LOCUS       NM_053204               8760 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus ELKS/RAB6-interacting/CAST family member 1 (Erc1),
            transcript variant 1, mRNA.
ACCESSION   NM_053204 NM_024466 XM_001003358 XM_917703 XM_925136 XM_925141
            XM_925144 XM_925146 XM_925148 XM_925150 XM_925151 XM_925155
            XM_925160 XM_925162
VERSION     NM_053204.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 8760)
  AUTHORS   Emperador-Melero,J., Andersen,J.W., Metzbower,S.R., Levy,A.D.,
            Dharmasri,P.A., de Nola,G., Blanpied,T.A. and Kaeser,P.S.
  TITLE     Distinct active zone protein machineries mediate Ca2+ channel
            clustering and vesicle priming at hippocampal synapses
  JOURNAL   Nat Neurosci 27 (9), 1680-1694 (2024)
   PUBMED   39160372
REFERENCE   2  (bases 1 to 8760)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 8760)
  AUTHORS   Cao,Y., Fajardo,D., Guerrero-Given,D., Samuel,M.A., Ohtsuka,T.,
            Boye,S.E., Kamasawa,N. and Martemyanov,K.A.
  TITLE     Post-developmental plasticity of the primary rod pathway allows
            restoration of visually guided behaviors
  JOURNAL   Curr Biol 32 (22), 4783-4796 (2022)
   PUBMED   36179691
REFERENCE   4  (bases 1 to 8760)
  AUTHORS   Tan,C., de Nola,G., Qiao,C., Imig,C., Born,R.T., Brose,N. and
            Kaeser,P.S.
  TITLE     Munc13 supports fusogenicity of non-docked vesicles at synapses
            with disrupted active zones
  JOURNAL   Elife 11, e79077 (2022)
   PUBMED   36398873
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 8760)
  AUTHORS   Tan,C., Wang,S.S.H., de Nola,G. and Kaeser,P.S.
  TITLE     Rebuilding essential active zone functions within a synapse
  JOURNAL   Neuron 110 (9), 1498-1515 (2022)
   PUBMED   35176221
REFERENCE   6  (bases 1 to 8760)
  AUTHORS   Schoch,S., Mittelstaedt,T., Kaeser,P.S., Padgett,D., Feldmann,N.,
            Chevaleyre,V., Castillo,P.E., Hammer,R.E., Han,W., Schmitz,F.,
            Lin,W. and Sudhof,T.C.
  TITLE     Redundant functions of RIM1alpha and RIM2alpha in Ca(2+)-triggered
            neurotransmitter release
  JOURNAL   EMBO J 25 (24), 5852-5863 (2006)
   PUBMED   17124501
REFERENCE   7  (bases 1 to 8760)
  AUTHORS   Deguchi-Tawarada,M., Inoue,E., Takao-Rikitsu,E., Inoue,M.,
            Ohtsuka,T. and Takai,Y.
  TITLE     CAST2: identification and characterization of a protein
            structurally related to the presynaptic cytomatrix protein CAST
  JOURNAL   Genes Cells 9 (1), 15-23 (2004)
   PUBMED   14723704
REFERENCE   8  (bases 1 to 8760)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Aizawa,H., Yuasa,S.,
            Nakajima,D., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: II. The complete nucleotide sequences of 400 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (1), 35-48 (2003)
   PUBMED   12693553
REFERENCE   9  (bases 1 to 8760)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   10 (bases 1 to 8760)
  AUTHORS   Monier,S., Jollivet,F., Janoueix-Lerosey,I., Johannes,L. and
            Goud,B.
  TITLE     Characterization of novel Rab6-interacting proteins involved in
            endosome-to-TGN transport
  JOURNAL   Traffic 3 (4), 289-297 (2002)
   PUBMED   11929610
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC125102.4, AC161060.6 and AC128662.4.
