LOCUS       NM_015774               4435 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus endoplasmic reticulum oxidoreductase 1 alpha (Ero1a),
            mRNA.
ACCESSION   NM_015774 XM_905202
VERSION     NM_015774.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4435)
  AUTHORS   Germani,S., Van Ho,A.T., Cherubini,A., Varone,E., Chernorudskiy,A.,
            Renna,G.M., Fumagalli,S., Gobbi,M., Lucchetti,J., Bolis,M.,
            Guarrera,L., Craparotta,I., Rastelli,G., Piccoli,G., de Napoli,C.,
            Nogara,L., Poggio,E., Brini,M., Cattaneo,A., Bachi,A., Simmen,T.,
            Cali,T., Quijano-Roy,S., Boncompagni,S., Blaauw,B., Ferreiro,A. and
            Zito,E.
  TITLE     SEPN1-related myopathy depends on the oxidoreductase ERO1A and is
            druggable with the chemical chaperone TUDCA
  JOURNAL   Cell Rep Med 5 (3), 101439 (2024)
   PUBMED   38402623
  REMARK    GeneRIF: SEPN1-related myopathy depends on the oxidoreductase ERO1A
            and is druggable with the chemical chaperone TUDCA.
REFERENCE   2  (bases 1 to 4435)
  AUTHORS   Jha,V., Xiong,B., Kumari,T., Brown,G., Wang,J., Kim,K., Lee,J.,
            Asquith,N., Gallagher,J., Asherman,L., Lambert,T., Bai,Y., Du,X.,
            Min,J.K., Sah,R., Javaheri,A., Razani,B., Lee,J.M., Italiano,J.E.
            and Cho,J.
  TITLE     A Critical Role for ERO1alpha in Arterial Thrombosis and Ischemic
            Stroke
  JOURNAL   Circ Res 132 (11), e206-e222 (2023)
   PUBMED   37132383
  REMARK    GeneRIF: A Critical Role for ERO1alpha in Arterial Thrombosis and
            Ischemic Stroke.
REFERENCE   3  (bases 1 to 4435)
  AUTHORS   Xie,H., Wang,Y.H., Liu,X., Gao,J., Yang,C., Huang,T., Zhang,L.,
            Luo,X., Gao,Z., Wang,T., Yan,T., Liu,Y., Yang,P., Yu,Q., Liu,S.,
            Wang,Y., Xiong,F., Zhang,S., Zhou,Q. and Wang,C.Y.
  TITLE     SUMOylation of ERp44 enhances Ero1alpha ER retention contributing
            to the pathogenesis of obesity and insulin resistance
  JOURNAL   Metabolism 139, 155351 (2023)
   PUBMED   36427672
REFERENCE   4  (bases 1 to 4435)
  AUTHORS   Shen,J., Jiao,Y., Ding,N., Xie,L., Ma,S., Zhang,H., Yang,A.,
            Zhang,H. and Jiang,Y.
  TITLE     Homocysteine facilitates endoplasmic reticulum stress and apoptosis
            of hepatocytes by suppressing ERO1alpha expression via cooperation
            between DNMT1 and G9a
  JOURNAL   Cell Biol Int 46 (8), 1236-1248 (2022)
   PUBMED   35347798
  REMARK    GeneRIF: Homocysteine facilitates endoplasmic reticulum stress and
            apoptosis of hepatocytes by suppressing ERO1alpha expression via
            cooperation between DNMT1 and G9a.
REFERENCE   5  (bases 1 to 4435)
  AUTHORS   Liu,Y., Hu,R., Shen,H., Mo,Q., Wang,X., Zhang,G., Li,S., Liang,G.,
            Hou,N. and Luo,J.
  TITLE     Endophilin A2-mediated alleviation of endoplasmic reticulum
            stress-induced cardiac injury involves the suppression of
            ERO1alpha/IP3R signaling pathway
  JOURNAL   Int J Biol Sci 17 (13), 3672-3688 (2021)
   PUBMED   34512174
  REMARK    GeneRIF: Endophilin A2-mediated alleviation of endoplasmic
            reticulum stress-induced cardiac injury involves the suppression of
            ERO1alpha/IP3R signaling pathway.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4435)
  AUTHORS   May,D., Itin,A., Gal,O., Kalinski,H., Feinstein,E. and Keshet,E.
