LOCUS       NM_010154              12037 bp    mRNA    linear   ROD 04-FEB-2025
DEFINITION  Mus musculus erb-b2 receptor tyrosine kinase 4 (Erbb4), mRNA.
ACCESSION   NM_010154 XM_001002143 XM_136682 XM_909965 XM_986918
VERSION     NM_010154.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 12037)
  AUTHORS   Cools,J.M.T., Goovaerts,B.K., Feyen,E., Van den Bogaert,S., Fu,Y.,
            Civati,C., Van Fraeyenhove,J., Tubeeckx,M.R.L., Ott,J., Nguyen,L.,
            Wulfers,E.M., Van Berlo,B., De Vries,A.A.F., Vandersickel,N.,
            Pijnappels,D.A., Audenaert,D., Roderick,H.L., De Winter,H., De
            Keulenaer,G.W. and Segers,V.F.M.
  TITLE     Small-molecule-induced ERBB4 activation to treat heart failure
  JOURNAL   Nat Commun 16 (1), 576 (2025)
   PUBMED   39794341
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 12037)
  AUTHORS   Sung,K., Jeong,M.J., Yoo,T., Jung,J.H., Kang,S., Yoo,J.Y.,
            Kim,H.J., Park,K., Pyo,J.H., Lee,H.Y., Koo,N., Choi,S.H. and
            Kim,J.H.
  TITLE     ErbB4 precludes the occurrence of PTSD-like fear responses by
            supporting the bimodal activity of the central amygdala
  JOURNAL   Exp Mol Med 56 (12), 2703-2713 (2024)
   PUBMED   39623093
REFERENCE   3  (bases 1 to 12037)
  AUTHORS   da Cunha Menezes,E., de Abreu,F.F., Davis,J.B., Maurer,S.V.,
            Roshko,V.C., Richardson,A., Dowell,J., Cassella,S.N. and
            Stevens,H.E.
  TITLE     Effects of gestational hypothyroidism on mouse brain development:
            Gabaergic systems and oxidative stress
  JOURNAL   Dev Biol 515, 112-120 (2024)
   PUBMED   39048051
REFERENCE   4  (bases 1 to 12037)
  AUTHORS   Miyoshi,G., Ueta,Y., Yagasaki,Y., Kishi,Y., Fishell,G.,
            Machold,R.P. and Miyata,M.
  TITLE     Developmental trajectories of GABAergic cortical interneurons are
            sequentially modulated by dynamic FoxG1 expression levels
  JOURNAL   Proc Natl Acad Sci U S A 121 (16), e2317783121 (2024)
   PUBMED   38588430
REFERENCE   5  (bases 1 to 12037)
  AUTHORS   Huang,J., Zhang,Y.Y., Qiu,Y.Y., Yao,S., Qiu,W.T., Peng,J.L.,
            Li,Y.Q., You,Q.L., Wu,C.H., Wu,E.J., Wang,J., Zhou,Y.L., Ning,Y.P.,
            Wang,H.S., Chen,W.B., Hu,B.J., Liu,Y. and Sun,X.D.
  TITLE     NRG1-ErbB4 signaling in the medial amygdala controls mating
            motivation in adult male mice
  JOURNAL   Cell Rep 43 (3), 113905 (2024)
   PUBMED   38446660
REFERENCE   6  (bases 1 to 12037)
  AUTHORS   Kramer,R., Bucay,N., Kane,D.J., Martin,L.E., Tarpley,J.E. and
            Theill,L.E.
  TITLE     Neuregulins with an Ig-like domain are essential for mouse
            myocardial and neuronal development
  JOURNAL   Proc Natl Acad Sci U S A 93 (10), 4833-4838 (1996)
   PUBMED   8643489
REFERENCE   7  (bases 1 to 12037)
  AUTHORS   Gassmann,M., Casagranda,F., Orioli,D., Simon,H., Lai,C., Klein,R.
            and Lemke,G.
  TITLE     Aberrant neural and cardiac development in mice lacking the ErbB4
            neuregulin receptor
  JOURNAL   Nature 378 (6555), 390-394 (1995)
   PUBMED   7477376
REFERENCE   8  (bases 1 to 12037)
  AUTHORS   Meyer,D. and Birchmeier,C.
  TITLE     Multiple essential functions of neuregulin in development
  JOURNAL   Nature 378 (6555), 386-390 (1995)
   PUBMED   7477375
  REMARK    Erratum:[Nature 1995 Dec 14;378(6558):753]
REFERENCE   9  (bases 1 to 12037)
  AUTHORS   Moscoso,L.M., Chu,G.C., Gautam,M., Noakes,P.G., Merlie,J.P. and
            Sanes,J.R.