            
            On Dec 28, 2006 this sequence version replaced NM_053204.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF340029.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-274               AC125102.4         144431-144704       c
            275-413             AC125102.4         122235-122373       c
            414-1237            AC125102.4         120940-121763       c
            1238-1654           AC125102.4         93461-93877         c
            1655-1729           AC125102.4         79943-80017         c
            1730-1885           AC125102.4         76031-76186         c
            1886-1969           AC125102.4         74542-74625         c
            1970-2137           AC125102.4         70288-70455         c
            2138-2305           AC125102.4         57698-57865         c
            2306-2443           AC161060.6         4499-4636
            2444-2584           AC161060.6         6555-6695
            2585-2725           AC161060.6         7917-8057
            2726-2919           AC161060.6         14414-14607
            2920-2931           AC161060.6         23803-23814
            2932-3067           AC161060.6         35587-35722
            3068-3199           AC161060.6         44084-44215
            3200-3360           AC161060.6         63164-63324
            3361-3505           AC128662.4         30896-31040
            3506-3604           AC128662.4         41234-41332
            3605-3793           AC128662.4         66670-66858
            3794-8760           AC128662.4         85881-90847
FEATURES             Location/Qualifiers
     source          1..8760
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 56.86 cM"
     gene            1..8760
                     /gene="Erc1"
                     /gene_synonym="4930404L01Rik; 5033405M01Rik;
                     9630025C19Rik; B430107L16Rik; CAST2; ELKS; Elks1;
                     mKIAA1081; Rab6ip2; RAB6IP2A; RAB6IP2B"
                     /note="ELKS/RAB6-interacting/CAST family member 1"
                     /db_xref="GeneID:111173"
                     /db_xref="MGI:MGI:2151013"
     exon            1..274
                     /gene="Erc1"
                     /gene_synonym="4930404L01Rik; 5033405M01Rik;
                     9630025C19Rik; B430107L16Rik; CAST2; ELKS; Elks1;
                     mKIAA1081; Rab6ip2; RAB6IP2A; RAB6IP2B"
                     /inference="alignment:Splign:2.1.0"
     exon            275..413
                     /gene="Erc1"
                     /gene_synonym="4930404L01Rik; 5033405M01Rik;
                     9630025C19Rik; B430107L16Rik; CAST2; ELKS; Elks1;
                     mKIAA1081; Rab6ip2; RAB6IP2A; RAB6IP2B"
                     /inference="alignment:Splign:2.1.0"
     exon            414..1237
                     /gene="Erc1"
                     /gene_synonym="4930404L01Rik; 5033405M01Rik;
                     9630025C19Rik; B430107L16Rik; CAST2; ELKS; Elks1;
                     mKIAA1081; Rab6ip2; RAB6IP2A; RAB6IP2B"
                     /inference="alignment:Splign:2.1.0"
     CDS             569..3931
                     /gene="Erc1"
                     /gene_synonym="4930404L01Rik; 5033405M01Rik;
                     9630025C19Rik; B430107L16Rik; CAST2; ELKS; Elks1;
                     mKIAA1081; Rab6ip2; RAB6IP2A; RAB6IP2B"
