LOCUS       NM_001412415            3352 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus Ets2 repressor factor (Erf), transcript variant 1,
            mRNA.
ACCESSION   NM_001412415 XM_030242128
VERSION     NM_001412415.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3352)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3352)
  AUTHORS   Vogiatzi,A., Keklikoglou,K., Makris,K., Argyrou,D.S.,
            Zacharopoulos,A., Sotiropoulou,V., Parthenios,N., Gkikas,A.,
            Kokkori,M., Richardson,M.S.W., Fenwick,A.L., Archontidi,S.,
            Arvanitidis,C., Robertson,J., Parthenios,J., Zacharakis,G.,
            Twigg,S.R.F., Wilkie,A.O.M. and Mavrothalassitis,G.
  TITLE     Development of Erf-Mediated Craniosynostosis and Pharmacological
            Amelioration
  JOURNAL   Int J Mol Sci 24 (9), 7961 (2023)
   PUBMED   37175668
  REMARK    GeneRIF: Development of Erf-Mediated Craniosynostosis and
            Pharmacological Amelioration.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3352)
  AUTHORS   Tsiomita,S., Liveri,E.M., Vardaka,P., Vogiatzi,A., Skiadaresis,A.,
            Saridis,G., Tsigkas,I., Michaelidis,T.M., Mavrothalassitis,G. and
            Thyphronitis,G.
  TITLE     ETS2 repressor factor (ERF) is involved in T lymphocyte maturation
            acting as regulator of thymocyte lineage commitment
  JOURNAL   J Leukoc Biol 112 (4), 641-657 (2022)
   PUBMED   35258130
  REMARK    GeneRIF: ETS2 repressor factor (ERF) is involved in T lymphocyte
            maturation acting as regulator of thymocyte lineage commitment.
REFERENCE   4  (bases 1 to 3352)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3352)
  AUTHORS   Mayor-Ruiz,C., Olbrich,T., Drosten,M., Lecona,E., Vega-Sendino,M.,
            Ortega,S., Dominguez,O., Barbacid,M., Ruiz,S. and
            Fernandez-Capetillo,O.
  TITLE     ERF deletion rescues RAS deficiency in mouse embryonic stem cells
  JOURNAL   Genes Dev 32 (7-8), 568-576 (2018)
   PUBMED   29650524
  REMARK    GeneRIF: deletion of Erf rescues the proliferative defects of
            RAS-devoid embryonic stem cells and restores their capacity to
            differentiate.
REFERENCE   6  (bases 1 to 3352)
  AUTHORS   Perkins,K.J., Basu,U., Budak,M.T., Ketterer,C., Baby,S.M.,
            Lozynska,O., Lunde,J.A., Jasmin,B.J., Rubinstein,N.A. and
            Khurana,T.S.
  TITLE     Ets-2 repressor factor silences extrasynaptic utrophin by N-box
            mediated repression in skeletal muscle
  JOURNAL   Mol Biol Cell 18 (8), 2864-2872 (2007)
   PUBMED   17507653
  REMARK    GeneRIF: These studies suggest 'repressing repressors' as a
            potential strategy for achieving utrophin up-regulation in
            Duchenne's muscular dystrophy, and they provide a model for
            utrophin-A regulation in muscle.
REFERENCE   7  (bases 1 to 3352)
  AUTHORS   Papadaki,C., Alexiou,M., Cecena,G., Verykokakis,M., Bilitou,A.,
            Cross,J.C., Oshima,R.G. and Mavrothalassitis,G.
  TITLE     Transcriptional repressor erf determines extraembryonic ectoderm
            differentiation
  JOURNAL   Mol Cell Biol 27 (14), 5201-5213 (2007)
   PUBMED   17502352
  REMARK    GeneRIF: These data suggest that attenuation of FGF/Erk signaling
            and consecutive Erf nuclear localization and function is required
            for extraembryonic ectoderm differentiation, ectoplacental cone
            cavity closure, and chorioallantoic attachment.
REFERENCE   8  (bases 1 to 3352)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   9  (bases 1 to 3352)
  AUTHORS   Bidder,M., Loewy,A.P., Latifi,T., Newberry,E.P., Ferguson,G.,
            Willis,D.M. and Towler,D.A.
  TITLE     Ets domain transcription factor PE1 suppresses human interstitial
            collagenase promoter activity by antagonizing protein-DNA
            interactions at a critical AP1 element
  JOURNAL   Biochemistry 39 (30), 8917-8928 (2000)
   PUBMED   10913304
REFERENCE   10 (bases 1 to 3352)
  AUTHORS   Liu,D., Pavlopoulos,E., Modi,W., Moschonas,N. and
            Mavrothalassitis,G.
  TITLE     ERF: genomic organization, chromosomal localization and promoter
            analysis of the human and mouse genes
  JOURNAL   Oncogene 14 (12), 1445-1451 (1997)
   PUBMED   9136988
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC156992.13.
