LOCUS       NM_027698               3569 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus exoribonuclease 2 (Eri2), transcript variant 1, mRNA.
ACCESSION   NM_027698
VERSION     NM_027698.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3569)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3569)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: III. the complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (4), 167-180 (2003)
   PUBMED   14621295
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY019377.1, AK165163.1 and AC164158.3.
            
            On Jul 29, 2009 this sequence version replaced NM_027698.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC090961.1, AK165163.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-91                BY019377.1         2-92
            92-2709             AK165163.1         2-2619
            2710-3547           AK165163.1         2621-3458
            3548-3569           AC164158.3         63143-63164
FEATURES             Location/Qualifiers
     source          1..3569
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 64.18 cM"
     gene            1..3569
                     /gene="Eri2"
                     /gene_synonym="4933424N09Rik; Exod1; mKIAA1504"
                     /note="exoribonuclease 2"
                     /db_xref="GeneID:71151"
                     /db_xref="MGI:MGI:1918401"
     exon            1..141
                     /gene="Eri2"
                     /gene_synonym="4933424N09Rik; Exod1; mKIAA1504"
                     /inference="alignment:Splign:2.1.0"
     CDS             119..2185
                     /gene="Eri2"
                     /gene_synonym="4933424N09Rik; Exod1; mKIAA1504"
                     /EC_number="3.1.-.-"
                     /note="isoform 1 is encoded by transcript variant 1; ERI1
                     exoribonuclease 2; exonuclease domain-containing protein
                     1; exonuclease domain containing 1"
                     /codon_start=1
                     /product="ERI1 exoribonuclease 2 isoform 1"
                     /protein_id="NP_081974.3"
                     /db_xref="CCDS:CCDS40107.1"
                     /db_xref="GeneID:71151"
                     /db_xref="MGI:MGI:1918401"
                     /translation="MATKRLARRLGLIRRKSVTPASGNPGGSRLKQLYAYLIVVDFES
                     TCWNDGKHHSSPEIIEFPAVLLNTATGEIESEFHAYVQPQEHPILSEFCTELTGIKQV
                     QVDEGVPLKICLSQFCKWIHKLQQQQTISFAAGDSEPSTSEVKLCAFVTWSDWDLGVC
                     LEYECRRKQLLKPVFLNSWIDLRATYRLFYKRKPKGLSGALQEVGIEFSGREHSGLDD
                     SRNTALLAWKMIRDGCLMKITRSLNKVLTKKNPKILARNLGTDQVEEAATCNMSIQGP
                     SIYQKELQSTVNAEENAQMNSVCVNSSCIKGQLQPKSNMKADLYNIRHSFPLFTTKSS
                     TSVDQLHSPTLNPPLTMQKPSKSDQLALNDSSKSSTLNSNLVLVSTTIPSVNHVSDVE
                     MGHTFDCLPMLAEWEDVVLLPASQAEPDTDCMPPVSDTNVSTSLNSAERSLVPEEPET
                     LSYENFEDLQETPQNSETSKSIVYKSPHSTVYDVKGAKHPGSDASAFKLPKCKPFPFT
                     SVHASAAYPSVLRKDPLLSGGTKRNSLSPPASPRTKRQTFTIHEEKPTSSICSPGTTS
                     CRVSPSVLTSTVNLQEPWKTGKMTPPLCKCGRRSKRLIVSNNGPNHGKAFYCCPVGKY
                     QQDRKCCGYFKWEQTLQKERTNGKALSHSSEGLTFSSPETSRIHDRNLSFPIKNSLRL
