LOCUS       NM_153592               3927 bp    mRNA    linear   ROD 21-SEP-2024
DEFINITION  Mus musculus ER lipid raft associated 2 (Erlin2), transcript
            variant 1, mRNA.
ACCESSION   NM_153592
VERSION     NM_153592.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3927)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3927)
  AUTHORS   Gao,X., Bonzerato,C.G. and Wojcikiewicz,R.J.H.
  TITLE     Binding of the erlin1/2 complex to the third intralumenal loop of
            IP3R1 triggers its ubiquitin-proteasomal degradation
  JOURNAL   J Biol Chem 298 (6), 102026 (2022)
   PUBMED   35568199
REFERENCE   3  (bases 1 to 3927)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3927)
  AUTHORS   Wright,F.A., Bonzerato,C.G., Sliter,D.A. and Wojcikiewicz,R.J.H.
  TITLE     The erlin2 T65I mutation inhibits erlin1/2 complex-mediated
            inositol 1,4,5-trisphosphate receptor ubiquitination and
            phosphatidylinositol 3-phosphate binding
  JOURNAL   J Biol Chem 293 (40), 15706-15714 (2018)
   PUBMED   30135210
  REMARK    GeneRIF: The erlin2 threonine to isoleucine 65 substitution
            inhibits erlin1/erlin2 complex-mediated inositol
            1,4,5-trisphosphate receptor ubiquitination and
            phosphatidylinositol 3-phosphate binding.
REFERENCE   5  (bases 1 to 3927)
  AUTHORS   Yang,B., Qu,M., Wang,R., Chatterton,J.E., Liu,X.B., Zhu,B.,
            Narisawa,S., Millan,J.L., Nakanishi,N., Swoboda,K., Lipton,S.A. and
            Zhang,D.
  TITLE     The critical role of membralin in postnatal motor neuron survival
            and disease
  JOURNAL   Elife 4, e06500 (2015)
   PUBMED   25977983
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3927)
  AUTHORS   Pearce,M.M., Wormer,D.B., Wilkens,S. and Wojcikiewicz,R.J.
  TITLE     An endoplasmic reticulum (ER) membrane complex composed of SPFH1
            and SPFH2 mediates the ER-associated degradation of inositol
            1,4,5-trisphosphate receptors
  JOURNAL   J Biol Chem 284 (16), 10433-10445 (2009)
   PUBMED   19240031
REFERENCE   7  (bases 1 to 3927)
  AUTHORS   Lyssand,J.S., DeFino,M.C., Tang,X.B., Hertz,A.L., Feller,D.B.,
            Wacker,J.L., Adams,M.E. and Hague,C.
  TITLE     Blood pressure is regulated by an alpha1D-adrenergic
            receptor/dystrophin signalosome
  JOURNAL   J Biol Chem 283 (27), 18792-18800 (2008)
   PUBMED   18468998
REFERENCE   8  (bases 1 to 3927)
  AUTHORS   Pearce,M.M., Wang,Y., Kelley,G.G. and Wojcikiewicz,R.J.
  TITLE     SPFH2 mediates the endoplasmic reticulum-associated degradation of
            inositol 1,4,5-trisphosphate receptors and other substrates in
            mammalian cells
  JOURNAL   J Biol Chem 282 (28), 20104-20115 (2007)
   PUBMED   17502376
REFERENCE   9  (bases 1 to 3927)
  AUTHORS   Bailey,P.J., Klos,J.M., Andersson,E., Karlen,M., Kallstrom,M.,
            Ponjavic,J., Muhr,J., Lenhard,B., Sandelin,A. and Ericson,J.
  TITLE     A global genomic transcriptional code associated with CNS-expressed
            genes
  JOURNAL   Exp Cell Res 312 (16), 3108-3119 (2006)
   PUBMED   16919269
REFERENCE   10 (bases 1 to 3927)
  AUTHORS   Carninci,P., Waki,K., Shiraki,T., Konno,H., Shibata,K., Itoh,M.,
            Aizawa,K., Arakawa,T., Ishii,Y., Sasaki,D., Bono,H., Kondo,S.,
            Sugahara,Y., Saito,R., Osato,N., Fukuda,S., Sato,K., Watahiki,A.,
            Hirozane-Kishikawa,T., Nakamura,M., Shibata,Y., Yasunishi,A.,
            Kikuchi,N., Yoshiki,A., Kusakabe,M., Gustincich,S., Beisel,K.,
            Pavan,W., Aidinis,V., Nakagawara,A., Held,W.A., Iwata,H., Kono,T.,
            Nakauchi,H., Lyons,P., Wells,C., Hume,D.A., Fagiolini,M.,
            Hensch,T.K., Brinkmeier,M., Camper,S., Hirota,J., Mombaerts,P.,
            Muramatsu,M., Okazaki,Y., Kawai,J. and Hayashizaki,Y.