                     /note="isoform 1 is encoded by transcript variant 1; Rab6
                     interacting protein 2; RAB6-interacting protein 2;
                     CAZ-associated structural protein 2"
                     /codon_start=1
                     /product="ELKS/Rab6-interacting/CAST family member 1
                     isoform 1"
                     /protein_id="NP_444434.2"
                     /db_xref="CCDS:CCDS39611.1"
                     /db_xref="GeneID:111173"
                     /db_xref="MGI:MGI:2151013"
                     /translation="MYGSARSVGKVEPSSQSPGRSPRLPRSPRLGHRRTNSTGGSSGN
                     SVGGGSGKTLSMENIQSLNAAYATSGPMYLSDHENVGAETPKSTMTLGRSGGRLPYGV
                     RMTAMGSSPNIASSGVASDTIAFGEHHLPPVSMASTVPHSLRQARDNTIMDLQTQLKE
                     VLRENDLLRKDVEVKESKLSSSMNSIKTFWSPELKKERALRKDEASKITIWKEQYRVV
                     QEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQRLHAEHER
                     QAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHERTR
                     RLAEAEMHVHHLESLLEQKEKENNMLREEMHRRFENAPDSAKTKALQTVIEMKDSKIS
                     SMERGLRDLEEEIQMLKSNGALSSEEREEEMKQMEVYRSHSKFMKNKVEQLKEELSSK
                     DAQGEELKKRAAGLQSEIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKE
                     SLTAKEQRAAILQTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDML
                     DVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAD
                     KERTIERLKEQRDRDEREKQEEIDTYKKDLKDLREKVSLLQGDLSEKEASLLDIKEHA
                     SSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKAHEATLEARASPEMSDRIQQL
                     EREISRYKDESSKAQTEVDRLLEILKEVENEKNDKDKKIAELESLTSRQVKDQNKKVA
                     NLKHKEQVEKKKSAQMLEEARRREDSLSDSSQQLQDSLRKKDDRIEELEEALRESVQI
                     TAEREMVLAQEESARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQQSLAEKETHLT
                     NLRAERRKHLEEVLEMKQEALLAAISEKDANIALLELSSSKKKTQEEVAALKREKDRL
                     VQQLKQQTQNRMKLMADNYEDDHFRSSRSNQTNHKPSPDQIIQPLLELDQNRSKLKLY
                     IGHLTALCHDRDPLILRGLTPPASYNADGEQAAWENELQKMTQEQLQNELEKVEGDNA
                     ELQEFANTILQQIADHCPDILEQVVNALEESS"
     exon            1238..1654
                     /gene="Erc1"
                     /gene_synonym="4930404L01Rik; 5033405M01Rik;
                     9630025C19Rik; B430107L16Rik; CAST2; ELKS; Elks1;
                     mKIAA1081; Rab6ip2; RAB6IP2A; RAB6IP2B"
                     /inference="alignment:Splign:2.1.0"
     exon            1655..1729
                     /gene="Erc1"
                     /gene_synonym="4930404L01Rik; 5033405M01Rik;
                     9630025C19Rik; B430107L16Rik; CAST2; ELKS; Elks1;
                     mKIAA1081; Rab6ip2; RAB6IP2A; RAB6IP2B"
                     /inference="alignment:Splign:2.1.0"
     exon            1730..1885
                     /gene="Erc1"
                     /gene_synonym="4930404L01Rik; 5033405M01Rik;
                     9630025C19Rik; B430107L16Rik; CAST2; ELKS; Elks1;
                     mKIAA1081; Rab6ip2; RAB6IP2A; RAB6IP2B"
                     /inference="alignment:Splign:2.1.0"
     exon            1886..1969
                     /gene="Erc1"
                     /gene_synonym="4930404L01Rik; 5033405M01Rik;
                     9630025C19Rik; B430107L16Rik; CAST2; ELKS; Elks1;
                     mKIAA1081; Rab6ip2; RAB6IP2A; RAB6IP2B"
