LOCUS       NM_001003817            4998 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus erb-b2 receptor tyrosine kinase 2 (Erbb2), mRNA.
ACCESSION   NM_001003817 XM_109715
VERSION     NM_001003817.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4998)
  AUTHORS   Miao,L., Lu,Y., Nusrat,A., Zhao,L., Castillo,M., Xiao,Y., Guo,H.,
            Liu,Y., Gunaratne,P., Schwartz,R.J., Burns,A.R., Kumar,A.,
            DiPersio,C.M. and Wu,M.
  TITLE     beta1 integrins regulate cellular behaviour and cardiomyocyte
            organization during ventricular wall formation
  JOURNAL   Cardiovasc Res 120 (11), 1279-1294 (2024)
   PUBMED   38794925
REFERENCE   2  (bases 1 to 4998)
  AUTHORS   Yang,H., Wang,X., Blanco-Gomez,A., He,L., Garcia-Sancha,N.,
            Corchado-Cobos,R., Perez-Baena,M.J., Jimenez-Navas,A., Wang,P.,
            Inman,J.L., Snijders,A.M., Threadgill,D.W., Balmain,A., Chang,H.,
            Perez-Losada,J. and Mao,J.H.
  TITLE     A susceptibility gene signature for ERBB2-driven mammary tumour
            development and metastasis in collaborative cross mice
  JOURNAL   EBioMedicine 106, 105260 (2024)
   PUBMED   39067134
  REMARK    GeneRIF: A susceptibility gene signature for ERBB2-driven mammary
            tumour development and metastasis in collaborative cross mice.
REFERENCE   3  (bases 1 to 4998)
  AUTHORS   Dunston,K., Hunter,M.I., Johannesen,E., Jung,J.S., Kim,T.H.,
            Yoo,J.Y. and Jeong,J.W.
  TITLE     ERBB2 Targeting Reveals a Significant Suppression of Tumorigenesis
            in Murine Endometrial Cancer with Pten Mutation
  JOURNAL   Reprod Sci 31 (8), 2458-2467 (2024)
   PUBMED   38637476
  REMARK    GeneRIF: ERBB2 Targeting Reveals a Significant Suppression of
            Tumorigenesis in Murine Endometrial Cancer with Pten Mutation.
REFERENCE   4  (bases 1 to 4998)
  AUTHORS   Shi,Q., Huang,F., Wang,Y., Liu,H., Deng,H. and Chen,Y.G.
  TITLE     HER2 phosphorylation induced by TGF-beta promotes mammary
            morphogenesis and breast cancer progression
  JOURNAL   J Cell Biol 223 (4) (2024)
   PUBMED   38407425
  REMARK    GeneRIF: HER2 phosphorylation induced by TGF-beta promotes mammary
            morphogenesis and breast cancer progression.
REFERENCE   5  (bases 1 to 4998)
  AUTHORS   Diamantopoulou,S., Yapijakis,C., Papakosta,V., Ebeling,M.,
            Lazaris,A.C., Derka,S., Vylliotis,A., Diamantopoulos,P.,
            Vairaktari,G. and Vassiliou,S.
  TITLE     EGFR and HER-2 oncogenes expression in an experimental model of
            two-stage chemically induced carcinogenesis in mouse skin
  JOURNAL   J Craniomaxillofac Surg 52 (4), 413-419 (2024)
   PUBMED   38443188
  REMARK    GeneRIF: EGFR and HER-2 oncogenes expression in an experimental
            model of two-stage chemically induced carcinogenesis in mouse skin.
            Erratum:[J Craniomaxillofac Surg. 2024 Dec
            10:S1010-5182(24)00333-0. doi: 10.1016/j.jcms.2024.12.001.. PMID:
            39658469]
REFERENCE   6  (bases 1 to 4998)
  AUTHORS   Guy,C.T., Webster,M.A., Schaller,M., Parsons,T.J., Cardiff,R.D. and
            Muller,W.J.
  TITLE     Expression of the neu protooncogene in the mammary epithelium of
            transgenic mice induces metastatic disease
  JOURNAL   Proc Natl Acad Sci U S A 89 (22), 10578-10582 (1992)
   PUBMED   1359541
REFERENCE   7  (bases 1 to 4998)
  AUTHORS   Stetler-Stevenson,W.G., Liotta,L.A. and Seldin,M.F.