  TITLE     Synapse-associated expression of an acetylcholine receptor-inducing
            protein, ARIA/heregulin, and its putative receptors, ErbB2 and
            ErbB3, in developing mammalian muscle
  JOURNAL   Dev Biol 172 (1), 158-169 (1995)
   PUBMED   7589796
REFERENCE   10 (bases 1 to 12037)
  AUTHORS   Plowman,G.D., Green,J.M., Culouscou,J.M., Carlton,G.W.,
            Rothwell,V.M. and Buckley,S.
  TITLE     Heregulin induces tyrosine phosphorylation of HER4/p180erbB4
  JOURNAL   Nature 366 (6454), 473-475 (1993)
   PUBMED   7902537
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK144050.1 and AC167658.2.
            
            On Jul 17, 2015 this sequence version replaced NM_010154.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK144050.1, SRR7652917.663251.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4044              AK144050.1         2-4045
            4045-12037          AC167658.2         6615-14607
FEATURES             Location/Qualifiers
     source          1..12037
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 33.8 cM"
     gene            1..12037
                     /gene="Erbb4"
                     /gene_synonym="c-erbB-4; Her4"
                     /note="erb-b2 receptor tyrosine kinase 4"
                     /db_xref="GeneID:13869"
                     /db_xref="MGI:MGI:104771"
     exon            1..385
                     /gene="Erbb4"
                     /gene_synonym="c-erbB-4; Her4"
                     /inference="alignment:Splign:2.1.0"
     CDS             304..4182
                     /gene="Erbb4"
                     /gene_synonym="c-erbB-4; Her4"
                     /EC_number="2.7.10.1"
                     /note="avian erythroblastosis oncogene B 4; receptor
                     tyrosine-protein kinase erbB-4; proto-oncogene-like
                     protein c-ErbB-4; v-erb-a erythroblastic leukemia viral
                     oncogene homolog 4"
                     /codon_start=1
                     /product="receptor tyrosine-protein kinase erbB-4
                     precursor"
                     /protein_id="NP_034284.1"
                     /db_xref="CCDS:CCDS48285.1"
                     /db_xref="GeneID:13869"
                     /db_xref="MGI:MGI:104771"
                     /translation="MKLATGLWVWGSLLMAAGTVQPSASQSVCAGTENKLSSLSDLEQ
                     QYRALRKYYENCEVVMGNLEITSIEHNRDLSFLRSIREVTGYVLVALNQFRYLPLENL
                     RIIRGTKLYEDRYALAIFLNYRKDGNFGLQELGLKNLTEILNGGVYVDQNKFLCYADT
                     IHWQDIVRNPWPSNMTLVSTNGSSGCGRCHKSCTGRCWGPTENHCQTLTRTVCAEQCD
                     GRCYGPYVSDCCHRECAGGCSGPKDTDCFACMNFNDSGACVTQCPQTFVYNPTTFQLE
                     HNFNAKYTYGAFCVKKCPHNFVVDSSSCVRACPSSKMEVEENGIKMCKPCTDICPKAC
                     DGIGTGSLMSAQTVDSSNIDKFINCTKINGNLIFLVTGIHGDPYNAIDAIDPEKLNVF
                     RTVREITGFLNIQSWPPNMTDFSVFSNLVTIGGRVLYSGLSLLILKQQGITSLQFQSL
                     KEISAGNIYITDNSNLCYYHTINWTTLFSTINQRIVIRDNRRAENCTAEGMVCNHLCS
                     NDGCWGPGPDQCLSCRRFSRGKICIESCNLYDGEFREFENGSICVECDSQCEKMEDGL
                     LTCHGPGPDNCTKCSHFKDGPNCVEKCPDGLQGANSFIFKYADQDRECHPCHPNCTQG
                     CNGPTSHDCIYYPWTGHSTLPQHARTPLIAAGVIGGLFILVIMALTFAVYVRRKSIKK
                     KRALRRFLETELVEPLTPSGTAPNQAQLRILKETELKRVKVLGSGAFGTVYKGIWVPE
                     GETVKIPVAIKILNETTGPKANVEFMDEALIMASMDHPHLVRLLGVCLSPTIQLVTQL
                     MPHGCLLDYVHEHKDNIGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNH
