LOCUS       NM_023913               3976 bp    mRNA    linear   ROD 07-FEB-2025
DEFINITION  Mus musculus endoplasmic reticulum to nucleus signalling 1 (Ern1),
            mRNA.
ACCESSION   NM_023913
VERSION     NM_023913.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3976)
  AUTHORS   Jin,H., Yeom,J.H., Shin,E., Ha,Y., Liu,H., Kim,D., Joo,M.,
            Kim,Y.H., Kim,H.K., Ryu,M., Kim,H.M., Kim,J., Kim,K.P., Hahn,Y.,
            Bae,J. and Lee,K.
  TITLE     5'-tRNAGly(GCC) halves generated by IRE1alpha are linked to the ER
            stress response
  JOURNAL   Nat Commun 15 (1), 9273 (2024)
   PUBMED   39468069
  REMARK    GeneRIF: 5'-tRNA[Gly(GCC)] halves generated by IRE1alpha are linked
            to the ER stress response.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3976)
  AUTHORS   Xu,L., Tan,C., Barr,J., Talaba,N., Verheyden,J., Chin,J.S.,
            Gaboyan,S., Kasaraneni,N., Elgamal,R.M., Gaulton,K.J., Lin,G.,
            Afshar,K., Golts,E., Meier,A., Crotty Alexander,L.E., Borok,Z.,
            Shen,Y., Chung,W.K., McCulley,D.J. and Sun,X.
  TITLE     Context-dependent roles of mitochondrial LONP1 in orchestrating the
            balance between airway progenitor versus progeny cells
  JOURNAL   Cell Stem Cell 31 (10), 1465-1483 (2024)
   PUBMED   39181129
REFERENCE   3  (bases 1 to 3976)
  AUTHORS   Choi,H.J., Wu,Y., McDaniel Mims,B., Pugel,A., Tang,C.A., Tian,L.,
            Hu,C.A. and Yu,X.Z.
  TITLE     Endoplasmic Reticulum Stress Response Mediator IRE-1alpha Promotes
            Host Dendritic Cells in Graft-versus-Host Disease Development
  JOURNAL   J Immunol 213 (3), 384-393 (2024)
   PUBMED   38864663
  REMARK    GeneRIF: Endoplasmic Reticulum Stress Response Mediator IRE-1alpha
            Promotes Host Dendritic Cells in Graft-versus-Host Disease
            Development.
REFERENCE   4  (bases 1 to 3976)
  AUTHORS   Joshi,A.S., Tomaz da Silva,M., Roy,A., Koike,T.E., Wu,M.,
            Castillo,M.B., Gunaratne,P.H., Liu,Y., Iwawaki,T. and Kumar,A.
  TITLE     The IRE1alpha/XBP1 signaling axis drives myoblast fusion in adult
            skeletal muscle
  JOURNAL   EMBO Rep 25 (8), 3627-3650 (2024)
   PUBMED   38982191
REFERENCE   5  (bases 1 to 3976)
  AUTHORS   Borisova,E., Newman,A.G., Couce Iglesias,M., Dannenberg,R.,
            Schaub,T., Qin,B., Rusanova,A., Brockmann,M., Koch,J., Daniels,M.,
            Turko,P., Jahn,O., Kaplan,D.R., Rosario,M., Iwawaki,T.,
            Spahn,C.M.T., Rosenmund,C., Meierhofer,D., Kraushar,M.L.,
            Tarabykin,V. and Ambrozkiewicz,M.C.
  TITLE     Protein translation rate determines neocortical neuron fate
  JOURNAL   Nat Commun 15 (1), 4879 (2024)
   PUBMED   38849354
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3976)
  AUTHORS   Miyoshi,K., Katayama,T., Imaizumi,K., Taniguchi,M., Mori,Y.,
            Hitomi,J., Yui,D., Manabe,T., Gomi,F., Yoneda,T. and Tohyama,M.
  TITLE     Characterization of mouse Ire1 alpha: cloning, mRNA localization in
            the brain and functional analysis in a neural cell line
  JOURNAL   Brain Res Mol Brain Res 85 (1-2), 68-76 (2000)
   PUBMED   11146108
REFERENCE   7  (bases 1 to 3976)
  AUTHORS   Harding,H.P., Zhang,Y., Bertolotti,A., Zeng,H. and Ron,D.
