LOCUS       NM_007949               3571 bp    mRNA    linear   ROD 05-AUG-2024
DEFINITION  Mus musculus excision repair cross-complementing rodent repair
            deficiency, complementation group 2 (Ercc2), transcript variant 1,
            mRNA.
ACCESSION   NM_007949
VERSION     NM_007949.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3571)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3571)
  AUTHORS   Dalke,C., Neff,F., Bains,S.K., Bright,S., Lord,D., Reitmeir,P.,
            Rossler,U., Samaga,D., Unger,K., Braselmann,H., Wagner,F.,
            Greiter,M., Gomolka,M., Hornhardt,S., Kunze,S., Kempf,S.J.,
            Garrett,L., Holter,S.M., Wurst,W., Rosemann,M., Azimzadeh,O.,
            Tapio,S., Aubele,M., Theis,F., Hoeschen,C., Slijepcevic,P.,
            Kadhim,M., Atkinson,M., Zitzelsberger,H., Kulka,U. and Graw,J.
  TITLE     Lifetime study in mice after acute low-dose ionizing radiation: a
            multifactorial study with special focus on cataract risk
  JOURNAL   Radiat Environ Biophys 57 (2), 99-113 (2018)
   PUBMED   29327260
REFERENCE   3  (bases 1 to 3571)
  AUTHORS   Baar,M.P., Brandt,R.M.C., Putavet,D.A., Klein,J.D.D., Derks,K.W.J.,
            Bourgeois,B.R.M., Stryeck,S., Rijksen,Y., van Willigenburg,H.,
            Feijtel,D.A., van der Pluijm,I., Essers,J., van Cappellen,W.A., van
            IJcken,W.F., Houtsmuller,A.B., Pothof,J., de Bruin,R.W.F., Madl,T.,
            Hoeijmakers,J.H.J., Campisi,J. and de Keizer,P.L.J.
  TITLE     Targeted Apoptosis of Senescent Cells Restores Tissue Homeostasis
            in Response to Chemotoxicity and Aging
  JOURNAL   Cell 169 (1), 132-147 (2017)
   PUBMED   28340339
REFERENCE   4  (bases 1 to 3571)
  AUTHORS   Matsumura,H., Mohri,Y., Binh,N.T., Morinaga,H., Fukuda,M., Ito,M.,
            Kurata,S., Hoeijmakers,J. and Nishimura,E.K.
  TITLE     Hair follicle aging is driven by transepidermal elimination of stem
            cells via COL17A1 proteolysis
  JOURNAL   Science 351 (6273), aad4395 (2016)
   PUBMED   26912707
REFERENCE   5  (bases 1 to 3571)
  AUTHORS   Kunze,S., Dalke,C., Fuchs,H., Klaften,M., Rossler,U., Hornhardt,S.,
            Gomolka,M., Puk,O., Sabrautzki,S., Kulka,U., Hrabe de Angelis,M.
            and Graw,J.
  TITLE     New mutation in the mouse Xpd/Ercc2 gene leads to recessive
            cataracts
  JOURNAL   PLoS One 10 (5), e0125304 (2015)
   PUBMED   25951169
  REMARK    GeneRIF: Results describe a recessive cataract caused by a mutation
            in the Xpd/Ercc2 gene and demonstrate the importance of the gene
            not only for lens fiber cell differentiation, but also for the
            sensitivity to ionizing radiation.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3571)
  AUTHORS   Rudert,F., Saunders,A.M., Rebstock,S., Thompson,J.A. and
            Zimmermann,W.
  TITLE     Characterization of murine carcinoembryonic antigen gene family
            members
  JOURNAL   Mamm Genome 3 (5), 262-273 (1992)
   PUBMED   1638085
REFERENCE   7  (bases 1 to 3571)
  AUTHORS   Levy,H.P., Schultz,R.A. and Cohen,M.M.
  TITLE     Comparative gene mapping in the species Muntiacus muntjac
  JOURNAL   Cytogenet Cell Genet 61 (4), 276-281 (1992)
   PUBMED   1486805
REFERENCE   8  (bases 1 to 3571)
  AUTHORS   Saunders,A.M. and Seldin,M.F.
  TITLE     A molecular genetic linkage map of mouse chromosome 7
  JOURNAL   Genomics 8 (3), 525-535 (1990)
   PUBMED   1981054
REFERENCE   9  (bases 1 to 3571)
  AUTHORS   Saunders,A.M. and Seldin,M.F.
