LOCUS       NM_026067               5067 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus exoribonuclease 1 (Eri1), mRNA.
ACCESSION   NM_026067
VERSION     NM_026067.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5067)
  AUTHORS   Guo,L., Salian,S., Xue,J.Y., Rath,N., Rousseau,J., Kim,H.,
            Ehresmann,S., Moosa,S., Nakagawa,N., Kuroda,H., Clayton-Smith,J.,
            Wang,J., Wang,Z., Banka,S., Jackson,A., Zhang,Y.M., Wei,Z.J.,
            Huning,I., Brunet,T., Ohashi,H., Thomas,M.F., Bupp,C., Miyake,N.,
            Matsumoto,N., Mendoza-Londono,R., Costain,G., Hahn,G., Di
            Donato,N., Yigit,G., Yamada,T., Nishimura,G., Ansel,K.M.,
            Wollnik,B., Hrabe de Angelis,M., Megarbane,A., Rosenfeld,J.A.,
            Heissmeyer,V., Ikegawa,S. and Campeau,P.M.
  TITLE     Null and missense mutations of ERI1 cause a recessive phenotypic
            dichotomy in humans
  JOURNAL   Am J Hum Genet 110 (7), 1068-1085 (2023)
   PUBMED   37352860
REFERENCE   2  (bases 1 to 5067)
  AUTHORS   Pirouz,M., Munafo,M., Ebrahimi,A.G., Choe,J. and Gregory,R.I.
  TITLE     Exonuclease requirements for mammalian ribosomal RNA biogenesis and
            surveillance
  JOURNAL   Nat Struct Mol Biol 26 (6), 490-500 (2019)
   PUBMED   31160785
  REMARK    GeneRIF: 7SB ribosomal RNA can be oligoadenylated by an unknown
            enzyme and/or oligouridylated by TUT4/7 and subsequently processed
            by Dis3l2 and Eri1.
REFERENCE   3  (bases 1 to 5067)
  AUTHORS   Hoefig,K.P., Rath,N., Heinz,G.A., Wolf,C., Dameris,J., Schepers,A.,
            Kremmer,E., Ansel,K.M. and Heissmeyer,V.
  TITLE     Eri1 degrades the stem-loop of oligouridylated histone mRNAs to
            induce replication-dependent decay
  JOURNAL   Nat Struct Mol Biol 20 (1), 73-81 (2013)
   PUBMED   23202588
  REMARK    GeneRIF: data demonstrate how degradation of histone mRNAs is
            initiated when 3' oligouridylation creates a cis element that
            enables Eri1 to process the double-stranded stem-loop structure
REFERENCE   4  (bases 1 to 5067)
  AUTHORS   Thomas,M.F., Abdul-Wajid,S., Panduro,M., Babiarz,J.E., Rajaram,M.,
            Woodruff,P., Lanier,L.L., Heissmeyer,V. and Ansel,K.M.
  TITLE     Eri1 regulates microRNA homeostasis and mouse lymphocyte
            development and antiviral function
  JOURNAL   Blood 120 (1), 130-142 (2012)
   PUBMED   22613798
  REMARK    GeneRIF: Mouse Eri1 regulates miRNA homeostasis in lymphocytes and
            is required for normal NK-cell development and antiviral immunity.
REFERENCE   5  (bases 1 to 5067)
  AUTHORS   Bian,Y., Zhou,W., Zhao,Y., Li,X., Geng,W., Hao,R., Yang,Q. and
            Huang,W.
  TITLE     High-dose siRNAs upregulate mouse Eri-1 at both transcription and
            posttranscription levels
  JOURNAL   PLoS One 6 (10), e26466 (2011)
   PUBMED   22039495
REFERENCE   6  (bases 1 to 5067)
  AUTHORS   Guo,G., Huss,M., Tong,G.Q., Wang,C., Li Sun,L., Clarke,N.D. and
            Robson,P.
  TITLE     Resolution of cell fate decisions revealed by single-cell gene
            expression analysis from zygote to blastocyst
  JOURNAL   Dev Cell 18 (4), 675-685 (2010)
   PUBMED   20412781
REFERENCE   7  (bases 1 to 5067)
  AUTHORS   Yokoyama,S., Ito,Y., Ueno-Kudoh,H., Shimizu,H., Uchibe,K.,
            Albini,S., Mitsuoka,K., Miyaki,S., Kiso,M., Nagai,A., Hikata,T.,
            Osada,T., Fukuda,N., Yamashita,S., Harada,D., Mezzano,V., Kasai,M.,
            Puri,P.L., Hayashizaki,Y., Okado,H., Hashimoto,M. and Asahara,H.
