LOCUS       NM_011729               4010 bp    mRNA    linear   ROD 06-DEC-2023
DEFINITION  Mus musculus excision repair cross-complementing rodent repair
            deficiency, complementation group 5 (Ercc5), mRNA.
ACCESSION   NM_011729
VERSION     NM_011729.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4010)
  AUTHORS   Gyenis A, Chang J, Demmers JJPG, Bruens ST, Barnhoorn S, Brandt
            RMC, Baar MP, Raseta M, Derks KWJ, Hoeijmakers JHJ and Pothof J.
  TITLE     Genome-wide RNA polymerase stalling shapes the transcriptome during
            aging
  JOURNAL   Nat Genet 55 (2), 268-279 (2023)
   PUBMED   36658433
REFERENCE   2  (bases 1 to 4010)
  AUTHORS   Milanese C, Bombardieri CR, Sepe S, Barnhoorn S, Payan-Gomez C,
            Caruso D, Audano M, Pedretti S, Vermeij WP, Brandt RMC, Gyenis A,
            Wamelink MM, de Wit AS, Janssens RC, Leen R, van Kuilenburg ABP,
            Mitro N, Hoeijmakers JHJ and Mastroberardino PG.
  TITLE     DNA damage and transcription stress cause ATP-mediated redesign of
            metabolism and potentiation of anti-oxidant buffering
  JOURNAL   Nat Commun 10 (1), 4887 (2019)
   PUBMED   31653834
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4010)
  AUTHORS   Ogrodnik M, Miwa S, Tchkonia T, Tiniakos D, Wilson CL, Lahat A, Day
            CP, Burt A, Palmer A, Anstee QM, Grellscheid SN, Hoeijmakers JHJ,
            Barnhoorn S, Mann DA, Bird TG, Vermeij WP, Kirkland JL, Passos JF,
            von Zglinicki T and Jurk D.
  TITLE     Cellular senescence drives age-dependent hepatic steatosis
  JOURNAL   Nat Commun 8, 15691 (2017)
   PUBMED   28608850
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4010)
  AUTHORS   Treekitkarnmongkol W, Katayama H, Kai K, Sasai K, Jones JC, Wang J,
            Shen L, Sahin AA, Gagea M, Ueno NT, Creighton CJ and Sen S.
  TITLE     Aurora kinase-A overexpression in mouse mammary epithelium induces
            mammary adenocarcinomas harboring genetic alterations shared with
            human breast cancer
  JOURNAL   Carcinogenesis 37 (12), 1180-1189 (2016)
   PUBMED   27624071
REFERENCE   5  (bases 1 to 4010)
  AUTHORS   Vermeij WP, Dolle ME, Reiling E, Jaarsma D, Payan-Gomez C,
            Bombardieri CR, Wu H, Roks AJ, Botter SM, van der Eerden BC,
            Youssef SA, Kuiper RV, Nagarajah B, van Oostrom CT, Brandt RM,
            Barnhoorn S, Imholz S, Pennings JL, de Bruin A, Gyenis A, Pothof J,
            Vijg J, van Steeg H and Hoeijmakers JH.
  TITLE     Restricted diet delays accelerated ageing and genomic stress in
            DNA-repair-deficient mice
  JOURNAL   Nature 537 (7620), 427-431 (2016)
   PUBMED   27556946
REFERENCE   6  (bases 1 to 4010)
  AUTHORS   Levy N, Boettger-Tong H, Dohmae K, Agoulnik AI, Ty TI, Nishimune Y
            and Bishop CE.
  TITLE     Physical and genetic linkage of glutaminase (Gls), signal
            transducer and activator of transcription 1 (Stat1), and xeroderma
            pigmentosum complementation group G (Xpg) on mouse proximal
            chromosome 1
  JOURNAL   Genomics 54 (2), 355-356 (1998)
   PUBMED   9828143
REFERENCE   7  (bases 1 to 4010)
  AUTHORS   Koike M, Matsuda Y, Mimori T, Harada YN, Shiomi N and Shiomi T.
