LOCUS       NM_015769               6703 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus excision repair cross-complementing rodent repair
            deficiency, complementation group 4 (Ercc4), transcript variant 1,
            mRNA.
ACCESSION   NM_015769
VERSION     NM_015769.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6703)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 6703)
  AUTHORS   Elango,R., Panday,A., Lach,F.P., Willis,N.A., Nicholson,K.,
            Duffey,E.E., Smogorzewska,A. and Scully,R.
  TITLE     The structure-specific endonuclease complex SLX4-XPF regulates
            Tus-Ter-induced homologous recombination
  JOURNAL   Nat Struct Mol Biol 29 (8), 801-812 (2022)
   PUBMED   35941380
  REMARK    GeneRIF: The structure-specific endonuclease complex SLX4-XPF
            regulates Tus-Ter-induced homologous recombination.
REFERENCE   3  (bases 1 to 6703)
  AUTHORS   Chatzinikolaou,G., Apostolou,Z., Aid-Pavlidis,T., Ioannidou,A.,
            Karakasilioti,I., Papadopoulos,G.L., Aivaliotis,M., Tsekrekou,M.,
            Strouboulis,J., Kosteas,T. and Garinis,G.A.
  TITLE     ERCC1-XPF cooperates with CTCF and cohesin to facilitate the
            developmental silencing of imprinted genes
  JOURNAL   Nat Cell Biol 19 (5), 421-432 (2017)
   PUBMED   28368372
  REMARK    GeneRIF: ERCC1-XPF cooperates with CTCF and cohesin to facilitate
            the developmental silencing of imprinted genes and that persistent
            DNA damage triggers chromatin changes that affect gene expression
            programs associated with NER disorders.
REFERENCE   4  (bases 1 to 6703)
  AUTHORS   Perez-Oliva,A.B., Lachaud,C., Szyniarowski,P., Munoz,I.,
            Macartney,T., Hickson,I., Rouse,J. and Alessi,D.R.
  TITLE     USP45 deubiquitylase controls ERCC1-XPF endonuclease-mediated DNA
            damage responses
  JOURNAL   EMBO J 34 (3), 326-343 (2015)
   PUBMED   25538220
  REMARK    GeneRIF: these results establish USP45 as a new regulator of
            XPF-ERCC1 crucial for efficient DNA repair
REFERENCE   5  (bases 1 to 6703)
  AUTHORS   Hodskinson,M.R., Silhan,J., Crossan,G.P., Garaycoechea,J.I.,
            Mukherjee,S., Johnson,C.M., Scharer,O.D. and Patel,K.J.
  TITLE     Mouse SLX4 is a tumor suppressor that stimulates the activity of
            the nuclease XPF-ERCC1 in DNA crosslink repair
  JOURNAL   Mol Cell 54 (3), 472-484 (2014)
   PUBMED   24726326
  REMARK    GeneRIF: SLX4 is a tumor suppressor, which activates XPF-ERCC1
            nuclease specificity in DNA crosslink repair.
REFERENCE   6  (bases 1 to 6703)
  AUTHORS   Niedernhofer,L.J., Odijk,H., Budzowska,M., van Drunen,E., Maas,A.,
            Theil,A.F., de Wit,J., Jaspers,N.G., Beverloo,H.B.,
            Hoeijmakers,J.H. and Kanaar,R.
  TITLE     The structure-specific endonuclease Ercc1-Xpf is required to
            resolve DNA interstrand cross-link-induced double-strand breaks
  JOURNAL   Mol Cell Biol 24 (13), 5776-5787 (2004)
   PUBMED   15199134
  REMARK    GeneRIF: mitomycin C triggered sister chromatid exchanges in
            wild-type cells but chromatid fusions in Ercc1(-/-) and Xpf mutant
            cells, indicating that in their absence, repair of double-strand
            breaks(DSBs)is prevented.
REFERENCE   7  (bases 1 to 6703)
  AUTHORS   Tian,M., Shinkura,R., Shinkura,N. and Alt,F.W.
