LOCUS       NM_025516               1409 bp    mRNA    linear   ROD 06-JUN-2024
DEFINITION  Mus musculus ERGIC and golgi 3 (Ergic3), transcript variant 3,
            mRNA.
ACCESSION   NM_025516
VERSION     NM_025516.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1409)
  AUTHORS   Guan,L., Yang,Y., Liang,J., Miao,Y., Shang,A., Wang,B., Wang,Y. and
            Ding,M.
  TITLE     ERGIC2 and ERGIC3 regulate the ER-to-Golgi transport of gap
            junction proteins in metazoans
  JOURNAL   Traffic 23 (3), 140-157 (2022)
   PUBMED   34994051
  REMARK    GeneRIF: ERGIC2 and ERGIC3 regulate the ER-to-Golgi transport of
            gap junction proteins in metazoans.
REFERENCE   2  (bases 1 to 1409)
  AUTHORS   Nakano,Y., Wiechert,S. and Banfi,B.
  TITLE     Overlapping Activities of Two Neuronal Splicing Factors Switch the
            GABA Effect from Excitatory to Inhibitory by Regulating REST
  JOURNAL   Cell Rep 27 (3), 860-871 (2019)
   PUBMED   30995482
REFERENCE   3  (bases 1 to 1409)
  AUTHORS   Nakano,Y., Jahan,I., Bonde,G., Sun,X., Hildebrand,M.S.,
            Engelhardt,J.F., Smith,R.J., Cornell,R.A., Fritzsch,B. and Banfi,B.
  TITLE     A mutation in the Srrm4 gene causes alternative splicing defects
            and deafness in the Bronx waltzer mouse
  JOURNAL   PLoS Genet 8 (10), e1002966 (2012)
   PUBMED   23055939
REFERENCE   4  (bases 1 to 1409)
  AUTHORS   Evsikov,A.V., Graber,J.H., Brockman,J.M., Hampl,A., Holbrook,A.E.,
            Singh,P., Eppig,J.J., Solter,D. and Knowles,B.B.
  TITLE     Cracking the egg: molecular dynamics and evolutionary aspects of
            the transition from the fully grown oocyte to embryo
  JOURNAL   Genes Dev 20 (19), 2713-2727 (2006)
   PUBMED   17015433
REFERENCE   5  (bases 1 to 1409)
  AUTHORS   Orci,L., Ravazzola,M., Mack,G.J., Barlowe,C. and Otte,S.
  TITLE     Mammalian Erv46 localizes to the endoplasmic reticulum-Golgi
            intermediate compartment and to cis-Golgi cisternae
  JOURNAL   Proc Natl Acad Sci U S A 100 (8), 4586-4591 (2003)
   PUBMED   12663859
REFERENCE   6  (bases 1 to 1409)
  AUTHORS   Klingenspor,M., Xu,P., Cohen,R.D., Welch,C. and Reue,K.
  TITLE     Altered gene expression pattern in the fatty liver dystrophy mouse
            reveals impaired insulin-mediated cytoskeleton dynamics
  JOURNAL   J Biol Chem 274 (33), 23078-23084 (1999)
   PUBMED   10438476
REFERENCE   7  (bases 1 to 1409)
  AUTHORS   Briquet-Laugier,V., Xia,Y.R., Rooke,K., Mehrabian,M., Lusis,A.J.
            and Doolittle,M.H.
  TITLE     Mapping of three members of the mouse protein disulfide isomerase
            family
  JOURNAL   Mamm Genome 9 (2), 176-177 (1998)
   PUBMED   9457688
REFERENCE   8  (bases 1 to 1409)
  AUTHORS   Welch,C.L., Xia,Y.R., Shechter,I., Farese,R., Mehrabian,M.,
            Mehdizadeh,S., Warden,C.H. and Lusis,A.J.
  TITLE     Genetic regulation of cholesterol homeostasis: chromosomal
            organization of candidate genes
  JOURNAL   J Lipid Res 37 (7), 1406-1421 (1996)
   PUBMED   8827514
  REMARK    Erratum:[J Lipid Res 1996 Oct;37(10):2269]
REFERENCE   9  (bases 1 to 1409)
  AUTHORS   Jiang,Y., Yu,V.C., Buchholz,F., O'Connell,S., Rhodes,S.J.,
            Candeloro,C., Xia,Y.R., Lusis,A.J. and Rosenfeld,M.G.
  TITLE     A novel family of Cys-Cys, His-Cys zinc finger transcription
            factors expressed in developing nervous system and pituitary gland
  JOURNAL   J Biol Chem 271 (18), 10723-10730 (1996)
   PUBMED   8631881
REFERENCE   10 (bases 1 to 1409)
  AUTHORS   Warden,C.H., Mehrabian,M., He,K.Y., Yoon,M.Y., Diep,A., Xia,Y.R.,
            Wen,P.Z., Svenson,K.L., Sparkes,R.S. and Lusis,A.J.