  TITLE     Chromosomal localization of the mouse and rat DNA double-strand
            break repair genes Ku p70 and Ku p80/XRCC5 and their mRNA
            expression in various mouse tissues
  JOURNAL   Genomics 38 (1), 38-44 (1996)
   PUBMED   8954777
REFERENCE   8  (bases 1 to 4010)
  AUTHORS   Ludwig DL, Mudgett JS, Park MS, Perez-Castro AV and MacInnes MA.
  TITLE     Molecular cloning and structural analysis of the functional mouse
            genomic XPG gene
  JOURNAL   Mamm Genome 7 (9), 644-649 (1996)
   PUBMED   8703115
REFERENCE   9  (bases 1 to 4010)
  AUTHORS   Harada YN, Matsuda Y, Shiomi N and Shiomi T.
  TITLE     Complementary DNA sequence and chromosomal localization of xpg, the
            mouse counterpart of human repair gene XPG/ERCC5
  JOURNAL   Genomics 28 (1), 59-65 (1995)
   PUBMED   7590748
REFERENCE   10 (bases 1 to 4010)
  AUTHORS   Shiomi T, Harada Y, Saito T, Shiomi N, Okuno Y and Yamaizumi M.
  TITLE     An ERCC5 gene with homology to yeast RAD2 is involved in group G
            xeroderma pigmentosum
  JOURNAL   Mutat Res 314 (2), 167-175 (1994)
   PUBMED   7510366
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK047192.1, AK137563.1, AK140825.1 and AC123800.4.
            
            [WARNING] On Jan 9, 2024 this sequence was replaced by NM_011729.3.
            
            On Mar 18, 2008 this sequence version replaced NM_011729.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            transcript and genomic sequence to make the sequence consistent
            with the reference genome assembly. The genomic coordinates used
            for the transcript record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U40796.1, BC092235.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-169               AK047192.1         1-169
            170-2273            AK137563.1         2-2105
            2274-3388           AK140825.1         2103-3217
            3389-3817           AK137563.1         3221-3649
            3818-4010           AC123800.4         157199-157391
FEATURES             Location/Qualifiers
     source          1..4010
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 23.55 cM"
     gene            1..4010
                     /gene="Ercc5"
                     /gene_synonym="Xpg"
                     /note="excision repair cross-complementing rodent repair
                     deficiency, complementation group 5"
                     /db_xref="GeneID:22592"
                     /db_xref="MGI:MGI:103582"
     exon            1..407
                     /gene="Ercc5"
                     /gene_synonym="Xpg"
                     /inference="alignment:Splign:2.1.0"
     CDS             320..3832
                     /gene="Ercc5"
                     /gene_synonym="Xpg"
                     /note="DNA repair protein complementing XP-G cells
                     homolog; xeroderma pigmentosum group G-complementing
                     protein homolog; xeroderma pigmentosum, complementation
                     group G"
                     /codon_start=1
