LOCUS       NM_173395               2835 bp    mRNA    linear   ROD 17-JUL-2024
DEFINITION  Mus musculus erythroferrone (Erfe), mRNA.
ACCESSION   NM_173395
VERSION     NM_173395.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2835)
  AUTHORS   Sardo,U., Perrier,P., Cormier,K., Sotin,M., Personnaz,J.,
            Medjbeur,T., Desquesnes,A., Cannizzo,L., Ruiz-Martinez,M.,
            Thevenin,J., Billore,B., Jung,G., Abboud,E., Peyssonnaux,C.,
            Nemeth,E., Ginzburg,Y.Z., Ganz,T. and Kautz,L.
  TITLE     The hepatokine FGL1 regulates hepcidin and iron metabolism during
            anemia in mice by antagonizing BMP signaling
  JOURNAL   Blood 143 (13), 1282-1292 (2024)
   PUBMED   38232308
REFERENCE   2  (bases 1 to 2835)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2835)
  AUTHORS   Ozaki,Y., Ohashi,K., Otaka,N., Kawanishi,H., Takikawa,T., Fang,L.,
            Takahara,K., Tatsumi,M., Ishihama,S., Takefuji,M., Kato,K.,
            Shimizu,Y., Bando,Y.K., Inoue,A., Kuzuya,M., Miura,S., Murohara,T.
            and Ouchi,N.
  TITLE     Myonectin protects against skeletal muscle dysfunction in male mice
            through activation of AMPK/PGC1alpha pathway
  JOURNAL   Nat Commun 14 (1), 4675 (2023)
   PUBMED   37542026
  REMARK    GeneRIF: Myonectin protects against skeletal muscle dysfunction in
            male mice through activation of AMPK/PGC1alpha pathway.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2835)
  AUTHORS   Sangkhae,V., Yu,V., Coffey,R., O'Brien,K.O., Ganz,T. and Nemeth,E.
  TITLE     Erythroferrone contributes to iron mobilization for embryo
            erythropoiesis in iron-deficient mouse pregnancies
  JOURNAL   Am J Hematol 97 (10), 1348-1358 (2022)
   PUBMED   36071577
REFERENCE   5  (bases 1 to 2835)
  AUTHORS   Tan,W.H., Peng,Z.L., You,T. and Sun,Z.L.
  TITLE     CTRP15 promotes macrophage cholesterol efflux and attenuates
            atherosclerosis by increasing the expression of ABCA1
  JOURNAL   J Physiol Biochem 78 (3), 653-666 (2022)
   PUBMED   35286626
  REMARK    GeneRIF: CTRP15 promotes macrophage cholesterol efflux and
            attenuates atherosclerosis by increasing the expression of ABCA1.
REFERENCE   6  (bases 1 to 2835)
  AUTHORS   Kautz,L., Jung,G., Nemeth,E. and Ganz,T.
  TITLE     Erythroferrone contributes to recovery from anemia of inflammation
  JOURNAL   Blood 124 (16), 2569-2574 (2014)
   PUBMED   25193872
  REMARK    GeneRIF: Compared with wild-type mice, Fam132b-deficient mice
            exhibited a more severe anemia, had higher hepcidin levels and
            consequently lower serum iron concentration on days 14 and 21, and
            manifested impaired mobilization of iron from stores (liver and
            spleen).
REFERENCE   7  (bases 1 to 2835)
  AUTHORS   Kautz,L., Jung,G., Valore,E.V., Rivella,S., Nemeth,E. and Ganz,T.
  TITLE     Identification of erythroferrone as an erythroid regulator of iron
            metabolism
  JOURNAL   Nat Genet 46 (7), 678-684 (2014)
   PUBMED   24880340
  REMARK    Erratum:[Nat Genet. 2020 Apr;52(4):463. doi:
            10.1038/s41588-019-0548-y. PMID: 32107478]
REFERENCE   8  (bases 1 to 2835)
  AUTHORS   Seldin,M.M., Lei,X., Tan,S.Y., Stanson,K.P., Wei,Z. and Wong,G.W.
  TITLE     Skeletal muscle-derived myonectin activates the mammalian target of
            rapamycin (mTOR) pathway to suppress autophagy in liver
  JOURNAL   J Biol Chem 288 (50), 36073-36082 (2013)
   PUBMED   24187137
  REMARK    GeneRIF: myonectin is a novel regulator of cellular autophagy
REFERENCE   9  (bases 1 to 2835)
  AUTHORS   Seldin,M.M., Peterson,J.M., Byerly,M.S., Wei,Z. and Wong,G.W.
