LOCUS       NM_029972               3633 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus ermin, ERM-like protein (Ermn), mRNA.
ACCESSION   NM_029972
VERSION     NM_029972.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3633)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3633)
  AUTHORS   Wang,S., Wang,T., Liu,T., Xie,R.G., Zhao,X.H., Wang,L., Yang,Q.,
            Jia,L.T. and Han,J.
  TITLE     Ermin is a p116RIP -interacting protein promoting oligodendroglial
            differentiation and myelin maintenance
  JOURNAL   Glia 68 (11), 2264-2276 (2020)
   PUBMED   32530539
REFERENCE   3  (bases 1 to 3633)
  AUTHORS   Liang,F., Hwang,J.H., Tang,N.W. and Hunziker,W.
  TITLE     Juxtanodin in retinal pigment epithelial cells: Expression and
            biological activities in regulating cell morphology and actin
            cytoskeleton organization
  JOURNAL   J Comp Neurol 526 (2), 205-215 (2018)
   PUBMED   28815590
  REMARK    GeneRIF: This study demonstrated that the Juxtanodin expression in
            rat retinal pigment epithelial cells, and Juxtanodin functional
            roles in regulating actin cytoskeleton architecture and morphology.
REFERENCE   4  (bases 1 to 3633)
  AUTHORS   He,D., Marie,C., Zhao,C., Kim,B., Wang,J., Deng,Y., Clavairoly,A.,
            Frah,M., Wang,H., He,X., Hmidan,H., Jones,B.V., Witte,D., Zalc,B.,
            Zhou,X., Choo,D.I., Martin,D.M., Parras,C. and Lu,Q.R.
  TITLE     Chd7 cooperates with Sox10 and regulates the onset of CNS
            myelination and remyelination
  JOURNAL   Nat Neurosci 19 (5), 678-689 (2016)
   PUBMED   26928066
REFERENCE   5  (bases 1 to 3633)
  AUTHORS   Garaffo,G., Provero,P., Molineris,I., Pinciroli,P., Peano,C.,
            Battaglia,C., Tomaiuolo,D., Etzion,T., Gothilf,Y., Santoro,M. and
            Merlo,G.R.
  TITLE     Profiling, Bioinformatic, and Functional Data on the Developing
            Olfactory/GnRH System Reveal Cellular and Molecular Pathways
            Essential for This Process and Potentially Relevant for the
            Kallmann Syndrome
  JOURNAL   Front Endocrinol (Lausanne) 4, 203 (2013)
   PUBMED   24427155
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3633)
  AUTHORS   Brockschnieder,D., Sabanay,H., Riethmacher,D. and Peles,E.
  TITLE     Ermin, a myelinating oligodendrocyte-specific protein that
            regulates cell morphology
  JOURNAL   J Neurosci 26 (3), 757-762 (2006)
   PUBMED   16421295
  REMARK    GeneRIF: plays a role in cytoskeletal rearrangements during the
            late wrapping and/or compaction phases of myelinogenesis
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL928564.8.