  TITLE     Linkage analysis demonstrates that the Timp-2 locus is on mouse
            chromosome 11
  JOURNAL   Genomics 14 (3), 828-829 (1992)
   PUBMED   1427919
REFERENCE   8  (bases 1 to 4998)
  AUTHORS   Remmers,E.F., Goldmuntz,E.A., Cash,J.M., Crofford,L.J.,
            Misiewicz-Poltorak,B., Zha,H. and Wilder,R.L.
  TITLE     Genetic map of nine polymorphic loci comprising a single linkage
            group on rat chromosome 10: evidence for linkage conservation with
            human chromosome 17 and mouse chromosome 11
  JOURNAL   Genomics 14 (3), 618-623 (1992)
   PUBMED   1358809
REFERENCE   9  (bases 1 to 4998)
  AUTHORS   Lucchini,F., Sacco,M.G., Hu,N., Villa,A., Brown,J., Cesano,L.,
            Mangiarini,L., Rindi,G., Kindl,S., Sessa,F. et al.
  TITLE     Early and multifocal tumors in breast, salivary, harderian and
            epididymal tissues developed in MMTY-Neu transgenic mice
  JOURNAL   Cancer Lett 64 (3), 203-209 (1992)
   PUBMED   1322235
REFERENCE   10 (bases 1 to 4998)
  AUTHORS   White,M.R. and Hung,M.C.
  TITLE     Cloning and characterization of the mouse neu promoter
  JOURNAL   Oncogene 7 (4), 677-683 (1992)
   PUBMED   1348855
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB648397.1, AK129487.1, AK031099.1 and AL591390.8.
            
            On Nov 15, 2004 this sequence version replaced XM_109715.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK142296.1, AK129487.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-296               BB648397.1         15-310
            297-938             AK129487.1         267-908
            939-2940            AK031099.1         807-2808
            2941-4536           AK129487.1         2911-4506
            4537-4998           AL591390.8         67853-68314         c
FEATURES             Location/Qualifiers
     source          1..4998
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 61.75 cM"
     gene            1..4998
                     /gene="Erbb2"
                     /gene_synonym="c-erbB2; c-neu; Erbb-2; HER-2; HER2;
                     l11Jus8; mKIAA3023; Neu"
                     /note="erb-b2 receptor tyrosine kinase 2"
                     /db_xref="GeneID:13866"
                     /db_xref="MGI:MGI:95410"
     exon            1..252
                     /gene="Erbb2"
                     /gene_synonym="c-erbB2; c-neu; Erbb-2; HER-2; HER2;
                     l11Jus8; mKIAA3023; Neu"
                     /inference="alignment:Splign:2.1.0"
     CDS             180..3950
                     /gene="Erbb2"
                     /gene_synonym="c-erbB2; c-neu; Erbb-2; HER-2; HER2;
                     l11Jus8; mKIAA3023; Neu"
                     /EC_number="2.7.10.1"
                     /note="avian erythroblastosis oncogene B 2; receptor
                     tyrosine-protein kinase erbB-2; c-erbB-2; p185erbB2;
                     proto-oncogene NEU; proto-oncogene c-ErbB-2; Neu oncogene;
                     v-erb-b2 erythroblastic leukemia viral oncogene homolog 2,
                     neuro/glioblastoma derived oncogene homolog"
                     /codon_start=1
                     /product="receptor tyrosine-protein kinase erbB-2
                     precursor"
                     /protein_id="NP_001003817.1"
                     /db_xref="CCDS:CCDS25349.1"
                     /db_xref="GeneID:13866"
                     /db_xref="MGI:MGI:95410"
                     /translation="MELAAWCRWGFLLALLSPGAAGTQVCTGTDMKLRLPASPETHLD