  TITLE     Growth retardation, early death, and DNA repair defects in mice
            deficient for the nucleotide excision repair enzyme XPF
  JOURNAL   Mol Cell Biol 24 (3), 1200-1205 (2004)
   PUBMED   14729965
REFERENCE   8  (bases 1 to 6703)
  AUTHORS   Zhu,X.D., Niedernhofer,L., Kuster,B., Mann,M., Hoeijmakers,J.H. and
            de Lange,T.
  TITLE     ERCC1/XPF removes the 3' overhang from uncapped telomeres and
            represses formation of telomeric DNA-containing double minute
            chromosomes
  JOURNAL   Mol Cell 12 (6), 1489-1498 (2003)
   PUBMED   14690602
  REMARK    GeneRIF: Data reveal an unanticipated involvement of the ERCC1/XPF
            NER endonuclease in the regulation of telomere integrity.
REFERENCE   9  (bases 1 to 6703)
  AUTHORS   VanBuren,V., Piao,Y., Dudekula,D.B., Qian,Y., Carter,M.G.,
            Martin,P.R., Stagg,C.A., Bassey,U.C., Aiba,K., Hamatani,T.,
            Kargul,G.J., Luo,A.G., Kelso,J., Hide,W. and Ko,M.S.
  TITLE     Assembly, verification, and initial annotation of the NIA mouse
            7.4K cDNA clone set
  JOURNAL   Genome Res 12 (12), 1999-2003 (2002)
   PUBMED   12466305
REFERENCE   10 (bases 1 to 6703)
  AUTHORS   Shannon,M., Lamerdin,J.E., Richardson,L., McCutchen-Maloney,S.L.,
            Hwang,M.H., Handel,M.A., Stubbs,L. and Thelen,M.P.
  TITLE     Characterization of the mouse Xpf DNA repair gene and differential
            expression during spermatogenesis
  JOURNAL   Genomics 62 (3), 427-435 (1999)
   PUBMED   10644440
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC166826.4, AK149326.1, BQ559127.1, CD352377.1, CX210668.1 and
            CO433666.1.
            
            On Jun 23, 2009 this sequence version replaced NM_015769.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF189285.1, BC026792.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-168               AC166826.4         111998-112165       c
            169-1655            AK149326.1         2-1488
            1656-1911           BQ559127.1         215-470
            1912-2053           CD352377.1         172-313
            2054-2459           CX210668.1         208-613
            2460-2841           CO433666.1         251-632
            2842-6703           AC166826.4         69892-73753         c
FEATURES             Location/Qualifiers
     source          1..6703
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 8.93 cM"
     gene            1..6703
                     /gene="Ercc4"
                     /gene_synonym="Xpf"
                     /note="excision repair cross-complementing rodent repair
                     deficiency, complementation group 4"
                     /db_xref="GeneID:50505"
                     /db_xref="MGI:MGI:1354163"
     exon            1..406
                     /gene="Ercc4"
                     /gene_synonym="Xpf"
                     /inference="alignment:Splign:2.1.0"
     CDS             200..2953
                     /gene="Ercc4"
                     /gene_synonym="Xpf"
                     /note="DNA repair endonuclease subunit; DNA excision