  TITLE     The syntenic relationship of proximal mouse chromosome 7 and the
            myotonic dystrophy gene region on human chromosome 19q
  JOURNAL   Genomics 6 (2), 324-332 (1990)
   PUBMED   2307474
REFERENCE   10 (bases 1 to 3571)
  AUTHORS   Baden,H.P., Jackson,C.E., Weiss,L., Jimbow,K., Lee,L., Kubilus,J.
            and Gold,R.J.
  TITLE     The physicochemical properties of hair in the BIDS syndrome
  JOURNAL   Am J Hum Genet 28 (5), 514-521 (1976)
   PUBMED   984047
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC118017.15.
            
            On Jun 3, 2018 this sequence version replaced NM_007949.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK145969.1, AK082761.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-43                AC118017.15        72456-72498         c
            44-143              AC118017.15        72137-72236         c
            144-221             AC118017.15        70494-70571         c
            222-284             AC118017.15        70354-70416         c
            285-398             AC118017.15        70100-70213         c
            399-515             AC118017.15        68776-68892         c
            516-632             AC118017.15        68569-68685         c
            633-756             AC118017.15        67685-67808         c
            757-853             AC118017.15        67487-67583         c
            854-987             AC118017.15        67269-67402         c
            988-1156            AC118017.15        67018-67186         c
            1157-1275           AC118017.15        66257-66375         c
            1276-1345           AC118017.15        64339-64408         c
            1346-1415           AC118017.15        64197-64266         c
            1416-1517           AC118017.15        64015-64116         c
            1518-1581           AC118017.15        62925-62988         c
            1582-1703           AC118017.15        62429-62550         c
            1704-1796           AC118017.15        61174-61266         c
            1797-1869           AC118017.15        61010-61082         c
            1870-1940           AC118017.15        60815-60885         c
            1941-2084           AC118017.15        60596-60739         c
            2085-2228           AC118017.15        60333-60476         c
            2229-3571           AC118017.15        58821-60163         c
FEATURES             Location/Qualifiers
     source          1..3571
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 9.62 cM"
     gene            1..3571
                     /gene="Ercc2"
                     /gene_synonym="CXPD; Ercc-2; Mhdarco15; RCO015; XPD"
                     /note="excision repair cross-complementing rodent repair
                     deficiency, complementation group 2"
                     /db_xref="GeneID:13871"
                     /db_xref="MGI:MGI:95413"
     exon            1..43
                     /gene="Ercc2"
                     /gene_synonym="CXPD; Ercc-2; Mhdarco15; RCO015; XPD"
                     /inference="alignment:Splign:2.1.0"
     CDS             39..2321
                     /gene="Ercc2"
                     /gene_synonym="CXPD; Ercc-2; Mhdarco15; RCO015; XPD"
                     /EC_number="5.6.2.3"
                     /note="isoform 1 is encoded by transcript variant 1; TFIIH
                     basal transcription factor complex helicase XPD subunit;
                     xeroderma pigmentosum group D-complementing protein; DNA
                     excision repair protein ERCC-2; DNA repair protein