                     /inference="alignment:Splign:2.1.0"
     exon            1970..2137
                     /gene="Erc1"
                     /gene_synonym="4930404L01Rik; 5033405M01Rik;
                     9630025C19Rik; B430107L16Rik; CAST2; ELKS; Elks1;
                     mKIAA1081; Rab6ip2; RAB6IP2A; RAB6IP2B"
                     /inference="alignment:Splign:2.1.0"
     exon            2138..2305
                     /gene="Erc1"
                     /gene_synonym="4930404L01Rik; 5033405M01Rik;
                     9630025C19Rik; B430107L16Rik; CAST2; ELKS; Elks1;
                     mKIAA1081; Rab6ip2; RAB6IP2A; RAB6IP2B"
                     /inference="alignment:Splign:2.1.0"
     exon            2306..2443
                     /gene="Erc1"
                     /gene_synonym="4930404L01Rik; 5033405M01Rik;
                     9630025C19Rik; B430107L16Rik; CAST2; ELKS; Elks1;
                     mKIAA1081; Rab6ip2; RAB6IP2A; RAB6IP2B"
                     /inference="alignment:Splign:2.1.0"
     exon            2444..2584
                     /gene="Erc1"
                     /gene_synonym="4930404L01Rik; 5033405M01Rik;
                     9630025C19Rik; B430107L16Rik; CAST2; ELKS; Elks1;
                     mKIAA1081; Rab6ip2; RAB6IP2A; RAB6IP2B"
                     /inference="alignment:Splign:2.1.0"
     exon            2585..2725
                     /gene="Erc1"
                     /gene_synonym="4930404L01Rik; 5033405M01Rik;
                     9630025C19Rik; B430107L16Rik; CAST2; ELKS; Elks1;
                     mKIAA1081; Rab6ip2; RAB6IP2A; RAB6IP2B"
                     /inference="alignment:Splign:2.1.0"
     exon            2726..2919
                     /gene="Erc1"
                     /gene_synonym="4930404L01Rik; 5033405M01Rik;
                     9630025C19Rik; B430107L16Rik; CAST2; ELKS; Elks1;
                     mKIAA1081; Rab6ip2; RAB6IP2A; RAB6IP2B"
                     /inference="alignment:Splign:2.1.0"
     exon            2920..2931
                     /gene="Erc1"
                     /gene_synonym="4930404L01Rik; 5033405M01Rik;
                     9630025C19Rik; B430107L16Rik; CAST2; ELKS; Elks1;
                     mKIAA1081; Rab6ip2; RAB6IP2A; RAB6IP2B"
                     /inference="alignment:Splign:2.1.0"
     exon            2932..3067
                     /gene="Erc1"
                     /gene_synonym="4930404L01Rik; 5033405M01Rik;
                     9630025C19Rik; B430107L16Rik; CAST2; ELKS; Elks1;
                     mKIAA1081; Rab6ip2; RAB6IP2A; RAB6IP2B"
                     /inference="alignment:Splign:2.1.0"
     exon            3068..3199
                     /gene="Erc1"
                     /gene_synonym="4930404L01Rik; 5033405M01Rik;
                     9630025C19Rik; B430107L16Rik; CAST2; ELKS; Elks1;
                     mKIAA1081; Rab6ip2; RAB6IP2A; RAB6IP2B"
                     /inference="alignment:Splign:2.1.0"
     exon            3200..3360
                     /gene="Erc1"
                     /gene_synonym="4930404L01Rik; 5033405M01Rik;
                     9630025C19Rik; B430107L16Rik; CAST2; ELKS; Elks1;
                     mKIAA1081; Rab6ip2; RAB6IP2A; RAB6IP2B"
                     /inference="alignment:Splign:2.1.0"
     exon            3361..3505
                     /gene="Erc1"