  TITLE     Ero1-L alpha plays a key role in a HIF-1-mediated pathway to
            improve disulfide bond formation and VEGF secretion under hypoxia:
            implication for cancer
  JOURNAL   Oncogene 24 (6), 1011-1020 (2005)
   PUBMED   15592500
REFERENCE   7  (bases 1 to 4435)
  AUTHORS   Marciniak,S.J., Yun,C.Y., Oyadomari,S., Novoa,I., Zhang,Y.,
            Jungreis,R., Nagata,K., Harding,H.P. and Ron,D.
  TITLE     CHOP induces death by promoting protein synthesis and oxidation in
            the stressed endoplasmic reticulum
  JOURNAL   Genes Dev 18 (24), 3066-3077 (2004)
   PUBMED   15601821
REFERENCE   8  (bases 1 to 4435)
  AUTHORS   Nishimura,M., Yokoi,N., Miki,T., Horikawa,Y., Yoshioka,H.,
            Takeda,J., Ohara,O. and Seino,S.
  TITLE     Construction of a multi-functional cDNA library specific for mouse
            pancreatic islets and its application to microarray
  JOURNAL   DNA Res 11 (5), 315-323 (2004)
   PUBMED   15747579
REFERENCE   9  (bases 1 to 4435)
  AUTHORS   Gess,B., Hofbauer,K.H., Wenger,R.H., Lohaus,C., Meyer,H.E. and
            Kurtz,A.
  TITLE     The cellular oxygen tension regulates expression of the endoplasmic
            oxidoreductase ERO1-Lalpha
  JOURNAL   Eur J Biochem 270 (10), 2228-2235 (2003)
   PUBMED   12752442
  REMARK    GeneRIF: Oxygen regulation of ERO1-Lalpha expression likely
            maintains the transfer rate of oxidizing equivalents to PDI in
            situations of an altered cellular redox state induced by changes in
            the cellular oxygen tension
REFERENCE   10 (bases 1 to 4435)
  AUTHORS   Cabibbo,A., Pagani,M., Fabbri,M., Rocchi,M., Farmery,M.R.,
            Bulleid,N.J. and Sitia,R.
  TITLE     ERO1-L, a human protein that favors disulfide bond formation in the
            endoplasmic reticulum
  JOURNAL   J Biol Chem 275 (7), 4827-4833 (2000)
   PUBMED   10671517
  REMARK    GeneRIF: Describes mouse Ero1-l in addition to the human gene.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC154575.2, AK142595.1,
            AK009667.1, BP753202.1 and CJ215857.1.
            
            On Feb 8, 2011 this sequence version replaced NM_015774.2.
            
            Summary: This gene encodes a member of the endoplasmic reticulum
            oxidoreductin family. The encoded protein is localized to the
            endoplasmic reticulum and promotes the formation of disulfide bonds
            by oxidizing protein disulfide isomerase. This gene may play a role
            in endoplasmic reticulum stress-induced apoptosis and the cellular
            response to hypoxia. [provided by RefSeq, Feb 2011].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK142595.1, BC025102.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139, SAMN01164140
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-10                AC154575.2         35570-35579
            11-2312             AK142595.1         2-2303
            2313-3184           AK009667.1         1538-2409
            3185-3925           AK142595.1         3175-3915
            3926-4416           BP753202.1         16-506              c
            4417-4435           CJ215857.1         386-404
FEATURES             Location/Qualifiers
     source          1..4435
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 22.86 cM"
     gene            1..4435
                     /gene="Ero1a"
                     /gene_synonym="ERO1-L; Ero1l"
                     /note="endoplasmic reticulum oxidoreductase 1 alpha"
                     /db_xref="GeneID:50527"
                     /db_xref="MGI:MGI:1354385"
