LOCUS       NM_026168               3935 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus ERGIC and golgi 2 (Ergic2), transcript variant 1,
            mRNA.
ACCESSION   NM_026168
VERSION     NM_026168.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3935)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3935)
  AUTHORS   Guan,L., Yang,Y., Liang,J., Miao,Y., Shang,A., Wang,B., Wang,Y. and
            Ding,M.
  TITLE     ERGIC2 and ERGIC3 regulate the ER-to-Golgi transport of gap
            junction proteins in metazoans
  JOURNAL   Traffic 23 (3), 140-157 (2022)
   PUBMED   34994051
  REMARK    GeneRIF: ERGIC2 and ERGIC3 regulate the ER-to-Golgi transport of
            gap junction proteins in metazoans.
REFERENCE   3  (bases 1 to 3935)
  AUTHORS   Zak,M., Bress,A., Brandt,N., Franz,C., Ruth,P., Pfister,M.,
            Knipper,M. and Blin,N.
  TITLE     Ergic2, a brain specific interacting partner of Otoferlin
  JOURNAL   Cell Physiol Biochem 29 (5-6), 941-948 (2012)
   PUBMED   22613993
  REMARK    GeneRIF: Co-localization studies revealed an overlap of Ergic2 and
            Otoferlin signals in IHCs and neurons of cerebral cortical layer I
            making Ergic2 the promising binding candidate
REFERENCE   4  (bases 1 to 3935)
  AUTHORS   Mirabella,F., Baxter,E.W., Boissinot,M., James,S.R. and
            Cockerill,P.N.
  TITLE     The human IL-3/granulocyte-macrophage colony-stimulating factor
            locus is epigenetically silent in immature thymocytes and is
            progressively activated during T cell development
  JOURNAL   J Immunol 184 (6), 3043-3054 (2010)
   PUBMED   20147630
REFERENCE   5  (bases 1 to 3935)
  AUTHORS   Smith,T.M., Wang,X., Zhang,W., Kulyk,W. and Nazarali,A.J.
  TITLE     Hoxa2 plays a direct role in murine palate development
  JOURNAL   Dev Dyn 238 (9), 2364-2373 (2009)
   PUBMED   19653318
  REMARK    GeneRIF: Hoxa2 also repressed the expression of its downstream
            targets Ptx1 within the palate.
REFERENCE   6  (bases 1 to 3935)
  AUTHORS   Hrabe de Angelis,M.H., Flaswinkel,H., Fuchs,H., Rathkolb,B.,
            Soewarto,D., Marschall,S., Heffner,S., Pargent,W., Wuensch,K.,
            Jung,M., Reis,A., Richter,T., Alessandrini,F., Jakob,T., Fuchs,E.,
            Kolb,H., Kremmer,E., Schaeble,K., Rollinski,B., Roscher,A.,
            Peters,C., Meitinger,T., Strom,T., Steckler,T., Holsboer,F.,
            Klopstock,T., Gekeler,F., Schindewolf,C., Jung,T., Avraham,K.,
            Behrendt,H., Ring,J., Zimmer,A., Schughart,K., Pfeffer,K., Wolf,E.
            and Balling,R.
  TITLE     Genome-wide, large-scale production of mutant mice by ENU
            mutagenesis
  JOURNAL   Nat Genet 25 (4), 444-447 (2000)
   PUBMED   10932192
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK016275.1, AC132613.4 and AK030045.1.
