LOCUS       NM_146235               4198 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus excision repair cross-complementing rodent repair
            deficiency complementation group 6 like (Ercc6l), mRNA.
ACCESSION   NM_146235
VERSION     NM_146235.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4198)
  AUTHORS   Geng,X., Zhang,C., Li,M., Wang,J., Ji,F., Feng,H., Xing,M., Li,F.,
            Zhang,L., Li,W., Chen,Z., Hickson,I.D., Shen,H. and Ying,S.
  TITLE     PICH Supports Embryonic Hematopoiesis by Suppressing a
            cGAS-STING-Mediated Interferon Response
  JOURNAL   Adv Sci (Weinh) 9 (7), e2103837 (2022)
   PUBMED   35037428
REFERENCE   2  (bases 1 to 4198)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4198)
  AUTHORS   Albers,E., Sbroggio,M., Pladevall-Morera,D., Bizard,A.H., Avram,A.,
            Gonzalez,P., Martin-Gonzalez,J., Hickson,I.D. and
            Lopez-Contreras,A.J.
  TITLE     Loss of PICH Results in Chromosomal Instability, p53 Activation,
            and Embryonic Lethality
  JOURNAL   Cell Rep 24 (12), 3274-3284 (2018)
   PUBMED   30232008
  REMARK    GeneRIF: Ercc6l is essential to preserve chromosomal integrity
            during embryonic development.
REFERENCE   4  (bases 1 to 4198)
  AUTHORS   Albino,D., Brizzolara,A., Moretti,S., Falugi,C., Mirisola,V.,
            Scaruffi,P., Di Candia,M., Truini,M., Coco,S., Bonassi,S. and
            Tonini,G.P.
  TITLE     Gene expression profiling identifies eleven DNA repair genes
            down-regulated during mouse neural crest cell migration
  JOURNAL   Int J Dev Biol 55 (1), 65-72 (2011)
   PUBMED   21425081
REFERENCE   5  (bases 1 to 4198)
  AUTHORS   Xu,Y., Chen,X. and Li,Y.
  TITLE     Ercc6l, a gene of SNF2 family, may play a role in the teratogenic
            action of alcohol
  JOURNAL   Toxicol Lett 157 (3), 233-239 (2005)
   PUBMED   15917148
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL807784.11 and AK029015.1.
            
            On Aug 25, 2009 this sequence version replaced NM_146235.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY172688.1, BC037660.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-86                AL807784.11        101882-101967       c
            87-3743             AK029015.1         2-3658
            3744-4198           AL807784.11        87696-88150         c
FEATURES             Location/Qualifiers
     source          1..4198
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 45.16 cM"
     gene            1..4198
                     /gene="Ercc6l"
                     /gene_synonym="D330021P09Rik"
                     /note="excision repair cross-complementing rodent repair
                     deficiency complementation group 6 like"
                     /db_xref="GeneID:236930"
                     /db_xref="MGI:MGI:2654144"
     exon            1..184
                     /gene="Ercc6l"
                     /gene_synonym="D330021P09Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             117..3839
                     /gene="Ercc6l"
                     /gene_synonym="D330021P09Rik"
                     /EC_number="3.6.4.12"
                     /note="SNF2/RAD54 family protein; ATP-dependent helicase
                     ERCC6-like; excision repair cross-complementing rodent
                     repair deficiency complementation group 6 - like"
                     /codon_start=1
                     /product="DNA excision repair protein ERCC-6-like"
                     /protein_id="NP_666347.2"
                     /db_xref="CCDS:CCDS30321.1"
                     /db_xref="GeneID:236930"
                     /db_xref="MGI:MGI:2654144"
                     /translation="MEASQGLAEVETLSPQLAESYLRYVQEAKEAAKNGDLEESLKLF
