LOCUS       NM_001081221            8423 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus excision repair cross-complementing rodent repair
            deficiency, complementation group 6 (Ercc6), mRNA.
ACCESSION   NM_001081221 NM_177043 XM_484360
VERSION     NM_001081221.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 8423)
  AUTHORS   Mulderrig,L., Garaycoechea,J.I., Tuong,Z.K., Millington,C.L.,
            Dingler,F.A., Ferdinand,J.R., Gaul,L., Tadross,J.A., Arends,M.J.,
            O'Rahilly,S., Crossan,G.P., Clatworthy,M.R. and Patel,K.J.
  TITLE     Aldehyde-driven transcriptional stress triggers an anorexic DNA
            damage response
  JOURNAL   Nature 600 (7887), 158-163 (2021)
   PUBMED   34819667
REFERENCE   2  (bases 1 to 8423)
  AUTHORS   Okur,M.N., Fang,E.F., Fivenson,E.M., Tiwari,V., Croteau,D.L. and
            Bohr,V.A.
  TITLE     Cockayne syndrome proteins CSA and CSB maintain mitochondrial
            homeostasis through NAD+ signaling
  JOURNAL   Aging Cell 19 (12), e13268 (2020)
   PUBMED   33166073
REFERENCE   3  (bases 1 to 8423)
  AUTHORS   Collin,G.B., Gogna,N., Chang,B., Damkham,N., Pinkney,J., Hyde,L.F.,
            Stone,L., Naggert,J.K., Nishina,P.M. and Krebs,M.P.
  TITLE     Mouse Models of Inherited Retinal Degeneration with Photoreceptor
            Cell Loss
  JOURNAL   Cells 9 (4), 931 (2020)
   PUBMED   32290105
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 8423)
  AUTHORS   Mulderrig,L. and Garaycoechea,J.I.
  TITLE     XPF-ERCC1 protects liver, kidney and blood homeostasis outside the
            canonical excision repair pathways
  JOURNAL   PLoS Genet 16 (4), e1008555 (2020)
   PUBMED   32271760
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 8423)
  AUTHORS   Hill,R.J. and Crossan,G.P.
  TITLE     DNA cross-link repair safeguards genomic stability during
            premeiotic germ cell development
  JOURNAL   Nat Genet 51 (8), 1283-1294 (2019)
   PUBMED   31367016
REFERENCE   6  (bases 1 to 8423)
  AUTHORS   Okada,K., Fujita,T., Minamoto,K., Liao,H., Naka,Y. and Pinsky,D.J.
  TITLE     Potentiation of endogenous fibrinolysis and rescue from lung
            ischemia/reperfusion injury in interleukin (IL)-10-reconstituted
            IL-10 null mice
  JOURNAL   J Biol Chem 275 (28), 21468-21476 (2000)
   PUBMED   10806208
REFERENCE   7  (bases 1 to 8423)
  AUTHORS   Garssen,J., van Steeg,H., de Gruijl,F., de Boer,J., van der
            Horst,G.T., van Kranen,H., van Loveren,H., van Dijk,M.,
            Fluitman,A., Weeda,G. and Hoeijmakers,J.H.
  TITLE     Transcription-coupled and global genome repair differentially
            influence UV-B-induced acute skin effects and systemic
            immunosuppression
  JOURNAL   J Immunol 164 (12), 6199-6205 (2000)
   PUBMED   10843671
REFERENCE   8  (bases 1 to 8423)
  AUTHORS   de Boer,J., van Steeg,H., Berg,R.J., Garssen,J., de Wit,J., van
            Oostrum,C.T., Beems,R.B., van der Horst,G.T., van Kreijl,C.F., de
            Gruijl,F.R., Bootsma,D., Hoeijmakers,J.H. and Weeda,G.