                     complementing XP-D cells; general transcription and DNA
                     repair factor IIH helicase subunit XPD; DNA 5'-3' helicase
                     XPD"
                     /codon_start=1
                     /product="general transcription and DNA repair factor IIH
                     helicase subunit XPD isoform 1"
                     /protein_id="NP_031975.2"
                     /db_xref="CCDS:CCDS20900.1"
                     /db_xref="GeneID:13871"
                     /db_xref="MGI:MGI:95413"
                     /translation="MKLNVDGLLVYFPYDYIYPEQFSYMLELKRTLDAKGHGVLEMPS
                     GTGKTVSLLALIVAYQRAYPLEVTKLIYCSRTVPEIEKVIEELRKLLSFYEQQEGEKL
                     PFLGLALSSRKNLCIHPEVTPLRFGKDVDGKCHSLTASYVRAQYQQDASLPHCRFYEE
                     FDIHGRQMPLPAGIYNLDDLKALGQRQGWCPYFLARYSILHANVVVYSYHYLLDPKIA
                     DLVSKELARKAVVVFDEAHNIDNVCIDSMSVNLTRRTLDRCQSNLDTLQKTVLRIKET
                     DEQRLRDEYRRLVEGLREASVARETDAHLANPVLPDEVLQEAVPGSIRTAEHFLGFLR
                     RLLEYVKWRLRVQHVVQESPPAFLSGLAQRVCIQRKPLRFCAERLRSLLHTLEIADLA
                     DFSPLTLLANFATLVSTYAKGFTIIIEPFDDRTPTIANPVLHFSCMDASLAIKPVFER
                     FQSVIITSGTLSPLDIYPKILDFHPVTMATFTMTLARVCLCPMIIGRGNDQVAISSKF
                     ETREDIAVIRNYGNLLLEMSAVVPDGIVAFFTSYQYMESTVASWYEQGILENIQRNKL
                     LFIETQDGAETSVALEKYQEACENGRGAILLSVARGKVSEGIDFVHHYGRAVIMFGVP
                     YVYTQSRILKARLEYLRDQFQIRENDFLTFDAMRHAAQCVGRAIRGKTDYGLMVFADK
                     RFARADKRGKLPRWIQEHLTDSNLNLTVDEGVQVAKYFLRQMAQPFHREDQLGLSLLS
                     LEQLQSEETLQRIEQIAQQL"
     exon            44..143
                     /gene="Ercc2"
                     /gene_synonym="CXPD; Ercc-2; Mhdarco15; RCO015; XPD"
                     /inference="alignment:Splign:2.1.0"
     exon            144..221
                     /gene="Ercc2"
                     /gene_synonym="CXPD; Ercc-2; Mhdarco15; RCO015; XPD"
                     /inference="alignment:Splign:2.1.0"
     exon            222..284
                     /gene="Ercc2"
                     /gene_synonym="CXPD; Ercc-2; Mhdarco15; RCO015; XPD"
                     /inference="alignment:Splign:2.1.0"
     exon            285..398
                     /gene="Ercc2"
                     /gene_synonym="CXPD; Ercc-2; Mhdarco15; RCO015; XPD"
                     /inference="alignment:Splign:2.1.0"
     exon            399..515
                     /gene="Ercc2"
                     /gene_synonym="CXPD; Ercc-2; Mhdarco15; RCO015; XPD"
                     /inference="alignment:Splign:2.1.0"
     exon            516..632
                     /gene="Ercc2"
                     /gene_synonym="CXPD; Ercc-2; Mhdarco15; RCO015; XPD"
                     /inference="alignment:Splign:2.1.0"
     exon            633..756
                     /gene="Ercc2"
                     /gene_synonym="CXPD; Ercc-2; Mhdarco15; RCO015; XPD"
                     /inference="alignment:Splign:2.1.0"
     exon            757..853
                     /gene="Ercc2"
                     /gene_synonym="CXPD; Ercc-2; Mhdarco15; RCO015; XPD"
                     /inference="alignment:Splign:2.1.0"
     exon            854..987
                     /gene="Ercc2"
                     /gene_synonym="CXPD; Ercc-2; Mhdarco15; RCO015; XPD"
                     /inference="alignment:Splign:2.1.0"
     exon            988..1156
                     /gene="Ercc2"
                     /gene_synonym="CXPD; Ercc-2; Mhdarco15; RCO015; XPD"
                     /inference="alignment:Splign:2.1.0"
     exon            1157..1275
                     /gene="Ercc2"