                     VKITDFGLARLLEGDEKEYNADGGKMPIKWMALECIHYRKFTHQSDVWSYGVTIWELM
                     TFGGKPYDGIPTREIPDLLEKGERLPQPPICTIDVYMVMVKCWMIDADSRPKFKELAA
                     EFSRMARDPQRYLVIQGDDRMKLPSPNDSKFFQNLLDEEDLEDMMDAEEYLVPQAFNI
                     PPPIYTSRTRIDSNRNQFVYQDGGFATQQGMPMPYRATTSTIPEAPVAQGATAEMFDD
                     SCCNGTLRKPVAPHVQEDSSTQRYSADPTVFAPERNPRGELDEEGYMTPMHDKPKQEY
                     LNPVEENPFVSRRKNGDLQALDNPEYHSASSGPPKAEDEYVNEPLYLNTFANALGSAE
                     YMKNSVLSVPEKAKKAFDNPDYWNHSLPPRSTLQHPDYLQEYSTKYFYKQNGRIRPIV
                     AENPEYLSEFSLKPGTMLPPPPYRHRNTVV"
     exon            386..537
                     /gene="Erbb4"
                     /gene_synonym="c-erbB-4; Her4"
                     /inference="alignment:Splign:2.1.0"
     exon            538..724
                     /gene="Erbb4"
                     /gene_synonym="c-erbB-4; Her4"
                     /inference="alignment:Splign:2.1.0"
     exon            725..859
                     /gene="Erbb4"
                     /gene_synonym="c-erbB-4; Her4"
                     /inference="alignment:Splign:2.1.0"
     exon            860..925
                     /gene="Erbb4"
                     /gene_synonym="c-erbB-4; Her4"
                     /inference="alignment:Splign:2.1.0"
     exon            926..1044
                     /gene="Erbb4"
                     /gene_synonym="c-erbB-4; Her4"
                     /inference="alignment:Splign:2.1.0"
     exon            1045..1186
                     /gene="Erbb4"
                     /gene_synonym="c-erbB-4; Her4"
                     /inference="alignment:Splign:2.1.0"
     exon            1187..1300
                     /gene="Erbb4"
                     /gene_synonym="c-erbB-4; Her4"
                     /inference="alignment:Splign:2.1.0"
     exon            1301..1427
                     /gene="Erbb4"
                     /gene_synonym="c-erbB-4; Her4"
                     /inference="alignment:Splign:2.1.0"
     exon            1428..1501
                     /gene="Erbb4"
                     /gene_synonym="c-erbB-4; Her4"
                     /inference="alignment:Splign:2.1.0"
     exon            1502..1592
                     /gene="Erbb4"
                     /gene_synonym="c-erbB-4; Her4"
                     /inference="alignment:Splign:2.1.0"
     exon            1593..1792
                     /gene="Erbb4"
                     /gene_synonym="c-erbB-4; Her4"
                     /inference="alignment:Splign:2.1.0"
     exon            1793..1925
                     /gene="Erbb4"
                     /gene_synonym="c-erbB-4; Her4"
                     /inference="alignment:Splign:2.1.0"
     exon            1926..2019
                     /gene="Erbb4"
                     /gene_synonym="c-erbB-4; Her4"
                     /inference="alignment:Splign:2.1.0"
     exon            2020..2174
                     /gene="Erbb4"
                     /gene_synonym="c-erbB-4; Her4"
                     /inference="alignment:Splign:2.1.0"
     exon            2175..2249
                     /gene="Erbb4"
                     /gene_synonym="c-erbB-4; Her4"
                     /inference="alignment:Splign:2.1.0"
     exon            2250..2382
                     /gene="Erbb4"
                     /gene_synonym="c-erbB-4; Her4"
                     /inference="alignment:Splign:2.1.0"
     exon            2383..2505
