LOCUS       NM_133659               3259 bp    mRNA    linear   ROD 25-FEB-2025
DEFINITION  Mus musculus ETS transcription factor (Erg), transcript variant 1,
            mRNA.
ACCESSION   NM_133659 XM_489769
VERSION     NM_133659.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3259)
  AUTHORS   Niethamer,T.K., Planer,J.D., Morley,M.P., Babu,A., Zhao,G.,
            Basil,M.C., Cantu,E., Frank,D.B., Diamond,J.M., Nottingham,A.N.,
            Li,S., Sharma,A., Hallquist,H., Levin,L.I., Zhou,S., Vaughan,A.E.
            and Morrisey,E.E.
  TITLE     Longitudinal single-cell profiles of lung regeneration after viral
            infection reveal persistent injury-associated cell states
  JOURNAL   Cell Stem Cell 32 (2), 302-321 (2025)
   PUBMED   39818203
REFERENCE   2  (bases 1 to 3259)
  AUTHORS   Yamashita,T., Kaplan,U., Chakraborty,A., Marden,G., Gritli,S.,
            Roh,D., Bujor,A., Trojanowski,M., Ligresti,G., Browning,J.L. and
            Trojanowska,M.
  TITLE     ERG Regulates Lymphatic Vessel Specification Genes and Its
            Deficiency Impairs Wound Healing-Associated Lymphangiogenesis
  JOURNAL   Arthritis Rheumatol 76 (11), 1645-1657 (2024)
   PUBMED   38965683
  REMARK    GeneRIF: ERG Regulates Lymphatic Vessel Specification Genes and Its
            Deficiency Impairs Wound Healing-Associated Lymphangiogenesis.
REFERENCE   3  (bases 1 to 3259)
  AUTHORS   Pineiro-Sabaris,R., MacGrogan,D. and de la Pompa,J.L.
  TITLE     Deficient GATA6-CXCR7 signaling leads to bicuspid aortic valve
  JOURNAL   Dis Model Mech 17 (9) (2024)
   PUBMED   39253784
REFERENCE   4  (bases 1 to 3259)
  AUTHORS   Behrens,K., Brajanovski,N., Xu,Z., Viney,E.M., DiRago,L.,
            Hediyeh-Zadeh,S., Davis,M.J., Pearson,R.B., Sanij,E.,
            Alexander,W.S. and Ng,A.P.
  TITLE     ERG and c-MYC regulate a critical gene network in BCR::ABL1-driven
            B cell acute lymphoblastic leukemia
  JOURNAL   Sci Adv 10 (10), eadj8803 (2024)
   PUBMED   38457494
REFERENCE   5  (bases 1 to 3259)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   6  (bases 1 to 3259)
  AUTHORS   Fan,C.M., Kuwana,E., Bulfone,A., Fletcher,C.F., Copeland,N.G.,
            Jenkins,N.A., Crews,S., Martinez,S., Puelles,L., Rubenstein,J.L.
            and Tessier-Lavigne,M.
  TITLE     Expression patterns of two murine homologs of Drosophila
            single-minded suggest possible roles in embryonic patterning and in
            the pathogenesis of Down syndrome
  JOURNAL   Mol Cell Neurosci 7 (1), 1-16 (1996)
   PUBMED   8812055
  REMARK    Erratum:[Mol Cell Neurosci 1996 Jun;7(6):519]
REFERENCE   7  (bases 1 to 3259)
  AUTHORS   Mjaatvedt,A.E., Cabin,D.E., Cole,S.E., Long,L.J., Breitwieser,G.E.
            and Reeves,R.H.
  TITLE     Assessment of a mutation in the H5 domain of Girk2 as a candidate
            for the weaver mutation
  JOURNAL   Genome Res 5 (5), 453-463 (1995)
   PUBMED   8808466
REFERENCE   8  (bases 1 to 3259)
  AUTHORS   Rivera,R.R., Stuiver,M.H., Steenbergen,R. and Murre,C.
  TITLE     Ets proteins: new factors that regulate immunoglobulin heavy-chain
            gene expression
  JOURNAL   Mol Cell Biol 13 (11), 7163-7169 (1993)
   PUBMED   8413305
REFERENCE   9  (bases 1 to 3259)
  AUTHORS   Mjaatvedt,A.E., Citron,M.P. and Reeves,R.H.
  TITLE     High-resolution mapping of D16led-1, Gart, Gas-4, Cbr, Pcp-4, and
            Erg on distal mouse chromosome 16
  JOURNAL   Genomics 17 (2), 382-386 (1993)
   PUBMED   8406490
REFERENCE   10 (bases 1 to 3259)
  AUTHORS   Reddy,E.S., Rao,V.N. and Papas,T.S.
  TITLE     The erg gene: a human gene related to the ets oncogene
  JOURNAL   Proc Natl Acad Sci U S A 84 (17), 6131-6135 (1987)
   PUBMED   3476934
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK050922.1, AK078113.1, AC154691.3 and BP753340.1.
