LOCUS       NM_001356404            1408 bp    mRNA    linear   ROD 05-AUG-2023
DEFINITION  Mus musculus exoribonuclease 3 (Eri3), transcript variant 5, mRNA.
ACCESSION   NM_001356404 XM_017319968
VERSION     NM_001356404.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1408)
  AUTHORS   Koscielny G, Yaikhom G, Iyer V, Meehan TF, Morgan H,
            Atienza-Herrero J, Blake A, Chen CK, Easty R, Di Fenza A, Fiegel T,
            Grifiths M, Horne A, Karp NA, Kurbatova N, Mason JC, Matthews P,
            Oakley DJ, Qazi A, Regnart J, Retha A, Santos LA, Sneddon DJ,
            Warren J, Westerberg H, Wilson RJ, Melvin DG, Smedley D, Brown SD,
            Flicek P, Skarnes WC, Mallon AM and Parkinson H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   2  (bases 1 to 1408)
  AUTHORS   Lumayag S, Haldin CE, Corbett NJ, Wahlin KJ, Cowan C, Turturro S,
            Larsen PE, Kovacs B, Witmer PD, Valle D, Zack DJ, Nicholson DA and
            Xu S.
  TITLE     Inactivation of the microRNA-183/96/182 cluster results in
            syndromic retinal degeneration
  JOURNAL   Proc Natl Acad Sci U S A 110 (6), E507-E516 (2013)
   PUBMED   23341629
REFERENCE   3  (bases 1 to 1408)
  AUTHORS   Bian Y, Zhou W, Zhao Y, Li X, Geng W, Hao R, Yang Q and Huang W.
  TITLE     High-dose siRNAs upregulate mouse Eri-1 at both transcription and
            posttranscription levels
  JOURNAL   PLoS One 6 (10), e26466 (2011)
   PUBMED   22039495
  REMARK    GeneRIF: hd-siRNAs also abolish the 3' untranslated region (UTR)
            mediated posttranscriptional repression of meri-1. Our findings
            demonstrate the molecular mechanism underlying the upregulation of
            meri-1 by hd-siRNA
REFERENCE   4  (bases 1 to 1408)
  AUTHORS   Spielhaupter C and Schatzl HM.
  TITLE     PrPC directly interacts with proteins involved in signaling
            pathways
  JOURNAL   J Biol Chem 276 (48), 44604-44612 (2001)
   PUBMED   11571277
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY110468.1, BY288119.1, AK083017.1 and BE944838.1.
            
            [WARNING] On Jan 11, 2024 this sequence was replaced by
            NM_001356404.2.
            
            On Oct 4, 2017 this sequence version replaced XM_017319968.1.
            
