LOCUS       NM_012016               2988 bp    mRNA    linear   ROD 07-FEB-2025
DEFINITION  Mus musculus endoplasmic reticulum to nucleus signalling 2 (Ern2),
            transcript variant 1, mRNA.
ACCESSION   NM_012016
VERSION     NM_012016.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2988)
  AUTHORS   Zhao,L., Wang,L., Wang,H., Xi,T., Liu,S., Li,Y., Ruan,J. and
            Huang,Y.
  TITLE     Endoplasmic reticulum chaperone GRP78 participates in
            fluoride-induced autophagy in LS8 cells by regulating the
            IRE1-TRAF2-JNK pathway
  JOURNAL   Environ Toxicol 38 (7), 1756-1767 (2023)
   PUBMED   37070943
  REMARK    GeneRIF: Endoplasmic reticulum chaperone GRP78 participates in
            fluoride-induced autophagy in LS8 cells by regulating the
            IRE1-TRAF2-JNK pathway.
            Erratum:[Environ Toxicol. 2025 Jan;40(1):152-153. doi:
            10.1002/tox.24402.. PMID: 39189740]
REFERENCE   2  (bases 1 to 2988)
  AUTHORS   Li,Z., Xu,T., Peng,L., Tang,X., Chi,Q., Li,M. and Li,S.
  TITLE     Polystyrene nanoplastics aggravates lipopolysaccharide-induced
            apoptosis in mouse kidney cells by regulating IRE1/XBP1 endoplasmic
            reticulum stress pathway via oxidative stress
  JOURNAL   J Cell Physiol 238 (1), 151-164 (2023)
   PUBMED   36370432
  REMARK    GeneRIF: Polystyrene nanoplastics aggravates
            lipopolysaccharide-induced apoptosis in mouse kidney cells by
            regulating IRE1/XBP1 endoplasmic reticulum stress pathway via
            oxidative stress.
REFERENCE   3  (bases 1 to 2988)
  AUTHORS   Katzen,J., Rodriguez,L., Tomer,Y., Babu,A., Zhao,M., Murthy,A.,
            Carson,P., Barrett,M., Basil,M.C., Carl,J., Leach,J.P., Morley,M.,
            McGraw,M.D., Mulugeta,S., Pelura,T., Rosen,G., Morrisey,E.E. and
            Beers,M.F.
  TITLE     Disruption of proteostasis causes IRE1 mediated reprogramming of
            alveolar epithelial cells
  JOURNAL   Proc Natl Acad Sci U S A 119 (43), e2123187119 (2022)
   PUBMED   36252035
  REMARK    GeneRIF: Disruption of proteostasis causes IRE1 mediated
            reprogramming of alveolar epithelial cells.
REFERENCE   4  (bases 1 to 2988)
  AUTHORS   Grey,M.J., De Luca,H., Ward,D.V., Kreulen,I.A., Bugda Gwilt,K.,
            Foley,S.E., Thiagarajah,J.R., McCormick,B.A., Turner,J.R. and
            Lencer,W.I.
  TITLE     The epithelial-specific ER stress sensor ERN2/IRE1beta enables
            host-microbiota crosstalk to affect colon goblet cell development
  JOURNAL   J Clin Invest 132 (17), e153519 (2022)
   PUBMED   35727638
  REMARK    GeneRIF: The epithelial-specific ER stress sensor ERN2/IRE1beta
            enables host-microbiota crosstalk to affect colon goblet cell
            development.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2988)
  AUTHORS   Liang,Y., Qu,L., Liu,Z., Liang,L., Wang,Y., Quan,S., Wang,Y. and
            Tang,L.
  TITLE     The IRE1/JNK signaling pathway regulates inflammation cytokines and
            production of glomerular extracellular matrix in the acute kidney
            injury to chronic kidney disease transition
  JOURNAL   Mol Biol Rep 49 (8), 7709-7718 (2022)
   PUBMED   35696049
  REMARK    GeneRIF: The IRE1/JNK signaling pathway regulates inflammation
            cytokines and production of glomerular extracellular matrix in the
            acute kidney injury to chronic kidney disease transition.