                     MLRHLYQGCQVVQGNLELTYLPANASLSFLQDIQEVQGYMLIAHNRVKHVPLQRLRIV
                     RGTQLFEDKYALAVLDNRDPLDNVTTAAPGRTPEGLRELQLRSLTEILKGGVLIRGNP
                     QLCYQDMVLWKDVLRKNNQLAPVDMDTNRSRACPPCAPTCKDNHCWGESPEDCQILTG
                     TICTSGCARCKGRLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALITYN
                     TDTFESMLNPEGRYTFGASCVTTCPYNYLSTEVGSCTLVCPPNNQEVTAEDGTQRCEK
                     CSKPCAGVCYGLGMEHLRGARAITSDNIQEFAGCKKIFGSLAFLPESFDGNPSSGVAP
                     LKPEHLQVFETLEEITGYLYISAWPESFQDLSVFQNLRVIRGRILHDGAYSLTLQGLG
                     IHSLGLRSLRELGSGLALIHRNTHLCFVNTVPWDQLFRNPHQALLHSGNRPEEACGLE
                     GLVCNSLCARGHCWGPGPTQCVNCSQFLRGQECVEECRVWKGLPREYVRGKHCLPCHP
                     ECQPQNSSETCYGSEADQCEACAHYKDSSSCVARCPSGVKPDLSYMPIWKYPDEEGIC
                     QPCPINCTHSCVDLDERGCPAEQRASPVTFIIATVVGVLLFLIIVVVIGILIKRRRQK
                     IRKYTMRRLLQETELVEPLTPSGAVPNQAQMRILKETELRKLKVLGSGAFGTVYKGIW
                     IPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVSRLLGICLTSTVQLV
                     TQLMPYGCLLDHVREHRGRLGSQDLLNWCVQIAKGMSYLEEVRLVHRDLAARNVLVKS
                     PNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILRRRFTHQSDVWSYGVTVW
                     ELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWMIDSECRPRFRE
                     LVSEFSRMARDPQRFVVIQNEDLGPSSPMDSTFYRSLLEDDDMGELVDAEEYLVPQQG
                     FFSPDPALGTGSTAHRRHRSSSARSGGGELTLGLEPSEEEPPRSPLAPSEGAGSDVFD
                     GDLAVGVTKGLQSLSPHDLSPLQRYSEDPTLPLPPETDGYVAPLACSPQPEYVNQPEV
                     RPQSPLTPEGPPPPIRPAGATLERPKTLSPGKNGVVKDVFAFGGAVENPEYLAPRAGT
                     ASQPHPSPAFSPAFDNLYYWDQNSSEQGPPPSTFEGTPTAENPEYLGLDVPV"
     exon            253..404
                     /gene="Erbb2"
                     /gene_synonym="c-erbB2; c-neu; Erbb-2; HER-2; HER2;
                     l11Jus8; mKIAA3023; Neu"
                     /inference="alignment:Splign:2.1.0"
     exon            405..621
                     /gene="Erbb2"
                     /gene_synonym="c-erbB2; c-neu; Erbb-2; HER-2; HER2;
                     l11Jus8; mKIAA3023; Neu"
                     /inference="alignment:Splign:2.1.0"
     exon            622..756
                     /gene="Erbb2"
                     /gene_synonym="c-erbB2; c-neu; Erbb-2; HER-2; HER2;
                     l11Jus8; mKIAA3023; Neu"
                     /inference="alignment:Splign:2.1.0"
     exon            757..825
                     /gene="Erbb2"
                     /gene_synonym="c-erbB2; c-neu; Erbb-2; HER-2; HER2;
                     l11Jus8; mKIAA3023; Neu"
                     /inference="alignment:Splign:2.1.0"
     exon            826..941
                     /gene="Erbb2"
                     /gene_synonym="c-erbB2; c-neu; Erbb-2; HER-2; HER2;
                     l11Jus8; mKIAA3023; Neu"
                     /inference="alignment:Splign:2.1.0"
     exon            942..1083
                     /gene="Erbb2"
                     /gene_synonym="c-erbB2; c-neu; Erbb-2; HER-2; HER2;
                     l11Jus8; mKIAA3023; Neu"
                     /inference="alignment:Splign:2.1.0"
     exon            1084..1203
                     /gene="Erbb2"
                     /gene_synonym="c-erbB2; c-neu; Erbb-2; HER-2; HER2;
                     l11Jus8; mKIAA3023; Neu"
                     /inference="alignment:Splign:2.1.0"
     exon            1204..1330
