LOCUS       NM_007950               4136 bp    mRNA    linear   ROD 28-MAY-2024
DEFINITION  Mus musculus epiregulin (Ereg), mRNA.
ACCESSION   NM_007950
VERSION     NM_007950.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4136)
  AUTHORS   Cubillos,P., Ditzer,N., Kolodziejczyk,A., Schwenk,G., Hoffmann,J.,
            Schutze,T.M., Derihaci,R.P., Birdir,C., Kollner,J.E., Petzold,A.,
            Sarov,M., Martin,U., Long,K.R., Wimberger,P. and Albert,M.
  TITLE     The growth factor EPIREGULIN promotes basal progenitor cell
            proliferation in the developing neocortex
  JOURNAL   EMBO J 43 (8), 1388-1419 (2024)
   PUBMED   38514807
REFERENCE   2  (bases 1 to 4136)
  AUTHORS   Briata,P., Mastracci,L., Zapparoli,E., Caputo,L., Ferracci,E.,
            Silvestri,A., Garuti,A., Hamadou,M.H., Inga,A., Marcaccini,E.,
            Grillo,F., Bucci,G., Puri,P.L., Beznoussenko,G., Mironov,A.,
            Chiacchiera,F. and Gherzi,R.
  TITLE     LncRNA EPR regulates intestinal mucus production and protects
            against inflammation and tumorigenesis
  JOURNAL   Nucleic Acids Res 51 (10), 5193-5209 (2023)
   PUBMED   37070602
  REMARK    GeneRIF: LncRNA EPR regulates intestinal mucus production and
            protects against inflammation and tumorigenesis.
REFERENCE   3  (bases 1 to 4136)
  AUTHORS   Zhang,X., Xiao,G., Johnson,C., Cai,Y., Horowitz,Z.K., Mennicke,C.,
            Coffey,R., Haider,M., Threadgill,D., Eliscu,R., Oldham,M.C.,
            Greenbaum,A. and Ghashghaei,H.T.
  TITLE     Bulk and mosaic deletions of Egfr reveal regionally defined
            gliogenesis in the developing mouse forebrain
  JOURNAL   iScience 26 (3), 106242 (2023)
   PUBMED   36915679
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4136)
  AUTHORS   Yin,Y., Haller,M.E., Chadchan,S.B., Kommagani,R. and Ma,L.
  TITLE     Signaling through retinoic acid receptors is essential for
            mammalian uterine receptivity and decidualization
  JOURNAL   JCI Insight 6 (17), e150254 (2021)
   PUBMED   34292881
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4136)
  AUTHORS   Choi,N., Kim,W.S., Oh,S.H. and Sung,J.H.
  TITLE     Epiregulin promotes hair growth via EGFR-medicated epidermal and
            ErbB4-mediated dermal stimulation
  JOURNAL   Cell Prolif 53 (9), e12881 (2020)
   PUBMED   32700456
  REMARK    GeneRIF: Epiregulin promotes hair growth via EGFR-medicated
            epidermal and ErbB4-mediated dermal stimulation.
REFERENCE   6  (bases 1 to 4136)
  AUTHORS   Komurasaki,T., Toyoda,H., Uchida,D. and Morimoto,S.
  TITLE     Epiregulin binds to epidermal growth factor receptor and ErbB-4 and
            induces tyrosine phosphorylation of epidermal growth factor
            receptor, ErbB-2, ErbB-3 and ErbB-4
  JOURNAL   Oncogene 15 (23), 2841-2848 (1997)
   PUBMED   9419975
REFERENCE   7  (bases 1 to 4136)
  AUTHORS   Das,S.K., Das,N., Wang,J., Lim,H., Schryver,B., Plowman,G.D. and
            Dey,S.K.
  TITLE     Expression of betacellulin and epiregulin genes in the mouse uterus
            temporally by the blastocyst solely at the site of its apposition
            is coincident with the 'window' of implantation
  JOURNAL   Dev Biol 190 (2), 178-190 (1997)
   PUBMED   9344537
REFERENCE   8  (bases 1 to 4136)
  AUTHORS   Toyoda,H., Komurasaki,T., Uchida,D. and Morimoto,S.
  TITLE     Distribution of mRNA for human epiregulin, a differentially
            expressed member of the epidermal growth factor family
  JOURNAL   Biochem J 326 (Pt 1) (Pt 1), 69-75 (1997)
   PUBMED   9337852
REFERENCE   9  (bases 1 to 4136)
  AUTHORS   Toyoda,H., Komurasaki,T., Ikeda,Y., Yoshimoto,M. and Morimoto,S.
  TITLE     Molecular cloning of mouse epiregulin, a novel epidermal growth
            factor-related protein, expressed in the early stage of development
  JOURNAL   FEBS Lett 377 (3), 403-407 (1995)
   PUBMED   8549764
REFERENCE   10 (bases 1 to 4136)
  AUTHORS   Toyoda,H., Komurasaki,T., Uchida,D., Takayama,Y., Isobe,T.,
            Okuyama,T. and Hanada,K.