                     /gene_synonym="4930404L01Rik; 5033405M01Rik;
                     9630025C19Rik; B430107L16Rik; CAST2; ELKS; Elks1;
                     mKIAA1081; Rab6ip2; RAB6IP2A; RAB6IP2B"
                     /inference="alignment:Splign:2.1.0"
     exon            3506..3604
                     /gene="Erc1"
                     /gene_synonym="4930404L01Rik; 5033405M01Rik;
                     9630025C19Rik; B430107L16Rik; CAST2; ELKS; Elks1;
                     mKIAA1081; Rab6ip2; RAB6IP2A; RAB6IP2B"
                     /inference="alignment:Splign:2.1.0"
     exon            3605..3793
                     /gene="Erc1"
                     /gene_synonym="4930404L01Rik; 5033405M01Rik;
                     9630025C19Rik; B430107L16Rik; CAST2; ELKS; Elks1;
                     mKIAA1081; Rab6ip2; RAB6IP2A; RAB6IP2B"
                     /inference="alignment:Splign:2.1.0"
     exon            3794..8760
                     /gene="Erc1"
                     /gene_synonym="4930404L01Rik; 5033405M01Rik;
                     9630025C19Rik; B430107L16Rik; CAST2; ELKS; Elks1;
                     mKIAA1081; Rab6ip2; RAB6IP2A; RAB6IP2B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7680..7685
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Erc1"
                     /gene_synonym="4930404L01Rik; 5033405M01Rik;
                     9630025C19Rik; B430107L16Rik; CAST2; ELKS; Elks1;
                     mKIAA1081; Rab6ip2; RAB6IP2A; RAB6IP2B"
                     /note="hexamer: ATTAAA"
     polyA_site      7708
                     /gene="Erc1"
                     /gene_synonym="4930404L01Rik; 5033405M01Rik;
                     9630025C19Rik; B430107L16Rik; CAST2; ELKS; Elks1;
                     mKIAA1081; Rab6ip2; RAB6IP2A; RAB6IP2B"
                     /note="major polyA site"
     regulatory      8740..8745
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Erc1"
                     /gene_synonym="4930404L01Rik; 5033405M01Rik;
                     9630025C19Rik; B430107L16Rik; CAST2; ELKS; Elks1;
                     mKIAA1081; Rab6ip2; RAB6IP2A; RAB6IP2B"
                     /note="hexamer: TATAAA"
     polyA_site      8760
                     /gene="Erc1"
                     /gene_synonym="4930404L01Rik; 5033405M01Rik;
                     9630025C19Rik; B430107L16Rik; CAST2; ELKS; Elks1;
                     mKIAA1081; Rab6ip2; RAB6IP2A; RAB6IP2B"
ORIGIN      
        1 gggcgccggt cgtgctgtgg cggtggcggc ggcggcggcg gctgtggtag tgtcggcggc
       61 aggctgtccg ggaagcagta gcagcaaccg cagcagcagc ggcggccctg aggagagtaa
      121 ggcggccgcg tcggcagcgg ctcgctcgtc aggcggaacc tcgatctgcc cagaggtcgc
      181 aggcgccgag gcatttgtcg tttcctaccc ggctcggcgc tcccggccct ggctgggcag
      241 ggcagagcgc ccctggggag gggcggagct gtagctggcc catgagcttc tgggaatttt
      301 cccttctccg cctcccatct caccatagga gcactgggat ttcagatgca tgctatcgcc
      361 ttcagttcta cctcatttct ggggaagtga ccaagtgttc tcatccttgc atgatatggc
      421 ataagatatt tcttcaagat tggacagctg ctggcctgct acttctgtta gctgtaagct
      481 gactttatag ccatagagaa acctcacaga atcacattgt tgtttttttc ttcataccat
      541 ttctggcacc taagttcacc ctgcaaccat gtatggaagt gctcgatcag tagggaaggt
      601 ggaaccaagc agccagagtc ctgggcgatc acctcggctt cctcggtccc ctcgcttagg
      661 tcatcggcga acaaatagta caggagggag ttctggaaac agtgttggag gtggcagtgg
      721 gaaaaccctt tcaatggaga atatacagtc cttaaatgct gcctatgcta catctggccc