  TITLE     Perk is essential for translational regulation and cell survival
            during the unfolded protein response
  JOURNAL   Mol Cell 5 (5), 897-904 (2000)
   PUBMED   10882126
REFERENCE   8  (bases 1 to 3976)
  AUTHORS   Urano,F., Wang,X., Bertolotti,A., Zhang,Y., Chung,P., Harding,H.P.
            and Ron,D.
  TITLE     Coupling of stress in the ER to activation of JNK protein kinases
            by transmembrane protein kinase IRE1
  JOURNAL   Science 287 (5453), 664-666 (2000)
   PUBMED   10650002
REFERENCE   9  (bases 1 to 3976)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
REFERENCE   10 (bases 1 to 3976)
  AUTHORS   Wang,X.Z., Harding,H.P., Zhang,Y., Jolicoeur,E.M., Kuroda,M. and
            Ron,D.
  TITLE     Cloning of mammalian Ire1 reveals diversity in the ER stress
            responses
  JOURNAL   EMBO J 17 (19), 5708-5717 (1998)
   PUBMED   9755171
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AB031332.1.
            
            On Aug 24, 2001 this sequence version replaced NM_023913.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB031332.1, SRR10223970.14812.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3976
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 69.14 cM"
     gene            1..3976
                     /gene="Ern1"
                     /gene_synonym="9030414B18Rik; Ire1a; Ire1alpha; Ire1p"
                     /note="endoplasmic reticulum to nucleus signalling 1"
                     /db_xref="GeneID:78943"
                     /db_xref="MGI:MGI:1930134"
     exon            1..180
                     /gene="Ern1"
                     /gene_synonym="9030414B18Rik; Ire1a; Ire1alpha; Ire1p"
                     /inference="alignment:Splign:2.1.0"
     CDS             121..3054
                     /gene="Ern1"
                     /gene_synonym="9030414B18Rik; Ire1a; Ire1alpha; Ire1p"
                     /EC_number="2.7.11.1"
                     /note="serine/threonine-protein kinase/endoribonuclease
                     IRE1; ire1-alpha; inositol-requiring protein 1;
                     endoplasmic reticulum-to-nucleus signaling 1;
                     inositol-requiring 1 alpha; endoplasmic reticulum (ER) to
                     nucleus signalling 1"
                     /codon_start=1
                     /product="serine/threonine-protein kinase/endoribonuclease
                     IRE1 precursor"
                     /protein_id="NP_076402.1"
                     /db_xref="CCDS:CCDS25556.1"
                     /db_xref="GeneID:78943"
                     /db_xref="MGI:MGI:1930134"
                     /translation="MPARWLLLLLALLLPPPGPGSFGRTSTVTLPETLLFVSTLDGSL
                     HAVSKRTGSIKWTLKEDPVLQVPTHVEEPAFLPDPNDGSLYTLGGKNNEGLTKLPFTI
                     PELVQASPCRSSDGILYMGKKQDIWYVIDLLTGEKQQTLSSAFADSLCPSTSLLYLGR
                     TEYTITMYDTKTRELRWNATYFDYAASLPEDDVDYKMSHFVSNGDGLVVTVDSESGDV
                     LWIQNYASPVVAFYVWQGEVLRKVVHINVAVETLRYLTFMSGEVGRITKWKYPFPKET
                     EAKSKLTPTLYVGKYSTSLYASPSMVHEGVAVVPRGSTLPLLEGPQTDGVTIGDKGEC
                     VITPSTDLKFDPGLKGKSKLNYLRNYWLLIGHHETPLSASTKMLERFPNNLPKHRENV
                     IPADSEKRSFEEVINIVGQTSDNTPTTVSQDVEEKLARAPAKPEAPVDSMLKDMATII
                     LSTFLLVGWVAFIITYPLSVHQQRQLQHQQFQKELEKIQLLQQQQLPFHPHGDLTQDP