            
            On Dec 18, 2009 this sequence version replaced NM_026168.3.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK030045.1, AK086727.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-104               AK016275.1         3-106
            105-105             AC132613.4         7368-7368
            106-352             AK016275.1         107-353
            353-3935            AK030045.1         3-3585
FEATURES             Location/Qualifiers
     source          1..3935
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 78.49 cM"
     gene            1..3935
                     /gene="Ergic2"
                     /gene_synonym="1200009B18Rik; 4930572C01Rik; Ptx1"
                     /note="ERGIC and golgi 2"
                     /db_xref="GeneID:67456"
                     /db_xref="MGI:MGI:1914706"
     exon            1..405
                     /gene="Ergic2"
                     /gene_synonym="1200009B18Rik; 4930572C01Rik; Ptx1"
                     /inference="alignment:Splign:2.1.0"
     exon            406..548
                     /gene="Ergic2"
                     /gene_synonym="1200009B18Rik; 4930572C01Rik; Ptx1"
                     /inference="alignment:Splign:2.1.0"
     CDS             443..1576
                     /gene="Ergic2"
                     /gene_synonym="1200009B18Rik; 4930572C01Rik; Ptx1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     endoplasmic reticulum-Golgi intermediate compartment
                     protein 2"
                     /codon_start=1
                     /product="endoplasmic reticulum-Golgi intermediate
                     compartment protein 2 isoform 1"
                     /protein_id="NP_080444.1"
                     /db_xref="CCDS:CCDS20708.1"
                     /db_xref="GeneID:67456"
                     /db_xref="MGI:MGI:1914706"
                     /translation="MRRLNRRKTLSLVKELDAFPKVPDSYVETSASGGTVSLIAFTTM
                     ALLTIMEFSVYQDTWMKYEYEVDKDFSSKLRINIDITVAMKCHYVGADVLDLAETMVA
                     SADGLAYEPALFDLSPQQREWQRMLQLIQSRLQEEHSLQDVIFKSAFKSASTALPPRE
                     DDSSLTPDACRIHGHLYVNKVAGNFHITVGKAIPHPRGHAHLAALVNHDSYNFSHRID
                     HLSFGELVPGIINPLDGTEKIAVDHNQMFQYFITVVPTKLHTYKISADTHQFSVTERE
                     RIINHAAGSHGVSGIFMKYDLSSLMVTVTEEHMPFWQFFVRLCGIIGGIFSTTGMLHG
                     IGKFIVEIICCRFRLGSYKPVRSVPFADGHTDNHLPLLENNTH"
     exon            549..657
                     /gene="Ergic2"
                     /gene_synonym="1200009B18Rik; 4930572C01Rik; Ptx1"
                     /inference="alignment:Splign:2.1.0"
     exon            658..704
                     /gene="Ergic2"
                     /gene_synonym="1200009B18Rik; 4930572C01Rik; Ptx1"
                     /inference="alignment:Splign:2.1.0"
     exon            705..775
                     /gene="Ergic2"
                     /gene_synonym="1200009B18Rik; 4930572C01Rik; Ptx1"
                     /inference="alignment:Splign:2.1.0"
     exon            776..816
                     /gene="Ergic2"
                     /gene_synonym="1200009B18Rik; 4930572C01Rik; Ptx1"
                     /inference="alignment:Splign:2.1.0"
     exon            817..918
                     /gene="Ergic2"
                     /gene_synonym="1200009B18Rik; 4930572C01Rik; Ptx1"
                     /inference="alignment:Splign:2.1.0"
     exon            919..1014
                     /gene="Ergic2"
                     /gene_synonym="1200009B18Rik; 4930572C01Rik; Ptx1"
                     /inference="alignment:Splign:2.1.0"
     exon            1015..1070