  TITLE     Mouse model for the DNA repair/basal transcription disorder
            trichothiodystrophy reveals cancer predisposition
  JOURNAL   Cancer Res 59 (14), 3489-3494 (1999)
   PUBMED   10416615
REFERENCE   9  (bases 1 to 8423)
  AUTHORS   Jacobs,H., Fukita,Y., van der Horst,G.T., de Boer,J., Weeda,G.,
            Essers,J., de Wind,N., Engelward,B.P., Samson,L., Verbeek,S., de
            Murcia,J.M., de Murcia,G., te Riele,H. and Rajewsky,K.
  TITLE     Hypermutation of immunoglobulin genes in memory B cells of DNA
            repair-deficient mice
  JOURNAL   J Exp Med 187 (11), 1735-1743 (1998)
   PUBMED   9607915
REFERENCE   10 (bases 1 to 8423)
  AUTHORS   van der Horst,G.T., van Steeg,H., Berg,R.J., van Gool,A.J., de
            Wit,J., Weeda,G., Morreau,H., Beems,R.B., van Kreijl,C.F., de
            Gruijl,F.R., Bootsma,D. and Hoeijmakers,J.H.
  TITLE     Defective transcription-coupled repair in Cockayne syndrome B mice
            is associated with skin cancer predisposition
  JOURNAL   Cell 89 (3), 425-435 (1997)
   PUBMED   9150142
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC154412.3.
            
            On or before Apr 17, 2018 this sequence version replaced
            NM_177043.2, NM_001081221.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR10223971.14107.1,
                                           SRR13948564.893393.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-79                AC154412.3         98113-98191
            80-511              AC154412.3         101539-101970
            512-632             AC154412.3         103535-103655
            633-744             AC154412.3         105540-105651
            745-1474            AC154412.3         110741-111470
            1475-1603           AC154412.3         125818-125946
            1604-1762           AC154412.3         131337-131495
            1763-1898           AC154412.3         137167-137302
            1899-2069           AC154412.3         142431-142601
            2070-2246           AC154412.3         143020-143196
            2247-2363           AC154412.3         145301-145417
            2364-2459           AC154412.3         147148-147243
            2460-2675           AC154412.3         150835-151050
            2676-2786           AC154412.3         151376-151486
            2787-2906           AC154412.3         152100-152219
            2907-3001           AC154412.3         152579-152673
            3002-3147           AC154412.3         154105-154250
            3148-3840           AC154412.3         154331-155023
            3841-4045           AC154412.3         159398-159602
            4046-4118           AC154412.3         160346-160418
            4119-8423           AC154412.3         161278-165582
FEATURES             Location/Qualifiers
     source          1..8423
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 19.4 cM"
     gene            1..8423
                     /gene="Ercc6"
                     /gene_synonym="4732403I04; C130058G22Rik; CSB"
                     /note="excision repair cross-complementing rodent repair