            
            On Aug 21, 2018 this sequence version replaced NM_029972.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC089515.1, AK137305.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-389               AL928564.8         35806-36194         c
            390-482             AL928564.8         35081-35173         c
            483-3633            AL928564.8         28445-31595         c
FEATURES             Location/Qualifiers
     source          1..3633
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 32.99 cM"
     gene            1..3633
                     /gene="Ermn"
                     /gene_synonym="A330104H05Rik; ermin; mKIAA1189"
                     /note="ermin, ERM-like protein"
                     /db_xref="GeneID:77767"
                     /db_xref="MGI:MGI:1925017"
     exon            1..389
                     /gene="Ermn"
                     /gene_synonym="A330104H05Rik; ermin; mKIAA1189"
                     /inference="alignment:Splign:2.1.0"
     CDS             149..994
                     /gene="Ermn"
                     /gene_synonym="A330104H05Rik; ermin; mKIAA1189"
                     /note="JN; juxtanodin"
                     /codon_start=1
                     /product="ermin"
                     /protein_id="NP_084248.2"
                     /db_xref="CCDS:CCDS16047.1"
                     /db_xref="GeneID:77767"
                     /db_xref="MGI:MGI:1925017"
                     /translation="MTDTPETLSGTECNGDRPPENGQQPSSQTRQETTDADETQAYYK
                     VEPSLEDLPAKENQEETGNTKGNILPKGPEDEKILNENPEENLFVVHQAIKDLSLQEI
                     SAEDMAFREGHPWKKIPPNSSNLEVSRQKERTAQQQLEQRGDASTTEIEWLGFQKSRP
                     VDILHSKCDEEEEEEEEVWNEEINEEDVDECAEEEDEVRVIEFKRKHREGSPLKEESL
                     AREDSPLGSPGSQPGTPDEQPVFGKKGDIARNSYSRYNTISYRKIRKGNTKQRIDEFE
                     SMMHL"
     exon            390..482
                     /gene="Ermn"
                     /gene_synonym="A330104H05Rik; ermin; mKIAA1189"
                     /inference="alignment:Splign:2.1.0"
     exon            483..3633
                     /gene="Ermn"
                     /gene_synonym="A330104H05Rik; ermin; mKIAA1189"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2187..2192
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ermn"
                     /gene_synonym="A330104H05Rik; ermin; mKIAA1189"
                     /note="hexamer: ATTAAA"
     polyA_site      2211
                     /gene="Ermn"
                     /gene_synonym="A330104H05Rik; ermin; mKIAA1189"
                     /note="major polyA site"
     regulatory      3578..3583
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ermn"
                     /gene_synonym="A330104H05Rik; ermin; mKIAA1189"
                     /note="hexamer: AATAAA"
     polyA_site      3599
                     /gene="Ermn"
                     /gene_synonym="A330104H05Rik; ermin; mKIAA1189"
ORIGIN      
        1 attctgagcc ctgaaaacct ttcggaggaa tcttgctatt gcacgtcaga ctgagagttg
       61 gtttcgaact gtaggaacca cagcattaga gcttatcgaa gagcttgctt tcttcattgc
      121 gtccttaaat cagacctcag tgaacatcat gacagatact cctgagacac tgagcgggac
      181 agagtgcaat ggggacagac cacctgagaa tggccaacag cctagcagtc aaaccaggca
      241 ggagacaact gatgcagatg agacccaggc atactacaag gttgaaccca gtcttgaaga
      301 tttacctgca aaagaaaatc aagaagaaac tggaaacact aaagggaaca tacttcctaa
      361 agggcctgaa gatgagaaga tcctcaatga aaacccagaa gagaacctct tcgttgttca
      421 ccaggccatc aaagatcttt ctctccaaga aataagtgca gaagacatgg ctttccgaga
      481 agggcatccg tggaagaaga ttcctccgaa cagcagtaac ctggaagtga gtagacagaa
      541 ggaaagaact gcccagcaac agcttgagca gagaggagat gcgagtacaa ctgaaatcga
      601 atggctgggg ttccagaaat ctcgtccagt tgacatcttg cattctaagt gtgacgagga
