LOCUS       NM_133658               2695 bp    mRNA    linear   ROD 16-JUN-2024
DEFINITION  Mus musculus excision repair cross-complementing rodent repair
            deficiency, complementation group 3 (Ercc3), mRNA.
ACCESSION   NM_133658
VERSION     NM_133658.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2695)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2695)
  AUTHORS   Mourgues,S., Gautier,V., Lagarou,A., Bordier,C., Mourcet,A.,
            Slingerland,J., Kaddoum,L., Coin,F., Vermeulen,W., Gonzales de
            Peredo,A., Monsarrat,B., Mari,P.O. and Giglia-Mari,G.
  TITLE     ELL, a novel TFIIH partner, is involved in transcription restart
            after DNA repair
  JOURNAL   Proc Natl Acad Sci U S A 110 (44), 17927-17932 (2013)
   PUBMED   24127601
REFERENCE   3  (bases 1 to 2695)
  AUTHORS   Nonnekens,J., Perez-Fernandez,J., Theil,A.F., Gadal,O., Bonnart,C.
            and Giglia-Mari,G.
  TITLE     Mutations in TFIIH causing trichothiodystrophy are responsible for
            defects in ribosomal RNA production and processing
  JOURNAL   Hum Mol Genet 22 (14), 2881-2893 (2013)
   PUBMED   23562818
REFERENCE   4  (bases 1 to 2695)
  AUTHORS   Laugel-Haushalter,V., Langer,A., Marrie,J., Fraulob,V.,
            Schuhbaur,B., Koch-Phillips,M., Dolle,P. and Bloch-Zupan,A.
  TITLE     From the transcription of genes involved in ectodermal dysplasias
            to the understanding of associated dental anomalies
  JOURNAL   Mol Syndromol 3 (4), 158-168 (2012)
   PUBMED   23239958
REFERENCE   5  (bases 1 to 2695)
  AUTHORS   Godon,C., Mourgues,S., Nonnekens,J., Mourcet,A., Coin,F.,
            Vermeulen,W., Mari,P.O. and Giglia-Mari,G.
  TITLE     Generation of DNA single-strand displacement by compromised
            nucleotide excision repair
  JOURNAL   EMBO J 31 (17), 3550-3563 (2012)
   PUBMED   22863773
REFERENCE   6  (bases 1 to 2695)
  AUTHORS   Binato,R., Alvarez Martinez,C.E., Pizzatti,L., Robert,B. and
            Abdelhay,E.
  TITLE     SMAD 8 binding to mice Msx1 basal promoter is required for
            transcriptional activation
  JOURNAL   Biochem J 393 (Pt 1), 141-150 (2006)
   PUBMED   16101586
REFERENCE   7  (bases 1 to 2695)
  AUTHORS   Le May,N., Dubaele,S., Proietti De Santis,L., Billecocq,A.,
            Bouloy,M. and Egly,J.M.
  TITLE     TFIIH transcription factor, a target for the Rift Valley
            hemorrhagic fever virus
  JOURNAL   Cell 116 (4), 541-550 (2004)
   PUBMED   14980221
REFERENCE   8  (bases 1 to 2695)
  AUTHORS   De Graeve,F., Bahr,A., Chatton,B. and Kedinger,C.
  TITLE     A murine ATFa-associated factor with transcriptional repressing
            activity
  JOURNAL   Oncogene 19 (14), 1807-1819 (2000)
   PUBMED   10777215
REFERENCE   9  (bases 1 to 2695)
  AUTHORS   Hubank,M. and Mayne,L.
  TITLE     Expression of the excision repair gene, ERCC3 (excision repair
            cross-complementing), during mouse development
  JOURNAL   Brain Res Dev Brain Res 81 (1), 66-76 (1994)
   PUBMED   7805288
REFERENCE   10 (bases 1 to 2695)
  AUTHORS   Weeda,G., Ma,L., van Ham,R.C., Bootsma,D., van der Eb,A.J. and
            Hoeijmakers,J.H.
