LOCUS       NP_001013626            1537 aa            linear   ROD 01-MAY-2025
DEFINITION  DNA excision repair protein ERCC-6-like 2 isoform 1 [Mus musculus].
ACCESSION   NP_001013626 XP_484270
VERSION     NP_001013626.2
DBSOURCE    REFSEQ: accession NM_001013608.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 1537)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 1537)
  AUTHORS   Liu,X., Liu,T., Shang,Y., Dai,P., Zhang,W., Lee,B.J., Huang,M.,
            Yang,D., Wu,Q., Liu,L.D., Zheng,X., Zhou,B.O., Dong,J., Yeap,L.S.,
            Hu,J., Xiao,T., Zha,S., Casellas,R., Liu,X.S. and Meng,F.L.
  TITLE     ERCC6L2 promotes DNA orientation-specific recombination in
            mammalian cells
  JOURNAL   Cell Res 30 (9), 732-744 (2020)
   PUBMED   32355287
  REMARK    GeneRIF: ERCC6L2 promotes DNA orientation-specific recombination in
            mammalian cells.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC154248.2.
            
            On Mar 12, 2008 this sequence version replaced NP_001013626.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR10223971.13467.1,
                                           SRR10223970.16118.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1537
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 33.1 cM"
     Protein         1..1537
                     /product="DNA excision repair protein ERCC-6-like 2
                     isoform 1"
                     /note="stretch responsive protein 278; putative repair and
                     recombination helicase RAD26L; DNA repair and
                     recombination protein RAD26-like; DNA excision repair
                     protein ERCC-6-like 2"
                     /calculated_mol_wt=173742
     Region          17..72
                     /region_name="Tudor_SF"
                     /note="Tudor domain superfamily; cl02573"
                     /db_xref="CDD:470623"
     Site            order(27,32,34,57,59)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:410471"
     Region          <51..649
                     /region_name="HepA"
                     /note="Superfamily II DNA or RNA helicase, SNF2 family
                     [Transcription, Replication, recombination, and repair];
                     COG0553"
                     /db_xref="CDD:440319"
     Region          122..369
                     /region_name="DEXHc_ERCC6L2"
                     /note="DEXH-box helicase domain of ERCC6L2; cd18005"
                     /db_xref="CDD:350763"
     Site            order(149..155,213,270..271)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:350763"
     Region          270..273
                     /region_name="DEAH box"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JIM3.3)"
     Region          715..735
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JIM3.3)"
     Region          749..768
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JIM3.3)"
     Region          791..811
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JIM3.3)"
     Region          833..891
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JIM3.3)"
     Region          918..948
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JIM3.3)"
     Site            968
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q9JIM3.3)"
     Site            971
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q9JIM3.3)"
     Region          <1108..1131
                     /region_name="VIGSSK"
                     /note="Helicase-associated putative binding domain,
                     C-terminal; pfam14773"
                     /db_xref="CDD:464308"
     Region          1274..1306
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JIM3.3)"
     CDS             1..1537
                     /gene="Ercc6l2"
                     /gene_synonym="0610007P08Rik; 1700019D06Rik;
                     9330134C04Rik; Rad26l; Sr278"
                     /coded_by="NM_001013608.4:172..4785"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS26593.2"
                     /db_xref="GeneID:76251"
                     /db_xref="MGI:MGI:1923501"
ORIGIN      
        1 mdisapqsra dsrkdrwcpg erclapsldn kklceasiks itvdgngkpf avvlypdfqe
       61 ktiplqrlqe vkstkdysrs lifddkdlek pyfpdrkips lasafqlsed gdsipytinr
      121 ylrdyqrega qflyrhyieg rgcilgddmg lgktiqvisf laavlhkkgt rediennmpe
      181 fllksmkkkp pstakkmfli vaplsvlynw kdeldtwgyf rvtvlhgskk dnellrlkqr
      241 kceialttye tlrlcleeln slewsaiivd eahriknpka rvtevmkavk ckvrigltgt
      301 vlqnnmkelw cvmdwavpgl lgsrihfkkq fsdpvehgqr htatkrelat grkamhrlak
      361 kmsgwflrrt ktlikgqlpk kedrmvycsl tdfqkavyqt vletedvali ltssqpctcg
      421 sgqkrrkccy ktnsrgdtvr tlclsyltvl qkvanhvall qaastskhqe tvikricdrv
      481 fsrfpdfvqk skdaafetls dpkysgkmkv lqqllnhfrk qrdkvllfsf stklldvlqq
      541 ycmasgldyr rldgstksee rlkivkefns sqdvniclvs tmagglglnf vganvvilfd
      601 ptwnpandlq avdrayrigq crdvkvlrli slgtveeimy lrqvykqqlh cvvvgsenak
      661 ryfeavqgsk ehrgelfgvh nlfklrsqgs cltrdilere gqveagimta ttwlkgepsa
      721 qeletprdpd cqeptdvcel ysdisdeesv ghslgktdkh kfsdtsrtpg fpaqltllqc
      781 gfsklfeaky ksdqdgdgnp vpsdgssdeq pmclsaearq aarqktwdsv ctsehqksdn
      841 iqtpdekcvs dksektleqn vssesddetk dhrtaghhcm gqgdteseds dvifptqypt
      901 qripknhirf klllgeseds eaenpvkvnh gddrqnsgrg ngpvpnllcl enmtsksvrk
      961 rkgtddisde sddidmfpks rirkqratts lkfkrkkenk rkldnspvta keanqvcaad
     1021 gdrssqvied fsssddnlsl shlsftklsh raetvkdkis lspklpgpdk knntfisrkp
     1081 psflnegvis qeqicnsmdk ildgvqevay ihsnqnvigs sraenhmsrw atrdvfelkq
     1141 fsqlpanvav cssktyktqv kanivsptek dqppsdggis splyvshpvv qkkkdvyrtn
     1201 httfiigetp rgirrkqfee masyyklpvk efaeqvtrat seerqkmlrd fyslqhpevk
     1261 effvnsasel iksvhkkeer vrnkskekes llkenpsnds tlscydstnk msqvynrkic
     1321 egksvrsqnh vfhredtfss daeinkspvs fteelhserk dhtpkdtttv fcpnsnseal
     1381 eaelgnspgr qwdltgacgs rnrplfklrn krvenpgsen tpedgllgdt silndlfksh
     1441 gegptqlpkn vlsgpvakak qkpkdfwdil neqnddslsk ltdlavietl ctkapstsas
     1501 krkdeleasl wkanekflwk tlssdvddes isntere
//