                     /gene="Erbb4"
                     /gene_synonym="c-erbB-4; Her4"
                     /inference="alignment:Splign:2.1.0"
     exon            2506..2604
                     /gene="Erbb4"
                     /gene_synonym="c-erbB-4; Her4"
                     /inference="alignment:Splign:2.1.0"
     exon            2605..2790
                     /gene="Erbb4"
                     /gene_synonym="c-erbB-4; Her4"
                     /inference="alignment:Splign:2.1.0"
     exon            2791..2946
                     /gene="Erbb4"
                     /gene_synonym="c-erbB-4; Her4"
                     /inference="alignment:Splign:2.1.0"
     exon            2947..3022
                     /gene="Erbb4"
                     /gene_synonym="c-erbB-4; Her4"
                     /inference="alignment:Splign:2.1.0"
     exon            3023..3169
                     /gene="Erbb4"
                     /gene_synonym="c-erbB-4; Her4"
                     /inference="alignment:Splign:2.1.0"
     exon            3170..3267
                     /gene="Erbb4"
                     /gene_synonym="c-erbB-4; Her4"
                     /inference="alignment:Splign:2.1.0"
     exon            3268..3438
                     /gene="Erbb4"
                     /gene_synonym="c-erbB-4; Her4"
                     /inference="alignment:Splign:2.1.0"
     exon            3439..3736
                     /gene="Erbb4"
                     /gene_synonym="c-erbB-4; Her4"
                     /inference="alignment:Splign:2.1.0"
     exon            3737..12037
                     /gene="Erbb4"
                     /gene_synonym="c-erbB-4; Her4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      12020..12025
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Erbb4"
                     /gene_synonym="c-erbB-4; Her4"
                     /note="hexamer: AATAAA"
     polyA_site      12037
                     /gene="Erbb4"
                     /gene_synonym="c-erbB-4; Her4"
                     /note="major polyA site"
ORIGIN      
        1 actccgggaa ctagctgtac gttgtgctcg gagcaccagc cgcacagtcg cgctcactcc
       61 cacccgcgcg ccctcctccg cggccccttg ccgggtccgc gggtccacgg gtcctggaag
      121 ccgccgccgt cgccgactgg ctctccggcc ccgggaagcc cgtgcaccaa gcgcgccgcg
      181 cccgcccccc ttgcgccccc cacgcgctcc cggctgaggg ggggagatct cctccgcgtg
      241 ctcgcaagtg gctatggtat ttggacatgt aattgtcagc gcgggatctg agacttgcca
      301 aaaatgaagc tggcgacggg actctgggtc tgggggagcc ttctgatggc agcggggacc
      361 gtccagccca gcgcttctca gtcagtgtgc gcaggaacag agaacaaact gagctctctc
      421 tctgacctgg aacagcagta ccgagccttg cgcaaatact atgaaaactg cgaggtagtc
      481 atgggcaacc tggagatcac cagcatcgag cacaaccggg acctctcctt cctgcggtct
      541 atccgagaag tcacaggcta cgtcctggtg gccctcaacc agtttcgtta cttgcctctg
      601 gagaatttac gcattattcg tgggacaaaa ctatatgaag atcgctatgc cttagcgata
      661 ttcttaaact acaggaaaga tggcaacttt ggactccaag aacttggatt aaagaacctg
      721 accgaaatac taaatggtgg agtctatgta gaccagaaca aattcctatg ttatgctgac
      781 actatacact ggcaagatat tgttcggaat ccatggcctt ccaacatgac tctggtgtca
      841 acaaatggaa gttctggatg tggaagatgc cataagtctt gcactggccg atgctgggga
      901 cccacagaaa atcactgcca gaccttgacc agaactgtgt gtgctgaaca atgtgatggc
      961 aggtgctatg gaccctacgt tagtgactgc tgccatcgag aatgtgctgg aggctgctca
     1021 ggaccaaagg acactgactg ctttgcctgc atgaacttca atgacagtgg agcctgcgtt