                     deficiency, complementation group 6"
                     /db_xref="GeneID:319955"
                     /db_xref="MGI:MGI:1100494"
     exon            1..79
                     /gene="Ercc6"
                     /gene_synonym="4732403I04; C130058G22Rik; CSB"
                     /inference="alignment:Splign:2.1.0"
     exon            80..511
                     /gene="Ercc6"
                     /gene_synonym="4732403I04; C130058G22Rik; CSB"
                     /inference="alignment:Splign:2.1.0"
     CDS             90..4535
                     /gene="Ercc6"
                     /gene_synonym="4732403I04; C130058G22Rik; CSB"
                     /note="CS group B correcting; ATP-dependent helicase
                     ERCC6; cockayne syndrome protein CSB"
                     /codon_start=1
                     /product="DNA excision repair protein ERCC-6"
                     /protein_id="NP_001074690.1"
                     /db_xref="CCDS:CCDS36868.1"
                     /db_xref="GeneID:319955"
                     /db_xref="MGI:MGI:1100494"
                     /translation="MFHEEVPNSTHPQEQDCLPSQHANAYKDMPVGQENGGVSEAGEC
                     LSSTSCEYGPSTSAEACVLAATRRGPTLLHIDRHQIPAVEPSAQALELQGLGVDVYDQ
                     AVLEQGVLQQVDSAMHEASCVAQLADAEKEYQSVLDDLMSCTTSLRQINKIIEQLSPQ
                     AASNRDINRKLDSVKRQKYNKEQQLKKITAKQKRLQAILGGAGVQVELDHASLEEDDA
                     EPGPSCLGSMLMPAQETAWEELIRTGQMTPFGTPAPQKQEKKPRKIMLNEASGFEKYL
                     AEQAQLSFERKKQAATKRTAKKAIVISESSRAAIETKADQRSQVLSQTDKRLKKHSRK
                     LQRRALQFQGKVGLPSGKKPLEPEVRPEAEGDTEGEESGSSPTDGEEEEEQEEEEGVA
                     SLSSDDVSYELKPLRKRQKYQKKVPVQEIDDDFFPSSEEEDEAMEGRGGGRKVARRQD
                     DGDEDYYKQRLRRWNRLRLQDKEKRLKLEDDSEESDAEFDEGFKVPGFLFKKLFKYQQ
                     TGVRWLWELHCQQAGGILGDEMGLGKTIQIIAFLAGLSYSKIRTRGSNYRFEGLGPTI
                     IVCPTTVMHQWVKEFHTWWPPFRVAVLHETGSYTHKKERLIRDIVYCHGVLITSYSYI
                     RLMQDDISRHDWHYVILDEGHKIRNPNAAVTLACKQFRTPHRIILSGSPMQNNLRELW
                     SLFDFIFPGKLGTLPVFMEQFSVPITMGGYSNASPVQVKTAYKCACVLRDTINPYLLR
                     RMKSDVKMSLSLPDKNEQVLFCRLTDEQHKVYQNFIDSKAVYRILNGENQIFSGLVAL
                     RKICNHPDLFSGGPKNASGPPEDELEEEQFGHWRRSGKMIVVESLLKIWHRQGQRVLL
                     FSQSRQMLHILEVFLRAHKYSYLKMDGTTTIASRQPLITKYNEDTSIFVFLLTTRVGG
                     LGVNLTGANRVIIYDPDWNPSTDTQARERAWRIGQKKQVTVYRLLTAGTIEEKIYHRQ
                     IFKQFLTNRVLKDPKQRRFFKSNDLYELFTLTSPDASQGTETSAIFAGTGSSIQTPKC
                     QLKKRTSTVLGTDPKCKKPPVSDTPANAATLIGEKPKAAGATGRSVTSGESGPFKGDH
                     DTNGNRASSVAFGEETDAGSTLEHLSVMSGDGKHSDSPTVDHTSRPPVEASTSEKQGS
                     SYAGARCQAQTEPVPMSEQMEGQFSKYKSKRKHDASEEETTEKRPQPKQKAKNSKHCR
                     DAKFEGTRVPHLVKKRRYRQQTSEQEGGAKDRSSDDYVLEKLFKKSVGVHSVVRHDAI
                     IDGSSPDYVLVEAEANRVAQDALKALRLSRQQCLGAASGVPTWTGHRGISGAPTGVKN
                     RFGQKRDSSLPVQHPSSLTEKTQNNMKKEGKAHTPEHFSGKEDGASVSGAPSSSSLLA
                     RMRARNHMILPERLESDSEHLAEAAAVPPCGTEHDDLLVDMRNFIAFQAQVDGQASTQ
                     EILQEFESKLSVAQSCVFRELLRNLCNFHRTPGGEGIWKLKPEYC"