  TITLE     A systems approach reveals that the myogenesis genome network is
            regulated by the transcriptional repressor RP58
  JOURNAL   Dev Cell 17 (6), 836-848 (2009)
   PUBMED   20059953
REFERENCE   8  (bases 1 to 5067)
  AUTHORS   Yang,X.C., Torres,M.P., Marzluff,W.F. and Dominski,Z.
  TITLE     Three proteins of the U7-specific Sm ring function as the molecular
            ruler to determine the site of 3'-end processing in mammalian
            histone pre-mRNA
  JOURNAL   Mol Cell Biol 29 (15), 4045-4056 (2009)
   PUBMED   19470752
REFERENCE   9  (bases 1 to 5067)
  AUTHORS   Ansel,K.M., Pastor,W.A., Rath,N., Lapan,A.D., Glasmacher,E.,
            Wolf,C., Smith,L.C., Papadopoulou,N., Lamperti,E.D., Tahiliani,M.,
            Ellwart,J.W., Shi,Y., Kremmer,E., Rao,A. and Heissmeyer,V.
  TITLE     Mouse Eri1 interacts with the ribosome and catalyzes 5.8S rRNA
            processing
  JOURNAL   Nat Struct Mol Biol 15 (5), 523-530 (2008)
   PUBMED   18438418
  REMARK    GeneRIF: Findings indicate that Eri1 catalyzes the final trimming
            step in 5.8S rRNA processing, functionally and spatially connecting
            this regulator of RNAi with the basal translation machinery.
REFERENCE   10 (bases 1 to 5067)
  AUTHORS   Hong,J., Qian,Z., Shen,S., Min,T., Tan,C., Xu,J., Zhao,Y. and
            Huang,W.
  TITLE     High doses of siRNAs induce eri-1 and adar-1 gene expression and
            reduce the efficiency of RNA interference in the mouse
  JOURNAL   Biochem J 390 (Pt 3), 675-679 (2005)
   PUBMED   16004606
  REMARK    GeneRIF: The roles of meri-1 (mouse enhanced RNAi) and adar1 in the
            regulation of RNA interference are reported.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK014410.1, AK165026.1, AK161031.1 and AK050230.1.
            
            On Jan 17, 2008 this sequence version replaced NM_026067.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660815.248668.1, AK144223.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164143 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-72                AK014410.1         3-74
            73-1850             AK165026.1         2-1779
            1851-3997           AK161031.1         716-2862
            3998-5067           AK050230.1         3063-4132
FEATURES             Location/Qualifiers
     source          1..5067
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 21.16 cM"
     gene            1..5067
                     /gene="Eri1"
                     /gene_synonym="3'hexo; 3110010F15Rik; eri-1; Thex1"
                     /note="exoribonuclease 1"
                     /db_xref="GeneID:67276"
                     /db_xref="MGI:MGI:1914526"
     exon            1..262
                     /gene="Eri1"
                     /gene_synonym="3'hexo; 3110010F15Rik; eri-1; Thex1"
                     /inference="alignment:Splign:2.1.0"
     CDS             167..1204
                     /gene="Eri1"
                     /gene_synonym="3'hexo; 3110010F15Rik; eri-1; Thex1"
                     /note="three prime histone mRNA exonuclease 1; histone
                     mRNA 3' end-specific exonuclease; enhanced RNAi protein 1;
                     eri-1 homolog; 3'-5' exonuclease ERI1; histone mRNA
                     3'-exonuclease 1"
                     /codon_start=1
                     /product="3'-5' exoribonuclease 1"