REFERENCE   6  (bases 1 to 2988)
  AUTHORS   Lee,K., Tirasophon,W., Shen,X., Michalak,M., Prywes,R., Okada,T.,
            Yoshida,H., Mori,K. and Kaufman,R.J.
  TITLE     IRE1-mediated unconventional mRNA splicing and S2P-mediated ATF6
            cleavage merge to regulate XBP1 in signaling the unfolded protein
            response
  JOURNAL   Genes Dev 16 (4), 452-466 (2002)
   PUBMED   11850408
  REMARK    GeneRIF: IRE1-mediated unconventional mRNA splicing is involved in
            regulating XBP1 in signaling the unfolded protein response.
REFERENCE   7  (bases 1 to 2988)
  AUTHORS   Bertolotti,A., Wang,X., Novoa,I., Jungreis,R., Schlessinger,K.,
            Cho,J.H., West,A.B. and Ron,D.
  TITLE     Increased sensitivity to dextran sodium sulfate colitis in
            IRE1beta-deficient mice
  JOURNAL   J Clin Invest 107 (5), 585-593 (2001)
   PUBMED   11238559
REFERENCE   8  (bases 1 to 2988)
  AUTHORS   Iwawaki,T., Hosoda,A., Okuda,T., Kamigori,Y., Nomura-Furuwatari,C.,
            Kimata,Y., Tsuru,A. and Kohno,K.
  TITLE     Translational control by the ER transmembrane kinase/ribonuclease
            IRE1 under ER stress
  JOURNAL   Nat Cell Biol 3 (2), 158-164 (2001)
   PUBMED   11175748
REFERENCE   9  (bases 1 to 2988)
  AUTHORS   Urano,F., Wang,X., Bertolotti,A., Zhang,Y., Chung,P., Harding,H.P.
            and Ron,D.
  TITLE     Coupling of stress in the ER to activation of JNK protein kinases
            by transmembrane protein kinase IRE1
  JOURNAL   Science 287 (5453), 664-666 (2000)
   PUBMED   10650002
REFERENCE   10 (bases 1 to 2988)
  AUTHORS   Wang,X.Z., Harding,H.P., Zhang,Y., Jolicoeur,E.M., Kuroda,M. and
            Ron,D.
  TITLE     Cloning of mammalian Ire1 reveals diversity in the ER stress
            responses
  JOURNAL   EMBO J 17 (19), 5708-5717 (1998)
   PUBMED   9755171
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY098554.1, AK153659.1 and AK139291.1.
            
            On Oct 22, 2015 this sequence version replaced NM_012016.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK153659.1, AF071777.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849375,
                                           SAMN00849376 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-27                BY098554.1         1-27
            28-2924             AK153659.1         3-2899
            2925-2988           AK139291.1         2895-2958
FEATURES             Location/Qualifiers
     source          1..2988
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 65.53 cM"
     gene            1..2988
                     /gene="Ern2"
                     /gene_synonym="Ern1; Ire1; ire1-beta; Ire1b; mIre1"
                     /note="endoplasmic reticulum to nucleus signalling 2"
                     /db_xref="GeneID:26918"
                     /db_xref="MGI:MGI:1349436"
     exon            1..169
                     /gene="Ern2"
                     /gene_synonym="Ern1; Ire1; ire1-beta; Ire1b; mIre1"
                     /inference="alignment:Splign:2.1.0"
     CDS             80..2815
                     /gene="Ern2"
                     /gene_synonym="Ern1; Ire1; ire1-beta; Ire1b; mIre1"
                     /EC_number="2.7.11.1"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; serine/threonine-protein