  TITLE     Targeting a complex transcriptome: the construction of the mouse
            full-length cDNA encyclopedia
  JOURNAL   Genome Res 13 (6B), 1273-1289 (2003)
   PUBMED   12819125
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC115820.11.
            
            On Mar 24, 2020 this sequence version replaced NM_153592.2.
            
            Transcript Variant: This variant (1), as well as variants 2, 4, 5,
            and 8, encodes isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC038374.1, AK030557.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-88                AC115820.11        79719-79806         c
            89-210              AC115820.11        78447-78568         c
            211-292             AC115820.11        76375-76456         c
            293-339             AC115820.11        74680-74726         c
            340-401             AC115820.11        74225-74286         c
            402-527             AC115820.11        73956-74081         c
            528-601             AC115820.11        71854-71927         c
            602-660             AC115820.11        71640-71698         c
            661-752             AC115820.11        71300-71391         c
            753-842             AC115820.11        70150-70239         c
            843-922             AC115820.11        67532-67611         c
            923-3927            AC115820.11        64188-67192         c
FEATURES             Location/Qualifiers
     source          1..3927
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 15.91 cM"
     gene            1..3927
                     /gene="Erlin2"
                     /gene_synonym="Spfh2"
                     /note="ER lipid raft associated 2"
                     /db_xref="GeneID:244373"
                     /db_xref="MGI:MGI:2387215"
     exon            1..88
                     /gene="Erlin2"
                     /gene_synonym="Spfh2"
                     /inference="alignment:Splign:2.1.0"
     exon            89..210
                     /gene="Erlin2"
                     /gene_synonym="Spfh2"
                     /inference="alignment:Splign:2.1.0"
     CDS             104..1126
                     /gene="Erlin2"
                     /gene_synonym="Spfh2"
                     /note="isoform 1 is encoded by transcript variant 1; SPFH
                     domain family, member 2; erlin-2; SPFH domain-containing
                     protein 2; endoplasmic reticulum lipid raft-associated
                     protein 2; stomatin-prohibitin-flotillin-HflC/K
                     domain-containing protein 2"
                     /codon_start=1
                     /product="erlin-2 isoform 1"
                     /protein_id="NP_705820.1"
                     /db_xref="CCDS:CCDS22209.1"
                     /db_xref="GeneID:244373"
                     /db_xref="MGI:MGI:2387215"
                     /translation="MAQLGAVVAVASSFFCASLFSAVHKIEEGHIGVYYRGGALLTST
                     SGPGFHLMLPFITSYKSVQTTLQTDEVKNVPCGTSGGVMIYFDRIEVVNFLVPNAVYD
                     IVKNYTADYDKALIFNKIHHELNQFCSVHTLQEVYIELFDQIDENLKLALQQDLTSMA
                     PGLVIQAVRVTKPNIPEAIRRNYELMESEKTKLLIAAQKQKVVEKEAETERKKALIEA
                     EKVAQVAEITYGQKVMEKETEKKISEIEDAAFLAREKAKADAECYTALKIAEANKLKL
                     TPEYLQLMKYKAIASNSKIYFGKDIPNMFMDSAGGLGKQFEGLSDDKLGFGLEDEPLE
                     APTKEN"
     exon            211..292
                     /gene="Erlin2"
                     /gene_synonym="Spfh2"
                     /inference="alignment:Splign:2.1.0"
