LOCUS       NP_056584                917 aa            linear   ROD 30-APR-2024
DEFINITION  DNA repair endonuclease XPF [Mus musculus].
ACCESSION   NP_056584
VERSION     NP_056584.2
DBSOURCE    REFSEQ: accession NM_015769.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 917)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 917)
  AUTHORS   Elango,R., Panday,A., Lach,F.P., Willis,N.A., Nicholson,K.,
            Duffey,E.E., Smogorzewska,A. and Scully,R.
  TITLE     The structure-specific endonuclease complex SLX4-XPF regulates
            Tus-Ter-induced homologous recombination
  JOURNAL   Nat Struct Mol Biol 29 (8), 801-812 (2022)
   PUBMED   35941380
  REMARK    GeneRIF: The structure-specific endonuclease complex SLX4-XPF
            regulates Tus-Ter-induced homologous recombination.
REFERENCE   3  (residues 1 to 917)
  AUTHORS   Chatzinikolaou,G., Apostolou,Z., Aid-Pavlidis,T., Ioannidou,A.,
            Karakasilioti,I., Papadopoulos,G.L., Aivaliotis,M., Tsekrekou,M.,
            Strouboulis,J., Kosteas,T. and Garinis,G.A.
  TITLE     ERCC1-XPF cooperates with CTCF and cohesin to facilitate the
            developmental silencing of imprinted genes
  JOURNAL   Nat Cell Biol 19 (5), 421-432 (2017)
   PUBMED   28368372
  REMARK    GeneRIF: ERCC1-XPF cooperates with CTCF and cohesin to facilitate
            the developmental silencing of imprinted genes and that persistent
            DNA damage triggers chromatin changes that affect gene expression
            programs associated with NER disorders.
REFERENCE   4  (residues 1 to 917)
  AUTHORS   Perez-Oliva,A.B., Lachaud,C., Szyniarowski,P., Munoz,I.,
            Macartney,T., Hickson,I., Rouse,J. and Alessi,D.R.
  TITLE     USP45 deubiquitylase controls ERCC1-XPF endonuclease-mediated DNA
            damage responses
  JOURNAL   EMBO J 34 (3), 326-343 (2015)
   PUBMED   25538220
  REMARK    GeneRIF: these results establish USP45 as a new regulator of
            XPF-ERCC1 crucial for efficient DNA repair
REFERENCE   5  (residues 1 to 917)
  AUTHORS   Hodskinson,M.R., Silhan,J., Crossan,G.P., Garaycoechea,J.I.,
            Mukherjee,S., Johnson,C.M., Scharer,O.D. and Patel,K.J.
  TITLE     Mouse SLX4 is a tumor suppressor that stimulates the activity of
            the nuclease XPF-ERCC1 in DNA crosslink repair
  JOURNAL   Mol Cell 54 (3), 472-484 (2014)
   PUBMED   24726326
  REMARK    GeneRIF: SLX4 is a tumor suppressor, which activates XPF-ERCC1
            nuclease specificity in DNA crosslink repair.
REFERENCE   6  (residues 1 to 917)
  AUTHORS   Niedernhofer,L.J., Odijk,H., Budzowska,M., van Drunen,E., Maas,A.,
            Theil,A.F., de Wit,J., Jaspers,N.G., Beverloo,H.B.,
            Hoeijmakers,J.H. and Kanaar,R.
  TITLE     The structure-specific endonuclease Ercc1-Xpf is required to
            resolve DNA interstrand cross-link-induced double-strand breaks
  JOURNAL   Mol Cell Biol 24 (13), 5776-5787 (2004)
   PUBMED   15199134
  REMARK    GeneRIF: mitomycin C triggered sister chromatid exchanges in
            wild-type cells but chromatid fusions in Ercc1(-/-) and Xpf mutant
            cells, indicating that in their absence, repair of double-strand
            breaks(DSBs)is prevented.
REFERENCE   7  (residues 1 to 917)
  AUTHORS   Tian,M., Shinkura,R., Shinkura,N. and Alt,F.W.
  TITLE     Growth retardation, early death, and DNA repair defects in mice
            deficient for the nucleotide excision repair enzyme XPF
  JOURNAL   Mol Cell Biol 24 (3), 1200-1205 (2004)
   PUBMED   14729965
REFERENCE   8  (residues 1 to 917)
  AUTHORS   Zhu,X.D., Niedernhofer,L., Kuster,B., Mann,M., Hoeijmakers,J.H. and
            de Lange,T.
  TITLE     ERCC1/XPF removes the 3' overhang from uncapped telomeres and
            represses formation of telomeric DNA-containing double minute
            chromosomes
  JOURNAL   Mol Cell 12 (6), 1489-1498 (2003)
   PUBMED   14690602
  REMARK    GeneRIF: Data reveal an unanticipated involvement of the ERCC1/XPF
            NER endonuclease in the regulation of telomere integrity.
REFERENCE   9  (residues 1 to 917)
  AUTHORS   VanBuren,V., Piao,Y., Dudekula,D.B., Qian,Y., Carter,M.G.,
            Martin,P.R., Stagg,C.A., Bassey,U.C., Aiba,K., Hamatani,T.,
            Kargul,G.J., Luo,A.G., Kelso,J., Hide,W. and Ko,M.S.