      661 agaagaagaa gaagaagaag tttggaatga agagataaat gaggaagatg ttgatgagtg
      721 tgctgaagag gaagatgaag ttcgagtaat agaatttaag agaaaacaca gagaaggttc
      781 tccattaaaa gaggaaagcc ttgcaaggga ggactcccca ctaggcagcc ctggctccca
      841 acctgggacc ccagatgagc agccagtgtt cggaaagaag ggagatatcg ccaggaattc
      901 ttattccaga tacaacacga tatcctatcg gaaaataagg aaaggcaaca ccaaacagag
      961 aattgatgag tttgagtcaa tgatgcactt ataaactaac ggggaccgag gaatgtaggg
     1021 agtgttaaag gaaagctaac ttctaacttc cttccgctga gatgtcttct gctgcctcat
     1081 ttgcaagatg tgcaagctta atgtcttctt caccataaag caacatggaa ataaccatag
     1141 acaaaactta tttgggtaac tagaaaccaa tgagctttag attcattcct gggtttttgc
     1201 ttaaaaaaaa gtgaactaat atagcatcag gtaagcattg tcacagagcc aagcctggta
     1261 ggatttgtct ttaaaagtag caatagtaag agaggcaagt caagggaaag agaacagtag
     1321 acatgcctct catcattctc ttggtgtctc tttttcttct tcaggccaat gagaagccga
     1381 aaattaaacc ccacctccat caaacacagt ttttatagat tctgactttt ttaaaaattc
     1441 ttttctaatt attgtaaaaa gtatattata tcttaagtca gtttccgtgg catctactga
     1501 ataaaaattc agcagatctc ctttctaggt gcaactgttc agtgaattcc ctcactaaaa
     1561 gcttaagcaa ttgtcagtca gaattctgtt tgctgagtgc tggtgcaggc tttatgcttt
     1621 ccacgtgaat taaatcaaat gtgaagttga tccagagaga gcctaggtga ctggggagcc
     1681 attgagtagg gaattgtatt ggatgatggt tttcattttt gttactgaaa acaaagtctt
     1741 gtctagcacc gtgagaatca ttaaaaataa aatggcaatt ttagcacaat gttaagaaaa
     1801 tgccctactt cattaccgca ctttcttgta ttaatagtat cttaaagctg tttttatttt
     1861 tcttagaaat gagagacact ggcagtcata actgtactag ttactatgaa catgaaaaaa
     1921 taattatctt agactatttt agaagtaggg tgtgaacata tatttttaga ggaaaagctg
     1981 atagtcatag ggaatatatg atttattgga ccaacaccca aatcaagaag cttaaaactg
     2041 cacctgtgga gtgccacccg agccaacaca tcaaataatg cattgaatat ttatgaaaaa
     2101 gtatatttat actctcagat agtttgctcc acaaattttc atttcgtgat tctgtatata
     2161 ttgccctgaa ctttctgtga tcacagatta aaaatatctt ttggttccaa atagaaagac
     2221 aattctttat tgtctgactg taatacagcc ttcattgtgc tattcatccc attgtttgct
     2281 tcactctgtc tgtgtaaaag ccagggctat tcccgcttag atgattgctt atttatgtgt
     2341 aacaaatccc acacaatctc atggcaactt ccttaattcc tcctggtcat ataatatatt
     2401 tccatagtat cgtatactat tatggagtat ttaaaagact caagttcaaa ttaacatgct
     2461 tcttttattc ttcaaagcaa ttctttacaa cctgaccatg taaaagatct gttaccccta
     2521 gagtgttgag cctgctgatt tcatttagga caaatgtgca tgttctgaat gaaatgagag
     2581 aaatgctgta tttattgata acattggcta ggagactgat ggactggcac actttcctgt
     2641 tttaatttag agcctttgat tattccatag agacaacctg tgtgctttcc tggattcctg
     2701 atgagttctg ccattttcta cttaatttca aagcccagtt ttaagtaact ggactacact
     2761 gttgacctac ccatgtgaca gttgttttgt tagatggaga tgttgcgtta ctatggagct
     2821 tacatgaaat gggtagcata tagttaaagg tcgtgacaaa aactataaca taaccttgga
     2881 ctttttccac ggggtccttt tatcacaaaa ttaaacaatt atgaaacatt ctgtccacaa
     2941 agactatttt aaggcatatt caactggtat ttcatttatt cttatggaca aagcaatgca
     3001 gcatcaggag atcattggtg acattcttca gttatcatta tactttgccg aattctatca
     3061 cagcacagca ggtcgagagt taacacctgg atgacatggt ggtggatatt tgggtctgtg
     3121 aaatctgaaa aaaacaaagg tctattcgga ttgcataggg gtatattaat atattttaaa
     3181 ctcacctaga ttacactcaa ttgataccca ctcatgaaga ttttgctgag attttatgat
     3241 tccaggttca ggggtgagaa ggattctggt acctgatacc tgttggagat tatgtgactg
     3301 ctggcatgtc ttagatatct tagttatctt ttgttgacag atgaatggga attaacaata
     3361 gctttatgtc tttgtgaaaa tgaaatttac ttttagtttc atattatatt taaagacatg
     3421 gaatttgtct agttcagtat ctatctatct atctatctat ctatctatct atctatctat
     3481 ctatctatca tctatctatc tatctatcta tcatctatct atcatctata tatctagcta
     3541 actgactacc tatcatctac ctacctacct gctgttaaat aaagaatttc cttgtctgat
     3601 ttcctttcaa taaaagtttt tctttgtttc agg
//