     1081 actcaatgtc cccaaacatt tgtctacaat ccaaccacct ttcaactgga acacaacttc
     1141 aatgcaaagt acacgtatgg agcattctgt gttaagaaat gtccacataa cttcgtggta
     1201 gattccagtt cttgtgtacg agcctgccct agttctaaga tggaagtaga agaaaatggg
     1261 attaaaatgt gtaagccttg caccgatatt tgccccaaag catgtgatgg aatcggcacg
     1321 ggatcactga tgtctgctca gactgtggat tcaagtaaca ttgacaaatt cataaactgc
     1381 acaaagatca atggcaatct catctttctt gtcactggca ttcatggaga cccttacaat
     1441 gctattgacg ccatagatcc agagaaactg aatgtctttc ggactgtcag agaaataaca
     1501 ggtttcctga acatacagtc ttggccccca aatatgacag atttcagtgt tttctccaac
     1561 ctcgtcacaa ttggaggaag agtcctctac agtggtctct cattgctgat cctcaaacaa
     1621 caaggtatca cttccctaca gttccagtct ctgaaggaaa tcagtgcggg caatatctac
     1681 atcactgaca acagcaacct gtgttattac cataccatta actggacaac actcttcagc
     1741 accattaacc agagaatagt gatccgagat aacagaagag ctgagaattg tactgctgaa
     1801 ggcatggtat gcaaccacct gtgttcaaat gatggttgtt ggggacctgg gccggaccag
     1861 tgcctgtcat gtcggcgctt cagcagggga aagatctgca tagagtcttg caacctttat
     1921 gatggggaat ttcgagagtt tgaaaacggc tccatctgtg ttgagtgtga ctcccagtgt
     1981 gagaaaatgg aagatggact cctcacatgc catggaccgg gacctgacaa ctgcacaaag
     2041 tgctctcatt ttaaggatgg tccaaactgt gtggagaaat gtccagatgg cctacaggga
     2101 gcaaacagtt tcatttttaa gtatgcagat caggatcggg agtgccaccc ttgccatcca
     2161 aactgcaccc aggggtgtaa cggtcccact agtcatgact gcatttacta cccatggacg
     2221 ggccattcca ctttaccaca acacgctaga actccactga ttgcagccgg agtcattgga
     2281 ggcctcttca tcctggtgat catggctttg acatttgctg tctatgtcag aagaaagagc
     2341 atcaaaaaga aacgtgcttt gaggagattc ctggagacag agctggtaga gcccttaact
     2401 cccagtggca cggcacccaa tcaagctcaa cttcgcattt tgaaggaaac cgaactaaag
     2461 agggtaaagg tccttggctc gggagctttt ggaaccgttt ataaaggtat ttgggtgcct
     2521 gaaggtgaaa cagtgaaaat ccctgtggct ataaagatcc tcaatgaaac aactggcccc
     2581 aaagccaacg tggagttcat ggatgaggct ctgatcatgg caagtatgga tcacccacac
     2641 ctagttcgcc tattgggagt gtgtctgagt cccactatcc agttggttac gcagctgatg
     2701 ccgcatggct gcctactgga ctatgttcat gaacacaagg ataacattgg atcacagctg
     2761 ctgttgaact ggtgtgtcca gattgctaag ggaatgatgt acctagaaga aagacggctt
     2821 gttcatcggg atctggcagc ccgcaatgtc ttagtgaaat ctccaaatca tgttaaaatc
     2881 acagattttg gactggcccg gctcttggaa ggagatgaaa aagaatacaa tgctgatggt
     2941 ggcaagatgc caattaaatg gatggctctg gaatgtatac attataggaa attcacacat
     3001 caaagtgatg tttggagcta tggcgtcact atatgggaac tgatgacctt tggaggaaag
     3061 ccctatgatg gaattccaac ccgagaaatc cccgatttac tggagaaagg agagcgtctg
     3121 cctcagcctc ccatctgcac tattgatgtt tacatggtca tggtcaaatg ttggatgatc
     3181 gatgctgaca gcagacctaa attcaaagaa ctggctgctg agttttcaag aatggctaga
     3241 gaccctcaaa gatacctagt tattcagggt gatgatcgta tgaagcttcc cagtccaaat
     3301 gacagcaaat tcttccagaa tctcttggat gaagaggatt tggaagacat gatggatgct
     3361 gaggaatatt tggtccccca ggctttcaac atacctcctc ccatctacac atccagaaca
     3421 agaattgact ccaataggaa tcagtttgtg taccaagatg ggggctttgc tacacaacaa
     3481 ggaatgccca tgccctacag agccacaacc agcaccatac cagaggctcc agtagctcag
     3541 ggtgcaacgg ctgagatgtt tgatgactcc tgctgtaatg gtaccctacg aaagccagtg
     3601 gcaccccatg tccaagagga cagtagcact cagaggtata gtgctgatcc cacagtgttc
     3661 gccccagaac ggaatcctcg aggagaactg gatgaagaag gctacatgac tccaatgcat
     3721 gacaagccca aacaagaata tctgaatcct gtggaagaga acccttttgt gtcccgaagg
     3781 aagaatggag atcttcaagc tttagataat ccggagtatc acagtgcttc cagcggtcca