                     /protein_id="NP_080343.4"
                     /db_xref="CCDS:CCDS22244.1"
                     /db_xref="GeneID:67276"
                     /db_xref="MGI:MGI:1914526"
                     /translation="MEDERGRERGGDAAQQKTPRPECEESRPLSVEKKQRCRLDGKET
                     DGSKFISSNGSDFSDPVYKEIAMTNGCINRMSKEELRAKLSEFKLETRGVKDVLKKRL
                     KNYYKKQKLMLKESSAGDSYYDYICIIDFEATCEEGNPAEFLHEIIEFPVVLLNTHTL
                     EIEDTFQQYVRPEVNDQLSEFCIGLTGITQDQVDRADAFPQVLKKVIEWMKSKELGTK
                     YKYCILTDGSWDMSKFLSIQCRLSRLKHPAFAKKWINIRKSYGNFYKVPRSQTKLTIM
                     LEKLGMDYDGRPHSGLDDSKNIARIAIRMLQDGCELRINEKILGGQLMSVSSSLPVEG
                     APAPQMPHSRK"
     exon            263..441
                     /gene="Eri1"
                     /gene_synonym="3'hexo; 3110010F15Rik; eri-1; Thex1"
                     /inference="alignment:Splign:2.1.0"
     exon            442..652
                     /gene="Eri1"
                     /gene_synonym="3'hexo; 3110010F15Rik; eri-1; Thex1"
                     /inference="alignment:Splign:2.1.0"
     exon            653..736
                     /gene="Eri1"
                     /gene_synonym="3'hexo; 3110010F15Rik; eri-1; Thex1"
                     /inference="alignment:Splign:2.1.0"
     exon            737..846
                     /gene="Eri1"
                     /gene_synonym="3'hexo; 3110010F15Rik; eri-1; Thex1"
                     /inference="alignment:Splign:2.1.0"
     exon            847..961
                     /gene="Eri1"
                     /gene_synonym="3'hexo; 3110010F15Rik; eri-1; Thex1"
                     /inference="alignment:Splign:2.1.0"
     exon            962..5067
                     /gene="Eri1"
                     /gene_synonym="3'hexo; 3110010F15Rik; eri-1; Thex1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1562..1567
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Eri1"
                     /gene_synonym="3'hexo; 3110010F15Rik; eri-1; Thex1"
                     /note="hexamer: AATACA"
     polyA_site      1582
                     /gene="Eri1"
                     /gene_synonym="3'hexo; 3110010F15Rik; eri-1; Thex1"
                     /note="major polyA site"
     regulatory      3069..3074
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Eri1"
                     /gene_synonym="3'hexo; 3110010F15Rik; eri-1; Thex1"
                     /note="hexamer: ATTAAA"
     polyA_site      3095
                     /gene="Eri1"
                     /gene_synonym="3'hexo; 3110010F15Rik; eri-1; Thex1"
                     /note="major polyA site"
     regulatory      3981..3986
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Eri1"
                     /gene_synonym="3'hexo; 3110010F15Rik; eri-1; Thex1"
                     /note="hexamer: ATTAAA"
     polyA_site      4007
                     /gene="Eri1"
                     /gene_synonym="3'hexo; 3110010F15Rik; eri-1; Thex1"
                     /note="major polyA site"
     regulatory      4392..4397
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Eri1"
                     /gene_synonym="3'hexo; 3110010F15Rik; eri-1; Thex1"
                     /note="hexamer: ATTAAA"
     polyA_site      4418
                     /gene="Eri1"
                     /gene_synonym="3'hexo; 3110010F15Rik; eri-1; Thex1"
     regulatory      5047..5052