      781 tatgtaccta agtgaccatg aaaacgtggg tgcagaaaca cctaaaagca ccatgacact
      841 tggccgttct gggggacgct tgccttacgg tgttaggatg actgctatgg gcagtagccc
      901 caacatagca agcagtgggg ttgctagtga taccatagca tttggagaac atcacctccc
      961 tcctgttagt atggcatcta ctgtacctca ctctcttcgt caggcaagag ataacaccat
     1021 catggatctg cagacacagc tgaaggaagt attaagagaa aacgatcttt tgaggaaaga
     1081 tgtggaagta aaggagagca aattaagttc atcaatgaat agtatcaaga ccttctggag
     1141 cccagagtta aagaaagagc gggccttgag aaaagatgaa gcttccaaaa tcaccatttg
     1201 gaaggagcag taccgagttg tacaggagga aaaccagcac atgcagatga caatccaggc
     1261 tctccaggat gagctgcgga tccagaggga cttgaatcag ctgtttcagc aagatagcag
     1321 cagtaggact ggggagcctt gcgtggcaga gctcacagag gagaacttcc agaggctgca
     1381 tgctgagcac gagaggcaag ccaaagagct gtttcttctg cggaagaccc tggaggaaat
     1441 ggagctgagg attgagactc agaagcagac cctaaatgct cgggatgagt ccatcaagaa
     1501 gcttctggag atgctccaga gcaaaggact ttctgccaaa gctacagagg aagaccatga
     1561 gagaacgcga cggctcgcag aggcggagat gcacgtccac cacctcgaga gtcttttgga
     1621 gcagaaggaa aaagagaata atatgttgag agaggagatg caccggagat ttgaaaatgc
     1681 ccctgattct gccaagacaa aagccttgca aactgttatt gaaatgaagg attcaaaaat
     1741 ttcttccatg gagcgtgggc tccgagacct ggaagaggaa attcagatgc tgaagtcaaa
     1801 tggggctttg agtagtgagg agcgggagga agagatgaag caaatggagg tgtacaggag
     1861 ccactcaaag tttatgaaaa ataaggtaga gcaactgaag gaggagctaa gttcgaaaga
     1921 tgctcaaggg gaggagctga aaaagagagc ggctggtctt cagtctgaga ttggccaggt
     1981 gaaacaggaa ctgtccagaa aggacacaga attactagcc ttacaaacaa agctagaaac
     2041 tctcacgaac caattctcag acagtaagca acatattgag gtgctgaaag agtccctcac
     2101 tgctaaggag caaagggctg ccatcctaca gactgaggtg gatgctcttc gattgcgttt
     2161 ggaagaaaaa gagactatgc tgaataaaaa aaccaagcaa atccaagata tggctgagga
     2221 gaagggcacc caggctggag agatccatga cctcaaggac atgctggacg tgaaggagcg
     2281 gaaggtcaat gtcctccaga agaagataga aaatcttcag gaacaactaa gagataaaga
     2341 aaagcagatg agcagcttga aagagcgagt caagtctctg caggcggaca ccactaacac
     2401 agacacagct ctgacaactt tggaggaggc tcttgcagat aaagaacgga caattgaacg
     2461 cttaaaggag cagcgggaca gggatgagcg ggagaagcag gaggagattg atacctacaa
     2521 aaaagacctc aaagacctga gagagaaagt cagcctgcta caaggagacc tctcagaaaa
     2581 ggaggcttct ctcttggata tcaaagagca tgcttcttcc ctggcttcct caggactcaa
     2641 aaaggactcg cggctcaaga ccctagaaat tgctcttgag cagaagaagg aagagtgcct
     2701 aaaaatggag tcacagttga aaaaggcgca tgaagcaaca ttggaagcca gagccagtcc
     2761 agagatgagt gaccgaatac agcaattgga gagagagatt tccaggtaca aagatgaatc
     2821 cagcaaggcc caaacagaag ttgaccgtct cttggaaatc ttgaaagaag tggaaaatga
     2881 gaagaatgac aaagataaga agatagctga gttggaaagt ctcacctcaa ggcaagtgaa
     2941 agaccagaat aagaaggtag caaatctgaa acacaaggaa caggtggaga agaagaagag
     3001 tgcccagatg ctggaggagg cccgcagaag ggaggacagt ctcagcgaca gctctcagca
     3061 actgcaggac agtctccgta agaaggatga caggattgaa gagctggaag aagcactgag
     3121 agaaagtgta cagataactg cagagcgtga aatggtgctg gcacaagagg aatcagccag
     3181 gaccaatgct gagaaacagg tggaagagct gttgatggct atggagaagg tgaagcagga
     3241 actggagtcc atgaaagcta agctgtcctc cacccagcag tctctggccg agaaggagac
     3301 gcacctaacc aatctccggg cagagaggag gaaacactta gaggaagttc tggaaatgaa
     3361 gcaagaagct cttctggctg ctataagtga aaaggatgct aacatagctc ttctagagct