                     repair protein ERCC-4"
                     /codon_start=1
                     /product="DNA repair endonuclease XPF"
                     /protein_id="NP_056584.2"
                     /db_xref="CCDS:CCDS37256.1"
                     /db_xref="GeneID:50505"
                     /db_xref="MGI:MGI:1354163"
                     /translation="MEPGLSGERRSMAPLLEYERQQVLELLDSDGLVVCARGLGTDRL
                     LYHFLRLHCHPACLVLVLNTQPAEEEYFINQLKIEGVEHLPRRVTNEIASNSRYEVYT
                     QGGIIFATSRILVVDFLTGRIPSDLITGILVYRAHRIIESCQEAFILRLFRQKNKRGF
                     IKAFTDNAVAFDTGFCHVERVMRNLFVRKLYLWPRFHVAVNSFLEQHKPEVVEIHVSM
                     TPAMLAIQTAILDILNACLKELKCHNPSLEVEDLSLENALGKPFDKTIRHYLDPLWHQ
                     LGAKTKSLVQDLKILRTLLQYLSQYDCVTFLNLLESLRATEKVFGQNSGWLFLDASTS
                     MFVNARARVYRVPDVKLNKKAKTSEKTSSPEVQETKKELVLESNPKWEALTDVLKEIE
                     AENKESEALGGPGRVLICASDDRTCCQLRDYLSAGAETFLLRLYRKTFEKDGKAEEVW
                     VNVRKGDGPKRTTKSDKRPKAAPNKERASAKRGAPLKRKKQELTLTQVLGSAEEPPED
                     KALEEDLCRQTSSSPEGCGVEIKRESFDLNVSSDAAYGILKEPLTIIHPLLGCSDPYA
                     LTRVLHEVEPRYVVLYDAELTFVRQLEIYRASRPGKPLRVYFLIYGGSTEEQRYLTAL
                     RKEKEAFEKLIREKASMVVPEEREGRDETNLDLARGSAALDAPTDTRKAGGQEQNGTQ
                     SSIVVDMREFRSELPSLIHRRGIDIEPVTLEVGDYILTPELCVERKSVSDLIGSLHSG
                     RLYSQCLAMSRYYRRPVLLIEFDPSKPFSLAPRGAFFQEMSSSDVSSKLTLLTLHFPR
                     LRLLWCPSPHATAELFEELKQNKPQPDAATAMAITADSETLPESDRYNPGPQDFVLKM
                     PGVNAKNCRSLMNQVKNIAELATLSLERLTTILGHSGNAKQLHDFLHTAYADLVSKGR
                     VRK"
     exon            407..587
                     /gene="Ercc4"
                     /gene_synonym="Xpf"
                     /inference="alignment:Splign:2.1.0"
     exon            588..783
                     /gene="Ercc4"
                     /gene_synonym="Xpf"
                     /inference="alignment:Splign:2.1.0"
     exon            784..991
                     /gene="Ercc4"
                     /gene_synonym="Xpf"
                     /inference="alignment:Splign:2.1.0"
     exon            992..1172
                     /gene="Ercc4"
                     /gene_synonym="Xpf"
                     /inference="alignment:Splign:2.1.0"
     exon            1173..1301
                     /gene="Ercc4"
                     /gene_synonym="Xpf"
                     /inference="alignment:Splign:2.1.0"
     exon            1302..1412
                     /gene="Ercc4"
                     /gene_synonym="Xpf"
                     /inference="alignment:Splign:2.1.0"
     exon            1413..2013
                     /gene="Ercc4"
                     /gene_synonym="Xpf"
                     /inference="alignment:Splign:2.1.0"
     exon            2014..2106
                     /gene="Ercc4"
                     /gene_synonym="Xpf"
                     /inference="alignment:Splign:2.1.0"
     exon            2107..2219
                     /gene="Ercc4"
                     /gene_synonym="Xpf"