     exon            293..339
                     /gene="Erlin2"
                     /gene_synonym="Spfh2"
                     /inference="alignment:Splign:2.1.0"
     exon            340..401
                     /gene="Erlin2"
                     /gene_synonym="Spfh2"
                     /inference="alignment:Splign:2.1.0"
     exon            402..527
                     /gene="Erlin2"
                     /gene_synonym="Spfh2"
                     /inference="alignment:Splign:2.1.0"
     exon            528..601
                     /gene="Erlin2"
                     /gene_synonym="Spfh2"
                     /inference="alignment:Splign:2.1.0"
     exon            602..660
                     /gene="Erlin2"
                     /gene_synonym="Spfh2"
                     /inference="alignment:Splign:2.1.0"
     exon            661..752
                     /gene="Erlin2"
                     /gene_synonym="Spfh2"
                     /inference="alignment:Splign:2.1.0"
     exon            753..842
                     /gene="Erlin2"
                     /gene_synonym="Spfh2"
                     /inference="alignment:Splign:2.1.0"
     exon            843..922
                     /gene="Erlin2"
                     /gene_synonym="Spfh2"
                     /inference="alignment:Splign:2.1.0"
     exon            923..3927
                     /gene="Erlin2"
                     /gene_synonym="Spfh2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3606..3611
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Erlin2"
                     /gene_synonym="Spfh2"
                     /note="hexamer: TATAAA"
     polyA_site      3626
                     /gene="Erlin2"
                     /gene_synonym="Spfh2"
     regulatory      3891..3896
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Erlin2"
                     /gene_synonym="Spfh2"
                     /note="hexamer: AATAAA"
     polyA_site      3927
                     /gene="Erlin2"
                     /gene_synonym="Spfh2"
                     /note="major polyA site"
ORIGIN      
        1 ggaaggaagt agggtgctga ggggtgtggc ggtttctacg gttgcacggg ggttcggctg
       61 tgtacggagc gcctggaggg acagcctgga tacaggttca ctgatggctc agttgggagc
      121 tgttgtggcc gtggcttcca gtttcttttg tgcatctctc ttctcagctg tgcacaagat
      181 agaagaggga catattggag tatattacag aggtggtgcc ctgctgacct ccaccagtgg
      241 cccgggtttc catctcatgc tcccgttcat cacatcctat aagtctgtac agaccactct
      301 ccaaactgat gaagtgaaga acgtaccatg tggaaccagt ggtggtgtga tgatctactt
      361 tgacagaatt gaagtggtga acttcctggt cccaaatgca gtgtatgata tagtgaagaa
      421 ctatactgca gactatgaca aggccctcat cttcaacaag atccatcatg agcttaacca
      481 gttctgcagc gttcatactc ttcaggaagt ctatatcgag ctgtttgatc aaattgatga
      541 aaacctcaag ttggctttgc agcaggacct gacttccatg gcccctgggc tggttatcca
      601 agctgtgcga gtgacaaagc ccaatatacc tgaggcaatc cgcaggaact atgagctgat
      661 ggaaagcgag aagacgaagc ttctcattgc agcccagaag cagaaggtgg tggaaaagga
      721 ggcagaaaca gagaggaaga aggccctcat tgaggcagaa aaagtggcac aggttgcaga
      781 aatcacctat gggcaaaagg tgatggagaa ggagacagag aagaagatct cagaaattga
      841 agatgctgcg ttcctggccc gggagaaggc gaaggccgac gctgagtgct acacagcgct
      901 gaagatcgca gaagcaaata agctcaagct gactccagaa tacctgcagc tgatgaagta
      961 caaggccatt gcttccaaca gcaagattta cttcggcaaa gacatcccca acatgtttat
     1021 ggattccgca ggggggctgg gcaagcagtt tgaggggctg agcgacgaca agctgggctt
     1081 tggcctagaa gatgagcccc tcgaggcacc cacaaaggag aactgaggaa acactgtctg
