LOCUS       NM_013848               4535 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus erythroblast membrane-associated protein (Ermap),
            transcript variant 1, mRNA.
ACCESSION   NM_013848
VERSION     NM_013848.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4535)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4535)
  AUTHORS   Su,M., Lin,Y., Cui,C., Tian,X. and Lai,L.
  TITLE     ERMAP is a B7 family-related molecule that negatively regulates T
            cell and macrophage responses
  JOURNAL   Cell Mol Immunol 18 (8), 1920-1933 (2021)
   PUBMED   32620788
  REMARK    GeneRIF: ERMAP is a B7 family-related molecule that negatively
            regulates T cell and macrophage responses.
REFERENCE   3  (bases 1 to 4535)
  AUTHORS   McClelland,K.S., Bell,K., Larney,C., Harley,V.R., Sinclair,A.H.,
            Oshlack,A., Koopman,P. and Bowles,J.
  TITLE     Purification and Transcriptomic Analysis of Mouse Fetal Leydig
            Cells Reveals Candidate Genes for Specification of Gonadal
            Steroidogenic Cells
  JOURNAL   Biol Reprod 92 (6), 145 (2015)
   PUBMED   25855264
REFERENCE   4  (bases 1 to 4535)
  AUTHORS   Xu,H., Foltz,L., Sha,Y., Madlansacay,M.R., Cain,C., Lindemann,G.,
            Vargas,J., Nagy,D., Harriman,B., Mahoney,W. and Schueler,P.A.
  TITLE     Cloning and characterization of human erythroid membrane-associated
            protein, human ERMAP
  JOURNAL   Genomics 76 (1-3), 2-4 (2001)
   PUBMED   11549310
REFERENCE   5  (bases 1 to 4535)
  AUTHORS   Ye,T.Z., Gordon,C.T., Lai,Y.H., Fujiwara,Y., Peters,L.L.,
            Perkins,A.C. and Chui,D.H.
  TITLE     Ermap, a gene coding for a novel erythroid specific
            adhesion/receptor membrane protein
  JOURNAL   Gene 242 (1-2), 337-345 (2000)
   PUBMED   10721728
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL606975.9.
            
            On Mar 15, 2019 this sequence version replaced NM_013848.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (a).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF153906.1, SRR13422598.207958.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135, SAMN01164140
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            RefSeq Select criteria           :: based on conservation,
                                                expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-190               AL606975.9         125818-126007       c
            191-275             AL606975.9         124871-124955       c
            276-365             AL606975.9         123642-123731       c
            366-704             AL606975.9         123108-123446       c
            705-986             AL606975.9         121553-121834       c
            987-1103            AL606975.9         119923-120039       c
            1104-1136           AL606975.9         119318-119350       c
            1137-1169           AL606975.9         118855-118887       c
            1170-1190           AL606975.9         117378-117398       c
            1191-1211           AL606975.9         116213-116233       c
            1212-1238           AL606975.9         116085-116111       c
            1239-1265           AL606975.9         115969-115995       c
            1266-4535           AL606975.9         111469-114738       c
FEATURES             Location/Qualifiers
     source          1..4535
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 55.34 cM"
     gene            1..4535
                     /gene="Ermap"
                     /note="erythroblast membrane-associated protein"
                     /db_xref="GeneID:27028"
                     /db_xref="MGI:MGI:1349816"
     exon            1..190
                     /gene="Ermap"
                     /inference="alignment:Splign:2.1.0"
     exon            191..275
                     /gene="Ermap"
                     /inference="alignment:Splign:2.1.0"
     exon            276..365
                     /gene="Ermap"
                     /inference="alignment:Splign:2.1.0"
     CDS             281..1981
                     /gene="Ermap"
                     /note="isoform a precursor is encoded by transcript
                     variant 1; erythroid membrane-associated protein"
                     /codon_start=1