                     EFLDSSGPFSESSGTSSPSPSPRASNHSLHPSSSASRAGTSPSLEQDDEDEETRMVIV
                     GKISFCPKDVLGHGAEGTIVYKGMFDNRDVAVKRILPECFSFADREVQLLRESDEHPN
                     VIRYFCTEKDRQFQYIAIELCAATLQEYVEQKDFAHLGLEPITLLHQTTSGLAHLHSL
                     NIVHRDLKPHNILLSMPNAHGRIKAMISDFGLCKKLAVGRHSFSRRSGVPGTEGWIAP
                     EMLSEDCKDNPTYTVDIFSAGCVFYYVISEGNHPFGKSLQRQANILLGACNLDCFHSD
                     KHEDVIARELIEKMIAMDPQQRPSAKHVLKHPFFWSLEKQLQFFQDVSDRIEKEALDG
                     PIVRQLERGGRAVVKMDWRENITVPLQTDLRKFRTYKGGSVRDLLRAMRNKKHHYREL
                     PVEVQETLGSIPDDFVRYFTSRFPHLLSHTYQAMELCRHERLFQTYYWHEPTEPQPPV
                     IPYAL"
     exon            181..301
                     /gene="Ern1"
                     /gene_synonym="9030414B18Rik; Ire1a; Ire1alpha; Ire1p"
                     /inference="alignment:Splign:2.1.0"
     exon            302..335
                     /gene="Ern1"
                     /gene_synonym="9030414B18Rik; Ire1a; Ire1alpha; Ire1p"
                     /inference="alignment:Splign:2.1.0"
     exon            336..408
                     /gene="Ern1"
                     /gene_synonym="9030414B18Rik; Ire1a; Ire1alpha; Ire1p"
                     /inference="alignment:Splign:2.1.0"
     exon            409..481
                     /gene="Ern1"
                     /gene_synonym="9030414B18Rik; Ire1a; Ire1alpha; Ire1p"
                     /inference="alignment:Splign:2.1.0"
     exon            482..604
                     /gene="Ern1"
                     /gene_synonym="9030414B18Rik; Ire1a; Ire1alpha; Ire1p"
                     /inference="alignment:Splign:2.1.0"
     exon            605..706
                     /gene="Ern1"
                     /gene_synonym="9030414B18Rik; Ire1a; Ire1alpha; Ire1p"
                     /inference="alignment:Splign:2.1.0"
     exon            707..968
                     /gene="Ern1"
                     /gene_synonym="9030414B18Rik; Ire1a; Ire1alpha; Ire1p"
                     /inference="alignment:Splign:2.1.0"
     exon            969..1047
                     /gene="Ern1"
                     /gene_synonym="9030414B18Rik; Ire1a; Ire1alpha; Ire1p"
                     /inference="alignment:Splign:2.1.0"
     exon            1048..1213
                     /gene="Ern1"
                     /gene_synonym="9030414B18Rik; Ire1a; Ire1alpha; Ire1p"
                     /inference="alignment:Splign:2.1.0"
     exon            1214..1332
                     /gene="Ern1"
                     /gene_synonym="9030414B18Rik; Ire1a; Ire1alpha; Ire1p"
                     /inference="alignment:Splign:2.1.0"
     exon            1333..1524
                     /gene="Ern1"
                     /gene_synonym="9030414B18Rik; Ire1a; Ire1alpha; Ire1p"
                     /inference="alignment:Splign:2.1.0"
     exon            1525..1792
                     /gene="Ern1"
                     /gene_synonym="9030414B18Rik; Ire1a; Ire1alpha; Ire1p"
                     /inference="alignment:Splign:2.1.0"
     exon            1793..1883
                     /gene="Ern1"
                     /gene_synonym="9030414B18Rik; Ire1a; Ire1alpha; Ire1p"
                     /inference="alignment:Splign:2.1.0"
     exon            1884..2073