     1141 caagctctgc tcgggcagct tagagagagc tgtattcttt aagatgagac agagcaaagc
     1201 gctcctcctt tccacactac cttccttgac tcttcttact gtggttaaaa aggaagaaat
     1261 ggacacaaac ttaccccctt ctgggaaggg agagcagatg gagagttgtt ttttgggttt
     1321 atttttaatt caggtaagta agttgtatga cttctgagaa ggtgtatgca ccgtagattt
     1381 gacctctgac ctgcagacac caacattgtc actttgaagc tggtttaagt ggagctactg
     1441 tcagtatgaa gagggagagt gtgtgctgcc tcctcgtgct tgaattcctt cagggaaaag
     1501 tgtactccac agttctctcc cttgcctcta gtgtaggcag tgtctgcgtg tggggctcgt
     1561 gacagaaggc cgtctgctgc ggaacatgag ctgcagagag cgttggccgg ctgggctttt
     1621 tgactgagtg gattacttga gagttaagct gtcttgagcc ctttttagga agaacttggt
     1681 gctaggtttt gcaaggtttt ctacacactg tactctgctc tagtgtttgt tggctacatc
     1741 tcaccgcagc agggcttggt cacaccacac actccttttc cgtactttga cctgatctgt
     1801 gatttcattt cttcttgaat aatctattca tgagttgcac tcagcgttaa gatgggaaca
     1861 aacaagtgct gttagctgat gacgtagctc cttatacccc ttagcactgt ggtgctgtgt
     1921 ggctaattat gcgtatgctt ttgagaccaa acatctttat cattatggag attcttcatt
     1981 gaagagccct taacactgtg gagaagggcc cagccagatg acacccaagt agtagtgcct
     2041 gtggcctgtg ctggggcttt gtctgacact gatgaagaga gcaggcagcc acttgagagt
     2101 cggctccagt gagtcaccct aggaaactga gaatgcgaag aatagatatg agagaaaggg
     2161 atttcttatc ctgaaattgc actgggggtg gggctctacc atggcctgtg agtgcacaca
     2221 gaatgcctct gtggagggca gctctgcagg taatctgcag acatggcagt accctgtgca
     2281 accatgactg gctctagctt aggacttggc cttgttagct ggtcccctac ctcatcctcc
     2341 ccccacacaa agcacctact gttctctctt aggtgactac tataaatggt attttctggc
     2401 atcaattccc acctcagttt tggttttgta agtcgggcca gtttgctcct aagtggcacc
     2461 agacttgtca ggtatttggg aagcattcag ccgacccaaa aagaggcagg gttcactgtg
     2521 cttacttcag atgttccctt ctctgtcctg actcctcagg ccactgaccc tggccacact
     2581 gtacaaacta caaaatgttc ctgaaaagga cattttaatg tgctcaaaag ctcttgcaaa
     2641 agtgggtttt tttccccaag accaactcat cttcttctca tttgttgctg ctaaccactt
     2701 gttgagagca acgtgctata cccagcatcc tctcttgtac gtgcacctga gaaaacacta
     2761 cttcagtgga gtcggtgcag gagggagggt accccgccat ccagcgccct cctagcccga
     2821 gaggctctgt aactagcatt ctgagagctc atccctccat tacaaagagc cacagtaaag
     2881 tcctgctgca gctgctcctt ccctgcccct ttaatgtcac ttctttaaca gaacagaaat
     2941 gtccccatgt catagcataa attcagtagc tattggtatc tgtcccagca gtaaaatcat
     3001 ggaactcaga tgtcttttta gcatgggatg cctagcccat ctgtctttat gaccttgttt
     3061 tttgtaatac tataaaatct gacttaggca tttgaattct aaacatgtaa aatgtgataa
     3121 gcctgcagtt ttgtaggcag tgaattcata gctgctattt ttaagtagaa cttctatcaa
     3181 aatacgttaa ccgtttgtaa aattcagttt ttgtaggact ttcccaaggc ccagccacct
     3241 tggtagaatg cttctcactc actaaatgtt gcagaagcaa tttatattcc atataggttt
     3301 ttaatcactt ttcaatatat ggttagaatg tttgtaagga agcctaagtt taataatttt
     3361 tatataacta aaaataggtg tggaggactc agtgtgggta ctgaggagga atgaagtgct
     3421 ctgaaaaggg aggtgtataa acggcctgtg gggccgtgtg tcttgtgaaa gtgagatagc
     3481 cgtgcttact gacctgggct gtcgtcagct ggccgtcggt aaactacctg gacaatagcc
     3541 cctctgtctg ggaactttac ctacttcctt gtcctcagtg ggcttctagc cactgtttgt
     3601 ttccttataa aagctgtaat gggcaatcat gtgtttgtac ttccattcct ttttatctct
     3661 acttctgtgt aaactggtga ttgaatagtt aaagcaattt tttcagtgtg ccccaagggc
     3721 attaatgagc ctttataact gagaaatgat tcttgttata gtaattattc cataaatgat
     3781 accactagat aaattacctt gggttaatag ctccaggatt tgtttcagac aacaaaaaaa
     3841 ggtctcaatg tgaatatact tacattttgg atttaatttc agtcttgcta aataaaatgt
     3901 ttttgtcttt ttttgattaa ggtaaaa
//