  TITLE     Characterization of the mouse homolog of the XPBC/ERCC-3 gene
            implicated in xeroderma pigmentosum and Cockayne's syndrome
  JOURNAL   Carcinogenesis 12 (12), 2361-2368 (1991)
   PUBMED   1747940
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY273530.1, S71186.1 and BC022956.1.
            
            On Jul 17, 2018 this sequence version replaced NM_133658.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK151188.1, AK152347.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849377, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4                 BY273530.1         2-5
            5-2677              S71186.1           1-2673
            2678-2695           BC022956.1         2778-2795
FEATURES             Location/Qualifiers
     source          1..2695
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 17.97 cM"
     gene            1..2695
                     /gene="Ercc3"
                     /gene_synonym="BTF2 p89; Ercc-3; XPB"
                     /note="excision repair cross-complementing rodent repair
                     deficiency, complementation group 3"
                     /db_xref="GeneID:13872"
                     /db_xref="MGI:MGI:95414"
     exon            1..95
                     /gene="Ercc3"
                     /gene_synonym="BTF2 p89; Ercc-3; XPB"
                     /inference="alignment:Splign:2.1.0"
     CDS             68..2419
                     /gene="Ercc3"
                     /gene_synonym="BTF2 p89; Ercc-3; XPB"
                     /EC_number="5.6.2.4"
                     /note="TFIIH basal transcription factor complex helicase
                     XPB subunit; xeroderma pigmentosum group B-complementing
                     protein; TFIIH 89 kDa subunit; DNA excision repair protein
                     ERCC-3; DNA repair protein complementing XP-B cells; basic
                     transcription factor 2 89 kDa subunit; general
                     transcription and DNA repair factor IIH helicase subunit
                     XPB; DNA 3'-5' helicase/translocase XPB"
                     /codon_start=1
                     /product="general transcription and DNA repair factor IIH
                     helicase/translocase subunit XPB"
                     /protein_id="NP_598419.1"
                     /db_xref="CCDS:CCDS29118.1"
                     /db_xref="GeneID:13872"
                     /db_xref="MGI:MGI:95414"
                     /translation="MGKRDRVDRDKKKSKKRQYEEEEEDEDDIPGNESQEAVPSAAGK
                     QVDESSTKVDEYGAKDYRQQMPLKGDHTSRPLWVAPDGHIFLEAFSPVYKYAQDFLVA
                     IAEPVCRPTHVHEYKLTAYSLYAAVSVGLQTSDITEYLRKLSKTGVPDGIIQFIKLCT
                     VSYGKVKLVLKHNRYFVESSHPDVIQHLLQDPVIRECRLRNAEGEATELITETFTSKS
                     AISKTAAEGSGGPSTSQGVDAQATSDIPKDLFDFYEQMDKDEEEEEETQTVSFEVKQE
                     MIEELQKRCICLEYPLLAEYDFRNDTLNPDINIDLKPTAVLRPYQEKSLRKMFGNGRA
                     RSGVIVLPCGAGKSLVGVTAACTVRKRCLVLGNSAVSVEQWKAQFKMWSTIDDSQICR
                     FTSDAKDKPIGCSVAISTYSMLGHTTKRSWEAERVMEWLKTQEWGLMILDEVHTIPAR
                     MFRRVLTIVQAHCKLGLTATLVREDDKIVDLNFLIGPKLYEANWMELQNNGYIAKVQC
                     AEVWCPMSPEFYREYVAIKTKKRILLYTMNPNKFRACQFLIKFHERRNDKIIVFADNV
                     FALKEYAIRLNKPYIYGPTSQGERMQILQNFKHNPKINTIFISKVGDTSFDLPEANVL