     3841 cccaaggcgg aggatgaata cgtgaatgag cctctatacc tcaacacctt cgccaatgcc
     3901 ttggggagtg cagagtacat gaaaaacagt gtactgtctg tgccagagaa agccaagaaa
     3961 gcatttgaca accccgacta ctggaaccac agcctgccac cccggagcac ccttcagcac
     4021 ccagactacc tgcaggaata cagcacaaaa tatttttata aacagaatgg acggatccgc
     4081 cccattgtgg cagagaatcc tgagtacctc tcggagttct cgctgaagcc tggcactatg
     4141 ctgccccctc cgccctacag acaccggaat actgtggtgt gagcttggct agagtgttag
     4201 gtggagaaac acacacccac tccatttccc ttccccctcc tctttctctg gtggtcttcc
     4261 ttcttctccc aaggccagta gttttgacac ttccaagtgg aagcagtaga gatgcaatga
     4321 tagttctgtg cttacctaac ttgaatatta gaaggaaaga ctgaaagaga aagacaggga
     4381 tacacacact gtttcttcgt ttcttcatat gggttggtta acagagtgtc aaagctagag
     4441 aaggtctagg aagtataagg caatactgcc tgctgtcaaa gagccccatc tttcttctct
     4501 ttgcacacac tctctccctc cttctccccc tgtccccacc accctttaat ctatctatgc
     4561 tggtggtcga aagtccagac tctgttccca tctgtagcca tagtcttgtg catattcagc
     4621 atccctgaaa tcatactacg gcttccatta ggacaaaaag acgagcgttt ggacgtcatt
     4681 tgatcgtaag tgagattgag aagccaattt ctttctccaa tagtttcttt cttggcaagt
     4741 aagaatggcc aacccagctt ttgtaatttt taaatctcca ttatagttat aactagtaat
     4801 tatgcttgga aggcatctct gtgttctttt tttcaatttt ggtttgattt ggcctattct
     4861 tttatattag ttgctcccca ttctggcttc agtttctagt tgtaaagata tttacataaa
     4921 aaagcttctt gacagagttc aaacaaaaat aatattatat gatgtagaga ttgttatttt
     4981 aaatcattca gtccttaaaa ttagaagaga aagccaagat actagtaaaa atagcatcaa
     5041 atctagatct cacattttac acttgcaagt tttgtcttcc cttttgtttc actctttacc
     5101 attttcttct ccccccaaat gattgtcagt gacaggcagt gagaatctta agagtggaag
     5161 ggatgctaag aaacagttct gtgtggttca caaaactact gatactttca ggggtggtcc
     5221 catgggggat ccatgcagtg gaagaaacac tggattgggt acgtctacat gaaaggtact
     5281 cagaaaagta gtttgcactt aagctataat tttatttgtg ctttttctga actccacttt
     5341 gaattgttga atgaagcaat atggaagcaa ccagcagatt aactaattta aatacttctt
     5401 ttttaaaaaa aaaaaagaac aaaaggatct aagataaata cagactgtgg aaatagcaaa
     5461 ccaagccaat tagggctttg gaacagtacc cagggattgg gatgagaggg ccagcacatt
     5521 aacttcatac tctgtgacat ttgctgtgta aggaagtctc ttaagtttgt acgctctgtg
     5581 tgaaggaatg caagttaagg actggcttga attctatgga atttctagaa tgagattctg
     5641 tttatatgga ctagaaggtg acttaactct tcacgcctaa gttgttataa ttagaagtaa
     5701 accatcaaca tttgaagcct atgaataggt ccacacttga gttaaaagtt gtaaataaac
     5761 atgaaaaccc ttctcatgca attattttat tgtccaatat attaatcttt taataagtta
     5821 tgtaatgact gtctcttcat atactaccat actatgtgca ggttgtaggt ccctatgtta
     5881 ggcttaattt tgaaagaaca cctatagtgt taagattagt gatgaggaca atgacaaatg
     5941 aatctctagg aaataaggaa atttaataca tccctctttt ctataaaatt atcctgcaaa
     6001 tcattgaggt ttttaaacat ttctttctac tgttaatgtg ttaagagacc attagattca
     6061 ctagccaaat aataataata ataatcaatt agattaaaat cttcttggta aaacagagtg
     6121 tacttaagga agaaaaaatt tcaagaaagt ttatgtttct acctatgcat aaaaactcat
     6181 gcagccaaat ctagatttat ttgatcgata tttaaagtct actgaaagta tgtgtgggtt
     6241 gggggtgggg tatgtccaaa taagtgaaac catccctgac ttcaaatttt aacagtctag
     6301 atttatttgc tgtgacattc ttatttctcc acgagtccaa gaaatcagat tgcattagtt
     6361 attttgtgaa tggcttcata gaactttttg taaaagttct gagaagtcat caggttgtaa
     6421 tgtaaacatc cttcaaacta ttgaagatga caaatataat cacttctgtg ttcttatcca
     6481 gacacaaagt gaaccacagg agcattgcat cactggtaaa ctgacttatc tggagtgtta