                     /gene="Ern1"
                     /gene_synonym="9030414B18Rik; Ire1a; Ire1alpha; Ire1p"
                     /inference="alignment:Splign:2.1.0"
     exon            2074..2173
                     /gene="Ern1"
                     /gene_synonym="9030414B18Rik; Ire1a; Ire1alpha; Ire1p"
                     /inference="alignment:Splign:2.1.0"
     exon            2174..2373
                     /gene="Ern1"
                     /gene_synonym="9030414B18Rik; Ire1a; Ire1alpha; Ire1p"
                     /inference="alignment:Splign:2.1.0"
     exon            2374..2521
                     /gene="Ern1"
                     /gene_synonym="9030414B18Rik; Ire1a; Ire1alpha; Ire1p"
                     /inference="alignment:Splign:2.1.0"
     exon            2522..2649
                     /gene="Ern1"
                     /gene_synonym="9030414B18Rik; Ire1a; Ire1alpha; Ire1p"
                     /inference="alignment:Splign:2.1.0"
     exon            2650..2773
                     /gene="Ern1"
                     /gene_synonym="9030414B18Rik; Ire1a; Ire1alpha; Ire1p"
                     /inference="alignment:Splign:2.1.0"
     exon            2774..2841
                     /gene="Ern1"
                     /gene_synonym="9030414B18Rik; Ire1a; Ire1alpha; Ire1p"
                     /inference="alignment:Splign:2.1.0"
     exon            2842..3976
                     /gene="Ern1"
                     /gene_synonym="9030414B18Rik; Ire1a; Ire1alpha; Ire1p"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tccgtgtcca ccgatcctcc gccggtgccg cgctgtcgtt gcggcgcccc cgtccagccc
       61 tctgttcgcg cgggctccag aaccggccgg cggggcccgg agtcagggcc acgtcctgcc
      121 atgccggccc ggtggctgtt gctcctgctg gcgctgctgc taccgccgcc cggccccggg
      181 agttttggaa gaaccagcac agttacactg cctgagacct tgttgtttgt ctcgaccctg
      241 gatggaagct tgcatgctgt tagcaagagg acgggctcca tcaagtggac tttaaaagaa
      301 gatccagtcc tgcaggtccc aacacacgtg gaagagccgg ctttcctccc agatcccaat
      361 gatggcagtc tgtacacact tggaggcaag aacaacgaag gcctgacgaa acttcccttt
      421 accatcccag aattggttca ggcctcccca tgccgaagtt cagatggaat cctctacatg
      481 ggtaaaaagc aagatatttg gtatgttatc gacctcctga ctggcgagaa gcagcagact
      541 ttgtcatcgg cctttgctga tagtctctgc ccatcaactt cccttctata tcttggacgg
      601 acagaataca ccatcaccat gtatgacacc aagacccggg agctccgctg gaatgccacc
      661 tattttgact atgcagcctc actgccggaa gacgacgtgg actacaagat gtcccacttt
      721 gtgtccaatg gcgatggact ggtggtaact gtggacagtg aatctgggga tgtcctgtgg
      781 atccaaaact atgcctctcc tgtggtggcc ttctacgtct ggcaggggga ggtcctgaga
      841 aaggtggtgc acatcaacgt tgctgtggag actctacgct acttgacctt catgtctggg
      901 gaagtggggc gcatcaccaa gtggaagtat ccattcccca aggagacaga ggccaagagc
      961 aagctaacgc ctactctgta tgttgggaag tattccacca gcctctatgc ctctccctca
     1021 atggtgcatg agggggttgc tgtcgtgcct cgaggcagca ctcttccttt gctggaaggc
     1081 ccccagacag atggcgtcac cattggagac aaaggagagt gtgtgatcac tcccagcaca
     1141 gacctcaagt ttgaccctgg actcaaaggg aagagcaagc tgaactactt gaggaattac
     1201 tggcttctca taggacacca tgaaactcct ctgtctgcat ccaccaagat gctggagaga
     1261 tttcctaaca acctgcccaa acatcgagaa aatgtgattc ctgctgattc agaaaaaagg
     1321 agctttgagg aagttatcaa catagttggc cagacttcag acaacacacc gaccaccgta
