LOCUS       NM_028042               2133 bp    mRNA    linear   ROD 01-MAY-2024
DEFINITION  Mus musculus excision repaiross-complementing rodent repair
            deficiency, complementation group 8 (Ercc8), transcript variant 1,
            mRNA.
ACCESSION   NM_028042 NM_027277
VERSION     NM_028042.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2133)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2133)
  AUTHORS   Kajitani,G.S., Brace,L., Trevino-Villarreal,J.H., Trocha,K.,
            MacArthur,M.R., Vose,S., Vargas,D., Bronson,R., Mitchell,S.J.,
            Menck,C.F.M. and Mitchell,J.R.
  TITLE     Neurovascular dysfunction and neuroinflammation in a Cockayne
            syndrome mouse model
  JOURNAL   Aging (Albany NY) 13 (19), 22710-22731 (2021)
   PUBMED   34628368
  REMARK    GeneRIF: Neurovascular dysfunction and neuroinflammation in a
            Cockayne syndrome mouse model.
REFERENCE   3  (bases 1 to 2133)
  AUTHORS   Rainey,R.N., Ng,S.Y., Llamas,J., van der Horst,G.T. and Segil,N.
  TITLE     Mutations in Cockayne Syndrome-Associated Genes (Csa and Csb)
            Predispose to Cisplatin-Induced Hearing Loss in Mice
  JOURNAL   J Neurosci 36 (17), 4758-4770 (2016)
   PUBMED   27122034
REFERENCE   4  (bases 1 to 2133)
  AUTHORS   Nagtegaal,A.P., Rainey,R.N., van der Pluijm,I., Brandt,R.M., van
            der Horst,G.T., Borst,J.G. and Segil,N.
  TITLE     Cockayne syndrome group B (Csb) and group a (Csa) deficiencies
            predispose to hearing loss and cochlear hair cell degeneration in
            mice
  JOURNAL   J Neurosci 35 (10), 4280-4286 (2015)
   PUBMED   25762674
  REMARK    GeneRIF: This study demonistrated that Cockayne syndrome group A
            deficiencies predispose to hearing loss and cochlear hair cell
            degeneration in mice.
REFERENCE   5  (bases 1 to 2133)
  AUTHORS   Jaarsma,D., van der Pluijm,I., de Waard,M.C., Haasdijk,E.D.,
            Brandt,R., Vermeij,M., Rijksen,Y., Maas,A., van Steeg,H.,
            Hoeijmakers,J.H. and van der Horst,G.T.
  TITLE     Age-related neuronal degeneration: complementary roles of
            nucleotide excision repair and transcription-coupled repair in
            preventing neuropathology
  JOURNAL   PLoS Genet 7 (12), e1002405 (2011)
   PUBMED   22174697
REFERENCE   6  (bases 1 to 2133)
  AUTHORS   Wijnhoven,S.W., Hoogervorst,E.M., de Waard,H., van der Horst,G.T.
            and van Steeg,H.
  TITLE     Tissue specific mutagenic and carcinogenic responses in NER
            defective mouse models
  JOURNAL   Mutat Res 614 (1-2), 77-94 (2007)
   PUBMED   16769089
  REMARK    Review article
REFERENCE   7  (bases 1 to 2133)
  AUTHORS   Tsai,P.S., Nielen,M., van der Horst,G.T., Colenbrander,B.,
            Heesterbeek,J.A. and van Vlissingen,J.M.
  TITLE     The effect of DNA repair defects on reproductive performance in
            nucleotide excision repair (NER) mouse models: an epidemiological
            approach
  JOURNAL   Transgenic Res 14 (6), 845-857 (2005)
   PUBMED   16315091
REFERENCE   8  (bases 1 to 2133)
  AUTHORS   de Waard,H., de Wit,J., Andressoo,J.O., van Oostrom,C.T., Riis,B.,
            Weimann,A., Poulsen,H.E., van Steeg,H., Hoeijmakers,J.H. and van
            der Horst,G.T.
  TITLE     Different effects of CSA and CSB deficiency on sensitivity to
            oxidative DNA damage
  JOURNAL   Mol Cell Biol 24 (18), 7941-7948 (2004)
   PUBMED   15340056
  REMARK    GeneRIF: difference in oxidative DNA damage sensitivity between
            CSA- and CSB-deficient cell lines and mice
REFERENCE   9  (bases 1 to 2133)
  AUTHORS   Nahari,D., McDaniel,L.D., Task,L.B., Daniel,R.L., Velasco-Miguel,S.
            and Friedberg,E.C.
  TITLE     Mutations in the Trp53 gene of UV-irradiated Xpc mutant mice
            suggest a novel Xpc-dependent DNA repair process
  JOURNAL   DNA Repair (Amst) 3 (4), 379-386 (2004)
   PUBMED   15010313
REFERENCE   10 (bases 1 to 2133)
  AUTHORS   van der Horst,G.T., Meira,L., Gorgels,T.G., de Wit,J.,
            Velasco-Miguel,S., Richardson,J.A., Kamp,Y., Vreeswijk,M.P.,
            Smit,B., Bootsma,D., Hoeijmakers,J.H. and Friedberg,E.C.
