LOCUS       NM_001379279            1769 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus exoribonuclease 3 (Eri3), transcript variant 7, mRNA.
ACCESSION   NM_001379279 XM_030253194
VERSION     NM_001379279.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1769)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1769)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   3  (bases 1 to 1769)
  AUTHORS   Lumayag,S., Haldin,C.E., Corbett,N.J., Wahlin,K.J., Cowan,C.,
            Turturro,S., Larsen,P.E., Kovacs,B., Witmer,P.D., Valle,D.,
            Zack,D.J., Nicholson,D.A. and Xu,S.
  TITLE     Inactivation of the microRNA-183/96/182 cluster results in
            syndromic retinal degeneration
  JOURNAL   Proc Natl Acad Sci U S A 110 (6), E507-E516 (2013)
   PUBMED   23341629
REFERENCE   4  (bases 1 to 1769)
  AUTHORS   Bian,Y., Zhou,W., Zhao,Y., Li,X., Geng,W., Hao,R., Yang,Q. and
            Huang,W.
  TITLE     High-dose siRNAs upregulate mouse Eri-1 at both transcription and
            posttranscription levels
  JOURNAL   PLoS One 6 (10), e26466 (2011)
   PUBMED   22039495
  REMARK    GeneRIF: hd-siRNAs also abolish the 3' untranslated region (UTR)
            mediated posttranscriptional repression of meri-1. Our findings
            demonstrate the molecular mechanism underlying the upregulation of
            meri-1 by hd-siRNA
REFERENCE   5  (bases 1 to 1769)
  AUTHORS   Spielhaupter,C. and Schatzl,H.M.
  TITLE     PrPC directly interacts with proteins involved in signaling
            pathways
  JOURNAL   J Biol Chem 276 (48), 44604-44612 (2001)
   PUBMED   11571277
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL645740.6 and AL671520.6.
            
            On Mar 28, 2020 this sequence version replaced XM_030253194.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR10662773.480784.1,
                                           SRR10662774.928483.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-366               AL645740.6         171165-171530
            367-442             AL671520.6         3103-3178
            443-720             AL671520.6         14756-15033
            721-837             AL671520.6         32735-32851
            838-897             AL671520.6         39233-39292
            898-989             AL671520.6         43206-43297
            990-1062            AL671520.6         65304-65376
            1063-1228           AL671520.6         99442-99607
            1229-1769           AL671520.6         123876-124416
FEATURES             Location/Qualifiers
     source          1..1769
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 53.46 cM"
     gene            1..1769
                     /gene="Eri3"
                     /gene_synonym="PINT1; Prnpip1"
                     /note="exoribonuclease 3"
                     /db_xref="GeneID:140546"
                     /db_xref="MGI:MGI:2153887"
     exon            1..366
                     /gene="Eri3"
                     /gene_synonym="PINT1; Prnpip1"
                     /inference="alignment:Splign:2.1.0"
     CDS             232..1311
                     /gene="Eri3"
                     /gene_synonym="PINT1; Prnpip1"
                     /note="isoform f is encoded by transcript variant 7; ERI1
                     exoribonuclease 3; prion interactor 1; prion
                     protein-interacting protein; prion protein interacting
                     protein 1"
                     /codon_start=1
                     /product="ERI1 exoribonuclease 3 isoform f"
                     /protein_id="NP_001366208.1"
                     /db_xref="GeneID:140546"
                     /db_xref="MGI:MGI:2153887"
                     /translation="MATASPAADGGRGRPWEGGLVSWPPAPPLTLPWTWMGPSWGQHP
                     GHWGFPALTDPSASPAASLGIFEVRRVLDASGCSMLAPLQTGAARFSSYLLSRARKVL
                     GSHLLSPCGVPELCSISTRKLAAHGFGAAMAAMVPFPPQRYHYFLVLDFEATCDKPQI
                     HPQEIIEFPILKLNGRTMEIESTFHMYVQPVVHPQLTPFCTELTGIIQAMVDGQPSLQ
                     QVLERVDEWMAKEGLLDPNVKSIFVTCGDWDLKVMLPGQCHYLGLPVADYFKQWINLK