     3421 ttcctcctca aagaaaaaga cccaagaaga agtggctgca ctgaaacggg aaaaggaccg
     3481 cctggtgcag cagctcaaac agcagacaca aaatcgaatg aaattaatgg ctgacaacta
     3541 tgaggatgac cacttcagat cctcccgttc caatcagacg aaccataaac cctccccaga
     3601 ccagatcatc cagcccctct tagaacttga ccaaaataga agcaagttaa agttgtatat
     3661 tggacacctg acagccctct gccatgaccg agacccctta atcctccgtg gactcactcc
     3721 accagcttct tataatgcag atggtgagca ggcagcttgg gagaatgagc tgcagaagat
     3781 gactcaggag cagcttcaga acgagttgga gaaagttgaa ggggacaacg ccgagctgca
     3841 ggagtttgcc aacaccattc tccagcagat agccgatcac tgccctgaca tcctcgaaca
     3901 agtggtcaat gccctggaag agtcctcctg atgtgctcct gacaaggagg gtgaccaagg
     3961 agccagagag ggaacctgag gaacaggtgt ctgagccgcc accacaccag actctgccag
     4021 ctggatgtgc cagtccggcc gtcggtgtct gtcatcgtac tctgccttct gctttgaatg
     4081 ttgcctgctc aagtctccct ggtctccatg aagaactgcc cttggcatca gcagtggagt
     4141 gctgcgagct gcactctgcc cttccagaaa caggaagcca gaagccactc agctcatctg
     4201 gagcccactc agattccgtg ctccgggagc ttggagctga agctttagca cgagtgcttt
     4261 ctcctcagag ggttacagaa ggagggagga ggtgaccagg gacaaagaga agaacgaata
     4321 ctcctctctg cgcccgcgct gccctcctgt ttaccatcat gagccccagg tacaggccag
     4381 cttcatgcag cttagctctc agcctgttgc ctgtctcacc tgcactgctt ttagttgaca
     4441 ggagaaggat gttcacagtg gtcaccctga tcgctcttta agtcctttga ccttcccatg
     4501 ctacattggt aggctaaatg tctgactgaa gagaagaggg cttaatttgt agggccctct
     4561 tgtcactgcc tgcagttttg ttcctcagaa gctgtcctgg agggccaggc tgattcctcc
     4621 tgagcatcac ccacagtgct ctctgctccc aacaccttgc cccaagctgc tgttgaccag
     4681 gggttgctag agtatgtgat ccactgccca ccttctcagc tttactctca agatacaacc
     4741 acagagccac agccttgtac ctgcctagaa acttcttttg gcacaactga gtttgtctta
     4801 atgcacacac attccctcct ccaattcatt cactcaaaaa atagtatgaa atgcctactt
     4861 gtgtgcacat ccatgtgcac agtgtcatcc ttggaaaagc ctcggatagg gatggtgtgg
     4921 aagccctgtg agatgtgctc agttgaatca tggcagtgaa cgcatacctt ctcccttcct
     4981 tcttcgcaga ccagcattct ttgttctcca ccctcatggc atctatgggc ttgggtgagc
     5041 cacctctctg cctggaaggt cccatgtggt aggtcaggat ctttgctgtc agtgttacta
     5101 ccctgaaaca tgttcgtttg tgtcagctgc ctgcttaaca cagccatgca cacctcatgg
     5161 gcttggccat gctgcaatca gatgcagatc cccccaaccc catccccagc tgtagaggac
     5221 agctatcaga tggagtcggg ccctaagaga gtgcagctca tgtctcattc ttcatccctg
     5281 aagcagactc ctgacactgc tgtcttctgg tgagaggcta aggcctctca gcctgcatct
     5341 ccccttctgc ccagttaaca ctctcaaagg aatttaatgt tgcccacaaa tctctctcac
     5401 cctcaaccta ggacatcatg cggccactac tgtcacagtc acagccctag ctccccttct
     5461 tccctgacat gaagtgttcc cttgtatggg atgctggaga gaattcctcg tgagggttgg
     5521 gtggcctctg ccatgaacct ctcatggagg tgcttttgga ggtcccagcc tggccaccag
     5581 gaatatggaa attaggctaa aagatgataa tcattgctgc tcagttctct caattttttt
     5641 taattgtcct atccataaat cctttagaaa atcccggtat ttcaggatag gaaggttagg
     5701 atcttattta ttctcataag gaaccactac ctagtaacag cttcacaggc tacagtggaa
     5761 atcagaaaac ttagaagagt ccaggcccac aggagtagcc tagcactgcc actggccagc
     5821 tgctgctcca gctgttctgt gagggatcac cacagacagg cctccttaca tgtacccatt
     5881 ttggtgttta ttagcagaag taccatctgc cacccttact aactgcacat atgaacccct
     5941 ccaccccttc cttctccatc aggtccctcc agagaggttg caggagccct gcaggacatg
     6001 tgcttaattg agaaggcaag tttgtaaggc agactgtgtc tgatctctgc actatagcaa
     6061 aggcttctcc tcctcaggga gtgatccagc agctcaagtg gctctggaga ctgtggagct