            
            On Sep 29, 2022 this sequence version replaced XM_030242128.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14777535.2469585.1,
                                           SRR13948564.731257.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-29                AC156992.13        129530-129558
            30-264              AC156992.13        131637-131871
            265-380             AC156992.13        132210-132325
            381-3352            AC156992.13        132428-135399
FEATURES             Location/Qualifiers
     source          1..3352
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 13.73 cM"
     gene            1..3352
                     /gene="Erf"
                     /note="Ets2 repressor factor"
                     /db_xref="GeneID:13875"
                     /db_xref="MGI:MGI:109637"
     exon            1..29
                     /gene="Erf"
                     /inference="alignment:Splign:2.1.0"
     CDS             5..1663
                     /gene="Erf"
                     /note="isoform a is encoded by transcript variant 1; ETS
                     domain-containing transcription factor ERF; Est2 repressor
                     factor"
                     /codon_start=1
                     /product="ETS domain-containing transcription factor ERF
                     isoform a"
                     /protein_id="NP_001399344.1"
                     /db_xref="GeneID:13875"
                     /db_xref="MGI:MGI:109637"
                     /translation="MLCPMRKAGFAFPDWAYKPESSPGSRQIQLWHFILELLRKEEYQ
                     GVIAWQGDYGEFVIKDPDEVARLWGVRKCKPQMNYDKLSRALRYYYNKRILHKTKGKR
                     FTYKFNFNKLVLVNYPFIDMGLAGGAVPQSAPPVPSGGSHFRFPPSTPSEVLSPTEDP
                     RSPPACSSSSSSLFSAVVARRLGRGSVSDCSDGTSELEEPLGEDPRARPPGPPELGAF
                     RGPPLARLPHDPGVFRVYPRPRGGPEPLSPFPVSPLAGPGSLLPPQLSPALPMTPTHL
                     AYTPSPTLSPMYPSGGGGPSGSGGGSHFSFSPEDMKRYLQAHTQSVYNYHLSPRAFLH
                     YPGLVVPQPQRPDKCPLPPMAPETPPVPSSASSSSSSSSSPFKFKLQPPPLGRRQRAA
                     GEKALGGTDKSSGGSGSGGLAEGAGAVAPPPPPPQIKVEPISEGESEEVEVTDISDED
                     EEDGEVFKTPRAPPAPPKPEPGEAPGVAQCMPLKLRFKRRWSEDCRLEGGGCLSGGPE
                     DEGEDKKVRGDVGPGESGGPLTPRRVSSDLQHATAQLSLEHRDS"
     exon            30..264
                     /gene="Erf"
                     /inference="alignment:Splign:2.1.0"
     exon            265..380
                     /gene="Erf"
                     /inference="alignment:Splign:2.1.0"
     exon            381..3352
                     /gene="Erf"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2566..2571
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Erf"
                     /note="hexamer: AATAAA"
     polyA_site      2584
                     /gene="Erf"
                     /note="major polyA site"
     regulatory      3328..3333
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Erf"
                     /note="hexamer: AATAAA"
     polyA_site      3352
                     /gene="Erf"
ORIGIN      
        1 gtgtatgctg tgtccgatga ggaaagccgg gtttgccttc ccagattggg cctacaaacc
       61 ggagtcatcc cctggctcca ggcagatcca gctgtggcac tttatcctgg agctgcttcg
      121 gaaagaggag taccagggcg tcatcgcttg gcagggggac tacggggagt ttgtcatcaa
      181 ggaccctgat gaagtggctc gcctctgggg ggtccgcaag tgcaaacccc agatgaacta
      241 tgacaagctg agccgggctt tgcgctatta ttacaacaag cgcattctac acaagaccaa
      301 ggggaaacgg ttcacctaca agttcaactt caacaaactg gtgctggtca attacccttt
      361 catcgatatg gggctggctg ggggtgcagt tccccaaagc gccccaccag tgccatcagg
      421 cggcagccat ttccgcttcc ctccctcaac accctctgag gtgctgtccc ccactgagga