                     NLAKDIFPTKKVMSRIQKLQEALEQLAEEEDDDEFIDVCSSGLLLYRELYEKLFEHQK
                     EGIAFLYSLYKDGRKGGILADDMGLGKTVQIIAFLSGMFDASLVNHVLLIMPTNLINT
                     WVNEFAKWTPGMRVKTFHGSSKSERTRSLTRIQQRNGVVITTYQMLLNNWQQLASFNG
                     QAFVWDYVILDEAHKIKSASTKSAVCARAIPASNRLLLTGTPVQNNLQELWSLFDFAC
                     QGSLLGTLKTFKMEYEHPIIRAREKDATPGEKALGLKISENLMEIIKPYFLRRTKEEV
                     QTKKADNPEARLGEKNPAGEAICDMFSLARKNDLIVWIRLLPLQEEIYRKFVSLDHIK
                     ELLMETRSPLAELGVLKKLCDHPRLLSARACRLLNLGTATFSAQDENEQEDVSNMNSI
                     DHLPDKTLIQESGKMIFLMSLLERLQDEGHQTLVFSQSIKILNIIERLLKNKHFKTLR
                     IDGTVTHLWEREKRIQLFQQNKEYSVFLLTTQVGGVGLTLTAATRVVIFDPSWNPATD
                     AQAVDRVYRIGQKENVVVYRLITCGTVEEKIYRRQVFKDSLIRQTTGEKKNPFRYFTK
                     QELKELFTVGDLQKSATQMQLQCLHAAQRRSDEKLDEHIAYLHLLGIAGISDHDLMFT
                     RDLSVKEELDMLEDSQYIHQRVQKAQFLVESESQNTVQRQTTGIEETWLKAQEFPSQQ
                     KKKGTEFNKPQPQPSRLLTKPTQVEAISSQMASITICDQSAESEPQEHSEVHDVTSLQ
                     GSHHFNSTSDAGTIASLPQGAESIGEVSTDSLLSPAKGFAAENDAMQKKGLQASPGQE
                     APSENLGSFHYLPRESSKASLGPNLDLQDSVVLYHRSPTANENQNLESDVPMIEISDD
                     LSEPPSALQGAQAIEAQLELKEDDPLKSPPQYACDFNLFLEDSADTRQNLSSKFLEHV
                     EKEKSLQSPAANSRAKSALTLSLDSSPKSDEESEVISVKTKSKTRRILSDDEDEDEED
                     AFKGSHTNSINISPFPFSSVKQFDASTPQSGSNPSRRFFSPKTPGEVNTSLHSRRSLA
                     SRRSLINVVLDDVEDMEERLDNSSEEESEPGLSEENNEEEALACTEEQPSGATLASGN
                     KSSNLTMSEPTSPAPQSSPCAPEPSSSDPMPDPPQDLAVEAGNDYESLVARGKELKEC
                     GKIQEALNCLVKALDIKSADPEVMLMTLSLYKQLNI"
     exon            185..4198
                     /gene="Ercc6l"
                     /gene_synonym="D330021P09Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4042..4047
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ercc6l"
                     /gene_synonym="D330021P09Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      4061
                     /gene="Ercc6l"
                     /gene_synonym="D330021P09Rik"
                     /note="major polyA site"
ORIGIN      
        1 agttggctct accagtctag tgcgtgagcc cagcctgggt aaggcgggag cgagcgaaat
       61 tcaagcgcgg ttttaactgg gagtctcctt tcctgggctc tccggattcc ctggccatgg
      121 aggcttccca aggcttagcg gaagtggaga ctttgagccc acaactggcc gagagttacc
      181 tgagatatgt gcaagaagcc aaagaagcag ctaagaatgg agatctggaa gaatcattga
      241 aacttttcaa tttggcaaag gacatttttc ccaccaaaaa ggtgatgagc agaatccaga
      301 aactccagga agctttggag cagttggcag aagaagaaga tgatgatgaa tttatagatg
      361 tgtgcagctc tggcttgctg ctttaccgag agctgtatga gaaactcttt gagcaccaga
      421 aagaaggcat cgcttttctc tatagcctgt ataaggatgg aagaaaaggg ggcatcttag
      481 cagatgatat gggactgggg aagactgttc agatcattgc tttcctgtca ggtatgtttg
      541 atgcttcact tgtgaatcat gtgctattga tcatgccaac caatctcatt aatacatggg
      601 tcaacgaatt tgccaagtgg actccaggaa tgagagtgaa aacctttcat ggctccagca
      661 agagtgaacg cactagaagc ctgacacgga ttcaacaaag gaacggcgtt gtgatcacta
      721 cctaccaaat gttactcaat aattggcagc aacttgcaag ctttaatgga caagcatttg
      781 tatgggacta cgtcatcctt gatgaagccc ataagatcaa aagcgcctct accaagtcag
      841 cagtgtgtgc acgtgctatt cctgcaagta atcgcctcct cctcacaggt acaccagtcc
      901 agaataacct gcaagaactc tggtccctgt ttgattttgc ttgccaaggc tccttgttag
      961 gaacattaaa aacttttaaa atggagtatg agcatccgat tattagagca agagagaagg
     1021 atgccacccc tggggaaaaa gccttgggac ttaagatatc tgaaaattta atggaaatca
     1081 taaaacccta ttttctaagg aggaccaaag aagaagtgca gacgaaaaag gcagacaatc
     1141 cagaggccag acttggtgaa aagaatccag ctggtgaagc catttgtgac atgttttccc
     1201 ttgccaggaa aaatgattta attgtttgga tacgccttct gcctttacaa gaggaaattt