     exon            512..632
                     /gene="Ercc6"
                     /gene_synonym="4732403I04; C130058G22Rik; CSB"
                     /inference="alignment:Splign:2.1.0"
     exon            633..744
                     /gene="Ercc6"
                     /gene_synonym="4732403I04; C130058G22Rik; CSB"
                     /inference="alignment:Splign:2.1.0"
     exon            745..1474
                     /gene="Ercc6"
                     /gene_synonym="4732403I04; C130058G22Rik; CSB"
                     /inference="alignment:Splign:2.1.0"
     exon            1475..1603
                     /gene="Ercc6"
                     /gene_synonym="4732403I04; C130058G22Rik; CSB"
                     /inference="alignment:Splign:2.1.0"
     exon            1604..1762
                     /gene="Ercc6"
                     /gene_synonym="4732403I04; C130058G22Rik; CSB"
                     /inference="alignment:Splign:2.1.0"
     exon            1763..1898
                     /gene="Ercc6"
                     /gene_synonym="4732403I04; C130058G22Rik; CSB"
                     /inference="alignment:Splign:2.1.0"
     exon            1899..2069
                     /gene="Ercc6"
                     /gene_synonym="4732403I04; C130058G22Rik; CSB"
                     /inference="alignment:Splign:2.1.0"
     exon            2070..2246
                     /gene="Ercc6"
                     /gene_synonym="4732403I04; C130058G22Rik; CSB"
                     /inference="alignment:Splign:2.1.0"
     exon            2247..2363
                     /gene="Ercc6"
                     /gene_synonym="4732403I04; C130058G22Rik; CSB"
                     /inference="alignment:Splign:2.1.0"
     exon            2364..2459
                     /gene="Ercc6"
                     /gene_synonym="4732403I04; C130058G22Rik; CSB"
                     /inference="alignment:Splign:2.1.0"
     exon            2460..2675
                     /gene="Ercc6"
                     /gene_synonym="4732403I04; C130058G22Rik; CSB"
                     /inference="alignment:Splign:2.1.0"
     exon            2676..2786
                     /gene="Ercc6"
                     /gene_synonym="4732403I04; C130058G22Rik; CSB"
                     /inference="alignment:Splign:2.1.0"
     exon            2787..2906
                     /gene="Ercc6"
                     /gene_synonym="4732403I04; C130058G22Rik; CSB"
                     /inference="alignment:Splign:2.1.0"
     exon            2907..3001
                     /gene="Ercc6"
                     /gene_synonym="4732403I04; C130058G22Rik; CSB"
                     /inference="alignment:Splign:2.1.0"
     exon            3002..3147
                     /gene="Ercc6"
                     /gene_synonym="4732403I04; C130058G22Rik; CSB"
                     /inference="alignment:Splign:2.1.0"
     exon            3148..3840
                     /gene="Ercc6"
                     /gene_synonym="4732403I04; C130058G22Rik; CSB"
                     /inference="alignment:Splign:2.1.0"
     exon            3841..4045
                     /gene="Ercc6"
                     /gene_synonym="4732403I04; C130058G22Rik; CSB"