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Eri1"
                     /gene_synonym="3'hexo; 3110010F15Rik; eri-1; Thex1"
                     /note="hexamer: AATAAA"
     polyA_site      5067
                     /gene="Eri1"
                     /gene_synonym="3'hexo; 3110010F15Rik; eri-1; Thex1"
ORIGIN      
        1 cacacgctcc cggaagtagg aggcgtccgg cggagtttgt gtggcggccg ccgcgggaac
       61 gtgaagcgcg gtagtttttc aagggagaga gcgaggcggc ttcccgcggg tctcggtgga
      121 ccgacagtga gcgtccgcgg ccgtctcgcg gcccgcgaga ggcggcatgg aggacgagcg
      181 gggccgggag cgtggcggcg acgcggcgca gcagaagacg ccgcggccgg agtgtgagga
      241 gtcccggccg ctgagcgtgg agaaaaagca gcgatgcaga cttgatggca aagagacaga
      301 tggatcgaag ttcatttcct ccaatggcag tgacttcagt gacccggttt acaaagagat
      361 cgcaatgaca aacggttgta tcaaccggat gagtaaggag gaactcagag ctaaactttc
      421 agaatttaag cttgaaacaa gaggagtcaa ggatgttcta aagaagagac tgaaaaacta
      481 ttacaagaag cagaagttga tgctgaaaga gagctccgct ggggacagtt actatgacta
      541 catttgtatc attgactttg aggctacttg tgaagagggg aacccagctg agttcctaca
      601 tgaaatcatt gagtttcctg ttgtcctgtt gaatacacac accttagaaa tcgaagatac
      661 gtttcagcag tatgtgaggc cagaagtcaa tgatcagctt tcagagttct gcatcggtct
      721 tactggaatc actcaggatc aggtagacag agccgatgct ttccctcagg tcctgaaaaa
      781 agtgattgag tggatgaagt caaaggagtt gggaactaag tacaagtact gtatactaac
      841 agatggctcc tgggatatga gtaagttcct gagcatccag tgccggctca gcagactcaa
      901 acacccggcc ttcgctaaga agtggatcaa tatccggaag tcatacggaa acttctataa
      961 ggttcccaga agccagacca aactaacaat aatgcttgaa aaattaggaa tggattatga
     1021 tggacggcct cacagcggtc tcgatgactc taagaacatt gctagaatag ctattcggat
     1081 gcttcaggat ggatgtgaac ttcgaatcaa tgaaaaaata cttggagggc agttgatgag
     1141 tgtgtcctca tccttaccag tagagggcgc tccagctcca cagatgccac atagtagaaa
     1201 gtaactgcag ttttgtctga tcagttgcta caaaagtagc aggcgaatga atctgagtta
     1261 atgcaacctt caagcacctt aaacatttaa gatcttatta caattacaga tagatgggta
     1321 tgtatgcaga cattttgtgg gaggacacac caaattcttt gtcaccagca cttttgatct
     1381 gagcagtatt tgttacacac agtaaccagt ctctgctcag aactgaattt tataatgtaa
     1441 ggtgtccaag atgtgtccct tggcttttaa gatggaagtt ttatcagaaa attctttaca
     1501 tgtcatgttc ttattgatac tggaatttaa aatgaatttc tacattacca ccatgaaatt
     1561 aaatacattt tttgaaaatg tggaaaggat tgaaaggtag tgtttgccca ttgagtttta
     1621 agtaaaacgt ggttctttta actttgtaag tttgtaggtg aagtgagggc tttgtcccaa
     1681 gaaggctgtg tgggtaccag attctgcaag tgttgaagtt ctatagttca agtggcataa
     1741 tgtttctata taacctacac gttctcccac atattttaat catctctggg tagcttatac
     1801 ttaataaact ataaagaaat ggttgtatca tttagggaat aatgacaagg aaaaaaaaaa
     1861 gcctgcaagt tgatgtagac acaaccatag tgggccttgc tacatagctc atgagctaaa
     1921 aaaaaaccaa gatctgagat ggtggaggca acttcagctg tcccctgcgt cactctctgg
     1981 ccagcagctg tccccccctg cgtcactcac tctggtccac tcagcaaagt gcttgctgag
     2041 cagcaaattc aggtgtttct tcttggaaca ttttcggcat atctgtgtat agcctatatt
     2101 caagccagga agttgtttct aaaggtgtct actttgacag ccctgaacac acatgacccc
     2161 cagaacacac gtgatagact aagagaatca actcagctca aggatgataa agtactggga
     2221 ccagtttcat attataactg gaaaccttgt aataggtcat agaatttagt taaaaatcta
     2281 gttactggag gctagcaaga tggctcagtg gttaaaagta cttgcttctc ttgtagaaga
     2341 tccaagttca attcccagaa cccacatggt ggctcacaac catctgtaag tttcaaagaa