                     /inference="alignment:Splign:2.1.0"
     exon            2220..6703
                     /gene="Ercc4"
                     /gene_synonym="Xpf"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3410..3415
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ercc4"
                     /gene_synonym="Xpf"
                     /note="hexamer: AATAAA"
     polyA_site      3428
                     /gene="Ercc4"
                     /gene_synonym="Xpf"
                     /note="major polyA site"
     regulatory      6664..6669
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ercc4"
                     /gene_synonym="Xpf"
                     /note="hexamer: AATAAA"
     polyA_site      6687
                     /gene="Ercc4"
                     /gene_synonym="Xpf"
ORIGIN      
        1 cgattccttt tcggctacaa tcggttggct ctcttgaact cggctccctt cggctacatc
       61 cggcctctct cagtcggcca ttgcagttac atctgttctg cgctccttcg gccctggcgt
      121 ctctccctgc gttcggccag cgttcggctg gactcggctc tttccgtcag cgtgcggccg
      181 cggtcccgga agggcgccca tggagccagg cctgtcgggc gaacggcgga gtatggcgcc
      241 gctgttggag tacgagaggc agcaggtgct ggaactgctc gacagcgacg ggctggtggt
      301 gtgtgcccgc ggactcggca ccgaccggct cctctaccat ttcctgcggc ttcactgcca
      361 cccggcctgc ctggtgctgg tgctcaacac gcagccggcc gaggaggaat attttatcaa
      421 tcagttgaag atagaaggag ttgaacatct ccctcgacga gtgacaaatg aaatcgcaag
      481 taacagtcgc tatgaagtct acacgcaggg tggtattata tttgcaacaa gccgaatact
      541 cgtggttgat ttcttgacag gtagaatacc ttcagattta ataactggca tcctcgtgta
      601 cagggcacac agaatcattg agtcctgcca ggaagccttc atcctgcgcc tcttccgcca
      661 gaaaaacaag cgcgggttca tcaaagcttt caccgacaac gctgttgcct ttgacactgg
      721 cttttgtcac gtggaaagag tgatgcggaa cctttttgtg aggaagctct acctgtggcc
      781 aaggttccat gtagcagtca actcattctt ggaacaacac aagcctgaag ttgtagagat
      841 tcacgtgtcc atgactcccg ccatgcttgc cattcagacg gccatactag acatcttaaa
      901 tgcatgtctg aaagaactga aatgtcacaa cccgtcactt gaagtagaag atttgtcact
      961 agaaaacgct cttgggaagc cattcgacaa gacaatccgc cattacttgg accctttgtg
     1021 gcatcagctt ggagccaaga ctaaatcctt ggtgcaggat ttaaagatac taagaacctt
     1081 actgcagtat ctctctcagt atgattgtgt tacatttctg aatcttctgg aatctctgag
     1141 agcaacagag aaggtgtttg gtcagaattc aggttggctt ttcctggatg ctagcacctc
     1201 catgtttgtg aatgctcgtg cccgagttta ccgagttcca gatgtcaaac tgaacaaaaa
     1261 ggccaaaaca tcagaaaaga cgtcgagtcc agaagttcaa gaaacaaaaa aagaactggt
     1321 tctagagagc aatccaaagt gggaggcgct gactgacgtc ctgaaagaaa tcgaagcaga
     1381 aaataaggag agcgaagccc ttggtggccc aggccgggtg ctgatctgtg caagcgatga
     1441 ccgcacgtgc tgccagctga gagactacct gtccgccgga gcagaaacct tcctgctgcg
     1501 actttatagg aaaacttttg agaaggatgg caaagctgaa gaagtgtggg taaatgttag
     1561 aaagggggac ggcccgaaga gaactacaaa atctgacaaa agaccaaaag ccgctccaaa
     1621 caaggagcgt gcttccgcca aaaggggggc ccctctcaaa aggaagaagc aagagctgac
     1681 tctgacgcaa gttttggggt ccgctgagga gccgccggag gacaaggctt tggaggaaga
     1741 cctgtgcaga cagaccagta gtagcccaga aggctgcggg gtagagatta agcgtgaatc