                     /inference="alignment:Splign:2.1.0"
     exon            4046..4118
                     /gene="Ercc6"
                     /gene_synonym="4732403I04; C130058G22Rik; CSB"
                     /inference="alignment:Splign:2.1.0"
     exon            4119..8423
                     /gene="Ercc6"
                     /gene_synonym="4732403I04; C130058G22Rik; CSB"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5913..5918
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ercc6"
                     /gene_synonym="4732403I04; C130058G22Rik; CSB"
                     /note="hexamer: AATAAA"
     polyA_site      5931
                     /gene="Ercc6"
                     /gene_synonym="4732403I04; C130058G22Rik; CSB"
                     /note="major polyA site"
     regulatory      7655..7660
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ercc6"
                     /gene_synonym="4732403I04; C130058G22Rik; CSB"
                     /note="hexamer: AATAAA"
     polyA_site      7673
                     /gene="Ercc6"
                     /gene_synonym="4732403I04; C130058G22Rik; CSB"
                     /note="major polyA site"
     regulatory      8031..8036
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ercc6"
                     /gene_synonym="4732403I04; C130058G22Rik; CSB"
                     /note="hexamer: AGTAAA"
     polyA_site      8052
                     /gene="Ercc6"
                     /gene_synonym="4732403I04; C130058G22Rik; CSB"
                     /note="major polyA site"
     regulatory      8401..8406
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ercc6"
                     /gene_synonym="4732403I04; C130058G22Rik; CSB"
                     /note="hexamer: ATTAAA"
     polyA_site      8423
                     /gene="Ercc6"
                     /gene_synonym="4732403I04; C130058G22Rik; CSB"
ORIGIN      
        1 gcatgcgcta aggtttgtct caacgctccg tcgcggcggt agcgacgaag aattcgtttg
       61 ggcagccgcg tggttctggt ttgtagagga tgttccacga ggaagttccc aactccactc
      121 accctcagga gcaagactgt ttaccaagtc agcatgccaa tgcttacaaa gacatgccag
      181 ttgggcagga gaatggtggg gtctcagagg ccggggagtg cctctcctct acttcctgtg
      241 agtatgggcc atccacatct gctgaagctt gtgtgttggc agccacaagg cgtgggccga
      301 ccctgctaca cattgatcgg catcagatcc ctgcagttga gcccagtgct caggccctgg
      361 agctgcaggg cctgggtgtg gacgtctatg accaggctgt cctggaacaa ggcgtgcttc
      421 agcaggtgga cagtgcgatg catgaggcca gctgtgtggc ccagcttgct gatgcggaga
      481 aggagtatca gtcagtcctg gatgacctca tgtcatgtac aacatccctg aggcaaatca
      541 ataaaattat agagcaactt agccctcaag ctgccagcaa cagagacatc aacaggaaac
      601 tagattccgt gaagcgacag aagtataaca aggaacaaca gctaaagaag ataactgcaa
      661 aacagaaacg tctccaggcc attctcggag gggctggggt ccaagtggaa ctggatcatg
      721 ccagcctaga ggaggacgat gcagagccag ggccatcatg tcttggcagt atgctcatgc
      781 ctgcccagga gaccgcctgg gaggagctta tccgcactgg ccagatgaca ccgtttggta
      841 ccccagcccc tcagaaacag gagaaaaagc ccagaaaaat aatgctgaat gaagcatcag
      901 gctttgaaaa atatttggca gagcaagcac aactttcgtt tgaaaggaag aaacaagctg