            
            On Oct 4, 2014 this sequence version replaced NM_133659.2.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB073080.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-845               AK050922.1         98-942
            846-917             AK078113.1         734-805
            918-1840            AK050922.1         943-1865
            1841-2392           AK078113.1         1660-2211
            2393-2393           AC154691.3         20248-20248
            2394-2440           AK078113.1         2212-2258
            2441-2443           AC154691.3         20296-20298
            2444-2886           AK078113.1         2262-2704
            2887-3259           BP753340.1         13-385              c
FEATURES             Location/Qualifiers
     source          1..3259
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 56.04 cM"
     gene            1..3259
                     /gene="Erg"
                     /gene_synonym="D030036I24Rik"
                     /note="ETS transcription factor"
                     /db_xref="GeneID:13876"
                     /db_xref="MGI:MGI:95415"
     exon            1..102
                     /gene="Erg"
                     /gene_synonym="D030036I24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            103..190
                     /gene="Erg"
                     /gene_synonym="D030036I24Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             152..1612
                     /gene="Erg"
                     /gene_synonym="D030036I24Rik"
                     /note="isoform 1 is encoded by transcript variant 1;
                     transcriptional regulator ERG; avian erythroblastosis
                     virus E-26 (v-ets) oncogene related"
                     /codon_start=1
                     /product="transcriptional regulator ERG isoform 1"
                     /protein_id="NP_598420.1"
                     /db_xref="CCDS:CCDS37411.1"
                     /db_xref="GeneID:13876"
                     /db_xref="MGI:MGI:95415"
                     /translation="MIQTVPDPAAHIKEALSVVSEDQSLFECAYGTPHLAKTEMTASS
                     SSDYGQTSKMSPRVPQQDWLSQAPARVTIKMECNPSQVNGSRNSPDECSVNKGGKMVG
                     SPDTVGMSYGSYMEEKHVPPPNMTTNERRVIVPADPTLWSTDHVRQWLEWAVKEYGLL
                     DVDVLLFQNIDGKELCKMTKDDFQRLTPSYNADILLSHLHYLRETPLPHLTSDDVDKA
                     LQNSPRLMHARNTGGAAFIFPNTSVYPEATQRITTRPDLPYEPPRRSAWTGHSHLTPQ
                     SKAAQPSPSAVPKTEDQRPQLDPYQILGPTSSRLANPGSGQIQLWQFLLELLSDSSNS
                     NCITWEGTNGEFKMTDPDEVARRWGERKSKPNMNYDKLSRALRYYYDKNIMTKVHGKR
                     YAYKFDFHGIAQALQPHPPESSLYKYPSDLPYMGSYHAHPQKMNFVSPHPPALPVTSS
                     SFFASPNPYWNSPTGGIYPNTRLPASHMPSHLGTYY"
     exon            191..408
                     /gene="Erg"
                     /gene_synonym="D030036I24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            409..560
                     /gene="Erg"
                     /gene_synonym="D030036I24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            561..764
                     /gene="Erg"
                     /gene_synonym="D030036I24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            765..845
                     /gene="Erg"
                     /gene_synonym="D030036I24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            846..917
                     /gene="Erg"
                     /gene_synonym="D030036I24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            918..986
                     /gene="Erg"
                     /gene_synonym="D030036I24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            987..1043
                     /gene="Erg"
                     /gene_synonym="D030036I24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1044..1091
                     /gene="Erg"
                     /gene_synonym="D030036I24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1092..3249
                     /gene="Erg"
                     /gene_synonym="D030036I24Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3214..3219
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Erg"
                     /gene_synonym="D030036I24Rik"
                     /note="hexamer: AATAAA"