            Transcript Variant: This variant (5) differs in the 5' UTR, lacks a
            portion of the 5' coding region, and initiates translation at a
            downstream in-frame start codon, compared to variant 1. The encoded
            isoform (c) is shorter at the N-terminus, compared to isoform a.
            Variants 3 and 5 encode the same isoform (c).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.2006747.1,
                                           SRR5189670.23475.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-39                BY110468.1         1-39
            40-120              BY288119.1         29-109
            121-1376            AK083017.1         319-1574
            1377-1408           BE944838.1         1-32                c
FEATURES             Location/Qualifiers
     source          1..1408
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 53.46 cM"
     gene            1..1408
                     /gene="Eri3"
                     /gene_synonym="PINT1; Prnpip1"
                     /note="exoribonuclease 3"
                     /db_xref="GeneID:140546"
                     /db_xref="MGI:MGI:2153887"
     exon            1..39
                     /gene="Eri3"
                     /gene_synonym="PINT1; Prnpip1"
                     /inference="alignment:Splign:2.1.0"
     exon            40..115
                     /gene="Eri3"
                     /gene_synonym="PINT1; Prnpip1"
                     /inference="alignment:Splign:2.1.0"
     exon            116..393
                     /gene="Eri3"
                     /gene_synonym="PINT1; Prnpip1"
                     /inference="alignment:Splign:2.1.0"
     CDS             139..918
                     /gene="Eri3"
                     /gene_synonym="PINT1; Prnpip1"
                     /note="isoform c is encoded by transcript variant 5; ERI1
                     exoribonuclease 3; prion interactor 1; prion
                     protein-interacting protein; prion protein interacting
                     protein 1"
                     /codon_start=1
                     /product="ERI1 exoribonuclease 3 isoform c"
                     /protein_id="NP_001343333.1"
                     /db_xref="GeneID:140546"
                     /db_xref="MGI:MGI:2153887"
                     /translation="MLAPLQTGAARFSSYLLSRARKVLGSHLLSPCGVPELCSISTRK
                     LAAHGFGAAMAAMVPFPPQRYHYFLVLDFEATCDKPQIHPQEIIEFPILKLNGRTMEI
                     ESTFHMYVQPVVHPQLTPFCTELTGIIQAMVDGQPSLQQVLERVDEWMAKEGLLDPNV
                     KSIFVTCGDWDLKVMLPGQCHYLGLPVADYFKQWINLKKAYSFAMGCWPKNGLLDMNK
                     GLSLQHIGRPHSGIDDCKNIANIMKTLAYRGFIFKQTSKPF"
     exon            394..510
                     /gene="Eri3"
                     /gene_synonym="PINT1; Prnpip1"
                     /inference="alignment:Splign:2.1.0"
     exon            511..570
                     /gene="Eri3"
                     /gene_synonym="PINT1; Prnpip1"
                     /inference="alignment:Splign:2.1.0"
     exon            571..662
                     /gene="Eri3"
                     /gene_synonym="PINT1; Prnpip1"
                     /inference="alignment:Splign:2.1.0"
     exon            663..735
                     /gene="Eri3"
                     /gene_synonym="PINT1; Prnpip1"
                     /inference="alignment:Splign:2.1.0"
     exon            736..835
                     /gene="Eri3"
                     /gene_synonym="PINT1; Prnpip1"
                     /inference="alignment:Splign:2.1.0"
     exon            836..1392
                     /gene="Eri3"
                     /gene_synonym="PINT1; Prnpip1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcccgtccac cgcgtcggtc ggggtcagag tgcgcggagc attggggctt tccagctctc
       61 acagaccctt cagcatctcc agctgccagt cttggcatct tcgaagtaag gagagtttta
      121 gatgcctctg gatgttcaat gctagcgccg ttacagacgg gagcggctcg gttctcttca
      181 tatttacttt caagagcaag aaaagtgctg ggctcccact tgttatctcc ctgtggcgtt
      241 ccggagctct gttccatatc caccagaaag ctggcggccc acggctttgg cgcggcaatg
      301 gcggcaatgg tgcccttccc tccccagagg tatcactact ttttagtgct ggactttgag
      361 gccacatgcg acaagccaca gatccaccct caggaaatca ttgagttccc catcctgaag
      421 ttaaatggcc ggaccatgga aatcgagtct acctttcaca tgtatgtcca gcctgtagtc
      481 cacccacagc ttaccccctt ctgtacagag ctcaccggga tcattcaagc catggtggat
      541 ggccagccaa gcctgcagca agtgctggag agggtcgatg agtggatggc gaaggaaggc
      601 ctcttagatc caaacgtcaa gtcaatcttt gtcacctgcg gagactggga cctgaaagtc
      661 atgcttccag gacagtgcca ttatctaggc ttgccagtgg cggattactt caagcagtgg
      721 attaatctaa aaaaggctta cagcttcgcc atgggctgct ggcccaagaa tggactacta
      781 gacatgaaca agggtctcag cctgcagcac ataggccggc cccacagcgg cattgatgac
      841 tgcaagaaca ttgccaacat catgaagaca ttggcatacc gaggcttcat cttcaagcag
      901 acatcaaagc ccttctgatt ggcagaggac gggatggggc aggacagggt agctgcttgg
      961 cccaaaccag aatcctcctc tccctcacca gagggaaaag ggagagtggc acagctctgc
     1021 gcccagagtg tcccccagct gccctacagg cttgtgccct gtgtgagggc atggccactt
     1081 ggcccctctg gagcagacac tttgtgcccc accccactcc cattcctcag tctcagccca
     1141 gtattagccc ctgccattat gggcctgggc tagggggaac ccaggtactc aactgccttc
     1201 tccctagtac acaggcttct gctggggcca ccaagccctc cctgtgcccc tcccatccat
     1261 agtgcatggt gtgtggtgcc cccagggctc caggacagat caggccccac cttgtgtcca
     1321 ccctcccctc atccctgctg tgaacgtgcc acttgaataa agtcggggaa acaaggtcct
     1381 agtgtgtctg gaaaaaaaaa aaaaaaaa
//