  TITLE     Myonectin (CTRP15), a novel myokine that links skeletal muscle to
            systemic lipid homeostasis
  JOURNAL   J Biol Chem 287 (15), 11968-11980 (2012)
   PUBMED   22351773
REFERENCE   10 (bases 1 to 2835)
  AUTHORS   Tang,T., Li,L., Tang,J., Li,Y., Lin,W.Y., Martin,F., Grant,D.,
            Solloway,M., Parker,L., Ye,W., Forrest,W., Ghilardi,N., Oravecz,T.,
            Platt,K.A., Rice,D.S., Hansen,G.M., Abuin,A., Eberhart,D.E.,
            Godowski,P., Holt,K.H., Peterson,A., Zambrowicz,B.P. and de
            Sauvage,F.J.
  TITLE     A mouse knockout library for secreted and transmembrane proteins
  JOURNAL   Nat Biotechnol 28 (7), 749-755 (2010)
   PUBMED   20562862
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC056923.1.
            
            On Jan 27, 2007 this sequence version replaced NM_173395.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC056923.1, AK029264.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2835              BC056923.1         1-2835
FEATURES             Location/Qualifiers
     source          1..2835
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 46.1 cM"
     gene            1..2835
                     /gene="Erfe"
                     /gene_synonym="4832406C22; Fam132b; myonectin"
                     /note="erythroferrone"
                     /db_xref="GeneID:227358"
                     /db_xref="MGI:MGI:3606476"
     exon            1..219
                     /gene="Erfe"
                     /gene_synonym="4832406C22; Fam132b; myonectin"
                     /inference="alignment:Splign:2.1.0"
     exon            220..336
                     /gene="Erfe"
                     /gene_synonym="4832406C22; Fam132b; myonectin"
                     /inference="alignment:Splign:2.1.0"
     exon            337..439
                     /gene="Erfe"
                     /gene_synonym="4832406C22; Fam132b; myonectin"
                     /inference="alignment:Splign:2.1.0"
     exon            440..696
                     /gene="Erfe"
                     /gene_synonym="4832406C22; Fam132b; myonectin"
                     /inference="alignment:Splign:2.1.0"
     exon            697..805
                     /gene="Erfe"
                     /gene_synonym="4832406C22; Fam132b; myonectin"
                     /inference="alignment:Splign:2.1.0"
     exon            806..896
                     /gene="Erfe"
                     /gene_synonym="4832406C22; Fam132b; myonectin"
                     /inference="alignment:Splign:2.1.0"
     exon            897..975
                     /gene="Erfe"
                     /gene_synonym="4832406C22; Fam132b; myonectin"
                     /inference="alignment:Splign:2.1.0"
     exon            976..2815
                     /gene="Erfe"
                     /gene_synonym="4832406C22; Fam132b; myonectin"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2791..2796
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Erfe"
                     /gene_synonym="4832406C22; Fam132b; myonectin"
                     /note="hexamer: ATTAAA"
     polyA_site      2812
                     /gene="Erfe"
                     /gene_synonym="4832406C22; Fam132b; myonectin"
                     /note="major polyA site"
ORIGIN      
        1 aaggcgccga cctgaccagc cgtgctcttt actgccgccg ccgccgccag catggcctcg
       61 acccgccgcc ccgtcggagc tcgcacgctg ctcgcctgcg ccagcctact cgccgccatg