     polyA_site      3249
                     /gene="Erg"
                     /gene_synonym="D030036I24Rik"
                     /note="major polyA site"
ORIGIN      
        1 gttgttctaa gatctttggt gatccaagaa aagctgtgtt ggtcaagggc aggacagatg
       61 actcccagag aaaaaagatg gcgaaaccaa ggacaatcag agtcgtcccg ggttctgcat
      121 ggctggtgag tgagctggcc tgctgaaggc catgatccag actgtacctg acccagcagc
      181 tcatattaag gaggccttgt cagttgtgag cgaggaccag tcactatttg agtgtgccta
      241 cggaacgcca cacctggcta agacagagat gaccgcatcc tcttccagtg actatggcca
      301 gacatccaag atgagtccca gagtccctca gcaggactgg ctgtctcaag ccccagccag
      361 ggtcaccatc aagatggagt gcaaccctag tcaggtgaat ggttccagga actcacctga
      421 tgagtgcagt gtgaacaaag gtgggaagat ggtgggcagc ccggatactg tggggatgag
      481 ctacggcagc tacatggagg agaagcatgt gccgcctccc aatatgacca caaatgagcg
      541 cagagtgatc gtccctgcag atcctactct gtggagcaca gaccatgtcc gacagtggct
      601 ggagtgggcg gtgaaagaat atggcctcct cgatgtggac gtcttactat ttcagaatat
      661 cgatgggaag gagctgtgca agatgacaaa ggatgacttc cagcggctca cgccgagcta
      721 caatgccgac attcttctct cacatctcca ctacctcaga gagactcccc ttccacatct
      781 gacttccgat gacgttgata aggctttaca aaactctcca cggttaatgc atgccagaaa
      841 cacagggggt gcagctttta ttttcccaaa tacttcagta tatcccgaag ctacgcaaag
      901 aattacaact aggccagatt taccttatga gcctcccagg agatcagcct ggaccggcca
      961 cagccacctc acccctcagt ccaaagctgc tcagccatct ccctctgcag tgcccaaaac
     1021 tgaagaccag cgtcctcagt tagatcctta ccagatcctg ggaccgacca gtagccgcct
     1081 tgctaatcca ggtagtggcc agatccagct gtggcagttc ctgctcgaac tcctgtcaga
     1141 cagctccaac tccaactgca tcacctggga aggcaccaac ggggagttca agatgacaga
     1201 cccggacgag gtggctcggc gctgggggga gaggaagagc aagcccaaca tgaactatga
     1261 caagctcagc cgcgccctcc gctactacta cgacaaaaac atcatgacca aggtgcacgg
     1321 gaagcgctac gcctacaagt ttgacttcca cgggattgcc caggccctgc agccccaccc
     1381 tcctgagtcg tccctgtaca agtacccctc cgacctgcca tacatgggct cctatcacgc
     1441 ccacccccag aagatgaact ttgtgtctcc ccaccctccc gctctcccag tcacatcttc
     1501 cagtttcttt gcttccccga acccatactg gaattcaccg actgggggca tctacccgaa
     1561 cactaggctc ccagccagcc atatgccctc tcacctgggc acctactact agagaccaga
     1621 tggaggcctt tcccaacagt gtacaatcgc ctagcagtcg ccacaaactc agcgaacaca
     1681 aatcaaaagt gcctcgtgag gagtggaaac ggttggccag agctggggaa ggaagctggg
     1741 gggggaaaaa aaaaccaaag actcgcaggg gagggtgggt gccacccaag tattactaca
     1801 gaaatagaag aagctcaaaa tatactgtac atggacatat aacctgtggt ccacccttgt
     1861 caaagacatt gtatgtagaa aagcttgacc aaaaagaaca actgcccaag gaagtggcct
     1921 taagtagtgt acaaactgta gagtgtggga ccttgcttga cctaccagga ttgagtgaaa
     1981 gcaatagaac aggaacagac ttggcctaac acaccatgta tgatgtcatt tgaagggaaa
     2041 ctacctgtgt ttaaaaatag aaaccatgtc aaaaccaaag aagaagcaga caaaaacaga
     2101 gatggcgggc ccctccacag accacaatgg ctgtggactt tcttggctgg catttgcttg
     2161 ttttctttga aatcagattc gttccatttg atagagagct gccagctctg tcaaactgtg
     2221 aagatgaccc agggtctcat ctccttttca gtattatggg aaatgtgagc catgtggtgg
     2281 gtgggggctg tgcatgttgt tgggagtatg agattgtagg agagaagctg aaatggagga
     2341 agtagaggaa gggctggggg agggagtgaa ggaggaggga aaggagaagg gggaaaggtg
     2401 gagggggaga ggaggaggag ggagaggaga agggggagag gtggaggggg agagaaggag
     2461 gagggagagg aggaggaaga agaggagaga gaggaagggg agagaaggag gagggagagg
     2521 aggaggaaga agaggagaga gaggaagggg agagaaggag gagggagagg gagaggagga
     2581 ggaagaggga gaagaggagg aaaggaaagg atagaaggca gctgctcaag ccaccacagc
     2641 tgaatttagg gcaccttggg accaaagggc atgagttgag agatgtttga tgctgtcagt
     2701 gttgtaagga cacagatttg tggaggactg ggagcagtag tattcagaac caaaaatatg
     2761 tctctttgtg aaaaggaaat cataactgga attgtctgat attttttaac aaaaattcag
     2821 aacctcagca ctcggtggag gcttttgtcc ttcccgggag cagtcgagag gtgaccttgg
     2881 tagccaccat ggtcagagac cacacaggca ttgtgggtag gtgggctcca gttttcctta
     2941 atgagtcgcg aacgctgtgc gttcgtcaga acgaagtcta caagtcaatg ggttttttct
     3001 ttttatataa taattatata acttatgcat ttatacacta cgagttgacc tcggccagcc
     3061 aaagacacac cacacacaaa caaacacaca cacacacaca cacacacaca caagagacaa
     3121 tcaaaacata tgatgtggcc ttgaatttta actctgtaat gcttaatgtt tacaatatga
     3181 agttactagt tcttagaatg cagaatgtat gttaataaaa tgagcttggc ctctcacggc
     3241 gaaccagaaa aaaaaaaaa
//