                     IQISSHGGSRRQEAQRLGRVLRAKKGMVAEEYNAFFYSLVSQDTQEMAYSTKRQRFLV
                     DQGYSFKVITKLAGMEEEELAFSTKEEQQQLLQKVLAATDLDAEEEVVAGEFGSRSGQ
                     ASRRCGTMSSLSGADDTVYMEYHSSRSKASSKHVHPLFKRFRK"
     exon            96..301
                     /gene="Ercc3"
                     /gene_synonym="BTF2 p89; Ercc-3; XPB"
                     /inference="alignment:Splign:2.1.0"
     exon            302..538
                     /gene="Ercc3"
                     /gene_synonym="BTF2 p89; Ercc-3; XPB"
                     /inference="alignment:Splign:2.1.0"
     exon            539..588
                     /gene="Ercc3"
                     /gene_synonym="BTF2 p89; Ercc-3; XPB"
                     /inference="alignment:Splign:2.1.0"
     exon            589..724
                     /gene="Ercc3"
                     /gene_synonym="BTF2 p89; Ercc-3; XPB"
                     /inference="alignment:Splign:2.1.0"
     exon            725..892
                     /gene="Ercc3"
                     /gene_synonym="BTF2 p89; Ercc-3; XPB"
                     /inference="alignment:Splign:2.1.0"
     exon            893..1097
                     /gene="Ercc3"
                     /gene_synonym="BTF2 p89; Ercc-3; XPB"
                     /inference="alignment:Splign:2.1.0"
     exon            1098..1412
                     /gene="Ercc3"
                     /gene_synonym="BTF2 p89; Ercc-3; XPB"
                     /inference="alignment:Splign:2.1.0"
     exon            1413..1597
                     /gene="Ercc3"
                     /gene_synonym="BTF2 p89; Ercc-3; XPB"
                     /inference="alignment:Splign:2.1.0"
     exon            1598..1800
                     /gene="Ercc3"
                     /gene_synonym="BTF2 p89; Ercc-3; XPB"
                     /inference="alignment:Splign:2.1.0"
     exon            1801..1897
                     /gene="Ercc3"
                     /gene_synonym="BTF2 p89; Ercc-3; XPB"
                     /inference="alignment:Splign:2.1.0"
     exon            1898..2015
                     /gene="Ercc3"
                     /gene_synonym="BTF2 p89; Ercc-3; XPB"
                     /inference="alignment:Splign:2.1.0"
     exon            2016..2134
                     /gene="Ercc3"
                     /gene_synonym="BTF2 p89; Ercc-3; XPB"
                     /inference="alignment:Splign:2.1.0"
     exon            2135..2287
                     /gene="Ercc3"
                     /gene_synonym="BTF2 p89; Ercc-3; XPB"
                     /inference="alignment:Splign:2.1.0"
     exon            2288..2681
                     /gene="Ercc3"
                     /gene_synonym="BTF2 p89; Ercc-3; XPB"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2653..2658
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ercc3"
                     /gene_synonym="BTF2 p89; Ercc-3; XPB"
                     /note="hexamer: TATAAA"
     polyA_site      2681
                     /gene="Ercc3"
                     /gene_synonym="BTF2 p89; Ercc-3; XPB"
                     /note="major polyA site"
ORIGIN      
        1 attagcaagt aactcctgcg gagaggaggt ggtgcggtgt gccggcctgc ctgcatctag
       61 agctgttatg ggcaaaagag atcgagtgga ccgcgacaaa aagaaatcca agaagaggca
