LOCUS       NM_007948               1062 bp    mRNA    linear   ROD 18-MAR-2025
DEFINITION  Mus musculus excision repair cross-complementing rodent repair
            deficiency, complementation group 1 (Ercc1), transcript variant 1,
            mRNA.
ACCESSION   NM_007948
VERSION     NM_007948.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1062)
  AUTHORS   van der Linden,J., Stefens,S.J.M., Heredia-Genestar,J.M.,
            Ridwan,Y., Brandt,R.M.C., van Vliet,N., de Beer,I., van Thiel,B.S.,
            Steen,H., Cheng,C., Roks,A.J.M., Danser,A.H.J., Essers,J. and van
            der Pluijm,I.
  TITLE     Ercc1 DNA repair deficiency results in vascular aging characterized
            by VSMC phenotype switching, ECM remodeling, and an increased
            stress response
  JOURNAL   Aging Cell 23 (5), e14126 (2024)
   PUBMED   38451018
  REMARK    GeneRIF: Ercc1 DNA repair deficiency results in vascular aging
            characterized by VSMC phenotype switching, ECM remodeling, and an
            increased stress response.
REFERENCE   2  (bases 1 to 1062)
  AUTHORS   Hama,E.Y., Nakamichi,R., Hishikawa,A., Kihara,M., Abe,T.,
            Yoshimoto,N., Nishimura,E.S., Itoh,H. and Hayashi,K.
  TITLE     Podocyte Ercc1 is indispensable for glomerular integrity
  JOURNAL   Biochem Biophys Res Commun 704, 149713 (2024)
   PUBMED   38428304
  REMARK    GeneRIF: Podocyte Ercc1 is indispensable for glomerular integrity.
REFERENCE   3  (bases 1 to 1062)
  AUTHORS   Jaarsma,D., Birkisdottir,M.B., van Vossen,R., Oomen,D.W.G.D.,
            Akhiyat,O., Vermeij,W.P., Koekkoek,S.K.E., De Zeeuw,C.I. and
            Bosman,L.W.J.
  TITLE     Different Purkinje cell pathologies cause specific patterns of
            progressive gait ataxia in mice
  JOURNAL   Neurobiol Dis 192, 106422 (2024)
   PUBMED   38286390
REFERENCE   4  (bases 1 to 1062)
  AUTHORS   Bona,N. and Crossan,G.P.
  TITLE     Fanconi anemia DNA crosslink repair factors protect against LINE-1
            retrotransposition during mouse development
  JOURNAL   Nat Struct Mol Biol 30 (10), 1434-1445 (2023)
   PUBMED   37580626
REFERENCE   5  (bases 1 to 1062)
  AUTHORS   Rousseau,V., Einig,E., Jin,C., Horn,J., Riebold,M., Poth,T.,
            Jarboui,M.A., Flentje,M. and Popov,N.
  TITLE     Trim33 masks a non-transcriptional function of E2f4 in replication
            fork progression
  JOURNAL   Nat Commun 14 (1), 5143 (2023)
   PUBMED   37612308
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1062)
  AUTHORS   Chao,C.C., Strgar,F., Tsang,M. and Peterson,P.K.
  TITLE     Effects of swimming exercise on the pathogenesis of acute murine
            Toxoplasma gondii Me49 infection
  JOURNAL   Clin Immunol Immunopathol 62 (2), 220-226 (1992)
   PUBMED   1730160
REFERENCE   7  (bases 1 to 1062)
  AUTHORS   Saunders,A.M. and Seldin,M.F.
  TITLE     A molecular genetic linkage map of mouse chromosome 7
  JOURNAL   Genomics 8 (3), 525-535 (1990)
   PUBMED   1981054
REFERENCE   8  (bases 1 to 1062)
  AUTHORS   Mohrenweiser,H.W., Carrano,A.V., Fertitta,A., Perry,B.,
            Thompson,L.H., Tucker,J.D. and Weber,C.A.
  TITLE     Refined mapping of the three DNA repair genes, ERCC1, ERCC2, and
            XRCC1, on human chromosome 19
  JOURNAL   Cytogenet Cell Genet 52 (1-2), 11-14 (1989)
   PUBMED   2558854
REFERENCE   9  (bases 1 to 1062)
  AUTHORS   van Duin,M., van den Tol,J., Warmerdam,P., Odijk,H., Meijer,D.,
            Westerveld,A., Bootsma,D. and Hoeijmakers,J.H.
  TITLE     Evolution and mutagenesis of the mammalian excision repair gene
            ERCC-1
  JOURNAL   Nucleic Acids Res 16 (12), 5305-5322 (1988)
   PUBMED   3290851
REFERENCE   10 (bases 1 to 1062)
  AUTHORS   Thompson,L.H., Mooney,C.L., Burkhart-Schultz,K., Carrano,A.V. and
            Siciliano,M.J.
  TITLE     Correction of a nucleotide-excision-repair mutation by human
            chromosome 19 in hamster-human hybrid cells
  JOURNAL   Somat Cell Mol Genet 11 (1), 87-92 (1985)
   PUBMED   3919454
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC148988.5.
            
            On Sep 29, 2022 this sequence version replaced NM_007948.2.