                     /gene="Ergic2"
                     /gene_synonym="1200009B18Rik; 4930572C01Rik; Ptx1"
                     /inference="alignment:Splign:2.1.0"
     exon            1071..1169
                     /gene="Ergic2"
                     /gene_synonym="1200009B18Rik; 4930572C01Rik; Ptx1"
                     /inference="alignment:Splign:2.1.0"
     exon            1170..1267
                     /gene="Ergic2"
                     /gene_synonym="1200009B18Rik; 4930572C01Rik; Ptx1"
                     /inference="alignment:Splign:2.1.0"
     exon            1268..1430
                     /gene="Ergic2"
                     /gene_synonym="1200009B18Rik; 4930572C01Rik; Ptx1"
                     /inference="alignment:Splign:2.1.0"
     exon            1431..1513
                     /gene="Ergic2"
                     /gene_synonym="1200009B18Rik; 4930572C01Rik; Ptx1"
                     /inference="alignment:Splign:2.1.0"
     exon            1514..3935
                     /gene="Ergic2"
                     /gene_synonym="1200009B18Rik; 4930572C01Rik; Ptx1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1957..1962
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ergic2"
                     /gene_synonym="1200009B18Rik; 4930572C01Rik; Ptx1"
                     /note="hexamer: AATAAA"
     polyA_site      1976
                     /gene="Ergic2"
                     /gene_synonym="1200009B18Rik; 4930572C01Rik; Ptx1"
                     /note="major polyA site"
     regulatory      3189..3194
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ergic2"
                     /gene_synonym="1200009B18Rik; 4930572C01Rik; Ptx1"
                     /note="hexamer: ATTAAA"
     polyA_site      3210
                     /gene="Ergic2"
                     /gene_synonym="1200009B18Rik; 4930572C01Rik; Ptx1"
                     /note="major polyA site"
     regulatory      3637..3642
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ergic2"
                     /gene_synonym="1200009B18Rik; 4930572C01Rik; Ptx1"
                     /note="hexamer: AATAAA"
     polyA_site      3668
                     /gene="Ergic2"
                     /gene_synonym="1200009B18Rik; 4930572C01Rik; Ptx1"
ORIGIN      
        1 ggaataaatg aagacgcaaa gccggaggcc tctcaaccac ctgagctgca gtgtggccgg
       61 cgccttaagg tggctggtga tcacttccgg tctgtagtgc ggagcgccgt tccagtcggt
      121 ttgtctcggg gtcaggcgga aggtaacttc cccttcctgg aaagggaccg gcctcctatt
      181 ttcacttagt ttccacgtag ccacgcccct ttcaggttga ccgcgccgct tgattagatc
      241 acataccgtc aacgcggaaa gtatcgcgag ttctccattt gcgctccctt cggacatggt
      301 cagccgtgag agttgctctt gttctcgcga gatcttcgtg tgcgccgggc tcgggcgacc
      361 cgggcttctg tgaaacatgg cggtcggctg ggaccgtacc actagtatga ctatatgaag
      421 gagaaggaag gtttttctga agatgaggcg tctgaatcgg agaaaaacct taagtttggt
      481 gaaagagtta gatgcctttc ccaaggttcc tgacagctat gtggagacgt cagccagtgg
      541 gggaacagtt tctctaatag catttaccac tatggcttta ttaacaataa tggaattctc
      601 agtctatcaa gatacatgga tgaagtacga atatgaagta gacaaggatt tttctagcaa
      661 gttgcgaatc aacatagaca ttactgttgc catgaagtgt cactatgttg gagcagatgt
      721 actggattta gcagagacca tggttgcttc tgcagatggt ctggcttatg aaccagcact
      781 gtttgacctt tcaccccagc agagagagtg gcagaggatg ctgcagctga ttcagagtag
      841 gctgcaggaa gagcattccc ttcaagacgt gatattcaag agtgctttta aaagtgcatc
      901 aactgcactg ccaccaaggg aagatgattc atcactgact ccagatgcgt gcagaatcca
      961 tggtcatctc tatgtcaata aagtagcagg gaattttcac ataactgtgg gcaaggcaat
     1021 cccacatcct cgagggcatg cacatttggc agcacttgtc aaccatgatt cttacaactt