                     kinase/endoribonuclease IRE2; inositol-requiring protein
                     2; endoplasmic reticulum-to-nucleus signaling 2;
                     inositol-requiring 1 (Yeast homologue); inositol-requiring
                     1 beta; endoplasmic reticulum (ER) to nucleus signalling
                     2"
                     /codon_start=1
                     /product="serine/threonine-protein kinase/endoribonuclease
                     IRE2 isoform 1 precursor"
                     /protein_id="NP_036146.2"
                     /db_xref="CCDS:CCDS21813.1"
                     /db_xref="GeneID:26918"
                     /db_xref="MGI:MGI:1349436"
                     /translation="MARPVQRFQLWSPLGFLLQLVTLLGKLGPQVQSVRPESLLFVST
                     LDGSLHALNKQTGDLKWTVKDDPIIQGPMYVTEMAFLSDPADGSLYVLGTQKQQGLMK
                     LPFTIPELVHASPCRSSDGVFYTGRKQDAWFVVDPESGETQMTLTTEGLSTPQLFIGR
                     TQYTVSMHDLRTPALRWNTTYRRYSAPLLNGSPGKYMSHLTSCGMGLLLTVDPGSGIV
                     LWTQDLGVPVTGIYTWHQDGLHQLPHLTLARDTLHFLVLRWGHIRLPASSYQDTATQF
                     SSLDTQLLMTLYVGKEEAGFYVSKALVHAGVALVPRGLTLAPMDGPTTDEVTLQVSGE
                     REGSPSTAVRYPSGSVALPSQWLLIGYHEPPPVLHTTMLRVHPIPGKVSAETRASEDL
                     HAPPVFFELLNLRREDPELHPEEKASDSYPGLGSQDLLAATFTAILLGAWVLYLMRQQ
                     QQSPSAPAGPPDLSQDAQGQLSRDILQDQRRFQSPSEPAQPPHDPEAGQPTVVGKISF
                     NPKDVLGRGAGGTFVFRGQFEGRAVAVKRLLRECFGLVRREVQLLQESDRHPNVLRYF
                     CTEHGPQFHYIALELCQASLQEYVESPDLDRWGLEPTTVLQQMMSGLAHLHSLHIVHR
                     DLKPANILMAGPDSQGQGRVVISDFGLCKKLPVGRCSFSLHSGIPGTEGWMAPELLQL
                     PPDSPTSAVDIFSAGCVFYYVLSGGSHPFGESLYRQANILSGDPCLAQLQEETHDKVV
                     ALDLVRAMLSLLPQDRPSAGWVLAHPLFWSRAKELQFFQDVSDWLEKEPDQGPLVSAL
                     EAGSYKVVREDWHKHISAPLQADLKRFRSYKGTSVRDLLRAMRNKKHHYRELPAEVRQ
                     TLGQLPAGFIQYFTQRFPRLLLHTHRAMRTCASESLFLPYYPPALEARRPDATKS"
     exon            170..275
                     /gene="Ern2"
                     /gene_synonym="Ern1; Ire1; ire1-beta; Ire1b; mIre1"
                     /inference="alignment:Splign:2.1.0"
     exon            276..309
                     /gene="Ern2"
                     /gene_synonym="Ern1; Ire1; ire1-beta; Ire1b; mIre1"
                     /inference="alignment:Splign:2.1.0"
     exon            310..382
                     /gene="Ern2"
                     /gene_synonym="Ern1; Ire1; ire1-beta; Ire1b; mIre1"
                     /inference="alignment:Splign:2.1.0"
     exon            383..455
                     /gene="Ern2"
                     /gene_synonym="Ern1; Ire1; ire1-beta; Ire1b; mIre1"
                     /inference="alignment:Splign:2.1.0"
     exon            456..563
                     /gene="Ern2"
                     /gene_synonym="Ern1; Ire1; ire1-beta; Ire1b; mIre1"
                     /inference="alignment:Splign:2.1.0"
     exon            564..665
                     /gene="Ern2"
                     /gene_synonym="Ern1; Ire1; ire1-beta; Ire1b; mIre1"
                     /inference="alignment:Splign:2.1.0"
     exon            666..930
                     /gene="Ern2"
                     /gene_synonym="Ern1; Ire1; ire1-beta; Ire1b; mIre1"