     6541 acaggaaacc aggtcaaact cctgggaaga gttaggtttg ctctcttcag caaagaaaag
     6601 ggtggcaaac tgaaagtgag aggtagagac agcagagggt ctgtgagatc ctctctagag
     6661 aagtttaacc ataaatttac cagatctaga atgatcgagg ggcctcagcc ttaaagccca
     6721 aagctcccta atccaattca gaggcatcta caaagataag ggaccttata taagtaccta
     6781 tttcctatga agagttaaag taagcttttg ttagtaaata catctatccc taaccattac
     6841 tgtcagcacc tttggaatgc tataaggaca ttttcttttc atttataata tttgtatggc
     6901 ttctagtggg ataaagacag cagaattatt tcattagtaa aagaaaaaga gataatcttt
     6961 tagctgttaa tgcgatgtaa atgtagccac tgagggctgc cttttccttc cctaaaagca
     7021 caggatttgc agttccaccc atcttcccct agagatagat gtaggtctaa gtgagaatga
     7081 cccaaggtgc catttttatc attccttttt tacgactttt taatatgtac ttgatttcag
     7141 ttgttctggt atttcatgtc tacttatatt tgactatcta ggccctaaat tctagggagg
     7201 aaattatcca aagagtgtat taaagggaca acaagcagga atcagggagg atgcacattc
     7261 atttgctcaa gagaattact tgtttaaccc agtaaaatga aattctaaga cactaattaa
     7321 agcctacaga ttgctgtgga atatcaggtc ccagaactga gcagcaccaa tccaaatatg
     7381 cagaatccat ttgtaaaacg gagtaaaata aatgggaaat tgagctgact atatatattt
     7441 tttaatcatc aaattgtaac acacaagctt atcttgggaa atcctaattt caggcctaac
     7501 aatatttttc agtggaatag ccacttaaaa gacaccattc ttgagcagat gaaaaacgat
     7561 gtcccctaag tcagggcaag tctagagtca ccaaactgct gctactcaag caaggttgat
     7621 aacaaaccta gtccctgttt tctgaattac attagcagcg caggtaagga tatggttcac
     7681 tctctctaga atcattcttg aaagagtacg aaagcaatgc aaattgcaaa ctactaaaaa
     7741 caaaaaacta aaactgtaag tcttactaag taagagtttg cttttcatag gtcaggaaga
     7801 atggctgata ggctctatct tgaaagaaaa tatgggggat ttttaagtgc aacacgctca
     7861 tgtgctatgc ctttggagga tgacacatat tgtcaatggt ggagaaaagt cagtagaggg
     7921 atatgaggct tcatgaatag agggagctag tgggatagtg tacttcctga ggtgtcaaaa
     7981 ctagaaagag tatacaaaag tggttttgcc tatgcctgat acagagttgt aaatacaaga
     8041 tcctctgaac atttatttaa aaactggaat ttgttgtcca tctgtaattg ttgattattt
     8101 acctagtaca tgtagttcgt acggtaataa aaatggtgac ctcaaaagca tgtgtaaaac
     8161 tggacacaat catggcaatg ctataagaga tagaattagc taggttatca aatgttaaat
     8221 gctttcaata gtaataagca aatcaaacta gaaaactagc catggagcat aaaataacaa
     8281 aataaagttc aggatttgaa aatataggat ggattttgca tagtagatta aaaataagtt
     8341 tcccatttaa aatgtttgtt ggttggactt agcaggtagt aggtatggtg aggtttcaat
     8401 tgtaaaaact ttctttaagg cactaaggtt gattttcccg tgttctctta ttccttcatt
     8461 acattttaat ttatttagta taaagagatg ctatatttgg ggattctggt ttgcagacat
     8521 cacattgaag ggtttagcat gcaaataaac cacaggagga tttaagagat ctttaaaatg
     8581 aataacagaa gtaaaaaaag agtctattgc cttttatggt tgcaaaaaat ttgagtattt
     8641 gacagtaatt tagaaagtga gcaaaatatt taatttttga agtggccttt cttttcctac
     8701 taccttgctg atataactaa tatgaaaccc attaccactt tttttttgat aaatagatgc
     8761 taaagcaaac atttttaact attctattgg tgttctttgg actcttgatt tttaactgtt
     8821 tatttgttat ggggcaaata ggaaattgta gagcagagct aaaaagccag acaaaccaat
     8881 ttctactgca tatatcatgg gaagagaact gggttgtgcc tctctgtgtc tgaaggacaa
     8941 tattactctc ctgcagacac acaagggcag gatctcatct cctgttgacc atctgttcaa
     9001 gaccaaatgc tatatgcata tgagtgtgaa tcagacataa ttttagaaga tctttgacag
     9061 ttgagacctt cttcttgttg acactaagat gaggccagta cttatgattt ctgaatcaac
     9121 actttttttt ttcttctaat cccagagatg ccttcgaagg tgttctctgt gctgttacaa
     9181 acatgaagat gagggcattt tatcagaccc agtgcccttg tgtttgtata tatcaaacct
     9241 tcaaacaacc agagactggt tgtttacttc atgaaataga actctataaa atggtaagaa