      121 ggcctcggtg tccctgagtc cgcggagccc gtggggactc atgcacgccc gcagccgccc
      181 ggggccgagc tgcccgcccc gccagccaac agcccgccgg aacccaccat tgcgcatgca
      241 cacagtgtgg atccccggga tgcttggatg ctgttcgtca agcagagtga caaggggatc
      301 aacagtaaga ggaggagcaa agccaggagg ctgaagcttg gcctgccagg acccccaggg
      361 ccaccaggtc ctcagggccc cccaggcccc tttatcccat ctgaggttct gctgaaggag
      421 ttccagctgt tgctgaaagg cgcagtacgg cagcgagaga gccatctgga gcactgcacc
      481 agggatctca ctacaccagc ctcgggtagc ccttcccgtg tcccagccgc ccaggagctt
      541 gatagccagg acccaggggc attgttagct ctgctggctg cgaccttggc ccagggcccg
      601 cgggcaccac gtgtggaggc cgcattccac tgtcgcttgc gccgggatgt gcaggtggat
      661 cggcgtgcgt tgcacgagct tgggatctac tacctgcccg aagttgaggg agccttccac
      721 cggggcccag gcttgaatct gaccagcggc cagtacaccg cacctgtggc tggcttctat
      781 gcgcttgctg ccactctgca cgtggcactc accgagcagc caagaaaggg accaacacga
      841 ccccgggatc gtctgcgcct gctgatctgc atccagtctc tctgccagca caatgcctcc
      901 ctggagactg tgatggggct ggagaacagc agcgagctct tcaccatctc agtaaatggt
      961 gtcctctatc tacaggcagg acactacact tctgtcttct tggacaatgc cagcggctcc
     1021 tccctcacgg tacgcagtgg ctctcacttc agtgctatcc tcctgggcct gtgagcagct
     1081 gctgcaggct cttaccctta ccaagcagag tggtgacagt ggccctgtgc acaaggaagc
     1141 ccactggacc tctgcacaca ctggccatcg caatacctct taccatagcc actgtattcc
     1201 tgcagaggtg atggaagcag gctctcccag aaccagcagc aatttgtgaa tatcctaagc
     1261 cctgcttggc tcttctggga ccatccagct tacatggtag cacttgctct attcccagct
     1321 acagagctgg catccttgta gctctattca ggctcaaatt ccttcctgtg gcccagcaaa
     1381 ctagtcaggc cactcactac ctgggacaac tcagcctgca cagggtagga aatgactgta
     1441 ggtccttagt gcttaagagg gaagcccaga ccttcttgga ccatacactg tctacctggg
     1501 ttcctgagtt cctatcctgc agtattctct atgtctgcct agagtacagc ctcagggacc
     1561 taggaacgtc aggggccagt aatcctaggc ctggcagcag tttctgtgtc tggggtaagc
     1621 acgatgacct gcaggcccct ggtgagcacc ctaacatact ggagctacac tcctttgcca
     1681 tccttatcct ctacaaaggc taccagccaa cttcccaacc ctcggaggct cgggctcact
     1741 gctagggccc acacactaaa ccaaagtttg agcacagtta tccacacagg gcacctgctc
     1801 acaagtttcc ctcctgagac tccattgtaa agggggtggg tggtctggct gaatggcagc
     1861 ttgggaggaa gaagctggct gagggctctt cccatgagaa gggctgccac cctgcagcct
     1921 gctttagtgg ttttcccatt tttaacaaaa tgtgggacca gatcctaata ggcagtggag
     1981 agggctggac cttccaagtc ctgatggcct gctgatgaaa gagctgacag ccagcagtcc
     2041 acacccacca gctgctttgg gatctcttgg cctagcagga gtgctcaagc ctgggacaga
     2101 ggggatagct ccagttgctt catctttcag ctgacaccag gatgaagcta ccacatcaga
     2161 acgcccttct ataatcggac ctgtccccaa atcaggcttc caacagagcg acaggtgcct
     2221 gggggagctg tccgtgagca ggcctggccc gattctcagt atggctggta cccaccctac
     2281 caggaagcac tgtgctggcc tgggtcctga ctccctggca ctctgataag gacatgaggt
     2341 ggaaacaccc cacccttttc tggatttcat tttgtatcca gtgggcacag acatgtcagt
     2401 gacgttatct tctacccttg agaaagccac ataagcacat atcttacctt ccaacaactg
     2461 tgttacacag caacttaaaa gtatttattg tgtcatattg ctaggcagaa tatatttatg
     2521 taatggatca cacaaagccc taacaatgaa gggcagaccc gagaagcatg acctctttcc
     2581 agctcacttc accaaagacc atgaggggta agctctggaa agcaagggag aaatgccttt
     2641 agtcttgaga ctcctactga agtagcagga gaggctctta ctaaccagga aggccacagt
     2701 gccaagagtt acccagacag aagcacttgg ggacatgggt cacagcctat ggggcactga
     2761 atgattcctg ggctgctatg aaattgctaa attaaactgt ttagctttct gatgaaaaaa
     2821 aaaaaaaaaa aaaaa
//