     1801 atttgattta aatgtgtcgt ctgatgcggc ctatggcatc ctgaaagagc ccctgaccat
     1861 catccatccg cttctagggt gcagcgaccc ctatgccctg acgcgggtac tgcacgaggt
     1921 ggagcccaga tacgtggttc tgtatgatgc agagctcacc tttgttcgcc aactggagat
     1981 ctacagggct agcaggcctg ggaaacctct gagggtttac tttcttatat acggaggctc
     2041 cacggaagag cagcgctacc tgactgctct gcggaaagaa aaggaagcct ttgaaaagct
     2101 cataagagaa aaagctagca tggttgtccc cgaagaacgg gaaggcagag atgagaccaa
     2161 cctggaccta gcaagaggct cagcagccct ggatgctccc acggacactc ggaaagccgg
     2221 tggccaggag cagaatggca cccagtccag catcgtggtg gacatgcgtg agtttcggag
     2281 cgagctccca tctctgatcc atcggcgggg tattgacata gagccagtga ctctggaggt
     2341 gggtgattac atcctgacac ctgagctgtg tgtggagcgc aaaagtgtga gcgacctcat
     2401 tggctcgctg cacagtggcc gcctgtacag ccagtgccta gccatgtctc gctactaccg
     2461 gaggcctgtg ctgctcattg agtttgaccc gagcaagccc ttctccctgg cgccacgagg
     2521 tgccttcttc caggagatga gcagcagcga tgtgagctcc aagcttacgc tcctcacctt
     2581 gcacttcccg cgtttgcggc tgctctggtg cccctcaccc cacgccacag ccgagctgtt
     2641 tgaggagctg aagcagaaca agccacagcc tgatgcggcc acagccatgg ccatcaccgc
     2701 agactcagag acactgcctg agtcggacag atataacccc ggcccccaag actttgtgct
     2761 gaagatgcct ggggtcaacg ccaagaactg tcgctccctg atgaaccaag tgaagaacat
     2821 cgcagagctg gccaccctgt ccctggaacg actcacaacc atcctggggc actcgggaaa
     2881 tgccaagcag ctgcacgact tcctgcacac tgcctatgca gacttggtgt ccaaaggcag
     2941 agtgagaaag tgactgttct cacatggcta tttattgatc atttgcatag caattcattc
     3001 tttcccccca ggaatgtccc ccagggcatt ggtccagagc cagaacttcc ccctgggctc
     3061 tgtactgagg tgtgggcctg tcttcccttg ctggctctca cccctctgtg ctctgtctgt
     3121 gccaggcctg cactgatcca ttttcaataa ggtgtggtga gatcttgccc cttgaagtaa
     3181 acacagacta tgtttacttt tcaggctggt aaaagcactg caccatggtc ctaacactgg
     3241 ctgcacaggg cttggtaggc ctgagacagg actgctgttg cttcttcccc acccacacag
     3301 agacaagcta gccctctagc ctcctggtca ccaggtatat gtaacgtgta ctgtgactcg
     3361 gttgtgtttt tcacagaatt aattgcttac ggacaagatt ggatgaggta ataaagggct
     3421 cctcagaatt cttggtttct cagtgtttga gctccaaatt cctactctaa gcccaaatga
     3481 caagtctaag tgtcccccac ttcactggtg ttagatgcca gtgccatacc agaagcacac
     3541 agggcatctc tgccctgccc gtggtcctgt cctgactgct tctcctttcc tgggtgagga
     3601 ctggatgtga gcaaaggtgg gccaggtgct tctagatgta gatttctctc cttcttagta
     3661 tagggttgtg aataaatggg taaatcagct cagagaacac ataaggattc aaaagaaata
     3721 cataggtgtt taaaggccca caaaccaatc tcatgattga ttgagacagg atgttctgtg
     3781 ttaaaatggg attcatcgca tcttcatgat gtttgcaaac tgtgatactt aagcgttagc
     3841 tgtttatgtg ttcagggaca agcagtaaag tttctacctc aagaactaat gccacgtgaa
     3901 ttctagcttg ccacatggtt gagtattcca tccgtgtcag ccgtctttgg ctgaactgat
     3961 aaaaaagtgg accttgtaac aaaaatactg tctcctccaa ctttaacaaa agcactctga
     4021 gctgaacctt atatgttggc atcatgattc ttgatactta acaatatagt tgtccctcag
     4081 tatccatagt tccaggaccc tctctgatgg tacattctgt gcaggctgca ggccttcagt
     4141 ggtgtttgct tatagcctct gcctccccct gtgaacttca aaccacagca acttcaagct
     4201 cacagcaact gcgtcgggac aggtggtaac agctggttcc ctgtgctccg gagcctgcgt