                     /product="erythroid membrane-associated protein isoform a
                     precursor"
                     /protein_id="NP_038876.3"
                     /db_xref="CCDS:CCDS18571.2"
                     /db_xref="GeneID:27028"
                     /db_xref="MGI:MGI:1349816"
                     /translation="MERPSPCGSWLVGCLFTIAVFQPPVQVLGDAGKVYIAPLRDTAN
                     LPCPLFLWPNMVLSEMRWYRPGHLPRTQAVHVFRDGQDRDEDLMPEYKGRTALVRDAH
                     KESYILQISNVRLEDRGLYQCQVWVGNSSREDNVTLQVAVLGSDPYIHVKGYDAGWIE
                     LLCQSVGWFPKPWTEWRDTTGRALLSLSEVHSLDENGLFRTAVSSRIRDNALGNVSCT
                     IHNEALGQEKTTAMIIGAPERGSLSSPAVALSVVLPVLGLLILLGIWLICKQKKSKEK
                     LLYEQAMEVENLLEDHAKEKGRLHKALKKLRSELKLKRAAANAGWRRARLHFVAVTLD
                     PDTAHPKLILSEDRRCVRLGDRKRPVPDNPERFDFVVSVLGSEYFTTGCHYWEVYVGE
                     KTKWILGVCSESVSRKGKVTASPANGHWLVRQSRGNEYEALTSPQTSFRLKESPKCVG
                     IFLDYEAGIISFYNVTDKSHIFTFTHSFSSPLRPFFEPCLHDEGKNTAPLIICTELQK
                     SEESIVPKQEGKDRANGDVSLKMNPSLLSPQGSELFLLNDTWPSNLGPALKGLKVPSL
                     "
     exon            366..704
                     /gene="Ermap"
                     /inference="alignment:Splign:2.1.0"
     exon            705..986
                     /gene="Ermap"
                     /inference="alignment:Splign:2.1.0"
     exon            987..1103
                     /gene="Ermap"
                     /inference="alignment:Splign:2.1.0"
     exon            1104..1136
                     /gene="Ermap"
                     /inference="alignment:Splign:2.1.0"
     exon            1137..1169
                     /gene="Ermap"
                     /inference="alignment:Splign:2.1.0"
     exon            1170..1190
                     /gene="Ermap"
                     /inference="alignment:Splign:2.1.0"
     exon            1191..1211
                     /gene="Ermap"
                     /inference="alignment:Splign:2.1.0"
     exon            1212..1238
                     /gene="Ermap"
                     /inference="alignment:Splign:2.1.0"
     exon            1239..1265
                     /gene="Ermap"
                     /inference="alignment:Splign:2.1.0"
     exon            1266..4535
                     /gene="Ermap"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4383..4388
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ermap"
                     /note="hexamer: AATATA"
     polyA_site      4402
                     /gene="Ermap"
     regulatory      4513..4518
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ermap"
                     /note="hexamer: AATAAA"
     polyA_site      4535
                     /gene="Ermap"
                     /note="major polyA site"
ORIGIN      
        1 gtagacagag agaacccttg gctttgagac tctggcatca gactagaata tgaacttttt
       61 gcagacccat ctcttgagat cttcctggca ctcttgcccg atgtcagacc accctgcctg
      121 tggggagccc agtgttccca ggtaggaggc cccagctctg ccgctaaagg acacaatctc
      181 cacctcaaag gtctgtgttg gaatgctgaa gcggctaaag aaacatgtgg tggcgtggaa
      241 aatgtgtgta atgccacact cacggaagat gtcagttcat atggagagac caagtccctg
      301 tggttcctgg cttgtcggct gtctcttcac catagctgtc ttccagccgc ctgttcaggt
      361 gttaggggat gctggcaagg tctacatagc ccctcttagg gacacagcca acttgccctg
      421 ccctctcttc ctctggccta acatggtact cagcgagatg aggtggtatc ggcccggaca
      481 cctacctcgc acccaggctg tccacgtgtt ccgggacggg caggacagag atgaagacct
      541 gatgccagaa tataagggca ggacggcact ggtgagggat gcccacaagg aaagctacat
      601 cctgcaaatc agtaatgtga ggctcgagga ccgagggcta taccagtgcc aggtctgggt
      661 cggaaactca agtcgagaag acaacgtgac cctgcaggtg gcagttttag gttctgatcc
      721 ctacatccac gtgaagggct atgatgctgg gtggatcgag ctgctgtgtc aatcagtggg
      781 atggttccca aagccgtgga ctgagtggag agacactacg ggtagagcgc tactctccct
      841 ttcagaggtt cactccctgg atgaaaatgg gctgttccga acagcagtgt ccagcagaat
      901 cagggacaat gccctgggaa atgtgtcttg cactatccat aatgaggccc ttggccaaga
      961 gaagacgacg gccatgatta ttggagcccc agaacgagga agtctgtcct ctccagcggt
     1021 ggctctttct gtggtcttgc ccgtcttggg gctcctcatc ctccttggca tctggctcat
     1081 ttgtaaacaa aaaaaatcaa aagagaagct gctgtatgag caagcgatgg aggtagaaaa
     1141 tcttctggaa gaccacgcca aagaaaaagg aagactccac aaagccctca agaaactccg