                     /product="DNA excision repair protein ERCC-5"
                     /protein_id="NP_035859.2"
                     /db_xref="CCDS:CCDS35553.1"
                     /db_xref="GeneID:22592"
                     /db_xref="MGI:MGI:103582"
                     /translation="MGVQGLWKLLECSGHRVSPEALEGKVLAVDISIWLNQALKGVRD
                     SHGNVIENAHLLTLFHRLCKLLFFRIRPIFVFDGDAPLLKKQTLAKRRQRKDSASIDS
                     RKTTEKLLKTFLKRQALKTAFRSSRHEAPPSLTQVQRQDDIYVLPPLPEEEKHSSEEE
                     DEKQWQARMDQKQALQEEFFHNPQAIDIESEDFSSLPPEVKHEILTDMKEFTKRRRTL
                     FEAMPEESNDFSQYQLKGLLKKNYLNQHIENVQKEMNQQHSGQIQRQYQDEGGFLKEV
                     ESRRVVSEDTSHYILIKGIQGKKVMDVDSESLPSSSNVHSVSSNLKSSPHEKVKPERE
                     PEAAPPSPRTLLAIQAAMLGSSSEDEPESREGRQSKERNSGATADAGSISPRTCAAIQ
                     KALDDDNDEKVSGSSDDLAEKMLLGSGLEQEEHADETAERGGGVPFDTAPLTPSVTEV
                     KECVTSGSSANGQTDSAHSFTTASHRCDTPKETVSLARAVKEASQISSECEVEGRPAA
                     LSPAFIGTPSSHVSGVLSEREPTLAPPTTRTHSDQGIDIHPEDPELQNGLYPLETKCN
                     SSRLSSDDETEGGQNPAPKACSTVHVPAEAMSNLENALPSNAEERGDFQETIQLREVP
                     EAAARELISAPKPMGPMEMESEESESDGSFIEVQSVVSNSELQTESSEASTHLSEKDA
                     EEPRETLEEGTSRDTECLLQDSSDIEAMEGHREADIDAEDMPNEWQDINLEELDALES
                     NLLAEQNSLKAQKQQQDRIAASVTGQMFLESQELLRLFGVPYIQAPMEAEAQCAMLDL
                     TDQTSGTITDDSDIWLFGARHVYKNFFNKNKFVEYYQYVDFYSQLGLDRNKLINLAYL
                     LGSDYTEGIPTVGCVTAMEILNEFPGRGLDPLLKFSEWWHEAQNNKKVAENPYDTKVK
                     KKLRKLQLTPGFPNPAVADAYLRPVVDDSRGSFLWGKPDVDKIREFCQRYFGWNRMKT
                     DESLYPVLKHLNAHQTQLRIDSFFRLAQQEKQDAKLIKSHRLNRAVTCILRKEREEKA
                     PELTKVTEALDDAKGKTQKRELPYKKETSVPKRRRPSGNGGFLGDPYCSESPQESSCE
                     DGEGSSVMSARQRSAAESSKISCSDVPDLVRDPPHGRQGCVSTSSSSEDDEDKAKTVL
                     VTARPVFGKKKLKLKSMKRRKKKT"
     exon            408..583
                     /gene="Ercc5"
                     /gene_synonym="Xpg"
                     /inference="alignment:Splign:2.1.0"
     exon            584..699
                     /gene="Ercc5"
                     /gene_synonym="Xpg"
                     /inference="alignment:Splign:2.1.0"
     exon            700..786
                     /gene="Ercc5"
                     /gene_synonym="Xpg"
                     /inference="alignment:Splign:2.1.0"
     exon            787..847
                     /gene="Ercc5"
                     /gene_synonym="Xpg"
                     /inference="alignment:Splign:2.1.0"
     exon            848..991
                     /gene="Ercc5"
                     /gene_synonym="Xpg"
                     /inference="alignment:Splign:2.1.0"
     exon            992..1199
                     /gene="Ercc5"
                     /gene_synonym="Xpg"
                     /inference="alignment:Splign:2.1.0"
     exon            1200..2273
                     /gene="Ercc5"
                     /gene_synonym="Xpg"
                     /inference="alignment:Splign:2.1.0"
     exon            2274..2515
                     /gene="Ercc5"