     1261 ataggaagtt tgtgtcttta gatcacatca aggagttgtt aatggagaca cgctcacctc
     1321 tagctgagct gggtgtctta aagaagctct gtgaccaccc taggctgctg tctgcacgag
     1381 cttgccgttt gctgaatcta ggaactgcca cattctctgc tcaggatgaa aacgagcaag
     1441 aagatgtctc aaatatgaac agcattgatc acttacctga caaaaccctg atacaagagt
     1501 ctggaaaaat gatattctta atgtccctgc tagaaagact tcaagatgaa ggacatcaaa
     1561 ctctggtgtt ttctcagtcg ataaaaattc tcaacatcat cgagcgtctc ttaaagaaca
     1621 agcactttaa gacattgcga attgatggca cagttactca tctttgggaa cgagaaaaaa
     1681 gaattcagtt attccagcaa aataaagaat actcagtttt tctacttacc actcaagtag
     1741 gtggtgttgg cctaacatta actgcagcga ctagagttgt catttttgac cctagctgga
     1801 accctgcaac tgatgctcag gctgtggata gagtttaccg aattggccaa aaagagaatg
     1861 ttgtggttta tcgactaatc acttgtggaa ctgtagaaga aaagatatat agaagacagg
     1921 ttttcaagga ctccttgatc agacaaacta ctggtgagaa gaagaaccca ttccgctatt
     1981 tcaccaaaca agagttaaaa gagctcttca cagttgggga cctgcagaag tctgcgaccc
     2041 agatgcagct tcagtgtcta catgctgctc agcggagatc tgatgagaaa ctagatgagc
     2101 atattgccta cctccacttg ctgggcatag caggaatctc agaccatgat ttgatgttca
     2161 cccgtgatct gtctgttaaa gaagagcttg acatgctaga agactctcag tacattcatc
     2221 agagagttca aaaagctcaa ttccttgttg aatctgagtc tcaaaataca gtgcaaagac
     2281 aaacgactgg aattgaggag acctggctca aagcacagga atttccttct caacagaaga
     2341 agaaaggtac tgaattcaac aaacctcagc cccagccttc acgccttctg actaaaccta
     2401 cccaggtaga ggctatcagt tctcaaatgg ccagtataac catttgcgat cagtctgcag
     2461 agagtgagcc ccaagagcac tctgaggtac atgatgtcac ttcactgcaa ggtagtcacc
     2521 acttcaacag tacatctgat gctggcacta tagcttcttt accccagggg gctgaaagta
     2581 taggcgaagt ttctactgac tctttattga gccctgcaaa aggttttgca gctgaaaatg
     2641 atgctatgca gaagaaggga ttacaagcat cacctgggca agaggcccca tcagagaacc
     2701 tgggaagttt tcattattta cctagagaat ccagcaaggc cagtcttggg ccaaatttag
     2761 atctacagga tagtgtggtt ttatatcacc gcagtcccac agcaaatgaa aaccaaaacc
     2821 tagaatcaga tgtacccatg attgaaatat ctgatgactt gtctgaacct cctagcgcac
     2881 tgcagggtgc tcaagcaatc gaggcccagt tggagttgaa agaggatgac cctttaaaat
     2941 caccaccaca atatgcatgt gatttcaatc ttttcctgga agactctgca gacactagac
     3001 aaaacctctc cagcaagttt ttggaacatg ttgagaaaga aaaaagcttg caaagccctg
     3061 cagctaactc cagggcaaag tcagcactta ctctcagttt ggattcttct cctaagagtg
     3121 atgaagaatc agaagtgatt agtgtgaaaa ccaaaagcaa aactagaagg atcctctcag
     3181 atgatgaaga tgaagatgaa gaagatgctt ttaaaggtag tcatacaaat tcaattaaca
     3241 tctctccctt tccattctca tctgtgaaac aatttgatgc ttcaactccc caaagtggca
     3301 gcaatccatc tcgaaggttc ttttcaccta aaacaccagg tgaagtgaat acgtccttac
     3361 attctaggag gtccctggct tctaggaggt ctctgatcaa tgtggtttta gatgatgtgg
     3421 aagatatgga ggaaaggctt gataacagca gcgaggagga gagtgagcca gggctttcag
     3481 aagagaacaa tgaagaagaa gccttagcct gcacagaaga gcagccttct ggggcaacac
     3541 tggcttcagg aaacaagtcc agcaacttga ccatgtctga gcctacttct ccagccccac
     3601 aaagctctcc ctgtgctcct gaaccttcgt caagtgaccc tatgcctgat cctccccagg
     3661 atctggcagt ggaggctggt aatgactatg agagtcttgt agctcgtggg aaagaactga
     3721 aagagtgcgg gaagatacag gaggctctca actgcttagt taaagcactt gatataaaaa
     3781 gtgcagatcc tgaggtcatg ctcatgactt taagtttgta taagcagctg aacatttgag
     3841 aactttatag cctatttctt atgtctaaaa tgcaattgaa tataaatgtt ttgttcagca
     3901 gttcttccct tgaatatttc attttttccc ctttaggcat actttgcaaa ctttcagaag
     3961 tgttacctaa agttttgtga agctgttctg gctattttta ctgtgaaaag ggccattttg
     4021 tctgttagct cagttctgaa aattaaagtg ccttttctcc agagtgtttc cattcatttt
     4081 ctttcacaag gtggtagaca gaaactcttt agttccaata agctcgtcat ttagcattcc
     4141 aaatctaaga tagccttaat aatgtgccgt ttgtgcttcc agcttagctg catacagt
//