                     KAYSFAMGCWPKNGLLDMNKGLSLQHIGRPHSGIGQSLHKSPWQLAQSPACMPQSPDD
                     CKNIANIMKTLAYRGFIFKQTSKPF"
     exon            367..442
                     /gene="Eri3"
                     /gene_synonym="PINT1; Prnpip1"
                     /inference="alignment:Splign:2.1.0"
     exon            443..720
                     /gene="Eri3"
                     /gene_synonym="PINT1; Prnpip1"
                     /inference="alignment:Splign:2.1.0"
     exon            721..837
                     /gene="Eri3"
                     /gene_synonym="PINT1; Prnpip1"
                     /inference="alignment:Splign:2.1.0"
     exon            838..897
                     /gene="Eri3"
                     /gene_synonym="PINT1; Prnpip1"
                     /inference="alignment:Splign:2.1.0"
     exon            898..989
                     /gene="Eri3"
                     /gene_synonym="PINT1; Prnpip1"
                     /inference="alignment:Splign:2.1.0"
     exon            990..1062
                     /gene="Eri3"
                     /gene_synonym="PINT1; Prnpip1"
                     /inference="alignment:Splign:2.1.0"
     exon            1063..1228
                     /gene="Eri3"
                     /gene_synonym="PINT1; Prnpip1"
                     /inference="alignment:Splign:2.1.0"
     exon            1229..1769
                     /gene="Eri3"
                     /gene_synonym="PINT1; Prnpip1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1749..1754
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Eri3"
                     /gene_synonym="PINT1; Prnpip1"
                     /note="hexamer: AATAAA"
     polyA_site      1769
                     /gene="Eri3"
                     /gene_synonym="PINT1; Prnpip1"
                     /note="major polyA site"
ORIGIN      
        1 gagtcggtgt gttgtggact cgtggtgctg gctgccgctg ttgaggctgc ctggaacggg
       61 ctgtgggaag cgggcggagc tggccctgct tctgcctggc cagcgccgca ggcggcgcgg
      121 gccgtgcccg ctgccgtcaa ctgcccggag cgtctgctga ggccgaggga gacgccgggg
      181 cctgcacctg gagagagcct gccgtgctgg cccggaggag ggggcgttgc catggcgaca
      241 gcctctccgg cagctgacgg ggggcggggg cggccctggg aaggagggct ggtctcctgg
      301 ccccctgccc ctccccttac gcttccctgg acctggatgg gcccgagctg ggggcaacac
      361 cctgggcatt ggggctttcc agctctcaca gacccttcag catctccagc tgccagtctt
      421 ggcatcttcg aagtaaggag agttttagat gcctctggat gttcaatgct agcgccgtta
      481 cagacgggag cggctcggtt ctcttcatat ttactttcaa gagcaagaaa agtgctgggc
      541 tcccacttgt tatctccctg tggcgttccg gagctctgtt ccatatccac cagaaagctg
      601 gcggcccacg gctttggcgc ggcaatggcg gcaatggtgc ccttccctcc ccagaggtat
      661 cactactttt tagtgctgga ctttgaggcc acatgcgaca agccacagat ccaccctcag
      721 gaaatcattg agttccccat cctgaagtta aatggccgga ccatggaaat cgagtctacc
      781 tttcacatgt atgtccagcc tgtagtccac ccacagctta cccccttctg tacagagctc
      841 accgggatca ttcaagccat ggtggatggc cagccaagcc tgcagcaagt gctggagagg
      901 gtcgatgagt ggatggcgaa ggaaggcctc ttagatccaa acgtcaagtc aatctttgtc
      961 acctgcggag actgggacct gaaagtcatg cttccaggac agtgccatta tctaggcttg
     1021 ccagtggcgg attacttcaa gcagtggatt aatctaaaaa aggcttacag cttcgccatg
     1081 ggctgctggc ccaagaatgg actactagac atgaacaagg gtctcagcct gcagcacata
     1141 ggccggcccc acagcggcat tggtcagtcc ctccacaaat ccccctggca gcttgctcag
     1201 tccccagcct gcatgcctca gtcccctgat gactgcaaga acattgccaa catcatgaag
     1261 acattggcat accgaggctt catcttcaag cagacatcaa agcccttctg attggcagag
     1321 gacgggatgg ggcaggacag ggtagctgct tggcccaaac cagaatcctc ctctccctca
     1381 ccagagggaa aagggagagt ggcacagctc tgcgcccaga gtgtccccca gctgccctac
     1441 aggcttgtgc cctgtgtgag ggcatggcca cttggcccct ctggagcaga cactttgtgc
     1501 cccaccccac tcccattcct cagtctcagc ccagtattag cccctgccat tatgggcctg
     1561 ggctaggggg aacccaggta ctcaactgcc ttctccctag tacacaggct tctgctgggg
     1621 ccaccaagcc ctccctgtgc ccctcccatc catagtgcat ggtgtgtggt gcccccaggg
     1681 ctccaggaca gatcaggccc caccttgtgt ccaccctccc ctcatccctg ctgtgaacgt
     1741 gccacttgaa taaagtcggg gaaacaagg
//