  TITLE     UVB radiation-induced cancer predisposition in Cockayne syndrome
            group A (Csa) mutant mice
  JOURNAL   DNA Repair (Amst) 1 (2), 143-157 (2002)
   PUBMED   12509261
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK010576.1 and BC056463.1.
            
            On Apr 14, 2018 this sequence version replaced NM_028042.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK157175.1, AK010576.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-930               AK010576.1         3-932
            931-2133            BC056463.1         915-2117
FEATURES             Location/Qualifiers
     source          1..2133
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 59.69 cM"
     gene            1..2133
                     /gene="Ercc8"
                     /gene_synonym="2410022P04Rik; 2810431L23Rik;
                     4631412O06Rik; B130065P18Rik; Ckn1; Csa"
                     /note="excision repaiross-complementing rodent repair
                     deficiency, complementation group 8"
                     /db_xref="GeneID:71991"
                     /db_xref="MGI:MGI:1919241"
     exon            1..133
                     /gene="Ercc8"
                     /gene_synonym="2410022P04Rik; 2810431L23Rik;
                     4631412O06Rik; B130065P18Rik; Ckn1; Csa"
                     /inference="alignment:Splign:2.1.0"
     CDS             57..1250
                     /gene="Ercc8"
                     /gene_synonym="2410022P04Rik; 2810431L23Rik;
                     4631412O06Rik; B130065P18Rik; Ckn1; Csa"
                     /note="isoform 1 is encoded by transcript variant 1; DNA
                     excision repair protein ERCC-8; cockayne syndrome WD
                     repeat protein CSA homolog; Cockayne syndrome 1 homolog"
                     /codon_start=1
                     /product="DNA excision repair protein ERCC-8 isoform 1"
                     /protein_id="NP_082318.2"
                     /db_xref="CCDS:CCDS26761.1"
                     /db_xref="GeneID:71991"
                     /db_xref="MGI:MGI:1919241"
                     /translation="MLSFLSARQSGLEDPLRLRRAQSTRRVLGLELNKDRDVERIHGS
                     GVNTLDIEPVEGRYMLSGGSDGVVVLYDLENASRQPHYTCKAVCSVGRSHPDVHKYSV
                     ETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQAADVFNFEETVYSHHMSPAATKHCLVA
                     VGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRHDYILATASADSRVKLWDVRR
                     ASGCLLTLDQHNGKKSQAAESANTAHNGKVNGLCFTSDGLHLLTIGTDNRMRLWNSSS
                     GDNTLVNYGKVCNDSRKGLQFAVSCGCSSEFVFVPHGSTIAVYAVHSGERLAMLKGHY
                     KSVDCCVFQPNFQELYSGSRDCNILAWVPPSYEPVPDDDDEAPAKSQLNPAFADAWSS
                     SDEDG"
     exon            134..229
                     /gene="Ercc8"
                     /gene_synonym="2410022P04Rik; 2810431L23Rik;
                     4631412O06Rik; B130065P18Rik; Ckn1; Csa"
                     /inference="alignment:Splign:2.1.0"
     exon            230..331
                     /gene="Ercc8"
                     /gene_synonym="2410022P04Rik; 2810431L23Rik;
                     4631412O06Rik; B130065P18Rik; Ckn1; Csa"
                     /inference="alignment:Splign:2.1.0"
     exon            332..455
                     /gene="Ercc8"
                     /gene_synonym="2410022P04Rik; 2810431L23Rik;
                     4631412O06Rik; B130065P18Rik; Ckn1; Csa"
                     /inference="alignment:Splign:2.1.0"
     exon            456..537
                     /gene="Ercc8"
                     /gene_synonym="2410022P04Rik; 2810431L23Rik;
                     4631412O06Rik; B130065P18Rik; Ckn1; Csa"
                     /inference="alignment:Splign:2.1.0"
     exon            538..606
                     /gene="Ercc8"
                     /gene_synonym="2410022P04Rik; 2810431L23Rik;
                     4631412O06Rik; B130065P18Rik; Ckn1; Csa"
                     /inference="alignment:Splign:2.1.0"
     exon            607..673
                     /gene="Ercc8"
                     /gene_synonym="2410022P04Rik; 2810431L23Rik;
                     4631412O06Rik; B130065P18Rik; Ckn1; Csa"
                     /inference="alignment:Splign:2.1.0"
     exon            674..774
                     /gene="Ercc8"
                     /gene_synonym="2410022P04Rik; 2810431L23Rik;