                     RPSMRH"
     exon            142..209
                     /gene="Eri2"
                     /gene_synonym="4933424N09Rik; Exod1; mKIAA1504"
                     /inference="alignment:Splign:2.1.0"
     exon            210..293
                     /gene="Eri2"
                     /gene_synonym="4933424N09Rik; Exod1; mKIAA1504"
                     /inference="alignment:Splign:2.1.0"
     exon            294..421
                     /gene="Eri2"
                     /gene_synonym="4933424N09Rik; Exod1; mKIAA1504"
                     /inference="alignment:Splign:2.1.0"
     exon            422..578
                     /gene="Eri2"
                     /gene_synonym="4933424N09Rik; Exod1; mKIAA1504"
                     /inference="alignment:Splign:2.1.0"
     exon            579..679
                     /gene="Eri2"
                     /gene_synonym="4933424N09Rik; Exod1; mKIAA1504"
                     /inference="alignment:Splign:2.1.0"
     exon            680..761
                     /gene="Eri2"
                     /gene_synonym="4933424N09Rik; Exod1; mKIAA1504"
                     /inference="alignment:Splign:2.1.0"
     exon            762..850
                     /gene="Eri2"
                     /gene_synonym="4933424N09Rik; Exod1; mKIAA1504"
                     /inference="alignment:Splign:2.1.0"
     exon            851..3569
                     /gene="Eri2"
                     /gene_synonym="4933424N09Rik; Exod1; mKIAA1504"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3528..3533
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Eri2"
                     /gene_synonym="4933424N09Rik; Exod1; mKIAA1504"
                     /note="hexamer: AATAAA"
     polyA_site      3550
                     /gene="Eri2"
                     /gene_synonym="4933424N09Rik; Exod1; mKIAA1504"
                     /note="major polyA site"
ORIGIN      
        1 gacggccgcc gccgctctac aagcgcccgc ttcccttgcc gcgccggcgt ttaaacagac
       61 cggaagtggg ggcgtccgac ttccggccgt tgaactctgc gaaacccagg gtccggggat
      121 ggcgaccaag agactggcgc ggcggcttgg attaattagg agaaagtcag ttacaccagc
      181 aagtggaaat ccaggaggga gcagattgaa acagttgtat gcctacttaa ttgtcgttga
      241 ctttgagtct acctgctgga atgatgggaa gcaccacagt agccctgaaa taattgaatt
      301 tccagcagtt ttgttgaata cagcaactgg agagattgaa tctgagtttc atgcttacgt
      361 tcagcctcaa gaacatccaa ttctttctga attttgcaca gaactgacag ggataaaaca
      421 ggttcaagtc gatgaaggag tccccctgaa gatttgcttg tcccagttct gtaaatggat
      481 ccataagctg cagcagcagc agacgatcag ctttgctgct ggggattcag agccttctac
      541 ttctgaagtg aaactgtgtg cttttgttac atggtcagac tgggacttgg gcgtttgcct
      601 agagtatgag tgtagaagaa agcagctgtt aaaacctgtg ttcttaaact cttggattga
      661 tctcagagca acttacaggc ttttttataa aagaaaaccc aaaggactga gtggtgcctt
      721 gcaggaagtg ggaatagaat tttcaggacg agaacattct ggcttagatg attctcggaa
      781 cactgctctt cttgcttgga aaatgatcag ggatggttgc ttaatgaaaa ttaccaggtc
      841 cttgaacaag gttctcacta agaagaatcc caagattttg gccagaaatt tgggtacaga
      901 tcaagttgaa gaagcagcta cttgcaacat gagtatccag ggccccagca tatatcaaaa
      961 ggagctccaa agtacagtaa atgcagagga aaatgcccag atgaattcag tctgtgtgaa