     1201 gagtgaactg aagttgaaaa gagcggcggc caatgcaggc tggagaagag cccggctaca
     1261 ttttgtggca gtgaccctgg accctgacac ggcacatccc aaactcatcc tgtctgagga
     1321 tcggagatgt gtgaggctcg gcgacaggaa gcggcctgtt cctgacaacc cagagaggtt
     1381 tgattttgtt gtcagcgtcc tgggctccga gtatttcaca accggctgtc actactggga
     1441 agtgtacgtg ggcgagaaga ccaaatggat tcttggagtg tgtagtgagt ctgtgagcag
     1501 gaaagggaag gtcacggcct cgcctgccaa tggccactgg cttgtgcgac agagccgtgg
     1561 gaatgagtat gaagctctca cgtccccaca gacctccttc cgcctcaaag agtccccgaa
     1621 gtgtgtgggg attttcctgg actatgaagc cggcatcatc tccttctaca acgtgactga
     1681 taagtcccac atcttcactt tcacccacag tttctcgagc ccacttcgcc ctttctttga
     1741 accttgtctt cacgatgagg ggaaaaacac ggcccctcta atcatttgta ctgagcttca
     1801 gaaatcagag gaatcgattg tccccaaaca agaaggaaaa gaccgtgcta atggagacgt
     1861 gtccctgaag atgaacccat ccttactgtc ccctcagggt tctgagctat ttctgcttaa
     1921 tgatacctgg ccctctaacc ttggccctgc ccttaagggc ctcaaagttc cttctttgta
     1981 gggctgtgcc ctgtgctcca ctctcgtgag catccggcct ggcacaggct cctggcccag
     2041 catctgtttc tccagtacct catctccttg accccagtcc agagccttct gtggtttctc
     2101 ttctgctttt ctcccagggc tcggttctga actctgcctt gttcttgaga catccccatt
     2161 gccctggaag atgacttttt gaaatcaaca aaatgcactc gggccaggtt taggaggaga
     2221 ccttggatgt aatgcagggg gactccgttc aggccagggg aaagggctct ctccctgagg
     2281 gaaccttggc accagcttct ctttgtcagc ctgatcaggg gttatcaggt gtgaacttac
     2341 agcccccaga cccaaatgtc ttccaccaga gactgttttc ttttccccca gtcaggcctc
     2401 taactcgcca cgccagcttt ttacaagtat gtatcttgag actcacacat cctttcttct
     2461 ctgttcaggg ttagagatgg aggggtaaat actccatggg tttctgtttt cttcaggctg
     2521 tttacagcag agtttcgaga cacccagagc tgttttcgac agctaatttg agatggagac
     2581 atccagaatg cacatggttt caaaaattaa gttacctaca tcatgacagg aaccagaatc
     2641 ccaagaaacc tgaacacagg ctggtaggaa cagctgtaac caaagcaatc cagctgtgca
     2701 gccctgagca gatgagttac tctgcagtct gtggctatgg cccttctgaa aacttcctga
     2761 cattcagaga ggcccagtga gaaaaaggtg gcagtttgaa ctactcacgt atacccacaa
     2821 gactattaga tttgacaaca gcctccaggt cagagattat tgaattcaag aaagttggtc
     2881 ttgttttaaa taagacacct tactgccagg tatggtggta cacatctgtg atcccaggtg
     2941 gattattgga agatatatct gtgtaaatga tagaccagac tggtctctgt agtaagttct
     3001 aggacagcca ggactttgtg gagaaacctt gtctcaatgc catgtcctca aaatgagata
     3061 agatatcata tttggaagat tataaggtga gacaacaaaa taatgaattc agggctgaaa
     3121 agatggttca gcgattaaga gctcattctg atcttgcaga ggacctgggt ttgcttttct
     3181 agcacccata ttgggcagtt cacaaccacc tgtaattcca tatctagagg atgagacttc
     3241 aagccttcaa aggcacctgc aactcgctgc acatgctaca catcaacaca cacacacaga
     3301 ctttttttat tagatatttt ctttatttac atttcaaatg ctatcccctt tcctagtttc
     3361 cctctgaaaa ccccttatcc tcttccccct ccccctgctc cccaacccac ccactcccac
     3421 ttcccggccc aggaattccc ctatactggg gcacagaacc ttcacaggac caaaaaacct
     3481 ctcctcccat tgatgaccaa ctaggccatc ctctgctaca tatgcagcta gagacacgag
     3541 tccctccttg tgttttcttt gattggtgat ttagtcccag ggagctctgt ggctactggt
     3601 tagttcatat tgatgttcct cctatggggc tgcaaacccc ttcagctcct tgggtacttt
     3661 ttctctggct ccttcattgg ggaccctgac acacaggctt tttaaattaa atacttaaat
     3721 aatgaatcca agttttggat gtggattggg gaaagaaggc aaggcacttt caagtcatac
     3781 ccacatatgt gtttcggcct gtttgtggag ttattaatta cagatttgca gatgggaagg
     3841 cagctggact ctacaggaac tagatctgct acaggctctt tccaatagag cctatattag
     3901 tgttccctag agaaagagaa ccaactgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgcgc
     3961 gcacacacat gcagacacag taagagatag agacagaaaa taaatacgag actgaagttg
     4021 gcaggtcaga gtactagaaa gagacaagtt ttagttgcag tgtaaggtag ggaaagagtt
     4081 gatatccgtc taaagcccga caggcagcga gactcttcta aggtcttcca ctggtcagat
     4141 gacgactccc actggttgga tgactcccac tggtcagatg actcccactg gacttaagga
     4201 gggtgactgc tttactcagg ctactgatta aatgctaatc tcgtccaagc tcctctcaca
     4261 gagacaccaa atgtgatgtc tgaccaagtg tctgggacct ttgtgacggg tcaaagtgat
     4321 atgtaaaatt tgccattaca gtacccaaaa agaatatttt gtttgtcttt gtacagttat
     4381 gaaatatacc ctttaatact tattgcttgg tatgttgtct tcattatgaa agaggctgtg
     4441 gagaaaacac attacggggt tggtttctga atagctcagc cacaattcaa gcaaacttta
     4501 gacatcattc ataataaacc cagttttact cctga
//