      481 tccccgatct ccaccggctt gttcttcatc atcctcttct ctcttctctg ctgtggttgc
      541 ccgacgcctg ggccgaggct cagtcagtga ctgtagtgat ggcacctcag agctggagga
      601 gcctctggga gaggacccca gggcacgacc acctggccct ccggagctgg gtgccttccg
      661 agggcccccc ctggcccgcc tcccgcatga ccctggtgtc ttccgtgtct atcctcggcc
      721 ccggggtggt cctgaacccc tgagtccctt ccctgtgtca cctttggctg ggcctggctc
      781 ccttctaccc cctcagctct ccccagctct gcccatgact cccacccacc tggcctacac
      841 accctcaccc acgctgagtc ctatgtaccc cagtggtggt gggggcccta gtggctcagg
      901 gggaggttcc cacttctcct tcagtcctga ggacatgaaa cggtacctgc aggcccacac
      961 ccaaagcgtc tacaactacc acctcagtcc ccgcgccttc ctgcactacc cagggctggt
     1021 ggtgccccag cctcagcgcc ctgacaagtg cccactgccg cccatggcac cggagacccc
     1081 gccggtcccc tcctcagcct cgtcttcctc ttcctcctct tcatccccgt tcaagtttaa
     1141 gctgcagcca cccccgctag gacgccggca gcgggcagct ggagagaagg ctctaggagg
     1201 cactgacaag agcagtggtg gcagtggctc gggtggactg gctgaggggg caggtgcagt
     1261 agctccccca ccgccaccac cccagattaa ggtggagccc atctcagaag gagagtcgga
     1321 ggaggtggag gtgactgaca tcagtgacga agatgaggaa gatggggagg tgttcaagac
     1381 tccccgtgcc ccgcctgcac cccccaagcc agagcccgga gaggcaccgg gggtggccca
     1441 gtgcatgccc cttaaactgc gctttaagcg gcgctggagt gaagactgtc gcctggaggg
     1501 gggcgggtgc ctgtctgggg gccctgaaga tgagggtgag gacaagaagg tgcgtgggga
     1561 cgtgggccct ggggagtctg ggggacccct taccccacga cgggtgagct ctgacctcca
     1621 gcacgccaca gcccaactct ccctggagca ccgagattcc tgagagctgt gggcacgggc
     1681 ccacccccac ccacccacca ccccactccc tgagcttttg ctgccttaac cgccccgtcc
     1741 ccgcctcccc cccccccccc cccccagtcc cggaggtgag gacagctctc tttagtctct
     1801 tccctgcctc ctccctttct cctcccccac attttgtata aaactgaatt ttttttttaa
     1861 tggtagggtg ggtgggtgcc cagagctggg ggctaatctg ttcctcatct gggtttctaa
     1921 gttctgggca aagtggtggt ggggggtggg aggggggtgt taaggggggg cacctccatt
     1981 ctgggaattt ctatttgaac agaggctttg gccttcaaac ccaggaactt ttttattaca
     2041 atcgtaggaa gaaaagcctt gtccccctcc ctcttctctg cctcttacct tgtcctcccc
     2101 caccccaatc catgcccctc ccccagccct aaccctgcct ttcttgcccc tccaggggct
     2161 gtgagtgcct gggtttctta taccccacaa ggttgcagca ggggcaggag ggacaaattt
     2221 tataaaccaa aaattctgtg gggggtggtg gggtgggagg cagaggaagg tgaggggtgc
     2281 cgcctgtggg ccacaaatct ctacaagtgc ctgttcccta caccacccag tactggtcca
     2341 gtcccttcac gcccaccccc tgctgctcct aggtctggcc catgggcagg tgggtcaggg
     2401 gacaggaagg gggggttgtc tctcaaaacc aaactggaag cccctctctg cctcctagct
     2461 ggggccccag gggtggcctg gagggctgcg gtcaagcctt attctgtatt gggaatggag
     2521 ggtggggtgg gacgtgaggg ggctgctgga gaatgtattc aaaacaataa aactttggac
     2581 ctttgcatgt ggtaatttat cctaggtgct gggcgcagcc acagtatcaa cagagacttg
     2641 gcttaattct ggacaggtct agacacctgc ttcccatctg tggccagaag gcctgactcc
     2701 acctgaacag gtcaactagg cctggggagt tattggccta ctttgagatg tcacaagcct
     2761 cagagctgat gattaaggtt tctggctttc cgtagtcttg tctttccttg actggttcct
     2821 tatcatccca tctgcctcta ggacccttaa caaggccctg ctgttcctgg ttctcctacc
     2881 tgaattgctt ttgccctcca gctctgactg ctaagccaca cccccatcgg ttccccaggg
     2941 aaggaagggt cccgtatttt gaatcctccc catcttactc caatgtactc ggaggaggct
     3001 ttagtggtcc acacctgtaa tcccaccagc acttgaggta ggaagttcaa agttaaggcc
     3061 aggaccatgt gaaagggagg tgtgcgatgt tagccttctg cttgggatcc tttgaccggg
     3121 aggcctgtag tgtcctgaag tgcagccctt gggctggaga gacgctcggc tctgtgttca
     3181 agggtgcttc tgctcttcgg agaacctccg tctgttgcag agtacctcat gtggggtggc
     3241 tcgtgacagc tcacagcttc agttccaggg gaggcagctt ctggcaacca ctcagaattg
     3301 gcatagagtc actcagatat atgcattaat aaagatcttt ttaagaaatt ta
//