  TITLE     Epiregulin. A novel epidermal growth factor with mitogenic activity
            for rat primary hepatocytes
  JOURNAL   J Biol Chem 270 (13), 7495-7500 (1995)
   PUBMED   7706296
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ056327.1, BB612312.1 and AC109311.12.
            
            On Dec 21, 2006 this sequence version replaced NM_007950.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D30782.1, BC027838.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-381               CJ056327.1         2-382
            382-635             BB612312.1         377-630
            636-4136            AC109311.12        52975-56475         c
FEATURES             Location/Qualifiers
     source          1..4136
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 44.78 cM"
     gene            1..4136
                     /gene="Ereg"
                     /gene_synonym="EPR"
                     /note="epiregulin"
                     /db_xref="GeneID:13874"
                     /db_xref="MGI:MGI:107508"
     exon            1..189
                     /gene="Ereg"
                     /gene_synonym="EPR"
                     /inference="alignment:Splign:2.1.0"
     CDS             144..632
                     /gene="Ereg"
                     /gene_synonym="EPR"
                     /note="proepiregulin"
                     /codon_start=1
                     /product="proepiregulin preproprotein"
                     /protein_id="NP_031976.1"
                     /db_xref="CCDS:CCDS19420.1"
                     /db_xref="GeneID:13874"
                     /db_xref="MGI:MGI:107508"
                     /translation="METLPASWVLTLLCLGSHLLQAVISTTVIPSCIPGESEDNCTAL
                     VQMEDDPRVAQVQITKCSSDMDGYCLHGQCIYLVDMREKFCRCEVGYTGLRCEHFFLT
                     VHQPLSKEYVALTVILIFLFLIITAGCIYYFCRWYKNRKSKKSREEYERVTSGDPVLP
                     QV"
     exon            190..276
                     /gene="Ereg"
                     /gene_synonym="EPR"
                     /inference="alignment:Splign:2.1.0"
     exon            277..400
                     /gene="Ereg"
                     /gene_synonym="EPR"
                     /inference="alignment:Splign:2.1.0"
     exon            401..550
                     /gene="Ereg"
                     /gene_synonym="EPR"
                     /inference="alignment:Splign:2.1.0"
     exon            551..4136
                     /gene="Ereg"
                     /gene_synonym="EPR"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3898..3903
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ereg"
                     /gene_synonym="EPR"
                     /note="hexamer: ATTAAA"
     polyA_site      3922
                     /gene="Ereg"
                     /gene_synonym="EPR"
                     /note="major polyA site"
ORIGIN      
        1 agctcagctc acttgcctgg ctgctcagag tcacagcgac ttggtgggct ctggtacctg
       61 gatcagctcg gttccaactc agccacaggc accttgctcc cgctggccgc cgcgcactcc
      121 gcaagctgca ccgagaaaga aggatggaga cgctccctgc ctcttgggtc ttgacgctgc
      181 tttgtctagg ttcccacctt ctacaggcag ttatcagcac aaccgtgatc ccatcatgca
      241 tcccaggaga atccgaggat aactgtaccg ccttagttca gatggaagac gatccccgtg
      301 tggctcaagt gcagattaca aagtgtagtt ctgacatgga cggctactgc ttgcatggcc
      361 agtgcatcta cctggtggac atgagagaga aattctgcag atgtgaagtg ggctacactg
      421 gtctgcgatg tgagcacttc tttctaactg ttcaccaacc cttgagcaaa gaatacgttg
      481 cgttgacagt gattctcatt ttcctgtttc tcatcataac cgctggatgc atatactatt
      541 tctgcagatg gtacaaaaat cgaaaaagta aaaaatcgag ggaggaatat gagagagtga
      601 cctcagggga cccagtgctg ccacaggtct gaacagtgcc atcaagttac ggacaaggat
      661 tcacagtgtg cctggctgat gtcaatattt tctcatgtta ataatattta tgttgggtca
      721 tctgttaggt caataactat atttttaata caattggaaa gtgttttatt tttgacagaa
      781 atatatttgc taatatatta tatgtaaaat atttaatatc aaaagaaatt tgatattttt
      841 gtaagaattt cctgagtaca atgctttatt gaaaagcttc aaagttcatt aagctgatgc
      901 agtgcttaga gagagcaatg tccaatctgt ggcttgggag gtgtctgcaa gtgacattcc