     1081 ttctcacaga atagatcatt tgtcttttgg agagcttgtt ccgggaatta ttaatccttt
     1141 ggatggaact gaaaagattg ctgtagatca caaccagatg ttccaatatt tcattacagt
     1201 tgtgccaaca aagctacaca catacaagat ctcagcagat acccatcagt tctctgtgac
     1261 agaaagggaa cgcatcatca accatgctgc aggcagccac ggcgtctctg gaatatttat
     1321 gaaatatgat ctcagttctc tcatggtgac agtcactgag gaacacatgc ctttctggca
     1381 gttttttgta agactctgtg gtataattgg aggaatcttt tcaacaacag gcatgttaca
     1441 tggaattgga aaatttatag tggaaataat ttgctgtcgt ttcagacttg gatcctacaa
     1501 gcctgtccgt tctgtcccct ttgcggatgg ccacacagac aaccacttac ctcttttaga
     1561 gaacaacaca cattagtacc ttgtgggtgg agaaaaactt tttgcctgag acataaagcc
     1621 ttttctaata ataacatgtt gtgcaatata ttcaaagaaa aagaaaatat gagaacccgg
     1681 aaacatattt aaaaaagaaa aaaacagcca aggaaaacaa caaactgcag tcgtcttgta
     1741 tatgttgtgt ctgttacaaa tgtcatagaa gaaattatgc agctaactgg agagtcagcc
     1801 cagccaacag tgccaggtga agacagcacc tctgatgcct cccagcaaac agacaatatg
     1861 gaaagcagat cctagaggat ggacgtcaac ccgagtttaa agaaaagggc attgataaat
     1921 gcaaatgtgt gcgtcctttg tttttaaaga tgtcagaata aaatgtgtaa aacatatgga
     1981 aaactagtct agactttaaa aaaactgtaa tcagctcaca tggttaataa aggaaacagg
     2041 gactggccct gtgttacagc catattaata ttaagccata ttgacaagat ggtgttgtcc
     2101 agtttggggt tctgatgaag gtcactgcat tcctttgaac tccagttgct gactttcctg
     2161 actgttgaag gttgagcctt agaaaactaa ggtgaagttt cctaaggccc aggtatatac
     2221 ttgctatgat gtgtaacagg tgtcactcac agcttgaaca agggacactg cagggagaag
     2281 aaagcataaa tgtttaaaaa gataaacagt ttgtaagatg tgaagggtaa agttgagtgt
     2341 tgtatgctta tgagtagtgg aaaactggac atctgagaca ggcaaggcag tgtccataca
     2401 agactgaagt ctgaagcagc ctagacacag ctgtaaccct ggacaggtgc tgccctcagg
     2461 ctctgcacag aactgatgag gctacggtaa cttgaaggag ccctgtcagg tactgctagg
     2521 aactgctgag tatgtgtgcc agcctcattt cattctgtct ttttgaaaga taaaggttaa
     2581 gtcattgagt gagaagactg agtttcagtc cctaccagac acaggacagt ggtggcttcg
     2641 agtgtggcct gtcacaatca gtgtttcaag tgaatgtttt taaggataaa aaaaaatgct
     2701 tgaaagaagg taggccatca gggaaggagg agacggcaac aaatcagcag caaagtgtat
     2761 gaaaaatggc attttataga aaataggaca ttttggttaa agtgcgagag gttaagagtc
     2821 aaggagttaa atgacttaat actattataa tgttttaaaa ttttttttaa aagaatccag
     2881 gaaatttcaa ataatgagtc ttttctgagg tttttgttct attttgtttt ggttttcccc
     2941 ttaaatttta tagtttgtct agaaacggga cagctctcca gaattttgtt agcaagaact
     3001 ggtcacttga gactgaatgt tgctcttcat gtctacttac tagggaattc agtcagtttt
     3061 cagggaagaa aatagtaatt tagagttatt ttcagtatta caatgttttt aaaaagattt
     3121 aaggttattt taaattattt caatgttttc taaatgccac gttaaaattt tattgatgta
     3181 tcttttccat taaaattgac tcttcgggaa tttgtttaaa gcaaactttt ctttgccgtt
     3241 gatagccatt ttaaaagtta aggctttgat tttcaaatag tcaggaacac attttttgtc
     3301 agtaaaagaa tgaaaatgtt aaccatctgt ttgggtgatg aaggcaacgt gtgtcctcac
     3361 tagggtttcc tttccaggtc agaaatttct cactgacctg ccagctacac agcgttcctt
     3421 atgcttgtgg gcccctggag acaccatacc caagtgtctg tccagtccag tcttttaaaa
     3481 ttgtgcgtgc gtgtgtgtgt gtgtgtgcgc gcgcgcgcgc gcgcgtgcgc gtgcccgtgt
     3541 gttccaatcc taatacttta agtctgacac ctttacttga aatgttttta tactatgtat
     3601 ttgtatatct tggcctataa agatgagtaa taggtgaata aattactgtc aggtgttcaa
     3661 acacttaact gtctacctcc tgagatagcc tgttcaatct accttgtgca atagcctggc
     3721 tcaatattag aactgcagat ccacttgttc tcaacttaga tgaataatgg acacgtttct
     3781 cataatttct tattagatac acagaaaagc tgtctatttc attatcagaa tttgtcattt
     3841 gaaacacaat ttacagtctt aactttcaaa tgcatgtgag actaagatgt attgtgattc
     3901 aaatgctaag aagtaaattt acttgtaatt tcttt
//