     exon            1..196
                     /gene="Ero1a"
                     /gene_synonym="ERO1-L; Ero1l"
                     /inference="alignment:Splign:2.1.0"
     CDS             83..1477
                     /gene="Ero1a"
                     /gene_synonym="ERO1-L; Ero1l"
                     /note="endoplasmic reticulum oxidoreductin-1-like protein;
                     endoplasmic reticulum oxidation 1; ERO1-like protein
                     alpha; ERO1-L-alpha; oxidoreductin-1-L-alpha; endoplasmic
                     oxidoreductin-1-like protein; endoplasmic reticulum
                     oxidoreductase alpha"
                     /codon_start=1
                     /product="ERO1-like protein alpha precursor"
                     /protein_id="NP_056589.1"
                     /db_xref="CCDS:CCDS36893.1"
                     /db_xref="GeneID:50527"
                     /db_xref="MGI:MGI:1354385"
                     /translation="MGRAWGLLVGLLGVVWLLRLGHGEERRPETAAQRCFCQVSGYLD
                     DCTCDVETIDKFNNYRLFPRLQKLLESDYFRYYKVNLKKPCPFWNDINQCGRRDCAVK
                     PCHSDEVPDGIKSASYKYSEEANRIEECEQAERLGAVDESLSEETQKAVLQWTKHDDS
                     SDSFCEIDDIQSPDAEYVDLLLNPERYTGYKGPDAWRIWSVIYEENCFKPQTIQRPLA
                     SGRGKSKENTFYNWLEGLCVEKRAFYRLISGLHASINVHLSARYLLQDTWLEKKWGHN
                     VTEFQQRFDGILTEGEGPRRLRNLYFLYLIELRALSKVLPFFERPDFQLFTGNKVQDA
                     ENKALLLEILHEIKSFPLHFDENSFFAGDKNEAHKLKEDFRLHFRNISRIMDCVGCFK
                     CRLWGKLQTQGLGTALKILFSEKLIANMPESGPSYEFQLTRQEIVSLFNAFGRISTSV
                     RELENFRHLLQNVH"
     exon            197..316
                     /gene="Ero1a"
                     /gene_synonym="ERO1-L; Ero1l"
                     /inference="alignment:Splign:2.1.0"
     exon            317..400
                     /gene="Ero1a"
                     /gene_synonym="ERO1-L; Ero1l"
                     /inference="alignment:Splign:2.1.0"
     exon            401..439
                     /gene="Ero1a"
                     /gene_synonym="ERO1-L; Ero1l"
                     /inference="alignment:Splign:2.1.0"
     exon            440..513
                     /gene="Ero1a"
                     /gene_synonym="ERO1-L; Ero1l"
                     /inference="alignment:Splign:2.1.0"
     exon            514..587
                     /gene="Ero1a"
                     /gene_synonym="ERO1-L; Ero1l"
                     /inference="alignment:Splign:2.1.0"
     exon            588..708
                     /gene="Ero1a"
                     /gene_synonym="ERO1-L; Ero1l"
                     /inference="alignment:Splign:2.1.0"
     exon            709..746
                     /gene="Ero1a"
                     /gene_synonym="ERO1-L; Ero1l"
                     /inference="alignment:Splign:2.1.0"
     exon            747..758
                     /gene="Ero1a"
                     /gene_synonym="ERO1-L; Ero1l"
                     /inference="alignment:Splign:2.1.0"
     exon            759..785
                     /gene="Ero1a"
                     /gene_synonym="ERO1-L; Ero1l"
                     /inference="alignment:Splign:2.1.0"
     exon            786..878
                     /gene="Ero1a"
                     /gene_synonym="ERO1-L; Ero1l"
                     /inference="alignment:Splign:2.1.0"
     exon            879..1125
                     /gene="Ero1a"
                     /gene_synonym="ERO1-L; Ero1l"
                     /inference="alignment:Splign:2.1.0"
     exon            1126..1195
                     /gene="Ero1a"
