"
     polyA_site      2652
                     /gene="Erp44"
                     /gene_synonym="1110001E24Rik; Txndc4"
     regulatory      5245..5250
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Erp44"
                     /gene_synonym="1110001E24Rik; Txndc4"
                     /note="hexamer: AATAAA"
     polyA_site      5267
                     /gene="Erp44"
                     /gene_synonym="1110001E24Rik; Txndc4"
ORIGIN      
        1 ctctggaagt tgtcccgggt gttcgccgct ggagctccgg gtcgagagga cgaggtgccg
       61 ctgccgccgg ccccggagcc cagccctttt ctagcccggt ccagtcccag ccgccacctc
      121 ctgaccccgc cgtcgacccc gtcgttacca tgaatcctgc ggtcttcctg tctttagcag
      181 acctcagatg ctccttgctg ctcctggtaa cttcaatttt tacacctata acagctgaaa
      241 tagcaagtct tgattcagag aatatagatg aaattttaaa taatgctgat gttgctttag
      301 taaattttta tgctgactgg tgtcgtttca gccagatgtt gcatccaatt tttgaggaag
      361 catctgatgt cattaaggaa gaatatccag ataaaaatca agtagtgttt gccagagttg
      421 attgtgatca gcactctgat atagcccaga ggtacaggat aagcaaatac ccaaccctga
      481 aattatttcg taatggaatg atgatgaaga gagaatacag gggccagcga tcagtgaaag
      541 cgcttgcaga ctacatcagg caacagaaaa gtaacccagt ccacgagatt cagagtctag
      601 atgaagtcac caatcttgat cgcagtaaga gaaatatcat tggatacttt gagcagaagg
      661 attcagaaaa ttacagagtt tttgaaagag tagcaagtat tttgcatgat gactgtgcct
      721 tcctttctgc ttttggagat ctttcaaaac cagaaaggta caacggagac aatgtaatct
      781 acaaaccacc cgggcgttct gcgccagaca tggtgtactt gggatctatg acaaattttg
      841 atgtaactta caactggatt caagataaat gtgtccctct tgtccgagaa ataacatttg
      901 aaaatggaga ggaattgaca gaagaaggac tgccttttct catactcttc cacatgaagg
      961 atgatacaga aagtttagaa atattccaga atgaagtagc ccggcagttg ataagtgaaa
     1021 aaggtacaat aaatttctta catgcagatt gtgacaaatt tagacatcct cttctccata
     1081 tccagaaaac gccagcagat tgccctgtca tagccattga cagttttagg catatgtatg
     1141 tttttggaga ctttaaggat gtattaattc ctggaaaact caagcagttt gtatttgacc
     1201 tacattctgg aaaattacac agagaattcc atcacggacc tgacccgact gacacagccc
     1261 caggagagca agaccaggat gtagcgagca gtcctccaga gagctccttc cagaagctgg
     1321 cgcccagcga gtataggtat actttattga gggatcgaga tgagctgtaa aaactcaaga
     1381 atactgcaag cctttccaca ccagcagagg cttacgtggt ggaaatagtg aacctatatt
     1441 ttcataattc tatgtgtatt tttattttga ataaactgaa agaagttttg ggtttttaat
     1501 ttttttcctc cccctgactc aattgcattg tcatttaata cagcctcttt tttacaaaat
     1561 ctgctagggt tttaaagaac aaaataaaaa ccagaggcct gtctccactt taaatctgtc
     1621 ctggacagtc tttatcatgc aagcggaagg tggcattgcc ggaagcacgc cgttaactta
     1681 cactgccact gcacaggcaa gagaatcggc ctgctccctg tgtgctatct gctttttctt
     1741 tcttcttttc tttgcatatg gtcaaaatct attggtattt ttattatcac atttctaaaa
     1801 gctaagggga tatatattct aggggcttgg gagggaaata aattaaaaat ttcacactgt
     1861 gtactgtgtt gtactgattg gttgggcatt gcttatgagg gttccatagt ggttcttctt
     1921 ggattcctaa tgtgtaactt aaacatacta tgaagaggag gagagccata agccagagca
     1981 tttggcaaag aaatggaagt attactaaat ttctatatgt ctgtctgaga caacagcata
     2041 tggatggcat ttaaaacttt gaatgaatta accctgaaat caggaaagca gggaccctgg
     2101 tggagcaggt taccagcgtt aaactagaca ttttaaggct ttctctgtct agaaattttc
     2161 attttcaaag aaaaactgta tttcaattat tgtaagtccc ctcctgtctt ttgtagtttt
     2221 gttattgttc tgtagatcaa aagcaaagat gttgaggaac aagcgtttta cattcttctg
     2281 tcatcaactg tctaggattg ttagagggcg ttcccctcgc ttccctggtt ccccacgcct
     2341 gcagtgggca gtcagaaggt ccctgccagg ccttgctgat gccagagata ggagcagagg
     2401 gagaagactc ttcacgttat atcaggaatc ccagtgccag aggtcaggca ggctctaaat