      961 ctactaaaag aacagctaaa aaagctatag tcatatccga gtcaagccga gcagcaattg
     1021 aaaccaaggc agaccagaga agccaagtgc tctctcagac agacaagcgc ctgaagaagc
     1081 acagcaggaa actccagagg agggcgctgc agttccaggg caaagtggga ttgccgagcg
     1141 ggaagaaacc tttggagcct gaggtgaggc cagaggccga gggagacact gagggtgagg
     1201 agtctgggtc ctctcccacc gatggggagg aggaggaaga acaagaggag gaggaagggg
     1261 tagccagcct gtcttctgat gacgttagct atgagctgaa gcctcttcgg aagaggcaga
     1321 aataccagaa gaaagtccca gttcaggaga tcgacgatga cttctttcca agttctgagg
     1381 aggaagatga agctatggaa ggaagaggag gaggccgaaa ggtagccagg cgccaagacg
     1441 atggagatga ggattattat aagcagcggt taaggaggtg gaacaggctg aggctgcagg
     1501 acaaagagaa acgcctgaag cttgaagatg attctgagga gagcgatgcc gaatttgacg
     1561 aaggtttcaa agtgccgggt tttctgttca aaaagctctt taagtatcag cagacaggtg
     1621 ttaggtggct gtgggaattg cactgccagc aggcaggagg aattctggga gacgaaatgg
     1681 gattgggcaa gaccatccag ataattgcct tcttggcagg tctgagctac agcaagatca
     1741 ggactcgcgg ttcaaattac aggttcgagg gactaggccc cactataatt gtctgcccaa
     1801 cgacagtgat gcatcagtgg gtgaaggaat tccacacgtg gtggcctcca ttcagagtgg
     1861 cagttctgca tgaaacaggt tcctacaccc acaaaaagga gaggctgatt cgagatattg
     1921 tttattgtca tggagttttg ataacttcat attcatacat ccgactgatg caagatgaca
     1981 ttagcagaca tgactggcac tacgtcatct tagatgaagg acacaaaatt cgaaatccaa
     2041 atgctgcagt cacccttgct tgcaaacagt tccggacacc tcatcggatt atcttgtctg
     2101 gctcaccgat gcagaataac ctccgagagc tgtggtcact cttcgacttc atcttcccag
     2161 gaaagctggg cacattgcct gtgtttatgg agcagttctc tgtccccatc accatgggag
     2221 gctattccaa tgcttcccca gtacaggtta aaactgctta taagtgtgca tgtgtcttaa
     2281 gagacacgat aaacccgtac ttactgcgga gaatgaaatc agatgtcaag atgagccttt
     2341 cgttgccaga taaaaatgag caggtcttat tttgccgtct aactgatgag cagcataaag
     2401 tctaccagaa tttcattgat tctaaagcag tctacaggat tctcaatgga gaaaatcaga
     2461 ttttctctgg acttgtagcg ctgaggaaga tctgcaacca ccctgacctc ttttctggcg
     2521 gccccaagaa cgccagtggt cctccagagg atgagctgga agaagagcag tttggacact
     2581 ggagacgctc tgggaaaatg attgttgttg agtctttgct gaaaatatgg cacaggcagg
     2641 gtcagcgggt gctgctgttt tcccagtcca ggcagatgct acacatactg gaagtgttcc
     2701 tgagagccca taagtattcc tatctcaaga tggatgggac caccaccata gcgtcaagac
     2761 agccgctgat tacaaaatac aatgaggaca cgtccatctt tgtctttctt ctgaccacac
     2821 gggtgggtgg cttaggagtg aacctgaccg gtgccaacag agtcatcatc tacgacccag
     2881 actggaatcc aagcaccgac acacaggccc gggagcgagc atggaggata ggtcagaaga
     2941 agcaggtgac tgtctacagg cttctgacgg ctggcaccat tgaggaaaag atctaccacc
     3001 gacaaatctt caagcaattt ttgacaaaca gagtgctaaa agacccaaaa caaaggcgct
     3061 ttttcaaatc caacgatctc tatgagctgt tcactctgac cagtcctgac gcctcccagg
     3121 gcactgagac aagtgctatt tttgcaggaa cgggctccag tattcagaca cccaaatgcc
     3181 agttaaaaaa aaggacttcc acagtcctgg gaacagatcc caaatgcaag aagccccctg
     3241 tttctgacac acctgcaaat gctgccaccc tgattggaga aaaacctaag gcggcgggag
     3301 ctacaggaag aagtgtcact tctggagaaa gtggtccttt caaaggcgac catgacacaa
     3361 atgggaacag agctagcagt gttgcttttg gagaagagac agatgcaggg tccacactgg
     3421 agcatctctc agtgatgagt ggagatggga agcattcaga ttctccaaca gttgaccaca