                     /gene_synonym="ERO1-L; Ero1l"
                     /inference="alignment:Splign:2.1.0"
     exon            1196..1282
                     /gene="Ero1a"
                     /gene_synonym="ERO1-L; Ero1l"
                     /inference="alignment:Splign:2.1.0"
     exon            1283..1416
                     /gene="Ero1a"
                     /gene_synonym="ERO1-L; Ero1l"
                     /inference="alignment:Splign:2.1.0"
     exon            1417..4418
                     /gene="Ero1a"
                     /gene_synonym="ERO1-L; Ero1l"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1619..1624
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ero1a"
                     /gene_synonym="ERO1-L; Ero1l"
                     /note="hexamer: AGTAAA"
     polyA_site      1639
                     /gene="Ero1a"
                     /gene_synonym="ERO1-L; Ero1l"
                     /note="major polyA site"
     regulatory      4287..4292
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ero1a"
                     /gene_synonym="ERO1-L; Ero1l"
                     /note="hexamer: AATAAA"
     polyA_site      4322
                     /gene="Ero1a"
                     /gene_synonym="ERO1-L; Ero1l"
     regulatory      4394..4399
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ero1a"
                     /gene_synonym="ERO1-L; Ero1l"
                     /note="hexamer: AATAAA"
     polyA_site      4416
                     /gene="Ero1a"
                     /gene_synonym="ERO1-L; Ero1l"
                     /note="major polyA site"
ORIGIN      
        1 aggctacttc agcgggcgcg cggcctgcgc cggggagcca agcacggcgg cgcgggtaga
       61 gggcggtggg cggcgagcgg cgatgggccg cgcctggggc ttgctcgttg gactcctggg
      121 cgtcgtgtgg ctgctgcgct tgggccacgg cgaggagcgg cggccggaga cagcggcaca
      181 gcgctgcttc tgccaggtta gtggttacct ggacgactgt acctgtgatg tcgagaccat
      241 cgataagttt aataactaca gacttttccc aagactacaa aagcttcttg aaagtgacta
      301 ctttagatat tacaaggtga acttgaagaa gccttgtcct ttctggaatg acatcaacca
      361 gtgtggaaga agagactgtg ccgtcaaacc ctgccattct gatgaagttc ctgatggaat
      421 taagtctgcg agctacaagt attctgagga agccaaccgc attgaagaat gtgagcaagc
      481 tgagcgactt ggagccgtgg atgagtctct gagtgaggag acccagaaag ctgtacttca
      541 gtggaccaag catgatgatt cgtcagacag cttctgcgaa attgacgata tacagtcccc
      601 cgatgctgag tatgtggact tactccttaa ccctgagcgc tacacaggct acaaggggcc
      661 agacgcttgg aggatatgga gtgtcatcta tgaagaaaac tgttttaagc cacagacaat
      721 tcaaaggcct ttggcttctg ggcgaggaaa aagtaaagag aacacatttt acaactggct
      781 agaaggcctc tgtgtagaaa agagagcatt ctacagactt atatctggcc tgcacgcaag
      841 cattaatgtg catttgagtg caaggtatct tttacaagat acttggctgg aaaagaaatg
      901 gggtcacaat gtcacagagt tccagcagcg ctttgatggg attctgactg aaggagaagg
      961 cccacgaagg ctgaggaact tgtacttcct gtacctgata gagttaaggg ctctctccaa
     1021 agtgcttcca ttttttgagc gtccagattt tcagctcttc actgggaata aagttcagga
     1081 tgcagaaaac aaagcgttac ttctggagat acttcatgaa atcaagtcat ttcctttgca
     1141 cttcgatgag aattcttttt ttgctgggga taaaaacgaa gcacataaac taaaggagga
     1201 cttccggcta cactttagga acatttcaag aatcatggac tgtgttggct gcttcaagtg
     1261 ccgcctgtgg ggcaagcttc agacgcaggg gctgggcact gctctgaaga tcttgttttc
     1321 cgaaaaactg atcgcaaata tgccggaaag cggaccaagt tatgagttcc agctaaccag
     1381 acaagaaata gtatcactgt ttaatgcatt tggaaggatt tccacaagtg tgagagaact
     1441 agagaacttc aggcacttgt tacagaatgt tcactgagga ggacggttgg aatgtgcctg
     1501 tttctgcaca ggggaatctg aagggcagaa tctctctgag caccatggtt gcaatgactg
     1561 tcctaagcca aacgtttata taaagctgct tttgtaaaag aagagataca ttgtcttaag