     2461 tggctctcct cagggcctgg gtgtggtgct ataggccaag gtcatttatc cttgggataa
     2521 gtcagtccca gtttggggag ataatatttt taagcttaaa agattgacat gtgccattat
     2581 atgtagtgtg taatatatgt aacacccttc aatcctttta aaataaaatg aatatttata
     2641 atggatattt aataactatc agcttccagt tcttaattat gcatgatttt gtccatagtt
     2701 tctgtagttt tattcagaat aatgagtatt aatgaggtga taaggggctt gtttagaatg
     2761 tctcaccaga ttgtttgtgg agaactagga cagaactttc tagaagccag gctccattct
     2821 gccacttcat tgcttttagt cagagtcttg aatatggtca cagtttttgt tttcatgacc
     2881 aaatctgaga ggctccagat gaaaactcac agttacacag cacgcgcgca tacaaggtca
     2941 aaaacagtgc caaaaaaaaa aatcagctga aataaatttg taatcctata attaggcttg
     3001 aaaaataata aaagatacca ctcaaatact gggctgcaga caactaactg aaaacagtta
     3061 ttagaaaaaa ggccaaaggg acacatcttc aatgtggtct aaaatgacag acatgctgta
     3121 aagtgaaaga tgtaatgtgt tacgtagctt tcctgcagat cggaacttgg gctgtagcct
     3181 gctaatgcct tctctgggtg atgaagccat tcagaacagt gatgctgagc cgtgtgtctg
     3241 tagtgcccac cagcttaaat acttaagtgg tcatcttcac gtgttcattg aaagaatcag
     3301 aaacagagtg gcctcgagtt gtgtttctgc cattgaaagt gcttagcgct ctgtaggact
     3361 tgatgccagt ttataaaaag ttcttgacaa gctcaagggc actccaagaa aagaggacag
     3421 taaaatgttt taaaacccaa gtatcaagac tgcttttagc ctggcatggt ggtggtatac
     3481 acctttaacc tcagcactca gaagacagaa gcagagggat ctccgagttc caggacagcc
     3541 agggctgcat cgtaagaccc tgtctcaaaa acaaaagact ttcttagaga aaatgggggt
     3601 ctgagagcag tctgtttatt tgaagtgttg atgttgtctg tataccaggg gctgaattag
     3661 aactggagga agccatcagg gagcaaatat cagttgacag ctactcacag taacgttctt
     3721 ggtgctgtaa ctttttacct agagttgctt ataatttgtt aggtcaatga ccttgtagaa
     3781 caccactgta acaagcgatt ccagattaaa catagaggaa atagagctaa tgtgcttggc
     3841 atagaaacac agggtcccaa aaatctcatg gagaaaattc tgctgaggtt ttaaaagatg
     3901 aacacctgaa aagagatagg atttggtgtg gatatgataa tctgaatgaa ggtagtaagc
     3961 tccatgatgc actaggaagg cgtactcgta gaaagaccaa ctcactggag gctcaggata
     4021 ccaaggaagg gatttacact gttttgcagg tcctgaggat ggtacttaga agcaggtctc
     4081 agacttaaga gttcagcaga accttgtcag tgcaacagag gttacctcac tcagtctgtg
     4141 ctgagcctca ggctcctctg ctgtagctag agaggctgcc caattgccct gaagaatgct
     4201 tgaataacta aggaccagaa gctagagaga cttcttgctc ctctgccagc atgaggaagc
     4261 aagacatcca ctgttctgtg gcacacactc aggcatgaca tgtatctaaa acatttacat
     4321 gaatgcataa ggtagagaat aaacatctga agtgtctcac agagagctca ctgatgaagc
     4381 cagtttgcca gggatcttgt ggaaactggc atgaaaaaag ttaacaggaa gtatgcaata
     4441 caaaacagtg tatggggggc tggagagatg gctcagtggt taagagcatt ggctactctt
     4501 ccagaggatc aggttcaaat ctcagcaccc acatggcaat tcataactgt ttctaagtca
     4561 agttccagtg gatcggattc ccttacacag atatacatgt aggccaaaca ccaaatgtac
     4621 attaaaaaag aaaaggaaaa ctgtgtttga aatgggaatg cttagaatgg actcaagaga
     4681 gagtgctgat ttggcttcct ttaaaaaaat gcaccaagga aaaggaatgg ggaatggatt
     4741 gataaagcgg gaaaaccaga gtaactcgct atttttcctt cgacactgtc tgctaagcca
     4801 aaagtaaaat gacatgaaat ttagaaccca tgtataccac acaagcaaac acaaaacttg
     4861 gcccccttaa attattaaag ctgttcagcc catactctgt atcacatggc agtgcttttt
     4921 gttgcaactg ttgggtcagc ccgggaaacc atggaggata tatggttaat ggggcacagt
     4981 gttccagttt cagaatgatt gtgctaatgg cagttagcta tgctgctgaa taaagtcttg
     5041 tgaagaacgt gcaatgccca tggtctgtgc tggaggagat ttaggttgct ttaagcagat
     5101 gagagcccga ggatcagctg ttccaggact ggagctgcgg actgctgcca gtaacggagt
     5161 tacatattca ttaaacagcc tgggtaggac ctctgcttag caacttttct agctgtgttt
     5221 gaaattttgt atgtatttcc aagtaataaa attatatttg caaaata
//