                     /gene_synonym="Xpg"
                     /inference="alignment:Splign:2.1.0"
     exon            2516..2635
                     /gene="Ercc5"
                     /gene_synonym="Xpg"
                     /inference="alignment:Splign:2.1.0"
     exon            2636..2849
                     /gene="Ercc5"
                     /gene_synonym="Xpg"
                     /inference="alignment:Splign:2.1.0"
     exon            2850..2994
                     /gene="Ercc5"
                     /gene_synonym="Xpg"
                     /inference="alignment:Splign:2.1.0"
     exon            2995..3195
                     /gene="Ercc5"
                     /gene_synonym="Xpg"
                     /inference="alignment:Splign:2.1.0"
     exon            3196..3280
                     /gene="Ercc5"
                     /gene_synonym="Xpg"
                     /inference="alignment:Splign:2.1.0"
     exon            3281..4010
                     /gene="Ercc5"
                     /gene_synonym="Xpg"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 actcgcgacc ggaggaaggc tcggcgctgg cgtcaccggt gctgcttctc agtactttta
       61 ggcgtgccag tactggggct gaaacctttc tgctcctccc accacattta aattccgctg
      121 ttctttcggg agaccgggtc cgctccggaa gtgcgtcagc gccgtgttcc tccttcaagc
      181 cctggtgaca gcgggttcca ggcggagagc ggtgggctct gcgtgagttg gtggcgctgc
      241 gtgctggtgc ggggcgcgtc ctttatccta acgggaaaca aaggccccgc gagcccggcc
      301 gagagagagc gcctgcgcca tgggagtgca ggggctgtgg aagctgctgg agtgctcggg
      361 ccaccgggtc agcccggagg cgctggaggg caaggtgctg gccgtggata ttagcatttg
      421 gctaaaccaa gcacttaaag gagtccgaga tagccatggg aatgtgatag aaaatgctca
      481 tcttctcaca ttattccacc ggctctgcaa actcttgttt tttcgtatcc gccctatttt
      541 tgtatttgat ggtgatgctc cgctgctaaa gaaacagacc ttggcaaaga gaaggcagag
      601 gaaggattct gcatccattg actcgagaaa aaccaccgag aaacttctga aaacctttct
      661 gaagagacag gctctgaaaa ctgctttcag aagctcaaga catgaagcgc cacccagtct
      721 cactcaggtt caaagacagg atgacatcta tgttttgcca cctttaccag aggaagaaaa
      781 acacagttca gaagaggaag atgaaaagca atggcaagca agaatggatc aaaaacaagc
      841 attgcaggaa gaattctttc ataatcctca ggccatagat atcgagtctg aggacttcag
      901 cagcctgcct cctgaagtaa agcatgagat cttgactgac atgaaagagt ttaccaagcg
      961 aaggcgaaca ctgtttgaag caatgccaga ggagtctaat gacttttcac agtaccagct
     1021 gaaaggcttg ctgaagaaga actacctaaa ccagcacata gaaaatgtcc aaaaggaaat
     1081 gaaccagcag cattcagggc aaatccagag gcaatatcaa gatgagggag gctttctgaa
     1141 ggaagtggag tccaggagag tggtctctga agacacctca cattacatct tgataaaagg
     1201 tattcaaggt aagaaagtca tggatgtgga ttcagaatct cttccttcct ccagcaacgt
     1261 acacagtgtg tcttccaacc tgaagtcatc accccacgag aaagtgaagc cggagagaga
     1321 gccagaggcc gcgcctcctt ctccaagaac tctactggct attcaggcag ccatgctggg
     1381 aagtagctca gaagatgagc cagagagtag agagggaagg cagtctaagg agaggaactc
     1441 aggggccact gcagatgcag gttccatctc accccggacc tgtgcagcta ttcagaaagc
     1501 tctggatgat gataacgatg agaaagtgtc tggcagcagt gatgatctag cagagaaaat