     4261 gtttagaaga gatcagttgt tcctctattt ccagtccttg gttagttaaa cccaaggatg
     4321 caagaggaca tcccctgagc atcctgtcca gagcccttca ggaacgaatg tcaagggctg
     4381 tcaaggcata gtcgattatt ggaggcatgg aaaacgggaa ggatgaagca gtaagcttat
     4441 gatggagagg ggtagagaat ggaaaggatg aagcagtaag cttacagtgg aaaggaatct
     4501 aagctacttg tttccaccca gggttaaaaa tgcatttgcc ttctggacca tgacagaact
     4561 gcctggtgag tcgcactggg cagtgtggtc attcccaact cgtgaacaca gacatccact
     4621 tctacttacg gtaacagtcc ccctcctcca tgtaactctg cctccctttt ctgttgtttt
     4681 gttccataaa acaaaaatct taacatagca catgctatgg tgggtgtttc gttcaaagtt
     4741 aaaatttcaa agctcttcta gacattgttt taaacagtcc ttgttaccta gtgcagcaat
     4801 ctgtaacccc gggcttcccg tgtctgtcag ctcgagtcgg ctgttcactg tgacacccat
     4861 ggctgggctt ctgttgcctc actccctcct ctgctgacag gctcacacgt tgccagaggt
     4921 ggaaggcttc ccgcacatcc atccgttgtt tggttttctg atactttttt ttttttttac
     4981 acatttttag aatctgactt tgtttcccag cagcattttg ctacctttga tgttgttgtt
     5041 gttgttcaaa attatagata ctgatgagct cccaggtagc ttttaaaagc taggtctgca
     5101 ctgtggttcc cggctgctta catagagcct tgataagaaa tgatccttga ttcgggcagt
     5161 ggtggcacat gcctttaatc ccagcacttg ggaggcagag gcaggtggat ttctgagttc
     5221 gaggccagcc tggtctacag agttcaagaa cagccagggc tacacagaga aaccctgtct
     5281 caagagaaaa aaaaagaaaa aagaaaaaaa agaaactatc cttgcttaag cacctctctt
     5341 ggtgttctta gaactatatg aggtgatagc ctccttaata gtagccatca aggcaaacct
     5401 ggtagcccac agccctaact aatcccagct ctagggagac agaggcaggt ggatctctgt
     5461 gactttaagg ctagcctgct ctatatagtg agttccaagt tagccagggc tatgtagtaa
     5521 tacctgtctt aaaaacaaat gtggtggcca tcagccctgt cctcagtagt cctgactccc
     5581 tttggtgagt gctcactgga ctgtaggccc acagctgttt gggagccctg tggtgtaatc
     5641 cccagttgac aggggacggg aaatgctctc gtccagccct caccaggtct gcgttgttga
     5701 gatgcaggga cttcgtgagg agggaggctc tgttccaggc ttcatttgct tctccggtgg
     5761 atttgctgtc acactgcctt ggagaacccg ttgagggaaa ttctccatta gttttgcttg
     5821 actttaaaat gtctcctcaa aaggatttta agaaaaagat gacagtgcag ccaggctttg
     5881 gcaaaaattg tcactttcct tggttatgtt gtcctcattc tgatgctatt tcctgtgtga
     5941 ttctgagcta cggcacacag ttgtccatct ttttcagcag gacttggtag tctgtaccat
     6001 tgggctgttg gagtattatt tatttctgtt gttttaattt atggctccat aagccaagat
     6061 ttggtaaaag ggagagaaaa ctgaaatata tttactcata atgggggagg gggattattt
     6121 agtatcttcc tcagcttcct gggcaaagta aaaatgtcag tgcatggtca gagggcgctt
     6181 gttgccagcc acgcaccagt gcacagtgag gtgttcttta tgcagaacag ttggctaacg
     6241 caggtttgct ctgagtcgct gcttctacct ggctccagta acgcacgttc ttgtgtcatc
     6301 aatgtgatgt tcttggctgc tccttcctaa tgctgtgacg tctccttaac caaagaagct
     6361 gcggggaaaa gctgttgtcc tttggaaata ccagttagtt gaaaatggca agcatgtggt
     6421 gtctggggca tccaaacaaa gggtcagccc ctgtattttt attcctttta actcacaggt
     6481 tggaagaggt aaattgttct tttgataacc caggaattta ttattatttc ttaagcaagt
     6541 ttaattatac tttgaattgg gtcaccacag tggtgtcccc gttgctgcct ctgctttgaa
     6601 tgtccgtgca cagccctttc taacgtccag gagaccggtt atttttcagc gttgtatcct
     6661 ctgaataaag actggcaaaa tattgaacca tttctttacg tag
//
