LOCUS       NM_001409595             964 bp    mRNA    linear   ROD 13-JUN-2024
DEFINITION  Mus musculus ERH mRNA splicing and mitosis factor (Erh), transcript
            variant 3, mRNA.
ACCESSION   NM_001409595 XM_011243995
VERSION     NM_001409595.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 964)
  AUTHORS   Pang,K., Zhang,Z., Hao,L., Shi,Z., Chen,B., Zang,G., Dong,Y.,
            Li,R., Liu,Y., Wang,J., Zhang,J., Cai,L., Han,X. and Han,C.
  TITLE     The ERH gene regulates migration and invasion in 5637 and T24
            bladder cancer cells
  JOURNAL   BMC Cancer 19 (1), 225 (2019)
   PUBMED   30866868
  REMARK    GeneRIF: Knock-down of ERH gene inhibits metastasis of bladder
            cancer cells.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 964)
  AUTHORS   Sutherland,J.M., Sobinoff,A.P., Fraser,B.A., Redgrove,K.A.,
            Davidson,T.L., Siddall,N.A., Koopman,P., Hime,G.R. and
            McLaughlin,E.A.
  TITLE     RNA binding protein Musashi-1 directly targets Msi2 and Erh during
            early testis germ cell development and interacts with IPO5 upon
            translocation to the nucleus
  JOURNAL   FASEB J 29 (7), 2759-2768 (2015)
   PUBMED   25782991
  REMARK    GeneRIF: Through expression studies and utilizing a transgenic Msi1
            testis-specific overexpression model, we have identified 2 unique
            RNA-binding targets of MSI1 in spermatogonia, Msi2 and Erh, and
            have demonstrated a role for MSI1 in translational regulation.
REFERENCE   3  (bases 1 to 964)
  AUTHORS   Krzyzanowski,M.K., Kozlowska,E. and Kozlowski,P.
  TITLE     Identification and functional analysis of the erh1(+) gene encoding
            enhancer of rudimentary homolog from the fission yeast
            Schizosaccharomyces pombe
  JOURNAL   PLoS One 7 (11), e49059 (2012)
   PUBMED   23145069
REFERENCE   4  (bases 1 to 964)
  AUTHORS   Foster,L.J., Zeemann,P.A., Li,C., Mann,M., Jensen,O.N. and
            Kassem,M.
  TITLE     Differential expression profiling of membrane proteins by
            quantitative proteomics in a human mesenchymal stem cell line
            undergoing osteoblast differentiation
  JOURNAL   Stem Cells 23 (9), 1367-1377 (2005)
   PUBMED   16210410
REFERENCE   5  (bases 1 to 964)
  AUTHORS   Li,H., Inoue,M., Yabuki,T., Aoki,M., Seki,E., Matsuda,T.,
            Nunokawa,E., Motoda,Y., Kobayashi,A., Terada,T., Shirouzu,M.,
            Koshiba,S., Lin,Y.J., Guntert,P., Suzuki,H., Hayashizaki,Y.,
            Kigawa,T. and Yokoyama,S.
  TITLE     Solution structure of the mouse enhancer of rudimentary protein
            reveals a novel fold
  JOURNAL   J Biomol NMR 32 (4), 329-334 (2005)
   PUBMED   16211485
  REMARK    GeneRIF: Molecular model of the protein conformation of the mouse
            enhancer of rudimentary protein.
REFERENCE   6  (bases 1 to 964)
  AUTHORS   Nelson,P.S., Pritchard,C., Abbott,D. and Clegg,N.
  TITLE     The human (PEDB) and mouse (mPEDB) Prostate Expression Databases
  JOURNAL   Nucleic Acids Res 30 (1), 218-220 (2002)
   PUBMED   11752298
REFERENCE   7  (bases 1 to 964)
  AUTHORS   Gelsthorpe,M., Pulumati,M., McCallum,C., Dang-Vu,K. and
            Tsubota,S.I.
  TITLE     The putative cell cycle gene, enhancer of rudimentary, encodes a
            highly conserved protein found in plants and animals
  JOURNAL   Gene 186 (2), 189-195 (1997)
   PUBMED   9074495
REFERENCE   8  (bases 1 to 964)
  AUTHORS   Sowden,J., Putt,W., Morrison,K., Beddington,R. and Edwards,Y.
  TITLE     The embryonic RNA helicase gene (ERH): a new member of the DEAD box
            family of RNA helicases
  JOURNAL   Biochem J 308 (Pt 3) (Pt 3), 839-846 (1995)
   PUBMED   8948440
REFERENCE   9  (bases 1 to 964)
  AUTHORS   Wojcik,E., Murphy,A.M., Fares,H., Dang-Vu,K. and Tsubota,S.I.