  TITLE     Linkage mapping of 40 randomly isolated liver cDNA clones in the
            mouse
  JOURNAL   Genomics 18 (2), 295-307 (1993)
   PUBMED   8288233
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DV662805.1, AK050285.1, AL833786.8 and AI837012.1.
            
            On Oct 4, 2017 this sequence version replaced NM_025516.4.
            
            Transcript Variant: This variant (3) lacks an alternate in-frame
            exon and uses an alternate in-frame splice junction compared to
            variant 1. The resulting isoform (3) has the same N- and C-termini
            but is shorter compared to isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC043720.2, AK009350.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-83                DV662805.1         1-83
            84-457              AK050285.1         2-375
            458-458             AL833786.8         59669-59669
            459-1391            AK050285.1         377-1309
            1392-1409           AI837012.1         1-18                c
FEATURES             Location/Qualifiers
     source          1..1409
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 77.32 cM"
     gene            1..1409
                     /gene="Ergic3"
                     /gene_synonym="2310015B14Rik; CGI-54; D2Ucla1; NY-BR-84;
                     Sdbcag84"
                     /note="ERGIC and golgi 3"
                     /db_xref="GeneID:66366"
                     /db_xref="MGI:MGI:1913616"
     exon            1..201
                     /gene="Ergic3"
                     /gene_synonym="2310015B14Rik; CGI-54; D2Ucla1; NY-BR-84;
                     Sdbcag84"
                     /inference="alignment:Splign:2.1.0"
     CDS             114..1265
                     /gene="Ergic3"
                     /gene_synonym="2310015B14Rik; CGI-54; D2Ucla1; NY-BR-84;
                     Sdbcag84"
                     /note="isoform 3 is encoded by transcript variant 3;
                     serologically defined breast cancer antigen 84;
                     endoplasmic reticulum-Golgi intermediate compartment
                     protein 3; serologically defined breast cancer antigen
                     NY-BR-84 homolog"
                     /codon_start=1
                     /product="endoplasmic reticulum-Golgi intermediate
                     compartment protein 3 isoform 3"
                     /protein_id="NP_079792.1"
                     /db_xref="CCDS:CCDS16959.1"
                     /db_xref="GeneID:66366"
                     /db_xref="MGI:MGI:1913616"
                     /translation="MEALGKLKQFDAYPKTLEDFRVKTCGGATVTIVSGLLMLLLFLS
                     ELQYYLTTEVHPELYVDKSRGDKLKINIDVLFPHMPCAYLSIDAMDVAGEQQLDVEHN
                     LFKKRLDKDGVPVSSEAERHELGKVEVTVFDPNSLDPNRCESCYGAESEDIKCCNSCE
                     DVREAYRRRGWAFKNPDTIEQCRREGFSQKMQEQKNEGCQVYGFLEVNKVAGNFHFAP
                     GKSFQQSHVHVHDLQSFGLDNINMTHYIKHLSFGEDYPGIVNPLDHTNVTAPQASMMF
                     QYFVKVVPTVYMKVDGEVLRTNQFSVTRHEKVANGLLGDQGLPGVFVLYELSPMMVKL
                     TEKHRSFTHFLTGVCAIIGGMFTVAGLIDSLIYHSARAIQKKIDLGKTT"
     exon            202..272
                     /gene="Ergic3"
                     /gene_synonym="2310015B14Rik; CGI-54; D2Ucla1; NY-BR-84;
                     Sdbcag84"
                     /inference="alignment:Splign:2.1.0"
     exon            273..360
                     /gene="Ergic3"
                     /gene_synonym="2310015B14Rik; CGI-54; D2Ucla1; NY-BR-84;
                     Sdbcag84"
                     /inference="alignment:Splign:2.1.0"
     exon            361..480
                     /gene="Ergic3"
                     /gene_synonym="2310015B14Rik; CGI-54; D2Ucla1; NY-BR-84;
                     Sdbcag84"
                     /inference="alignment:Splign:2.1.0"
     exon            481..574
                     /gene="Ergic3"
                     /gene_synonym="2310015B14Rik; CGI-54; D2Ucla1; NY-BR-84;
                     Sdbcag84"
                     /inference="alignment:Splign:2.1.0"
     exon            575..740