     3481 catccaggcc accagtggag gcaagcacca gtgagaagca gggttcttcc tatgcagggg
     3541 cgcgctgcca ggctcagaca gaacctgttc ccatgagtga acaaatggaa ggtcagtttt
     3601 ctaagtacaa atccaaaagg aagcatgatg catctgagga agagaccaca gagaaacgtc
     3661 cacagcccaa gcaaaaggcc aagaactcca agcattgcag agatgctaag tttgagggaa
     3721 ctcgagtccc gcacctggtg aagaaaagac ggtaccgcca gcaaaccagt gagcaggagg
     3781 gcggagccaa ggaccggagc agcgatgatt atgtgttgga aaagcttttc aaaaaatcag
     3841 tgggcgtgca cagcgtcgtg aggcatgatg ccatcataga tgggtccagt ccagattatg
     3901 tgctggtgga agcagaagcc aaccgagtgg ctcaggacgc cttgaaagct ctgaggctct
     3961 ctcgtcagca atgcctgggg gcagcatctg gtgttcccac ctggactggc cacaggggga
     4021 tttctggtgc accaacagga gtaaagaata ggttcggtca gaaaagggac tccagcctcc
     4081 ctgtgcagca tccttcatca ctaacagaaa agactcagaa caacatgaaa aaggagggaa
     4141 aagctcacac ccctgagcac ttcagtggca aagaagatgg agcatctgtg tctggagcgc
     4201 ccagttcctc ctccctcttg gccagaatgc gagcaagaaa ccacatgatt ttgccggagc
     4261 gcttagagag tgacagtgaa catcttgctg aggctgctgc cgtgcctccc tgcggcaccg
     4321 aacacgacga ccttctggtg gacatgagga acttcattgc tttccaggcc caggtggatg
     4381 gccaggccag cactcaggaa atcctgcagg agtttgagtc caagctgtcc gtggcacagt
     4441 cctgtgtctt ccgagaactg ctgagaaatc tgtgcaattt ccatagaact cctggtgggg
     4501 aagggatttg gaagctgaag ccagaatact gctaacagtg atgctctcta aactctttca
     4561 gatggaaagc ttggctcccc gagcctgtga ttagtgttcg tggggtgtgt gtgtgtgtgt
     4621 gtgtgtgtgt gtgcgcgcgc gcgcgcgcgc gtgtgcatga gtgactgtac ttggtattta
     4681 ctatgtcatc tacctcaaga ctaaaacttg aagaagaaaa taattggagg gtttttgttt
     4741 tgtttgtttg gtggcactgt gaattaagtt ataaaaccag ggacctaaca gttgtttaat
     4801 ggagcaaata cgttacttaa cccaaaagat gttgtcaggg agcacacagt atttaagaat
     4861 acatctcggt tcttcttact ggtgctgggc atatgtcttc tctttatcca ccccatctta
     4921 taagtcactt cacagtatcc gataatcttg gtaccttgat acagcatggg ttttctgacc
     4981 cactggttac atacagaaag acacttgcta tctgtcaaat cattaattac atataaataa
     5041 ttcttcatag cacttttaga ttagcaggct tgggttttgt tgtttgtttg tttgtttgtt
     5101 ttaaatgttg ctgaagacag actctggtgc cttgcacatg ctcagtatgt gctttaccac
     5161 caagttcctt cccagttcat acatacgtgt caaagtagga agtctggttt ttcttctctg
     5221 tcatcattat ctaaagatgg cggatggggt ttgtttaaat aggtcagtca gttctaaact
     5281 ttagtacttg gctcagaagg aagtcacaac acccgttcgt ttatttattt tttgttccag
     5341 tgatcagcct acaggaaatg ctattgccct tgtccttagg ctgactacca acctgactca
     5401 ctaacatgaa acatttgtgc tgtgcctgtg atgtctgaga tctaagttat actgagctag
     5461 agaatgtcgt atagacactt tttttgtttt tttttttcga gacagggttt ctctgtatag
     5521 tccaggctgt cctggaactc actttgtaga ccaggctggc ctcaaactca gaaatccgcc
     5581 tgcctctgcc tcccgagtgc tgggactaaa ggcgtgcgcc accacgcccg gctgtataga
     5641 cagtctttaa ctgtcgaaag ttacctacca cgcggtcagg aagggatccg tgttccacct
     5701 ctgccactga cctgcccagc ctgggaaggt tgaatctgta aacatggtta tccagccaag
     5761 ctgggagaag cttagagacc agttctccag gttaaagtac tttttaacaa tacacacctt
     5821 tatacattga gctgcaatct gatttctttg aactttaaat actttgtgcg gtataaatag
     5881 atttaatgta ttaaacatat taaataatta caaataaaag atttaaaaat actggttttt