                     /gene_synonym="CXPD; Ercc-2; Mhdarco15; RCO015; XPD"
                     /inference="alignment:Splign:2.1.0"
     exon            1276..1345
                     /gene="Ercc2"
                     /gene_synonym="CXPD; Ercc-2; Mhdarco15; RCO015; XPD"
                     /inference="alignment:Splign:2.1.0"
     exon            1346..1415
                     /gene="Ercc2"
                     /gene_synonym="CXPD; Ercc-2; Mhdarco15; RCO015; XPD"
                     /inference="alignment:Splign:2.1.0"
     exon            1416..1517
                     /gene="Ercc2"
                     /gene_synonym="CXPD; Ercc-2; Mhdarco15; RCO015; XPD"
                     /inference="alignment:Splign:2.1.0"
     exon            1518..1581
                     /gene="Ercc2"
                     /gene_synonym="CXPD; Ercc-2; Mhdarco15; RCO015; XPD"
                     /inference="alignment:Splign:2.1.0"
     exon            1582..1703
                     /gene="Ercc2"
                     /gene_synonym="CXPD; Ercc-2; Mhdarco15; RCO015; XPD"
                     /inference="alignment:Splign:2.1.0"
     exon            1704..1796
                     /gene="Ercc2"
                     /gene_synonym="CXPD; Ercc-2; Mhdarco15; RCO015; XPD"
                     /inference="alignment:Splign:2.1.0"
     exon            1797..1869
                     /gene="Ercc2"
                     /gene_synonym="CXPD; Ercc-2; Mhdarco15; RCO015; XPD"
                     /inference="alignment:Splign:2.1.0"
     exon            1870..1940
                     /gene="Ercc2"
                     /gene_synonym="CXPD; Ercc-2; Mhdarco15; RCO015; XPD"
                     /inference="alignment:Splign:2.1.0"
     exon            1941..2084
                     /gene="Ercc2"
                     /gene_synonym="CXPD; Ercc-2; Mhdarco15; RCO015; XPD"
                     /inference="alignment:Splign:2.1.0"
     exon            2085..2228
                     /gene="Ercc2"
                     /gene_synonym="CXPD; Ercc-2; Mhdarco15; RCO015; XPD"
                     /inference="alignment:Splign:2.1.0"
     exon            2229..3571
                     /gene="Ercc2"
                     /gene_synonym="CXPD; Ercc-2; Mhdarco15; RCO015; XPD"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3546..3551
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ercc2"
                     /gene_synonym="CXPD; Ercc-2; Mhdarco15; RCO015; XPD"
                     /note="hexamer: AATAAA"
     polyA_site      3571
                     /gene="Ercc2"
                     /gene_synonym="CXPD; Ercc-2; Mhdarco15; RCO015; XPD"
                     /note="major polyA site"
ORIGIN      
        1 attcaggagc gggcgtgtgg acgccgcgat cagccgccat gaagctcaac gtggacgggc
       61 tgctggtcta cttcccgtac gactacatct acccggagca gttctcctac atgctggagc
      121 tcaagcgcac gctggacgcc aagggtcatg gagtcctgga gatgccctcg ggcactggga
      181 agacagtgtc cctattggcc ctgattgtgg cctatcagcg ggcttatccg ctggaggtga
      241 ccaaacttat ctactgctca cggaccgtgc cagagattga gaaggtcata gaagagcttc
      301 gtaagctact cagcttctac gagcagcagg agggcgagaa gctgccgttc ttaggactgg
      361 ctctgagctc aagaaagaac ctgtgcattc atcccgaggt gactccactg cgctttggga
      421 aggatgttga tgggaagtgt cacagcctaa cggcgtcgta tgtgcgggca cagtaccagc
      481 aggatgccag cctgcctcac tgccgcttct atgaggaatt tgacatccat ggacgccaga
      541 tgccgctccc tgcgggcatc tacaacctgg atgacctgaa ggccctaggg cagcgccagg
      601 gctggtgccc ctacttcctg gctcgatact cgatcctgca tgccaacgtg gtggtttaca
      661 gctaccacta cctcctggac cccaagatcg cagacctggt atccaaagag ctggctcgca