                     /gene="Erbb2"
                     /gene_synonym="c-erbB2; c-neu; Erbb-2; HER-2; HER2;
                     l11Jus8; mKIAA3023; Neu"
                     /inference="alignment:Splign:2.1.0"
     exon            1331..1404
                     /gene="Erbb2"
                     /gene_synonym="c-erbB2; c-neu; Erbb-2; HER-2; HER2;
                     l11Jus8; mKIAA3023; Neu"
                     /inference="alignment:Splign:2.1.0"
     exon            1405..1495
                     /gene="Erbb2"
                     /gene_synonym="c-erbB2; c-neu; Erbb-2; HER-2; HER2;
                     l11Jus8; mKIAA3023; Neu"
                     /inference="alignment:Splign:2.1.0"
     exon            1496..1695
                     /gene="Erbb2"
                     /gene_synonym="c-erbB2; c-neu; Erbb-2; HER-2; HER2;
                     l11Jus8; mKIAA3023; Neu"
                     /inference="alignment:Splign:2.1.0"
     exon            1696..1828
                     /gene="Erbb2"
                     /gene_synonym="c-erbB2; c-neu; Erbb-2; HER-2; HER2;
                     l11Jus8; mKIAA3023; Neu"
                     /inference="alignment:Splign:2.1.0"
     exon            1829..1919
                     /gene="Erbb2"
                     /gene_synonym="c-erbB2; c-neu; Erbb-2; HER-2; HER2;
                     l11Jus8; mKIAA3023; Neu"
                     /inference="alignment:Splign:2.1.0"
     exon            1920..2080
                     /gene="Erbb2"
                     /gene_synonym="c-erbB2; c-neu; Erbb-2; HER-2; HER2;
                     l11Jus8; mKIAA3023; Neu"
                     /inference="alignment:Splign:2.1.0"
     exon            2081..2128
                     /gene="Erbb2"
                     /gene_synonym="c-erbB2; c-neu; Erbb-2; HER-2; HER2;
                     l11Jus8; mKIAA3023; Neu"
                     /inference="alignment:Splign:2.1.0"
     exon            2129..2267
                     /gene="Erbb2"
                     /gene_synonym="c-erbB2; c-neu; Erbb-2; HER-2; HER2;
                     l11Jus8; mKIAA3023; Neu"
                     /inference="alignment:Splign:2.1.0"
     exon            2268..2390
                     /gene="Erbb2"
                     /gene_synonym="c-erbB2; c-neu; Erbb-2; HER-2; HER2;
                     l11Jus8; mKIAA3023; Neu"
                     /inference="alignment:Splign:2.1.0"
     exon            2391..2489
                     /gene="Erbb2"
                     /gene_synonym="c-erbB2; c-neu; Erbb-2; HER-2; HER2;
                     l11Jus8; mKIAA3023; Neu"
                     /inference="alignment:Splign:2.1.0"
     exon            2490..2675
                     /gene="Erbb2"
                     /gene_synonym="c-erbB2; c-neu; Erbb-2; HER-2; HER2;
                     l11Jus8; mKIAA3023; Neu"
                     /inference="alignment:Splign:2.1.0"
     exon            2676..2831
                     /gene="Erbb2"
                     /gene_synonym="c-erbB2; c-neu; Erbb-2; HER-2; HER2;
                     l11Jus8; mKIAA3023; Neu"
                     /inference="alignment:Splign:2.1.0"
     exon            2832..2907
                     /gene="Erbb2"
                     /gene_synonym="c-erbB2; c-neu; Erbb-2; HER-2; HER2;
                     l11Jus8; mKIAA3023; Neu"
                     /inference="alignment:Splign:2.1.0"
     exon            2908..3054
                     /gene="Erbb2"