     1381 tctcaggatg tggaggagaa gctcgctcgc gcccctgcca agcctgaggc ccccgtggac
     1441 tccatgctca aggacatggc taccattatc ctgagcacct tcctgctggt tggatgggtg
     1501 gcgttcatca tcacttaccc cctgagcgtg catcagcagc gtcagctcca gcaccaacag
     1561 ttccagaagg agctggagaa gattcagctc ctgcagcagc agcagctgcc cttccaccca
     1621 cacggagacc ttacccagga ccctgagttc ctggattcat ctggcccctt ctcagagagc
     1681 tctggcacca gcagccccag cccatccccc agagcctcca accactccct ccaccccagc
     1741 agctctgcct ccagggccgg caccagcccc tctctggagc aggatgatga ggatgaggaa
     1801 accagaatgg tgattgttgg gaaaatttca ttctgcccca aggatgtcct gggtcatgga
     1861 gctgagggca caattgtata caaaggtatg tttgacaacc gagatgtggc cgtgaagagg
     1921 atcctccctg agtgttttag ctttgccgac cgtgaggtcc agctgcttcg agaatcagac
     1981 gagcacccaa atgtgatccg ctacttttgc acagagaagg accggcagtt ccagtacatt
     2041 gctatcgagc tgtgtgcagc caccctacaa gagtatgtgg agcagaagga ctttgcccac
     2101 cttggcctcg agcccatcac cctgcttcat cagaccacct caggcctggc acacctgcat
     2161 tctctcaaca ttgttcacag agacctgaag ccccacaaca ttctcctctc catgcccaac
     2221 gcacatggca ggatcaaggc gatgatctct gactttggcc tctgcaagaa gctggcagtg
     2281 ggcaggcaca gtttcagccg ccgttcaggg gtacctggca ctgaagggtg gatcgcccca
     2341 gagatgctga gtgaagactg taaggacaac cctacctaca cggtggacat cttttctgca
     2401 ggctgtgtct tttactatgt catctctgag ggcaaccatc cttttggcaa atccttgcag
     2461 cggcaggcca acatcctcct gggcgcctgc aaccttgact gtttccactc agacaagcat
     2521 gaggacgtca ttgctcgtga attgatagag aaaatgattg ctatggatcc ccagcagcgt
     2581 ccctctgcaa agcacgtgct gaaacacccc ttcttctgga gcctggagaa gcagctccag
     2641 tttttccagg atgtaagtga ccgaatagaa aaggaggcct tggacggtcc aatcgtacgg
     2701 cagttggaga gaggcgggag agctgtggtc aagatggact ggcgggagaa catcactgtc
     2761 cccctgcaga cagatctgcg caaattcaga acctacaaag gtggctctgt gagagacctc
     2821 ctccgagcca tgagaaacaa gaaacaccac taccgggagc tccccgtgga ggttcaggag
     2881 acgctgggct ccatcccgga tgactttgtg cgctacttca cttcccgctt cccccacctc
     2941 ctctctcaca cctaccaagc catggagctg tgcagacatg agagactctt tcagacctac
     3001 tactggcacg agcccacaga accccagcct ccagtgattc catatgccct ctgagctagg
     3061 gcagccctct ggtctggtgg ccccaataat gaccatgggc ccgatctctg cagtcatagt
     3121 ttgttgcctc tgggattagc aggaagacta agcttcgcaa atcaagtgcc ttgagctgct
     3181 gatctgcagc cagaagagga taacgctgat cctaggacgc aggggaagat ggtccctcat
     3241 gactacagag acctgaggag atgtggccct gaaaccttgt agtgaaggac gtctacgaag
     3301 gcagcctgtc ccagaggctg caaaggaaac agcatcagcc tttcaccgga tgagcttgct
     3361 cccacttctc tttctttcta aaattcctgt gggatggcat tttggggggc ctttcagtga
     3421 gagtagagga atctggtttt gcctgcatgg tggaagcagc ctggttgggg tattgcatgt
     3481 gcagcctctg atagaaatgg tttgagagat gtggggtgct aaggaagaga tgttcagagg
     3541 tgttgccatg gggataggag gcacctccaa gttactgata gcccgtgttg cctcatgcag
     3601 caagttgtga gagtgggttg tggagactcg ttagcaatgc tgtggacact gacatgtgct
     3661 gtgggtctgg aagatgaagc agacactcag ttctggatgt ggtgctggcc cagcacagtg
     3721 gcctaaatag tggcccctga taggttgaat cctggctatg tgggccagag atgagtttcc
     3781 tggccaccag gtggcagcta agaccagaca gggacagaga cagattgtca gggccagaga
     3841 ggagcaacta gagggagctt cccagtcact caaagatgct aagaactaga aggtgagtga
     3901 tatggtccct ctaccccaga ggccagcaga ttagcgcata gattatgaat caaggccctg
     3961 ggggtagaga gccaag
//