  TITLE     Enhancer of rudimentaryp1, e(r)p1, a highly conserved enhancer of
            the rudimentary gene
  JOURNAL   Genetics 138 (4), 1163-1170 (1994)
   PUBMED   7896098
REFERENCE   10 (bases 1 to 964)
  AUTHORS   Temeles,G.L., Ram,P.T., Rothstein,J.L. and Schultz,R.M.
  TITLE     Expression patterns of novel genes during mouse preimplantation
            embryogenesis
  JOURNAL   Mol Reprod Dev 37 (2), 121-129 (1994)
   PUBMED   7545925
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC134537.3.
            
            On Jul 20, 2022 this sequence version replaced XM_011243995.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.1432505.1,
                                           SRR13422600.231588.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384, SAMN01164133
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-195               AC134537.3         77774-77968         c
            196-252             AC134537.3         77097-77153         c
            253-340             AC134537.3         75265-75352         c
            341-461             AC134537.3         71798-71918         c
            462-964             AC134537.3         68333-68835         c
FEATURES             Location/Qualifiers
     source          1..964
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 36.9 cM"
     gene            1..964
                     /gene="Erh"
                     /gene_synonym="Mer; Prei1"
                     /note="ERH mRNA splicing and mitosis factor"
                     /db_xref="GeneID:13877"
                     /db_xref="MGI:MGI:108089"
     exon            1..195
                     /gene="Erh"
                     /gene_synonym="Mer; Prei1"
                     /inference="alignment:Splign:2.1.0"
     CDS             127..564
                     /gene="Erh"
                     /gene_synonym="Mer; Prei1"
                     /note="isoform 3 is encoded by transcript variant 3;
                     preimplantation protein 1; enhancer of rudimentary
                     homolog"
                     /codon_start=1
                     /product="enhancer of rudimentary homolog isoform 3"
                     /protein_id="NP_001396524.1"
                     /db_xref="GeneID:13877"
                     /db_xref="MGI:MGI:108089"
                     /translation="MVGGEVCGGQTMPSLPIAAWKRECLRQTEEGVRSPGLELPVMSH
                     TILLVQPTKRPEGRTYADYESVNECMEGVCKMYEEHLKRMNPNSPSITYDISQLFDFI
                     DDLADLSCLVYRADTQTYQPYNKDWIKEKIYVLLRRQAQQAGK"
     exon            196..252
                     /gene="Erh"
                     /gene_synonym="Mer; Prei1"
                     /inference="alignment:Splign:2.1.0"
     exon            253..340
                     /gene="Erh"
                     /gene_synonym="Mer; Prei1"
                     /inference="alignment:Splign:2.1.0"
     exon            341..461
                     /gene="Erh"
                     /gene_synonym="Mer; Prei1"
                     /inference="alignment:Splign:2.1.0"
     exon            462..964
                     /gene="Erh"
                     /gene_synonym="Mer; Prei1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      936..941
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Erh"
                     /gene_synonym="Mer; Prei1"
                     /note="hexamer: AAGAAA"
     polyA_site      964
                     /gene="Erh"
                     /gene_synonym="Mer; Prei1"
                     /note="major polyA site"
ORIGIN      
        1 gctgctcccc gcccccttcc ccccggctcg cgggtggacc cttccccttc ccggcgctga
       61 gccgcggggc ctgcccgtag gccccggacc tgatcctcct ccctgcggct gcgcgcctcc
      121 cgcctgatgg tggggggcga ggtatgcggt gggcagacga tgccctccct gccgatcgct
      181 gcctggaaga gggagtgcct gcgacagaca gaagagggcg tccgatcccc aggattggaa
      241 ttacctgtga tgtctcacac cattttgctg gtacagccta ccaagaggcc agagggcagg
      301 acttatgctg actatgagtc tgtgaatgag tgcatggaag gtgtttgtaa aatgtatgaa
      361 gaacatctga agaggatgaa tcccaacagc ccttccatca catacgatat cagccagttg
      421 tttgatttta ttgacgatct ggcagacctc agctgtctgg tttaccgagc tgatacacag
      481 acataccagc cgtataacaa agactggatc aaagagaaga tctacgtgct cctccgtcgg
      541 caggcccaac aggctgggaa gtaattgagt cggaagcatt ggggctgggg gtggacttgg
      601 aacaggtaca tacagcgtgc tgtagtgaac cttttgtatg atagcgatcc tgtttcaacg
      661 ttgttacact caagccaaga ttgaatgtct gacatgaacc gtgaatgatc ttgtcactct
      721 gaagccaccg tggccctttg ctcctttact ttcatttttt tacttaaaca tttttatgat
      781 aatacaaata gaaaacattt ttgccattta aggttggttc cggtccttga aactgtcgag
      841 tctgctttta agcagtgagc gcactaaccc tttgtggggg tggggtgggg acaaggttag
      901 tcatatagcc tctgggaaag tctcagtgaa aaataaagaa atgttctgta gttgtatttt
      961 ctca
//