                     4631412O06Rik; B130065P18Rik; Ckn1; Csa"
                     /inference="alignment:Splign:2.1.0"
     exon            775..899
                     /gene="Ercc8"
                     /gene_synonym="2410022P04Rik; 2810431L23Rik;
                     4631412O06Rik; B130065P18Rik; Ckn1; Csa"
                     /inference="alignment:Splign:2.1.0"
     exon            900..1097
                     /gene="Ercc8"
                     /gene_synonym="2410022P04Rik; 2810431L23Rik;
                     4631412O06Rik; B130065P18Rik; Ckn1; Csa"
                     /inference="alignment:Splign:2.1.0"
     exon            1098..1181
                     /gene="Ercc8"
                     /gene_synonym="2410022P04Rik; 2810431L23Rik;
                     4631412O06Rik; B130065P18Rik; Ckn1; Csa"
                     /inference="alignment:Splign:2.1.0"
     exon            1182..2108
                     /gene="Ercc8"
                     /gene_synonym="2410022P04Rik; 2810431L23Rik;
                     4631412O06Rik; B130065P18Rik; Ckn1; Csa"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1614..1619
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ercc8"
                     /gene_synonym="2410022P04Rik; 2810431L23Rik;
                     4631412O06Rik; B130065P18Rik; Ckn1; Csa"
                     /note="hexamer: AATATA"
     polyA_site      1639
                     /gene="Ercc8"
                     /gene_synonym="2410022P04Rik; 2810431L23Rik;
                     4631412O06Rik; B130065P18Rik; Ckn1; Csa"
                     /note="major polyA site"
ORIGIN      
        1 agttccccgg tctgtcatgg cagcgcccag gcctccagcc ggtgtgtgga cccgagatgt
       61 tgagcttttt gtccgctcga cagtcgggtt tggaggaccc tcttcgcttg cgtagagcgc
      121 agtccacacg gagggtcctg gggctggagt taaacaaaga cagggatgtg gaaagaatcc
      181 atggcagtgg ggttaacacc ctcgacattg agcccgttga aggaagatac atgttgtcag
      241 gtggctccga tggcgtggtt gtactctatg accttgagaa cgccagcaga cagccccatt
      301 acacatgtaa agcagtgtgt tccgttggca gaagccatcc cgatgttcac aaatacagcg
      361 tggagactgt tcagtggtat cctcatgaca ctggcatgtt cacatccagc tcatttgata
      421 aaactctgaa agtgtgggat acaaacacat tgcaggctgc agatgtgttt aattttgagg
      481 aaacagttta cagtcatcac atgtccccag cagccaccaa gcactgtctg gtagcagttg
      541 gaacaagagg acccaaggta caactttgtg acttaaagtc tggatcctgt tctcacattc
      601 tacagggtca cagacaggaa atcttggcag tttcctggtc accacgccat gactatatct
      661 tggcaacagc aagtgctgac agtagagtaa aattatggga tgtgagaaga gcgtcaggat
      721 gcttgcttac tcttgaccag cataatggga aaaagtcaca agctgctgaa tcagcaaaca
      781 ctgctcacaa tgggaaagtt aacggcttat gttttacaag tgacggcctt cacctgctca
      841 ccattggcac agacaaccga atgcgcctct ggaatagctc cagcggggac aacaccctgg
      901 tgaactatgg gaaggtgtgt aatgacagca ggaaagggct gcagttcgct gtctcctgtg
      961 gctgcagctc agagtttgtg tttgttcccc acggcagcac catcgctgtg tacgcagtcc
     1021 actcgggaga gcggctcgcc atgctcaagg gacattacaa aagcgtcgac tgctgtgtgt
     1081 tccagcctaa tttccaggaa ctttacagtg gaagcaggga ctgcaatatt cttgcttggg
     1141 taccaccttc ctatgagcca gttcctgatg atgacgatga agctccagcc aaatcccagt
     1201 taaacccagc attcgcggac gcctggagca gcagtgacga ggatgggtga ctgtcagccc
     1261 tggctccttg tccatcagac ttccacgaca gtgttgtgtg cacttcagca cgagcagggt
     1321 tgttcttccc gttattgttg gttttgagac agtgtctcac gatgtaaccc tggctagcct
     1381 ggactagcct ggaactctgt atagagcaga ctcggctcac actggcagct attctgcctc
     1441 tgctcccagg tgctggggtt agaggtgtat accacgtggc ccctcctgta catgtgtgtg
     1501 attgtttgtt tcattgtttg taaactcttc agtcagtttt taacctgtta atcctgagtt
     1561 tgggatattt ccctgtgtgc tttaaaatga gatcgatgtg tatgataccc tgaaatatac
     1621 ttttctgtcg gttaattaat cagaacttgt ctccttgagc gcattcacca gggtggtggg
     1681 ccagccccta cgggcacagc ccaagaacag acttgttatt cccagctggg accttcatat
     1741 gtgcatccaa ggagctgaaa gtatgaccca ggaagctctc agctctgact cctgactgtg
     1801 ctgccagcct gcccttccca ccttcaggga ggagtttagc aaggaggatt agagaaactt
     1861 gttgcaacag tggcatcata atgctagatt ttttactcaa actgaatggc ttcatgtaat
     1921 cgagcctctt ctccctcata ttgaatgtta gccactcatg catcttgcag tgtgaacatc
     1981 gtatcacata ggcaatccct gaccactttg tattgctctc agagggcagc ttacactcag
     2041 tcttaattcc ttcctgtgaa actcagcaaa atccatgcag ggatgtagat taaacatgaa
     2101 atgccataaa aaaaaaaaaa aaaaaaaaaa aaa
//