     2401 tccaacaggc aaaacattca taaacataaa ataactaaat ttagaatact gggctggaga
     2461 gatgcctcag aagttaagag tgctggctgc tctttgagag gccctgaagt tcaattccca
     2521 gcacccacat agtggctccc aaccccctac aatgagactg ctgtcctctt ctggcatgca
     2581 ggcagaatgt tgtatatata atatatacat cctttttaaa agtctaatta ctggtgagac
     2641 taatggaaag ttagaaaagg cagcctggta gcacagatgt gtaatttcag tcctcaagag
     2701 ttaaggcata ggtgaatctg aagccactct gagccatata atgagctcct gattccaaaa
     2761 tgtgtcagta gaaaatacaa gtgaacttgt gagagctata acttacaaat caatgggaaa
     2821 atctgaagat ttgctccttg ccttccctca ccattgtgaa tgtatattcg ccctgctttt
     2881 gagctcatgg taaacatttg tattcagtac tgtgaggtga aatgttttgt tccatagtaa
     2941 aaagtacctg gcttgtcttg gtgagtgacc agtatatatt ggaaagtaat tcctgcttct
     3001 aaagtcaaga tgtgctctgg agatgatgat gtcatactgt ctggaggcta acagtgggag
     3061 cttttggaat taaacccctc taatgctttc ctggacccat ctcattggca ttgcctgttg
     3121 ttttgttttt tcaactttcc ttaatgattg tgatcatatt atgtccatca ccactataat
     3181 caagtagatt gatcatgttt cctaactcgg acataggagg aacgacagcg atgcgcttgg
     3241 gaccatgaga atttgctacc caggcttgcg gtttcattcc ccagtgagct ctgtcttgaa
     3301 gcaaagggac aggaaatggt cattgtgagg gacagaagcc agcaggctct ctggactgac
     3361 ttactcttca ttttctcaca taagccatgg tgacacaggc aggttcatgc cctagaaaaa
     3421 taattgcttg tcacctgatt gcatagttgc tactgaatag ggaaactacc attgggaagt
     3481 tagagaatag caggacatac taatgccttc ctctttgttt tgtttttaaa tcaggctgtt
     3541 taaatttttt cctaatcaag tgcttaacat ttttttttta aagaacttaa cactgcaagc
     3601 ttttaaaatg cttttggctc tactaagtat ttcgccatct tcactcactc tgagtctctg
     3661 tcaaaccatt tgatttggct ttctgctgat ataacctgtc tgtaagttat agagtgagtc
     3721 ataattcttg aaaggaaact actgcagcct gcctgcctac gttgtgtgta aagatactgg
     3781 ttcttgttac tgctgggatg gcttacactg gtgctagtgt ttgctgatac ttacttaaag
     3841 ctttattttc tcagtcgcca tggtcatctc cttgttttcc ttttacttgc ttggacattg
     3901 agactgattt ttccccctgt attattttca aatccacaca aactggtata tattctcagc
     3961 tacattttgt ctgattttgt attaaatact gacattgact ctggaaattt ttctttctct
     4021 ccacttctcc ctctgactgg gtcaagcaaa agcaggaaga agaggttttc ttttttttca
     4081 gcatgtgttt ctgcgtgtat gtgtgcctgg gagagtttat gtgcaccatg tacccttaga
     4141 ttcctgtgga cgcctcagaa ctggagttgc aggtggccat gagcacctaa tgtgggtgct
     4201 gggatcctga gtcaatgcct ctgcaagagc cgtcgcactc aactctgggg ccatctctcc
     4261 agcctcaagg ccctttcttg tagcctttag agacctgctt gtcctgctgt agggataggt
     4321 tttctcagct gggttaacag gaaagaccat gggagtcatg ctaaactggt cctattgctg
     4381 acgagtcatt tattaaatgg tgatttgatt acttgaaagg tgaaagaact tttagttcat
     4441 cgtcccagat attaaagcac tattgcgaag gataaggaag aaggggtggg tagtaagatt
     4501 tctggggaag gagggatcac aagtgatcaa tacaaggagc accagtcaag tcacccacct
     4561 cgagtgagcc atgtcctttg tgaagtctgt gagtatgtgt cctgttgcaa ggaagacttt
     4621 gagctgctgg aggagactga cttccttagt gatgagctgt gaactcctcc tttattccag
     4681 cggggcctgt tgagatgctt tccgtgtgta atgattgcag tgttggtaaa tgagtagtcc
     4741 cactaagtat cgtccttagt gttgaccctc atttcagctc ttcctgcccc cacacagcat
     4801 caatgcacac actgtagcca cgaaccaaat ctgatagcca agtggcaagt taaaatcaag
     4861 agtgcttgta tgtatgcatg tgtgtatgta tgtatatatg tatgtatgtt tttgacaggg
     4921 tatgtctgtg tagtctaatc aggtttcaaa ttcttcggta ctggaattac aggtaagtgc
     4981 tacctaccat gccaatgatg tgacttgtag cataggaatt ttatgaaata aaattttgat
     5041 gttgtaaata aagctttgtg gaatagc
//