                     /inference="alignment:Splign:2.1.0"
     exon            931..1009
                     /gene="Ern2"
                     /gene_synonym="Ern1; Ire1; ire1-beta; Ire1b; mIre1"
                     /inference="alignment:Splign:2.1.0"
     exon            1010..1157
                     /gene="Ern2"
                     /gene_synonym="Ern1; Ire1; ire1-beta; Ire1b; mIre1"
                     /inference="alignment:Splign:2.1.0"
     exon            1158..1279
                     /gene="Ern2"
                     /gene_synonym="Ern1; Ire1; ire1-beta; Ire1b; mIre1"
                     /inference="alignment:Splign:2.1.0"
     exon            1280..1426
                     /gene="Ern2"
                     /gene_synonym="Ern1; Ire1; ire1-beta; Ire1b; mIre1"
                     /inference="alignment:Splign:2.1.0"
     exon            1427..1568
                     /gene="Ern2"
                     /gene_synonym="Ern1; Ire1; ire1-beta; Ire1b; mIre1"
                     /inference="alignment:Splign:2.1.0"
     exon            1569..1653
                     /gene="Ern2"
                     /gene_synonym="Ern1; Ire1; ire1-beta; Ire1b; mIre1"
                     /inference="alignment:Splign:2.1.0"
     exon            1654..1843
                     /gene="Ern2"
                     /gene_synonym="Ern1; Ire1; ire1-beta; Ire1b; mIre1"
                     /inference="alignment:Splign:2.1.0"
     exon            1844..1943
                     /gene="Ern2"
                     /gene_synonym="Ern1; Ire1; ire1-beta; Ire1b; mIre1"
                     /inference="alignment:Splign:2.1.0"
     exon            1944..2140
                     /gene="Ern2"
                     /gene_synonym="Ern1; Ire1; ire1-beta; Ire1b; mIre1"
                     /inference="alignment:Splign:2.1.0"
     exon            2141..2288
                     /gene="Ern2"
                     /gene_synonym="Ern1; Ire1; ire1-beta; Ire1b; mIre1"
                     /inference="alignment:Splign:2.1.0"
     exon            2289..2416
                     /gene="Ern2"
                     /gene_synonym="Ern1; Ire1; ire1-beta; Ire1b; mIre1"
                     /inference="alignment:Splign:2.1.0"
     exon            2417..2540
                     /gene="Ern2"
                     /gene_synonym="Ern1; Ire1; ire1-beta; Ire1b; mIre1"
                     /inference="alignment:Splign:2.1.0"
     exon            2541..2608
                     /gene="Ern2"
                     /gene_synonym="Ern1; Ire1; ire1-beta; Ire1b; mIre1"
                     /inference="alignment:Splign:2.1.0"
     exon            2609..2988
                     /gene="Ern2"
                     /gene_synonym="Ern1; Ire1; ire1-beta; Ire1b; mIre1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggagtctccc gtggagagag ctccgctatt gcctgaggca ctgagggagc tggatggaga
       61 ctttgtggtt gcccagacta tggcgagacc agtccagaga tttcaactgt ggtctcctct
      121 cgggttcctg ctgcagcttg tgacgttgct ggggaaactc ggtccacagg tccagtctgt
      181 caggccagag agccttctgt ttgtgtctac cttggacgga agtctccatg cactgaacaa
      241 gcagacaggg gacttgaagt ggacagtgaa ggatgacccc atcatccagg gcccaatgta
      301 tgtcacagaa atggcctttc tctctgaccc agctgacggc agcctgtatg tcttgggaac
      361 ccagaaacaa caggggctga tgaaactgcc attcaccatc ccagagctgg ttcatgcctc