     5941 cctgtattgt cactgttaga aatccttcaa gcactcctgc ctccctatcc tgtgcattcc
     6001 agagctctgt gcagttgccc aggcattggc atggctcctg gcatgggtta ctcctcctct
     6061 gtgtttcccc tggactcatg actgcccagc tgaaaattgt ttctcagcct ccctgcaggt
     6121 gtggccccat gacagttcca ggcagtgaga tggaagactt ctagcttgaa gcttacacag
     6181 aggcatggtg tgcatgcccc tgaaagttcc ctggcttgct ggtcaggatg tctgtgagag
     6241 cctcaggcgt ctcctggcat ttcaggagag ggtggatggt ctactagtca agaacagcta
     6301 tctttgacca gatactttgg agtgaaataa atgaagtgtt atttaatact gttttaacat
     6361 ctaattggtg taatgtatgt aacacactaa tgctgtaagt ttcctgtgta tctcacgttc
     6421 gcactatgca ggtcttttca cttatgtacc tctgctttcg ctgacctgct gatctccaaa
     6481 cccatcacag gctcactttc ctcaggcttg cccacagcaa ctagtttcca tcttggtaca
     6541 ttgttttaaa attagtcttg tttcataaaa taaccttact ttaatttgaa tttccctgat
     6601 ttaacaccag acagaatacc atattcacct agtttcctca gtataaatga aagacagtta
     6661 tgaaagaggc aagaacaaaa agccattctg ggctagtcca tcatccgcca ccactccaaa
     6721 tgccagcttc gactcatcgt agtgcactgc aaggctgacg tcagaccccg tgtctgtctg
     6781 ttccctcaca ctctgcacgc tgacgtttgt cacctgtggg aaagtccatt ttccttttta
     6841 tctcgtcctc tgtgtcttat ttttgtgcat ttcctgttcc aagcaaatga tagaattagc
     6901 ttattagatt ccactgaagt gttgctcttt tggccgggat tgcattagtt tgcccattaa
     6961 ttggaagata atagacttct ttataattaa tataattttc ccattagtat tatgagaggc
     7021 ctaattttat tgcttgggta acattcctca taagggttca gttttatatt agcttcgttc
     7081 tagatgtttt acagaatttt tgtttaggat tttaaaggat cttttacttt cacataaaaa
     7141 aaaaagtgga gatgcttgac tcattcctgt gtcacctctg tgttgcttat cactggaagc
     7201 gtttacattc aaagctgcta cattcagttt tttaatatcc tatggtcatg atgcaatctt
     7261 gtgaatggcc ttgttagtta caatgtggtt tggatgggaa gtgtcccacc tgtagactca
     7321 cgtctttgaa catgtggttc ctagctcatg atgccctttt ggacctcctg atggctgcta
     7381 tgacagactg tgtcacctgt aatgtgagcc aaaaatgaac ccttctttcc ttaggttctt
     7441 ttgtctgggt attttgtcag caataaggta aatgactaaa tgtaattata cagaaataga
     7501 tattttccta acatttgaaa actgtagatc attctctcct tcctgattta tacatttata
     7561 aagccaccaa tccaccatta tgtcccatgt ccatataatc atggaaatgt gcctgaactc
     7621 tatattttgt taactttgtc cattcatctt taccaataaa ccatttttaa tcatgtaggt
     7681 ttctaattga ctgtcaaaaa ttgtagagca actcttggat ctttgttata tcttggatat
     7741 attagatcat cttgtcacat tgggattttg tgactacaat gaatgagcag acttgttgag
     7801 gattatttat gatgctgggt cccgtgcatc tctgaataag ccatagctat gtatttttat
     7861 tacatgttta taaagaaata attgtgctat atctcgcatt ttgtaataga caacttacgt
     7921 atgcatagat agaaaatgtg tatcatgcaa gcaattctat caaatcttgg tgagaacagt
     7981 gagtctgatg tacaacttac gcttagtccc aaccttgatt ttgtacctgt agtaaaggac
     8041 accttctgaa aacccacgtg ttctcattta tacaggctcg tctcctgctt ctctctacgt
     8101 tggctttgct aactgatgtt atatgtatca tctagcaact ttgctgaact tgcactctga
     8161 tctgtaaatt gtcctataat acttggatca gctgtaatag taacgattgt gtttcacgtg
     8221 ttccaatatg cacacgctct gatacggagt agaaatgatt acaggtggca tagtacttcg
     8281 ccatctctct ttcctgccat cgaggagaag ctctaacacc tacagttgct gtttcctaat
     8341 agatggctta gttgggttaa gggaatattc tttccagttt taaatccact gctggatttc
     8401 attaaatgtt tctcctgctt tta
//