                     /gene="Ergic3"
                     /gene_synonym="2310015B14Rik; CGI-54; D2Ucla1; NY-BR-84;
                     Sdbcag84"
                     /inference="alignment:Splign:2.1.0"
     exon            741..798
                     /gene="Ergic3"
                     /gene_synonym="2310015B14Rik; CGI-54; D2Ucla1; NY-BR-84;
                     Sdbcag84"
                     /inference="alignment:Splign:2.1.0"
     exon            799..830
                     /gene="Ergic3"
                     /gene_synonym="2310015B14Rik; CGI-54; D2Ucla1; NY-BR-84;
                     Sdbcag84"
                     /inference="alignment:Splign:2.1.0"
     exon            831..927
                     /gene="Ergic3"
                     /gene_synonym="2310015B14Rik; CGI-54; D2Ucla1; NY-BR-84;
                     Sdbcag84"
                     /inference="alignment:Splign:2.1.0"
     exon            928..992
                     /gene="Ergic3"
                     /gene_synonym="2310015B14Rik; CGI-54; D2Ucla1; NY-BR-84;
                     Sdbcag84"
                     /inference="alignment:Splign:2.1.0"
     exon            993..1129
                     /gene="Ergic3"
                     /gene_synonym="2310015B14Rik; CGI-54; D2Ucla1; NY-BR-84;
                     Sdbcag84"
                     /inference="alignment:Splign:2.1.0"
     exon            1130..1185
                     /gene="Ergic3"
                     /gene_synonym="2310015B14Rik; CGI-54; D2Ucla1; NY-BR-84;
                     Sdbcag84"
                     /inference="alignment:Splign:2.1.0"
     exon            1186..1394
                     /gene="Ergic3"
                     /gene_synonym="2310015B14Rik; CGI-54; D2Ucla1; NY-BR-84;
                     Sdbcag84"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1371..1376
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ergic3"
                     /gene_synonym="2310015B14Rik; CGI-54; D2Ucla1; NY-BR-84;
                     Sdbcag84"
                     /note="hexamer: AATAAA"
     polyA_site      1394
                     /gene="Ergic3"
                     /gene_synonym="2310015B14Rik; CGI-54; D2Ucla1; NY-BR-84;
                     Sdbcag84"
                     /note="major polyA site"
ORIGIN      
        1 cttacgcacc gctacgcctg cgcaagacag cgaggggcgt gaccccgggt ccaggccgga
       61 agcgggaggc tggaggggcg ggccggctgg tgtccccttt ccggccggtc cccatggagg
      121 cgctggggaa gctgaagcag ttcgatgcct accctaagac tctggaggac ttccgggtca
      181 agacctgcgg gggtgccacg gtgaccatcg tcagtggcct tctcatgctc ctgcttttcc
      241 tatcggagtt gcagtattat ctcactacgg aggtgcatcc tgagctctac gtggacaagt
      301 ctcgggggga taaactgaag atcaacatcg atgttctttt cccgcacatg ccttgtgcct
      361 acttgagcat cgatgccatg gacgtggccg gggagcagca gctggatgtg gaacacaacc
      421 tgttcaagaa acgactagac aaggatggcg tccccgtgag ctcagaggct gaacggcacg
      481 agcttgggaa agtcgaggtg acagtgtttg accccaactc cttggacccc aatcgctgtg
      541 agagctgcta cggcgctgag tcagaagaca tcaagtgctg taacagttgt gaagatgtgc
      601 gggaggccta tcgccgtcga ggctgggcct tcaagaaccc ggacaccatt gagcagtgtc
      661 ggcgagaggg cttcagccag aagatgcagg agcagaagaa tgaaggctgc caggtgtacg
      721 gcttcttgga ggtcaacaag gtggctggaa acttccactt tgcccctggg aagagcttcc
      781 aacagtctca tgtgcatgtt catgacttgc agagctttgg ccttgacaat atcaacatga
      841 cacactacat caagcacctg tcattcgggg aggactatcc aggaatcgtg aaccccctag
      901 accacaccaa cgtgactgca ccccaagcct ccatgatgtt ccagtacttt gtgaaggtgg
      961 tgcccacagt gtacatgaag gtggacgggg aggtgctgag gactaaccag ttctccgtga
     1021 ccaggcacga gaaggttgcc aatgggctcc tgggtgacca gggcctgccg ggggtctttg
     1081 tgctgtatga gctctcacca atgatggtga agctgacgga gaaacacagg tccttcaccc
     1141 actttctgac aggtgtgtgc gccatcattg ggggcatgtt tacagtggcc ggcctcattg
     1201 actcgctcat ctaccactcc gctcgggcca tccagaagaa aattgaccta gggaagacaa
     1261 cgtagctctc tcccttcccc acagcttgtc ctgccctctc ttcccctgtg ggtttaccct
     1321 ccagcctgtc aactacccat atcctctcct cagccagccc agcccagggc aataaatatg
     1381 aattgtgata ggaaaaaaaa aaaaaaaaa
//