  TITLE     Assembly, verification, and initial annotation of the NIA mouse
            7.4K cDNA clone set
  JOURNAL   Genome Res 12 (12), 1999-2003 (2002)
   PUBMED   12466305
REFERENCE   10 (residues 1 to 917)
  AUTHORS   Shannon,M., Lamerdin,J.E., Richardson,L., McCutchen-Maloney,S.L.,
            Hwang,M.H., Handel,M.A., Stubbs,L. and Thelen,M.P.
  TITLE     Characterization of the mouse Xpf DNA repair gene and differential
            expression during spermatogenesis
  JOURNAL   Genomics 62 (3), 427-435 (1999)
   PUBMED   10644440
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC166826.4, AK149326.1, BQ559127.1, CD352377.1, CX210668.1 and
            CO433666.1.
            
            On Jun 23, 2009 this sequence version replaced NP_056584.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF189285.1, BC026792.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..917
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 8.93 cM"
     Protein         1..917
                     /product="DNA repair endonuclease XPF"
                     /note="DNA repair endonuclease subunit; DNA excision
                     repair protein ERCC-4"
                     /calculated_mol_wt=103559
     Region          1..457
                     /region_name="Helicase-like.
                     /evidence=ECO:0000250|UniProtKB:Q92889"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QZD4.3)"
     Region          21..165
                     /region_name="DEAD-like_helicase_N"
                     /note="N-terminal helicase domain of the DEAD-box helicase
                     superfamily; cl28899"
                     /db_xref="CDD:475120"
     Site            order(37..42,134)
                     /site_type="other"
                     /note="putative ATP binding site [chemical binding]"
                     /db_xref="CDD:350670"
     Region          97..908
                     /region_name="rad1"
                     /note="DNA repair protein (rad1); TIGR00596"
                     /db_xref="CDD:273163"
     Region          233..254
                     /region_name="Leucine-zipper 1.
                     /evidence=ECO:0000250|UniProtKB:Q92889"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QZD4.3)"
     Region          270..298
                     /region_name="Leucine-zipper 2.
                     /evidence=ECO:0000250|UniProtKB:Q92889"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QZD4.3)"
     Site            289
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q92889; propagated from
                     UniProtKB/Swiss-Prot (Q9QZD4.3)"
     Region          454..524
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QZD4.3)"
     Region          487..492
                     /region_name="Nuclear localization signal.
                     /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QZD4.3)"
     Site            522
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q9QZD4.3)"
     Region          643..681
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QZD4.3)"
     Region          659..814
                     /region_name="Nuclease.
                     /evidence=ECO:0000250|UniProtKB:Q92889"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QZD4.3)"
     Site            765
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q9QZD4.3)"
     Region          838..906
                     /region_name="HhH2, dimerization with ERCC1.
                     /evidence=ECO:0000250|UniProtKB:Q92889"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QZD4.3)"
     Site            912
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q92889; propagated from
                     UniProtKB/Swiss-Prot (Q9QZD4.3)"
     CDS             1..917
                     /gene="Ercc4"
                     /gene_synonym="Xpf"
                     /coded_by="NM_015769.2:200..2953"
                     /db_xref="CCDS:CCDS37256.1"
                     /db_xref="GeneID:50505"
                     /db_xref="MGI:MGI:1354163"
ORIGIN      
        1 mepglsgerr smaplleyer qqvlelldsd glvvcarglg tdrllyhflr lhchpaclvl
       61 vlntqpaeee yfinqlkieg vehlprrvtn eiasnsryev ytqggiifat srilvvdflt
      121 gripsdlitg ilvyrahrii escqeafilr lfrqknkrgf ikaftdnava fdtgfchver
      181 vmrnlfvrkl ylwprfhvav nsfleqhkpe vveihvsmtp amlaiqtail dilnaclkel
      241 kchnpsleve dlslenalgk pfdktirhyl dplwhqlgak tkslvqdlki lrtllqylsq
      301 ydcvtflnll eslratekvf gqnsgwlfld astsmfvnar arvyrvpdvk lnkkaktsek
      361 tsspevqetk kelvlesnpk wealtdvlke ieaenkesea lggpgrvlic asddrtccql
      421 rdylsagaet fllrlyrktf ekdgkaeevw vnvrkgdgpk rttksdkrpk aapnkerasa
      481 krgaplkrkk qeltltqvlg saeeppedka leedlcrqts sspegcgvei kresfdlnvs
      541 sdaaygilke pltiihpllg csdpyaltrv lhevepryvv lydaeltfvr qleiyrasrp
      601 gkplrvyfli yggsteeqry ltalrkekea feklirekas mvvpeeregr detnldlarg
      661 saaldaptdt rkaggqeqng tqssivvdmr efrselpsli hrrgidiepv tlevgdyilt
      721 pelcverksv sdligslhsg rlysqclams ryyrrpvlli efdpskpfsl aprgaffqem
      781 sssdvssklt lltlhfprlr llwcpsphat aelfeelkqn kpqpdaatam aitadsetlp
      841 esdrynpgpq dfvlkmpgvn akncrslmnq vkniaelatl slerlttilg hsgnakqlhd
      901 flhtayadlv skgrvrk
//