      421 tccctgtcgc agctctgatg gtgtcttcta cacaggccgg aagcaggatg cctggtttgt
      481 agtggaccct gagtcagggg agactcagat gacactgacc acagaaggcc tctctactcc
      541 tcaacttttc attggccgaa cacagtacac agtctccatg catgacctac ggaccccagc
      601 cctgcggtgg aacacaacct atcgccgcta ctcagcaccc ctcctgaatg gctcacccgg
      661 gaaatacatg agccacctga catcctgtgg gatgggcctg cttctcactg tggatccagg
      721 aagtggaatt gtgctgtgga cacaggacct gggagtgcct gtgacaggga tttacacatg
      781 gcaccaggat ggtctgcacc agctgcccca tctcacactg gctcgggaca ccctacattt
      841 ccttgtcctc cgctggggcc acatccgtct tcctgcctcc agctaccaag acacagccac
      901 ccagttctct tccttagaca cccagctttt gatgacactg tatgtgggga aagaagaagc
      961 tgggttctat gtctctaaag cactggtcca cgctggggtg gccctcgtgc cccgtggact
     1021 gaccctggca cccatggacg gtcccacaac agatgaggtg acacttcaag tctcggggga
     1081 gcgagagggc tcacccagca ctgctgtcag atacccctca ggcagcgtgg ccctccccag
     1141 ccagtggcta ctcattggat accacgaacc tccccccgtt ctacacacaa ccatgctgcg
     1201 ggttcatccc atcccaggga aagtgtctgc tgagacacga gcctcagagg acctccatgc
     1261 tccacctgtc ttttttgagc tcctaaacct gaggagggag gatccagaac tacatcctga
     1321 agagaaagct tcagactctt atccagggct gggatcccaa gacctgctag cagctacctt
     1381 cactgccatc ctcctgggag cctgggtcct ctacctgatg aggcagcagc agcagagccc
     1441 ttcagcacct gctggccctc ctgacctctc acaggatgct cagggacagc tctcaaggga
     1501 catcttacag gaccagagga gatttcaaag cccctcagag ccagcccagc cacctcatga
     1561 ccctgaagca gggcagccca ccgtggtggg gaagatttcc ttcaacccca aggatgtgct
     1621 gggccgtggg gcaggaggga cttttgtttt ccgaggacag tttgaggggc gggcagtagc
     1681 tgtgaagagg ctcctccgag agtgctttgg cttggttcgg cgagaggtgc agctgctgca
     1741 agagtctgac cggcacccca acgtgcttcg ctacttctgc actgagcatg gtccccagtt
     1801 ccactacatt gccttggagc tctgccaggc ctccttgcaa gagtacgtgg agagcccaga
     1861 cctagatcgc tggggcctgg agcccaccac agtgctgcag cagatgatgt ccggcctggc
     1921 ccatctacat tccttacaca tagtacaccg tgacctaaag ccagccaaca ttctcatggc
     1981 tgggcctgac agccagggcc aaggcagagt ggtcatctct gacttcggcc tctgcaagaa
     2041 gctacctgtt ggccgttgta gcttcagtct ccattctggt attcccggca cagaaggctg
     2101 gatggcacca gagctcctgc agctcccccc agacagcccg accagcgctg tggatatctt
     2161 ctccgcaggc tgcgtatttt attacgtgct ttccggtggc agccacccct ttggagagag
     2221 tctctaccga caggccaaca tcctctcagg ggatccctgt ctggctcagc tgcaggaaga
     2281 gacccatgac aaggttgtgg cattggactt agtgagagcc atgctgagct tgctgcccca
     2341 ggatcgcccc tcggcaggat gggtactggc tcaccccctc ttttggagca gagctaagga
     2401 gctccagttc ttccaggatg tcagtgactg gttggagaag gaaccagatc aggggcctct
     2461 cgtgtcggcg ctggaggcag gaagctacaa ggtggtccgg gaagactggc acaagcacat
     2521 ctcagcccct ctgcaggcag atctgaaaag gttccgctca tacaaaggga catcagttcg
     2581 agacctgctc cgggccatga ggaacaagaa gcaccactac agggagctcc cagctgaggt
     2641 gcgccagaca ctaggccaac ttcctgctgg cttcattcag tacttcacac agcgattccc
     2701 caggctgttg ctgcacactc accgtgccat gaggacctgc gcctctgaga gcctcttcct
     2761 gccctactac ccaccagctc tggaagccag gaggccagat gccacaaaga gctgagacat
     2821 ccagagggtc caaaggagga ccaaggagtt gagcctgtgg ctcagtctag tctcaggcgt
     2881 gacagaaaag atgggcagcg gtctaaggga ctcaggctgt taatgcaaaa aaaaaaaaaa
     2941 aaaaccaaaa acctctgggg gcaggggact cttaagaaat acaagacc
//