     1561 gctgcttgga agtgggctgg agcaggagga gcatgctgat gaaacggcag aaagaggtgg
     1621 aggcgtgcca tttgacacag cgcctctcac acccagtgtg actgaggtaa aggagtgtgt
     1681 aaccagtggc agcagtgcaa acggacagac agactcagct cattcattta caaccgcgag
     1741 tcaccgatgt gatactccaa aagaaacagt gtctcttgct cgtgccgtga aagaagcatc
     1801 tcagataagc agtgaatgtg aggtggaggg taggccagct gccctctcac cagcattcat
     1861 aggaactcca agcagtcatg tctctggagt cctcagtgaa agggaaccca ccctggcacc
     1921 tccgacgaca agaacacatt ctgatcaggg gatagacata caccctgaag atcctgagct
     1981 acaaaacgga ctctacccac ttgagaccaa gtgtaattcc tctcgccttt caagtgacga
     2041 tgaaacagaa ggtgggcaaa accctgctcc caaagcatgt agtacagttc atgtccctgc
     2101 agaggcaatg agtaacttag aaaatgcgtt gccttctaat gctgaagaac gtggagattt
     2161 ccaggaaacc atccagctac gggaggtgcc tgaggctgct gccagggagc tgatttcagc
     2221 tccaaagccc atgggaccaa tggagatgga gtctgaagaa agcgagtctg atggaagttt
     2281 cattgaggtg cagagtgtgg tcagcaatag tgaacttcaa acagagtcat ccgaggcttc
     2341 tacacatctc tctgaaaaag atgcagagga accaagagaa actctggagg aaggaacctc
     2401 cagggacaca gagtgcctcc tacaggacag ctctgacatt gaggcaatgg aaggacacag
     2461 agaagctgac atagatgctg aggacatgcc caacgaatgg caagatatta atttggagga
     2521 actggatgcc ctggaaagta acctcttagc agaacagaat tcactgaaag cgcaaaaaca
     2581 gcagcaagat cggattgctg cctctgtaac aggccagatg tttctggaaa gccaggaact
     2641 cctgcgcctg tttggcgttc cctacatcca ggctcccatg gaggcagagg cacagtgtgc
     2701 catgttggac ctcactgacc agacttctgg aacgattact gacgatagtg atatctggct
     2761 gtttggggcc cggcatgtct ataagaattt ttttaacaaa aacaagtttg tagagtacta
     2821 tcaatatgtg gacttttaca gtcaactagg actggaccgt aacaagctaa tcaacttggc
     2881 ctatctactg ggcagtgact atacggaagg gataccaact gtaggctgtg taacagccat
     2941 ggagattctc aatgaattcc ctggacgagg cctggaccca ctcctaaaat tctcagagtg
     3001 gtggcacgaa gctcaaaata acaagaaggt tgcagaaaat ccctatgaca ccaaagtgaa
     3061 aaaaaaatta cggaagttgc agctgacacc tggtttcccc aacccggcag ttgcagatgc
     3121 ttacctcagg cctgtggtgg atgactccag gggatcgttc ctgtggggca agcctgatgt
     3181 ggacaagatt agagaatttt gtcagaggta ttttggctgg aacaggatga agaccgatga
     3241 atccctgtat ccagtactaa agcacctgaa tgcccatcag acccagctcc ggattgattc
     3301 cttttttaga ctagctcagc aggaaaaaca agatgccaaa ctcataaaga gtcataggct
     3361 aaacagagca gtgacatgta tactgaggaa agaacgggaa gagaaagctc ctgagctgac
     3421 aaaagtgact gaggccctgg atgatgcaaa aggaaaaacc cagaaaagag agctaccata
     3481 taaaaaagag acttcagttc caaaaagaag gagaccttca ggcaatggtg ggtttctagg
     3541 ggacccctac tgctcagaat caccccagga atcttcctgt gaggatggag aaggttcatc
     3601 tgtgatgagt gcacgacaga gaagtgcagc tgagtcgtca aaaatcagct gctcagatgt
     3661 gcctgactta gtgagagacc ctcctcatgg gaggcaaggc tgtgtgtcca ctagtagctc
     3721 cagcgaggat gatgaggaca aagccaagac tgtcctagtg actgctagac ctgtatttgg
     3781 gaagaaaaaa ctgaaactaa agagtatgaa gagaaggaaa aagaaaacct aatttaaaga
     3841 gaaaaaaaaa agtcatttag aaacagaaag tgcttacaat gtattgagag cataagatta
     3901 aatctatttg tataatctct attttgaatg tatagtttta ttctcttttt tattttcttg
     3961 agtttattaa aaatcaaaga acagaaaaat tttacataaa agtacatctg
//