     9301 tttcagactc tctctgttca agtcccactc gtttagtcaa gagacaaaag tgtatggtgt
     9361 gtctgacctc agttttggct aagagattgg gcacaggaaa atgcttctag actcacaggc
     9421 tgtaaagact atataagctc caatatcaag ggaacatcca caggccttcc ttggaaagaa
     9481 ataacttgaa agtcaacctt gcaaggaagg gatcacctgg tcacaaatag aaaattttat
     9541 ttccctctga actttagagg aaaatggaat ctttactttc ctacccccaa ctctcacaaa
     9601 gcctttccca tgcttttact atctcaagtt ccaagtggct ttcctgggct atcgctttct
     9661 taagccatag tggatctcta aggaccacat cctcctttga aacactgacc tagcctttgc
     9721 cttcaaatgc ctgatttttt ttccattaaa atatccaacc actctagaag gtatttaaat
     9781 tgcttcttaa ataaaacaca gcacaaaaaa cttatttacg gtatgagaat tgtttattca
     9841 tgacaattaa ttctatcact gtgggcttct ctgtaggatt ttaagattag ttagctctgt
     9901 aatgtatctc aagactcaca ttgtatgtac atacacttct cgatcttaca ttaatctttc
     9961 catgaaaact atatatgtgt atatatagtt tttatgtata tatattaaac taagttattg
    10021 ctgccaacta acttatttac tttgatcacc ttattttatt tctgatataa atattttaca
    10081 gctgctagag tttttggttt ttttccaaat gaagaatttt attaccagaa aggaacaggc
    10141 aattcacctg taaaaacctc ctgtgacttt tgttggaaca tccatctatc taacacactt
    10201 ataataagca ccatttcact gtaatgaaag tccgtgttga ctgacagaac tctatctaca
    10261 ctttctctac tttaggagga aatttttctt ttaatacttt agtgtgtttt ccccatgcca
    10321 cttaaagtgt ttatatttgt atagatagac tagtacaaga aaacaagctt ttgcatctgt
    10381 aggcaatagt ccaatttgtc caaatcactt tgtctttact gctattttta ttcctgatat
    10441 gttatgtttt ccccaggcct gttgcccttt tgaagaaaag caaaccacac tccttctcta
    10501 ttgacagaaa cctgatgttc aagtatcatt tccagtgttt ttcagttaat ggaggggttg
    10561 tgtccttttc cttaatgtga gagtcatctc cctgtatagt tttggatctc tcaggggctg
    10621 ggagtgggga gtgaagaaac agctaccata gcgctccaag aacccttatg gaattactct
    10681 ggtaatcagc tatgaaagtt cctttctaac tgtagatata tgtaagccgt tcttttcaag
    10741 taaggtactt tgaaacatgt agcataaact ggtaaataag ctgttaaaat gggtcgacta
    10801 ttaaactgag cagctgtgca aggggcagct aactttgaat gcacaccttc ctggctggcc
    10861 tgtgtacatc tcatcatgtg taagcaacat ggcctccatt gctacacacc aagagtatgt
    10921 ctccacatgc tctggctgct tgatcatctc tcgctgagta tcattagtaa atgagatcaa
    10981 atgtaaatga gattaatgtg caagatcatt catggcacat gcacaaaact aggtcacgtt
    11041 aaatttttta aaaattcatc tcatgtacgc atcacagtag ttggctgaga tcagtttggg
    11101 tggtaaagga agtcaatttg cagaaaaggc agaaatgtgt tcgtttcctt attttcttga
    11161 catataaaca gaaaacaagc ccttgttcct ctgaagaatc atcaaaggac agggatgtaa
    11221 aaaaaataat aataataata gcttgctggt aagccatcca tgtttcattt aaatcccagc
    11281 attcaaagtt agctgccttt tttgaaacaa acaaacaaaa aatactactg tatgtttgaa
    11341 aatgtgaata gtatttttat agcttgttaa agacatggct agctgcattt gtaaataagg
    11401 ataatgttgc tttgattttc tttgatgaac atctttcttt ggaacataat tgtctttagg
    11461 gttgatttgt atataagtaa ttggcttgtg attgtttctc tttcggttgg aagttatcat
    11521 tttgacatta cctgtgattc tgtgttcagc actattgtga tgtgtccaac ctctgcactc
    11581 gcttacacaa taggatatgc caattgtgtg tggtgaaatg ttattttcat tttttttcta
    11641 ttttacctat gaaggattat gcacttaaca catactaact tttttaatgt taggtatatt
    11701 tttagtataa tttcccgatt ctttcttctc ctccaatctt taagcttctt ttccctcctt
    11761 cccctacttt ctgttattat tgaggatgag ggagaaaatg tattttaaat ggatgtaatt
    11821 aggctttttg aggtagttct caaggatcct cttttgactc ttgggaaaga attgtgcgtg
    11881 cacaaagcaa gtatagaatg cgagctgctt tgcctcattc cgtactgatc atcccagctg
    11941 aacaatttga aaactgttct gcctttttgt tacatgaatc tgtcagaaat atatttttaa
    12001 tttaatataa atgaaattca ataaaatatg aaacaaa
//
