LOCUS       NP_031974                298 aa            linear   ROD 18-MAR-2025
DEFINITION  DNA excision repair protein ERCC-1 isoform a [Mus musculus].
ACCESSION   NP_031974
VERSION     NP_031974.2
DBSOURCE    REFSEQ: accession NM_007948.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 298)
  AUTHORS   van der Linden,J., Stefens,S.J.M., Heredia-Genestar,J.M.,
            Ridwan,Y., Brandt,R.M.C., van Vliet,N., de Beer,I., van Thiel,B.S.,
            Steen,H., Cheng,C., Roks,A.J.M., Danser,A.H.J., Essers,J. and van
            der Pluijm,I.
  TITLE     Ercc1 DNA repair deficiency results in vascular aging characterized
            by VSMC phenotype switching, ECM remodeling, and an increased
            stress response
  JOURNAL   Aging Cell 23 (5), e14126 (2024)
   PUBMED   38451018
  REMARK    GeneRIF: Ercc1 DNA repair deficiency results in vascular aging
            characterized by VSMC phenotype switching, ECM remodeling, and an
            increased stress response.
REFERENCE   2  (residues 1 to 298)
  AUTHORS   Hama,E.Y., Nakamichi,R., Hishikawa,A., Kihara,M., Abe,T.,
            Yoshimoto,N., Nishimura,E.S., Itoh,H. and Hayashi,K.
  TITLE     Podocyte Ercc1 is indispensable for glomerular integrity
  JOURNAL   Biochem Biophys Res Commun 704, 149713 (2024)
   PUBMED   38428304
  REMARK    GeneRIF: Podocyte Ercc1 is indispensable for glomerular integrity.
REFERENCE   3  (residues 1 to 298)
  AUTHORS   Jaarsma,D., Birkisdottir,M.B., van Vossen,R., Oomen,D.W.G.D.,
            Akhiyat,O., Vermeij,W.P., Koekkoek,S.K.E., De Zeeuw,C.I. and
            Bosman,L.W.J.
  TITLE     Different Purkinje cell pathologies cause specific patterns of
            progressive gait ataxia in mice
  JOURNAL   Neurobiol Dis 192, 106422 (2024)
   PUBMED   38286390
REFERENCE   4  (residues 1 to 298)
  AUTHORS   Bona,N. and Crossan,G.P.
  TITLE     Fanconi anemia DNA crosslink repair factors protect against LINE-1
            retrotransposition during mouse development
  JOURNAL   Nat Struct Mol Biol 30 (10), 1434-1445 (2023)
   PUBMED   37580626
REFERENCE   5  (residues 1 to 298)
  AUTHORS   Rousseau,V., Einig,E., Jin,C., Horn,J., Riebold,M., Poth,T.,
            Jarboui,M.A., Flentje,M. and Popov,N.
  TITLE     Trim33 masks a non-transcriptional function of E2f4 in replication
            fork progression
  JOURNAL   Nat Commun 14 (1), 5143 (2023)
   PUBMED   37612308
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 298)
  AUTHORS   Chao,C.C., Strgar,F., Tsang,M. and Peterson,P.K.
  TITLE     Effects of swimming exercise on the pathogenesis of acute murine
            Toxoplasma gondii Me49 infection
  JOURNAL   Clin Immunol Immunopathol 62 (2), 220-226 (1992)
   PUBMED   1730160
REFERENCE   7  (residues 1 to 298)
  AUTHORS   Saunders,A.M. and Seldin,M.F.
  TITLE     A molecular genetic linkage map of mouse chromosome 7
  JOURNAL   Genomics 8 (3), 525-535 (1990)
   PUBMED   1981054
REFERENCE   8  (residues 1 to 298)
  AUTHORS   Mohrenweiser,H.W., Carrano,A.V., Fertitta,A., Perry,B.,
            Thompson,L.H., Tucker,J.D. and Weber,C.A.
  TITLE     Refined mapping of the three DNA repair genes, ERCC1, ERCC2, and
            XRCC1, on human chromosome 19
  JOURNAL   Cytogenet Cell Genet 52 (1-2), 11-14 (1989)
   PUBMED   2558854
REFERENCE   9  (residues 1 to 298)
  AUTHORS   van Duin,M., van den Tol,J., Warmerdam,P., Odijk,H., Meijer,D.,
            Westerveld,A., Bootsma,D. and Hoeijmakers,J.H.
  TITLE     Evolution and mutagenesis of the mammalian excision repair gene
            ERCC-1
  JOURNAL   Nucleic Acids Res 16 (12), 5305-5322 (1988)
   PUBMED   3290851
REFERENCE   10 (residues 1 to 298)
  AUTHORS   Thompson,L.H., Mooney,C.L., Burkhart-Schultz,K., Carrano,A.V. and
            Siciliano,M.J.
  TITLE     Correction of a nucleotide-excision-repair mutation by human
            chromosome 19 in hamster-human hybrid cells
  JOURNAL   Somat Cell Mol Genet 11 (1), 87-92 (1985)
   PUBMED   3919454
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC148988.5.
            
            On May 13, 2008 this sequence version replaced NP_031974.1.
            
            Transcript Variant: This variant (1) encodes the longer protein
            (isoform a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC011224.1, AK088271.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..298
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 9.6 cM"
     Protein         1..298
                     /product="DNA excision repair protein ERCC-1 isoform a"
                     /note="DNA excision repair protein ERCC-1"
                     /calculated_mol_wt=32779
     Region          1..24
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P07903.2)"
     Site            1
                     /site_type="acetylation"
                     /note="N-acetylmethionine.
                     /evidence=ECO:0000250|UniProtKB:P07992; propagated from
                     UniProtKB/Swiss-Prot (P07903.2)"
     Region          17..23
                     /region_name="Nuclear localization signal.
                     /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (P07903.2)"
     Region          66..99
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P07903.2)"
     Region          99..226
                     /region_name="ERCC1_C-like"
                     /note="Central domain of ERCC1; cd22325"
                     /db_xref="CDD:411729"
     Site            order(117..119,166,179,183,186,189..190,193..198,200,204,
                     207..208,210..212,214..216,218..219,221..222)
                     /site_type="other"
                     /note="XPF interaction interface [polypeptide binding]"
                     /db_xref="CDD:411729"
     Region          220..298
                     /region_name="HhH2, dimerization with ERRC4/XPF.
                     /evidence=ECO:0000250|UniProtKB:P07992"
                     /note="propagated from UniProtKB/Swiss-Prot (P07903.2)"
     Region          <251..293
                     /region_name="MUS81"
                     /note="ERCC4-type crossover junction endonuclease
                     [Replication, recombination and repair]; COG1948"
                     /db_xref="CDD:441551"
     CDS             1..298
                     /gene="Ercc1"
                     /gene_synonym="Ercc-1"
                     /coded_by="NM_007948.3:114..1010"
                     /note="isoform a is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS20898.1"
                     /db_xref="GeneID:13870"
                     /db_xref="MGI:MGI:95412"
ORIGIN      
        1 mdpgkdeesr pqpsgpptrr kfvipleeee vpcagvkplf rssrnptipa tsahvapqty
       61 aeyaitqppg gagatvptgs epaagenpsq tlktgaksns iivsprqrgn pvlkfvrnvp
      121 wefgevipdy vlgqstcalf lslryhnlhp dyiherlqsl gknfalrvll vqvdvkdpqq
      181 alkelakmci ladctlvlaw saeeagryle tykayeqkpa dllmekleqn flsrateclt
      241 tvksvnktds qtllatfgsl eqlftasred lalcpglgpq karrlfevlh epflkvpr
//