      121 gtatgaagag gaagaggaag acgaagacga cattcctggg aacgagtctc aggaggcggt
      181 gccctccgcc gctgggaaac aggtggacga gtccagcacc aaagtggatg agtatggagc
      241 aaaggactac agacagcaga tgccactaaa gggtgaccat acctccaggc ccctctgggt
      301 ggctcctgat ggccacattt tcttggaagc cttctctcca gtttacaaat atgcccaaga
      361 cttcctggtg gcaattgcag agccggtgtg ccggcctact catgtacatg aatacaagct
      421 aaccgcctac tccctctatg cagcggtcag tgttgggctg caaaccagtg acattactga
      481 gtacctcaga aagctcagta agactggagt tcctgatgga attatccagt ttattaagct
      541 gtgcactgtc agctatggga aggtcaagct ggtcctcaag cacaacaggt actttgttga
      601 aagttcccac cctgatgtta tccagcatct tcttcaagac ccagtgatcc gggaatgtcg
      661 cttgaggaac gccgagggcg aggccaccga actcatcaca gagactttta caagcaaatc
      721 tgctatttct aagacggcgg cggaaggcag tggcgggcct tctacttcgc agggggtaga
      781 tgcacaggcc acgtctgaca tacccaaaga cctgtttgat ttttatgagc aaatggacaa
      841 ggatgaggag gaggaggaag agacacagac agtgtccttt gaagttaagc aggaaatgat
      901 cgaggagctg cagaagcgct gcatctgctt agagtacccg ctgctggcag agtatgactt
      961 ccggaatgac actctcaatc ctgacatcaa cattgacctg aagcccacag ccgtactcag
     1021 accctatcag gagaagagcc tgcggaagat gtttgggaac ggacgagcac gctcaggagt
     1081 cattgttctt ccctgtggtg ctgggaagtc cctggtcggc gtgactgccg catgcactgt
     1141 cagaaagcgc tgtctcgtcc tgggcaactc ggctgtgtct gtggagcagt ggaaagccca
     1201 gtttaagatg tggtcaacca tcgatgacag ccagatctgc cgcttcacct cagatgccaa
     1261 ggacaagccc atcggctgct ccgttgccat tagcacttac tctatgctgg gccacaccac
     1321 caaaaggtcc tgggaagctg agagagtcat ggagtggctc aaaacccagg agtggggcct
     1381 catgatcctt gacgaggtgc acaccattcc agccaggatg ttccggcggg ttctgactat
     1441 tgtgcaggcg cactgtaagc ttggtttgac tgcaaccctt gtccgggaag atgacaaaat
     1501 tgttgactta aatttcctga ttgggcccaa gctctatgaa gccaactgga tggagctgca
     1561 gaacaatggg tacatcgcta aagtccagtg tgctgaggtt tggtgcccga tgtctcccga
     1621 gttctaccga gagtatgtgg caatcaaaac aaagaaacgg atcctgttgt acaccatgaa
     1681 tcccaacaaa ttcagagcct gccagtttct gatcaagttt catgaaagga ggaatgacaa
     1741 gattattgtc tttgctgaca acgtatttgc cttgaaggaa tatgccattc ggctgaacaa
     1801 accttatatc tacgggccca cgtcccaggg agaacgtatg cagattctcc agaacttcaa
     1861 gcacaacccc aaaatcaaca ccatcttcat ctccaaggtt ggtgacacat cctttgatct
     1921 gccagaagcc aatgtcctca ttcagatctc ttcccatggt ggctcccgac ggcaggaagc
     1981 ccagagactg ggacgggtac tcagagccaa gaaagggatg gtcgcagagg aatacaatgc
     2041 ctttttctac tccctggtat ctcaggacac acaggaaatg gcttattcta ccaagcgaca
     2101 gagattccta gtggatcaag gttacagctt taaggtaatc acaaagctag ctggcatgga
     2161 ggaagaggag ctggcgttct ccaccaaaga ggagcagcag cagctcctgc agaaggtgct
     2221 ggcagccacc gacttggatg cagaggagga agtggtggct ggagagtttg gctctagatc
     2281 tggccaggca tcccgacgct gtggcaccat gagctccctg tcaggcgcag acgacaccgt
     2341 gtacatggag taccactcct cccgaagcaa ggcctccagc aagcacgtgc acccgctttt
     2401 caaacgcttc aggaagtgac gcccaccctg tgctcaggtg aagactggct gcctggatcc
     2461 gtgttgaaga gagacttctt tcttcaccgg tgtgatcgtt tctatccaag actgtgtcct
     2521 ttcctattga ctgactgctg aaaaccagtc agtgtgaggc cttaactgcc ttcgtgggtc
     2581 ctaggtttaa aaaggaaaga aaagctactg ttgtttttta ttcaaacttg ttaagagtga
     2641 atcatttctg tatataaaaa ttataccact taattatacc aaaaaaaaaa aaaaa
//