      961 tgcgagctta gtgatatggt caagtccatt gcatcagtaa tttatttttt tcttcttctg
     1021 tctgtgataa ttgacttgac tgaattatgg cttggcacag tggttggcga gcctcgtagt
     1081 atagtcaaat caattgcata agtaatttat tttctacttc ttatgtctgt gataattgct
     1141 ttgactttat tatcatgtat taaacagtaa taacaatggg acttagagga ggtaaacata
     1201 acttatgtgc ctcaaaccag ctagtcctgg acaagatgtc tcttcagtat ctctgctatt
     1261 gggttcagat gtgtctaggg gaacaaagaa aaattcatta acaaacatta gctgctccac
     1321 ctatgtagag tatatcatgt gaggttgttg ctttgaatat caatcagaaa atccacatct
     1381 gaagacaaat ttgaacccca ttttagagta tttattttta tagggaattt actgaaggat
     1441 tgtagcatta aagcagaatc caaatcaaag taattgtatt tttaaaatac aggagggcgg
     1501 gcgctaacca gatcttgact gatatggaaa cgtacttttg tatttcatgc tcaagaggag
     1561 ttttgttttt gctttttgtt gttgttttgt tgttgttatt ttgtttgttt aacatggagt
     1621 ctcactctag tccagactgg cctcaagctc atggttaact ctcctgctat aacctcctgg
     1681 gttacagtca tacattacgg tgcccagatt caaaatggtt tttctttctt tctttgtttt
     1741 gttctgtttt tgtttgtttg tttgtttgtt tttgtttgtt ttgtgttttg ttttttacaa
     1801 tacacagttc agacaacatc tttttacaga ttttaaagct tcatttaaaa aacatatatc
     1861 caaatgcagg aagcaaagaa aatacaggaa aaaataaatc acaatctatt tttccaaagg
     1921 ggaaacacat ttgaaagctt ttaaaatgta gacttcatta tccataccca tggaaactaa
     1981 agagaagcct gccccatttc ttcgtccttt gtttgccttt gtggaaagac agaaggctgg
     2041 cctccactct cagcttgcag gtcttcgtga gtcactgaga ggattccagg cagctatctc
     2101 gagagccact gctagaacac cttttcctgg aggctgcccc accaaatgct caaccttagg
     2161 tggaatctcc ctggaacaca taccaggtca gggagggccg atccttcctc cacctttttc
     2221 ctggcatatg tttaaggtaa caaaaagatc aggagttgcc tctggcctct aaagtgccaa
     2281 gggaccaatc attgatgttc catggagcca gtcatggaaa tccctggaag gttcacacag
     2341 ctctcatcca aagccctggc cttgctatga gggaaagatt gaataagcag cgcacaaggc
     2401 attctggtgc actaacttgt gcacacacca gctccagcct ttgcagaatg acagctcttt
     2461 gtttctgaag taaccagcac accacactca tgtttaaaag gacaaagggg aatgaaggtc
     2521 agtgagatct aaaaagtgta tttctttgcc atttgatttg gctgaaggac agtcagcatc
     2581 ctgtgtgaga acacattttg aaagcccaat gacatcaact gggtaaagga aacactaacc
     2641 tgtttccagt ctccagacaa aggtttaaag cttttcaaga actgggctaa aactcatcca
     2701 gtttatctac agaagctgaa aacaggcgtt ttagatattg gtatattggt atatgatatg
     2761 gtatgatgct tatggtctgc tatgagcatt cctgggcata ccacataact agatgcaaga
     2821 accttggggt agcattctgt atttttaaat atgttttaaa agaactcagg aacaatttac
     2881 gtctctgtat ctttttttta ctattgttgt tttgacctca aagctgggaa taaaagtcag
     2941 agccttacac atgtccagca aaaactatgg ttgggataca cctattatcc cctaaaaaca
     3001 tacaaataat gcaaaaggat gatggagctt cctggtgtcg ggtgaacatg ttttaaaaac
     3061 tcattgttct agtgaagatt atgttaagca agcctaaaaa aagatgacaa ccagttcata
     3121 cacagatttc ccattatatt gtgtatacac acacacaggg acatcaacaa gggtagtaca
     3181 cacactatac tgagaaccaa agcaacccca ggtgcataat tgtataactt acagtctccc
     3241 atcaagacta cctcatagtc cagtagatcc actccgtgac caaggacatc atgctctgta
     3301 tttgacagta aagttttacc ttaaaaatga gacccccaac tacctaaagc acccatcttt
     3361 gtaactagac cataactata ctgctttcat ctggttcacc ccctctatgt caagagtcaa
     3421 actgtgtgag aaaagccaaa gatttttttt tgagtccttt tgaagacagc tagctaaatt
     3481 tgcctgccaa aagatgtcaa ttattgaatt gatacctgtt tctagcaaat atatgacatg
     3541 gcctagtgtc ttaatttttg tcccactccg tcagtaattt gaaaagttgc ctttaaatct
     3601 ttttattgaa ccaaatttgt cacgtttggt tcaatttttt attttgtaga tttcttttaa
     3661 agtttgattg atttccccgt tttttaaatc ttttctaatg ttctgggaaa gggggagcat
     3721 aaacagcact ttcaggctac attttaaagt tctaacggaa aactacattt gtctaagata
     3781 tctctgctat tgacacatga tgcctttgaa tgtcatagag catattttct ctttttgcct
     3841 gtttgcactc tgccattgca ctttgtaaat ctgtagaatc gctcgtataa aatttctatt
     3901 aaagattcta gtgaaacata aagttgtatt gtgttcacct taaaacttat tggattatga
     3961 atgttatcag agtactgaat tgtatcaatt tgtttgcagt taatatcagc tttgatagtc
     4021 atgtaccttg acatagtgaa ggacactata atgtatgagt tgttgtcagt ttttatttat
     4081 tttttgttag gaattggcca agatcgctat ggaaaaaata aaagaacaaa cacata
//