     1021 ttcctcctgt ataaagggcc aattgcaacc aaaaagcaac atgaaagcag atctttacaa
     1081 tatcagacat agctttcctc ttttcactac caagtcgtcg acatctgtgg accaactgca
     1141 ttctcccacc ttgaatccac ctctcactat gcaaaagcca agtaaaagtg atcagcttgc
     1201 actgaatgac agctcaaagt cctcaacact taactccaac ttagtgcttg tatctacaac
     1261 cattccgtca gttaatcatg tttctgatgt agaaatgggt catacttttg actgtttacc
     1321 gatgttggct gagtgggaag atgtagtttt actgccagca tctcaggctg agccagacac
     1381 agactgtatg cctcctgtta gtgacacaaa tgtcagtact tcacttaatt ctgcagagag
     1441 atcacttgtt ccagaagaac cagaaaccct tagttatgaa aactttgaag accttcagga
     1501 aactcctcaa aactctgaga catctaagtc tattgtgtat aagagtcctc acagtacagt
     1561 ctatgatgta aaaggagcca aacacccagg ttcggatgcc tctgctttta agttacccaa
     1621 atgcaaacca tttcctttca ccagtgttca tgccagtgca gcatatcctt cagttctgag
     1681 gaaagatcct ctcctttcag gtggcactaa aaggaattca cttagtcctc cagcttcccc
     1741 gagaaccaaa aggcagacct tcactattca tgaagaaaag cctacatcat ctatttgctc
     1801 cccaggaaca acttcttgta gagtttctcc ctctgtacta acatctacag ttaatctaca
     1861 ggagccttgg aagactggaa agatgacacc gcctctatgc aagtgtggca gaagatctaa
     1921 gcggcttatt gtttctaata atgggccaaa ccacgggaaa gccttctatt gttgcccagt
     1981 tgggaaatac caacaagaca gaaaatgctg tggttatttt aaatgggaac aaacacttca
     2041 aaaagaaagg accaatggca aagctctgtc tcattcctca gaagggctca ctttcagctc
     2101 tccagaaaca agccgtattc atgacagaaa tttaagtttt cctattaaga attctttacg
     2161 actcagacct tcaatgagac attgataaaa ctctcttcta aactgccttc agtgtatgtc
     2221 ttatctgact ttatgcagga aagatagcag tggggtttac cttacgcagc ctcagcatat
     2281 ctgagcactg cagctacacc ggagcagttc atacaaacag aagggacatg tctttcatgg
     2341 cgtgcactct tgccaagtag tctatcaact gtcatctgtt catgaagcaa tccttgttcc
     2401 tagatttcca agtatgaaca tttagataat gtcatatatt tcatatgtta acatttgctg
     2461 aatttatcaa actatcataa agaactacaa ggaaaaacta tttttacaaa ccatgtttat
     2521 taggttaaat ttaataacta gccacagaat gtgacagctt tctcttatac tttgaccttc
     2581 aaacaaattt caaactattt ttaaattact tgaataaaaa tatgactagt aaagttttag
     2641 gtaaatattc taagaattat gacagtttct taaaaatagg gttcttttca aagtttgaag
     2701 atttgttctg atttgtatat tagcatatta gaattgttca gttatgtttt gaaaatgcct
     2761 gggtacagat ttagtttaga atctgctcct aaaataaatt ttaagacatc tcagcatctg
     2821 gcgacattca ttttatgttg gcagattaca ggagcattga catgaatgca gaaggattca
     2881 ataatgatta tttgatttca gaattcaggc tctgatgtca taactacaaa atactttcaa
     2941 tccagtttca aagcagtctg cccacataat ctgtggttcc tgcagacttg tagacactgt
     3001 gtttatagct acacaggtga ttagtgggag gagttcaagt tgttacccat tcctttttcc
     3061 tcagttcatt tcttttgacc ttcccactga cagtcttcgg cagctcttca ataaattcta
     3121 cctgttggta gtaagggcag gaagaggtta gtccagcact tgttcacttc cttcaggtca
     3181 tgccggttac tcaagagctc tgtttcaaac tctaggtgaa aggataaagt taggttttgt
     3241 tctttttgtt ttttacatta aaattatgag ctaattgact gaattatgtt gggggcttcg
     3301 gtttagcctc ggagtttttg attaactatt gtcattagct ctgtttgaaa cctctcgcat
     3361 agtatatctg aggagaaaac tgtccaaagc actggactga catcactggt accagggacg
     3421 cctacctttc tggggtattt gtaaggcgct gtagtcttct tcacgtgctc ctggatctcc
     3481 tttttcagtt gctcttgatc atgggacttg taatcaggat tcaggacaat aaaagccttt
     3541 actacctaaa gaagacatgt agaacatca
//