            
            Transcript Variant: This variant (1) encodes the longer protein
            (isoform a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC011224.1, AK088271.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-106               AC148988.5         137046-137151
            107-218             AC148988.5         137561-137672
            219-434             AC148988.5         140356-140571
            435-538             AC148988.5         142116-142219
            539-638             AC148988.5         142648-142747
            639-715             AC148988.5         144584-144660
            716-815             AC148988.5         146281-146380
            816-887             AC148988.5         147056-147127
            888-956             AC148988.5         147248-147316
            957-1062            AC148988.5         148374-148479
FEATURES             Location/Qualifiers
     source          1..1062
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 9.6 cM"
     gene            1..1062
                     /gene="Ercc1"
                     /gene_synonym="Ercc-1"
                     /note="excision repair cross-complementing rodent repair
                     deficiency, complementation group 1"
                     /db_xref="GeneID:13870"
                     /db_xref="MGI:MGI:95412"
     exon            1..106
                     /gene="Ercc1"
                     /gene_synonym="Ercc-1"
                     /inference="alignment:Splign:2.1.0"
     exon            107..218
                     /gene="Ercc1"
                     /gene_synonym="Ercc-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             114..1010
                     /gene="Ercc1"
                     /gene_synonym="Ercc-1"
                     /note="isoform a is encoded by transcript variant 1; DNA
                     excision repair protein ERCC-1"
                     /codon_start=1
                     /product="DNA excision repair protein ERCC-1 isoform a"
                     /protein_id="NP_031974.2"
                     /db_xref="CCDS:CCDS20898.1"
                     /db_xref="GeneID:13870"
                     /db_xref="MGI:MGI:95412"
                     /translation="MDPGKDEESRPQPSGPPTRRKFVIPLEEEEVPCAGVKPLFRSSR
                     NPTIPATSAHVAPQTYAEYAITQPPGGAGATVPTGSEPAAGENPSQTLKTGAKSNSII
                     VSPRQRGNPVLKFVRNVPWEFGEVIPDYVLGQSTCALFLSLRYHNLHPDYIHERLQSL
                     GKNFALRVLLVQVDVKDPQQALKELAKMCILADCTLVLAWSAEEAGRYLETYKAYEQK
                     PADLLMEKLEQNFLSRATECLTTVKSVNKTDSQTLLATFGSLEQLFTASREDLALCPG
                     LGPQKARRLFEVLHEPFLKVPR"
     exon            219..434
                     /gene="Ercc1"
                     /gene_synonym="Ercc-1"
                     /inference="alignment:Splign:2.1.0"
     exon            435..538
                     /gene="Ercc1"
                     /gene_synonym="Ercc-1"
                     /inference="alignment:Splign:2.1.0"
     exon            539..638
                     /gene="Ercc1"
                     /gene_synonym="Ercc-1"
                     /inference="alignment:Splign:2.1.0"
     exon            639..715
                     /gene="Ercc1"
                     /gene_synonym="Ercc-1"
                     /inference="alignment:Splign:2.1.0"
     exon            716..815
                     /gene="Ercc1"
                     /gene_synonym="Ercc-1"
                     /inference="alignment:Splign:2.1.0"
     exon            816..887
                     /gene="Ercc1"
                     /gene_synonym="Ercc-1"
                     /inference="alignment:Splign:2.1.0"
     exon            888..956
                     /gene="Ercc1"
                     /gene_synonym="Ercc-1"
                     /inference="alignment:Splign:2.1.0"
     exon            957..1062
                     /gene="Ercc1"
                     /gene_synonym="Ercc-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1038..1043
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ercc1"
                     /gene_synonym="Ercc-1"
                     /note="hexamer: AATAAA"
     polyA_site      1062
                     /gene="Ercc1"
                     /gene_synonym="Ercc-1"
                     /note="major polyA site"
ORIGIN      
        1 agagcggccg gaagtgagtc tagcaggagt tgtgctggct gtgctggcgt tgtgtcgcct
       61 ctgtttcccc ccgtggtatt tccttctagg catcgggaaa gaccaggccc cagatggacc
      121 ctgggaagga cgaggaaagt cggccacagc cctcaggacc acccaccagg aggaagtttg
      181 ttatcccact ggaggaagaa gaggtgccct gtgcaggggt caagccctta ttcagatcgt
      241 cacggaatcc caccatccca gcaacctcag cccacgtggc ccctcagacg tatgctgagt
      301 acgccatcac ccagcctcca ggaggggctg gggccacagt gcccacaggc tctgaacctg
      361 cggcaggaga gaaccccagc cagaccctga aaacaggagc aaagtctaat agcatcatcg
      421 tgagcccgag gcagaggggc aaccccgtgt tgaagtttgt gcgcaatgtg ccctgggaat
      481 tcggtgaggt gattcccgat tatgtgctgg gccagagcac ctgcgccctt ttcctcagcc
      541 tccgctacca caacctccat ccagactaca tccatgaacg gctgcagagc ctggggaaga
      601 acttcgccct tcgtgtgctg ctggttcaag tggatgtgaa agatccccag caggctctca
      661 aggagctggc taagatgtgc atcttggctg actgcaccct ggtcctggcc tggagtgcag
      721 aggaagcagg gcggtacctg gagacctaca aggcgtatga gcagaagcca gccgacctcc
      781 ttatggaaaa gctggagcag aacttcctat cacgggccac tgagtgtctg accaccgtga
      841 aatctgtgaa caagaccgac agccagaccc tcctggctac atttggatcc ctggaacagc
      901 tcttcaccgc atcaagggag gatctagcct tatgcccggg cctgggccca cagaaggccc
      961 gcaggctctt tgaagtacta cacgaaccct tcctcaaagt gcctcgatga cctgctgcca
     1021 cctaggccca gtgtcacaat aaagaatttt ccatgcccag gc
//