     6121 aaagttgaac cataaatgta gtgtttgtgg tctttgtgtt aggcaaagtt aatagggtat
     6181 ctggcattgg gatcctactg actgccattc agtaagccaa tagttactaa atgcgtaact
     6241 gccattgcac tgtacatgtc attccatgac tgtctgcatg cacatgatcc ttaaggtagc
     6301 tggccctgag agctcactgc aggttggctg agatcatccc tgcctcttca ttccatcgtc
     6361 aagcctcata gccttcgcac ctaaggtaaa ggtggcctcc ccccaggcct tcctcattgg
     6421 cctcctccag gccttcctca ttggcctccc tccaggtctt tgaagaaggg tcaaagcaag
     6481 aatatgtcgc tatgtagggt atgataccca caggcctaag tgccagcaga cccctgtgtc
     6541 agcagtgtct accccaagtg acatcataaa gatgatagta ggaaaagagg gctagaagcc
     6601 aacctggggc tcccagctct gcatgcctta gtagactctg tcccaggccc tcattgagtg
     6661 actgggatta gcaagtactt acggacattt aagatgaaga agtcagagtg gggtttagca
     6721 actcagcaat gcggaggggc tcctgcaatt cctgccagcc tttattctcc cacttgagaa
     6781 ggcctgagtg tacctcttcc tcgccagtgg gctttagaag agcactggaa caaggagagc
     6841 agactggaac aagaccacca gtggtgttgg aggtcacgct gtggctggcc gtgtcctgtc
     6901 ccatccgttt ggcctcctgg gaagaatgtg ttggctcaat ttctttctca ggagagatga
     6961 agtcagtcca gatggttctc acgtgctact gtcctgccct ctgctattaa cactgggact
     7021 ggcttggcac cacaccctcc tatgtgactg aagcacagac tcattggcct ccctccaggt
     7081 ctttgaagaa gggtcaaagc aaggatatgt cactccgtag gatgtgatac ccacaggcct
     7141 aagtcccacc agaccctatg tcagcagtat tgataacaac tctcgagtct gcctcacctc
     7201 ctgcctgcag agtccagagt catgggaaag gagccagagg gatgaggccg caccacaggc
     7261 ctgttgggca cccgccgtca ctgccagtct cagagattct gactgttcaa agacatgttc
     7321 ttcctgtgaa ccaagaggac gttcagggaa aaagaaaaca tgttttacct agggatcctt
     7381 ctgaacaaaa tggctgtctg tactcttttt aaccagaaac tttccaaact ttttagtgtc
     7441 aaaattgtaa ccaagtgtct cctgattctt cccgatgtgc ttggcaagtg ctgtgaccct
     7501 gttgtaggta tttctcctcc tgcctcttct gagggagaag tgattttagg ggttgattgg
     7561 agggagccgg tgtctgtctg gctcctgcca cctctcttgt ttctctgctt gttgatattg
     7621 tttgtgtgat tcagagaacg gggcagttac attgtgtcca ttgttgagaa tattaaaata
     7681 ttaaaacagt agttatagaa ctaaaaaatt aaagagctgt gttttaaaag atgcaaaccc
     7741 atcaatatca tgttaacaaa ggaattcaag ctatgggcag cctagctcct ccccccaggt
     7801 cggtgtggtg gtagccaggc cagcccttgg gagacacact ctccacacct gagttaggta
     7861 gctgcctggg aacaagaatc tggggctcag agactctcag ttgtgtcagg gttttctcta
     7921 catcctcagg acctctgggt aggggtttca aagttggtga ccccagaacc accctcaccc
     7981 tcacattgga tcaagccttg tgtgcctagt gctatattgt aacctgggct tgggcctgga
     8041 gcccctgctt gcaaggccac aggacctctt cctgcccact tggtgctatc tcatcatgtc
     8101 catctatcag ggcagcctgg gctcctggag cctgtgggcc aggtgccgtg ggtggccctc
     8161 aagagcttag ctctctctgg ctcctgatcc tagatttttt tttcctttga agctttctct
     8221 tggctccaga gatgtcagag ttagggaagg aaatgagcca ggctgaggcg aggagatcca
     8281 cccctatgcc acagtgagca caccagccca gcccctttcc cgccacacca gtattacacc
     8341 cattctttaa agcatctagt cccacctgag gcacatgcca ttcagtggcc cagctgccca
     8401 gtgcagacta gaaacctagg ccggggatgg ggacgtttct ctgcacccct acttcagaag
     8461 aggcatgttg cactttagtg gggaacccag aacgttgggc actggcttcc tgtagcttga
     8521 gtccctgtag atagccatgg tggcagcctg atggcttgtg tgaagcagct gcagctgctg
     8581 ccagctgtgc acatgtgtgc agctcctaga gtcaaattgc cggcctgatg atgacatcac
     8641 aaagatgtgt tctgttcaac tttgccttgg taattattgt aaacactttg ttcaattttt
     8701 ttttcttttt ttattcacaa actaaatcca tcaggaaatt ataaacttat ttaaaaactg
//