      721 aggctgttgt ggtcttcgat gaagctcaca acatcgacaa tgtctgcatt gactccatga
      781 gtgtcaacct cacccgcagg actctggacc gttgccagag caacttagac accctacaga
      841 agaccgtgct caggatcaag gagacggatg agcagcggct gcgggatgag taccggcgcc
      901 tggtggaggg cctgcgggag gccagtgtgg cccgggagac agatgcccac ctggccaacc
      961 ctgtgctgcc ggacgaggtg ctgcaggagg ctgtgcctgg ctccatccgt acggctgagc
     1021 acttcctggg ctttctgcgg cggctgctgg agtatgtcaa gtggcgtctg cgcgtgcagc
     1081 atgtggtgca ggagagtcca cctgcctttc tgagcggcct ggcccagcgg gtgtgcatcc
     1141 agcgcaagcc cctcaggttc tgtgctgaac gcctgcgctc cctgctgcac accctggaga
     1201 ttgccgacct ggccgacttc tccccgctca cactccttgc taacttcgcc actctcgtca
     1261 gcacttacgc caagggcttc accattatca ttgagccctt tgacgacagg acccccacca
     1321 tcgccaaccc cgttctgcac ttcagctgta tggacgcctc cttggccatc aagcctgtgt
     1381 ttgagcgctt ccagtctgtc atcatcactt ctgggacact gtccccactg gacatctacc
     1441 ccaagatcct ggacttccac cctgtcacaa tggcaacctt caccatgacg ctggcccgag
     1501 tctgcctctg cccgatgatc attggccgtg gtaatgacca ggtagcaatc agctccaaat
     1561 ttgagaccag agaagatatt gctgtgatcc gaaactatgg caacctcctg ctggagatgt
     1621 ccgccgtggt cccagatggc attgtggcct tctttaccag ctaccagtac atggaaagca
     1681 ccgtggcctc ctggtatgag cagggcatcc ttgagaacat ccagaggaac aaactgctct
     1741 tcattgagac ccaggatggg gctgagacca gtgtggccct ggagaagtac caagaggcat
     1801 gcgagaatgg ccgtggggcc attctgctct cagtggctcg gggcaaagta tcagaaggga
     1861 ttgactttgt acaccactac ggacgggctg tgatcatgtt tggagttccc tatgtctata
     1921 cccagagccg aattctcaag gcccggctag agtatctgcg ggaccagttc cagatccgag
     1981 agaacgactt cctcaccttt gatgctatgc gccatgcagc ccagtgtgtg ggtcgtgcca
     2041 tcaggggcaa gacggactat ggactcatgg tctttgctga caagcggttt gctcgggcgg
     2101 acaagcgtgg taagctgcct cgctggatcc aggagcacct gaccgactcc aacctcaacc
     2161 tgaccgtgga tgagggtgta caggtcgcca agtacttcct gcggcagatg gcgcagccct
     2221 tccaccggga ggatcagctg ggcctgtcgc tgctcagcct ggagcagctg cagtcagagg
     2281 agacactaca gcgaattgag cagatcgcac agcagctctg aacagcgggg ctgtggggtg
     2341 accgcctgtg gctcctggga ggtgctggaa ggtcccaggg ccctcggcaa acacccagta
     2401 ccagtgcacc gcctttaatt gcagggagcg atctacaaga gctgcccagg cagggtgcag
     2461 ggtgaccacc cacccttcct gatccttgag aagctgtggc ctctgcagcc agtccactta
     2521 gcgcgggctc agatcttgtg tgctgatgct cagggtccga ggggcctcac tcaggtgccg
     2581 ggttgagagc tgggagagct gagagcacag gaatggttag agttcttttc cagttgacat
     2641 tggagccact tcatgccctg cccaccagct cctccctacc ttgagtcccc aggaggcggc
     2701 cccacctttc ctggcttgct gagcctgcca gcagcacccc actccatcac tgactcctca
     2761 cctgcgtccg ggcagccctg ggaccatcca cgttcagcat attgagtgac atggctctct
     2821 tcatcctgaa gaggagccca aaaagacagg agtgagacag ggaagactgc agatccctgg
     2881 ctctgactga tgtcacggat ggttcctgac agactgctga cctctcccgg cactcacccg
     2941 gcagcccctg ccatgccctc tcctcggagg cgggagacca gcttctcgct tcctcgcctg
     3001 atggattccc ggagcttaga gaaggaactg ctcctgcgca ggacctgggg agggcacagt
     3061 gatgtgtggg gacatggtgg gggcccaaca aggacctgag gtggagcctg cttacctgct
     3121 gctgtgtatc gcctgctgtg cctccctggg gggctcctgt gggacagaag ggacatggag
     3181 gcaggtgtga ggaatgccac catgcaggag ggggtgcagg aaggtgcagg ggtgggctca
     3241 ccaagtgggg cgggcagggc ctcctggctg aggatctcct tgtatagctc ctctgcctgc
     3301 tgatacttgt tctgtttcag gtaggctgag gcctgcgggg agggagggca ggggtagggt
     3361 gtggacatct tgtttaggcc tgggaacgtc tcagacctgc ccgccttccc cagcatcctg
     3421 cctcagctta ctgcagtgca gagccacccg cgcaggagac caggctacct gccactgggt
     3481 cctgcatctc tgtgccagtc tcctacctca gtgggtgaaa tgttcggggt cacccaccat
     3541 gacacaataa aatctgatag gactttgtga a
//