     1621 taaatgacat ttttaaaaat tgtgttcatg tttaatatta ttgtgaatag aagtagtatt
     1681 ttgataatat acaaatttta atactaagca aaagtaaggt cattaaactc ccttatgata
     1741 aagctaggta aatattgcct taggctctca aactagagtt gaatttaaga aggtaatgaa
     1801 agctaagcta aggtacctgt gacaagtgtt tggtaataaa atactaagag gctcagcagt
     1861 aaaccatggt tatcagcctc agataccaat gctttttcat ttgcctcata tacaaagaaa
     1921 atacagactg cccagttaga tttaagtttt agaaaagcaa ccagttttcc tttcaatgtt
     1981 aagtgtgttg aagtttatta gggcctattt atactacaag ttatttgctc gaagttcaag
     2041 tttaactggg agccctgtgt tttcctggca accttaaaat acactggtat gaaacattcc
     2101 ttttagagtt aaatagctat tttgattgtg ctgttttggt atgttgggaa gtagaacaat
     2161 tcaaaggcac aggagatttc taaacatcgt agaaagataa atagattata tatttattct
     2221 cataatagtt tccctaatgg aattttgggg aaaattttat ttttatataa tttcatattt
     2281 acagaaaagt ttcaaaaaca gttaaaaaaa aaaccaaact ggttttactc agattcatgg
     2341 attgttcaca tgtgttttaa cccctcaccc cagctcagag tggcgattga gcccaggacc
     2401 tcagtcatgc tgggctagcc ctgcattcat gagctgtgtc ctcaggcctt gcttaagctc
     2461 ctacatagac atagacaccc tgtttttatt taagggtttg agtcatgggc ctcatgattt
     2521 aacccaaaat acttcagtgt ggtggtcaat aatttcctaa aaactatttt ttgttttctt
     2581 tttaaaggaa tatccaaacc ttacaaatct gagctgaact acttactata agccttaaaa
     2641 taaggagaca tcccacatcc cagccacctg acgtttgaat ttggttgcct ttttcgacct
     2701 gtgtagtcac aggctataca actcatgttt ttacgcatga aactctgttt ttctccacag
     2761 gatggagctg taacgtagat aggatgggtt gttagtagaa gctctacact gagagcagta
     2821 tttgatgtgg cttaagaatt tacatcacat ggcaattata aatggcatat acctcaaaat
     2881 tatgccccct tgaggtcaca tctaatgtct tgagcagtta ggactggttg agatgtcaca
     2941 taagaaaaag caggacttac gtatgtaatg gctaggaatg tcactttaca ctgttgtgta
     3001 ttttctctgt ccctaagact tggtctagtg ccaggcatac agttggtgtc taatatttat
     3061 tgatggaaag tatatgtatt tagtatacgt taagtgatgg tgatgtagct tgtttagtaa
     3121 tgtatcctat ttccccctcc ctctcacttt ttcttttgga tctcataata aaagacatca
     3181 acccactaat taggtcagtt ttcttgggga cttaaaagaa ctaaatgatc accacacaca
     3241 agccagccct tttgaaaccc tcactgcttt cacgtgcttt tcccacttga ttggctatgt
     3301 cctctgtccc tccaagtgaa gtctaatacc taattctaag tttatagtta acaagcagtt
     3361 taatttttaa gaaatcttaa cttttcctgt acatgacaca attgacaatc cctattcctt
     3421 tgtgtccttg tgtttggatt actcctgggt atctttcttc tggtctcttc atttaaccta
     3481 agtatcattc ctcagacttt ttgctcttaa gtcactggac cgtacttttg agtaatttca
     3541 atgcagtaat ctcattttag cttctcagtc tgtctctctg ctgtgctcac ttggctgcct
     3601 gttgtcgctt ctgcatcttc aaggactcag tcaccacaaa cctactctat gtttgtgttc
     3661 cttacttggt taatttcaga gccgttgcac cgttcaaggc tttacagttc attcctgtat
     3721 cgtccacctg actattggtg tcttaagctc tgccgatttt ctctcaacat ttctatcagt
     3781 gtttttcagt ttttattacg atcaccaaag gattacctgt cttttcccat ctctctgttg
     3841 gctcctatca ccagattggg ctttctagaa accttcagcc taattcctgc tggcaagttt
     3901 catgagcttt ttggtgagag tctctgcttg atatccaaga ccctcctctt gtgtttgcca
     3961 ctgttctgat aagagtgtta aaacgttttc caaaagtcca gagttgttgg ccttccaaac
     4021 ctttgcaaac acagtatttg cattgagagc cctaggcttc tttctcatct gggaaattcc
     4081 atgcattttt gaaatctgtg aaattacccc tgtccccttc ctatggtcac cactgtaact
     4141 gcaacctacc tctactgaat cacttattgt actgtatatt ttattttatg aagtgtcctt
     4201 tattagaatg tgagctcctt aggggcagga aaagaaacta ttcattttgg cacctctata
     4261 gcataatgtt tggcacatga gcatttaata aatgtttgtt gaataaattg cttcacatga
     4321 cagctgttct gactgcaggt accttcactg cctttgctgc acagtgagga tcagtagact
     4381 gggcgtgggg ggcaataaag atgaaaataa ttgaaataaa aaaaaaaaaa aaaaa
//