                     /gene_synonym="c-erbB2; c-neu; Erbb-2; HER-2; HER2;
                     l11Jus8; mKIAA3023; Neu"
                     /inference="alignment:Splign:2.1.0"
     exon            3055..3152
                     /gene="Erbb2"
                     /gene_synonym="c-erbB2; c-neu; Erbb-2; HER-2; HER2;
                     l11Jus8; mKIAA3023; Neu"
                     /inference="alignment:Splign:2.1.0"
     exon            3153..3341
                     /gene="Erbb2"
                     /gene_synonym="c-erbB2; c-neu; Erbb-2; HER-2; HER2;
                     l11Jus8; mKIAA3023; Neu"
                     /inference="alignment:Splign:2.1.0"
     exon            3342..3594
                     /gene="Erbb2"
                     /gene_synonym="c-erbB2; c-neu; Erbb-2; HER-2; HER2;
                     l11Jus8; mKIAA3023; Neu"
                     /inference="alignment:Splign:2.1.0"
     exon            3595..4998
                     /gene="Erbb2"
                     /gene_synonym="c-erbB2; c-neu; Erbb-2; HER-2; HER2;
                     l11Jus8; mKIAA3023; Neu"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      4542
                     /gene="Erbb2"
                     /gene_synonym="c-erbB2; c-neu; Erbb-2; HER-2; HER2;
                     l11Jus8; mKIAA3023; Neu"
                     /note="major polyA site"
     regulatory      4974..4979
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Erbb2"
                     /gene_synonym="c-erbB2; c-neu; Erbb-2; HER-2; HER2;
                     l11Jus8; mKIAA3023; Neu"
                     /note="hexamer: CATAAA"
     polyA_site      4998
                     /gene="Erbb2"
                     /gene_synonym="c-erbB2; c-neu; Erbb-2; HER-2; HER2;
                     l11Jus8; mKIAA3023; Neu"
ORIGIN      
        1 cgaggaagtg cggcgtgaag ttgtggagct gagattgccc gccgctgggg acccggagcc
       61 caggagcgcc ccttcccagg cggccccttc cggcgccgcg cctgtgcctg ccctcgccgc
      121 gccccgcgcc cgcagcctgg tccagcctga gccatggggc cggagccgca gtgatcatca
      181 tggagctggc ggcctggtgc cgttgggggt tcctcctcgc cctcctgtcc cccggagccg
      241 cgggtaccca agtgtgtacc ggtaccgaca tgaagttgcg actccctgcc agtcctgaga
      301 cccacctgga catgcttcgc cacctctacc agggctgtca ggtggtgcag ggcaatttgg
      361 agcttaccta cctgcccgcc aatgccagcc tctcattcct gcaggacatc caggaagtcc
      421 agggatacat gctcatcgct cacaaccgag tgaaacacgt cccactgcag aggttgcgca
      481 tcgtgagagg gactcagctc tttgaggaca agtatgccct ggctgtgcta gacaaccgag
      541 accctttgga caacgtcacc accgccgccc caggcagaac cccagaaggg ctgcgggagc
      601 tgcagcttcg aagtctcaca gagatcttga agggaggagt tttgatccgt gggaaccctc
      661 agctctgcta ccaggacatg gttttgtgga aggatgtcct ccgtaagaat aaccagctgg
      721 ctcctgtcga catggacacc aatcgttccc gggcctgtcc accttgtgcc ccaacctgca
      781 aagacaatca ctgttggggt gagagtcctg aagactgtca gatcttgact ggcaccatct
      841 gtactagtgg ctgtgcccgg tgcaagggcc ggctgcccac tgactgttgc catgagcagt
      901 gtgctgcagg ctgcacgggt cccaagcatt ctgactgcct ggcctgcctc cacttcaatc
      961 atagtggtat ctgtgagctg cactgcccgg ccctcatcac ctacaacaca gacaccttcg
     1021 agtccatgct caaccctgag ggtcgctaca cctttggtgc cagctgtgtg accacctgcc
     1081 cctacaacta cctctccacg gaagtgggat cctgcactct ggtctgtccc ccgaacaacc
     1141 aagaggtcac agctgaggac ggaacacagc ggtgtgagaa atgcagcaag ccctgtgctg
     1201 gagtatgcta tggtctgggc atggagcacc tccgaggggc gagggccatc accagtgaca
     1261 atatccagga gtttgctggc tgcaagaaga tctttgggag cctggcattt ttgccggaga
     1321 gctttgatgg gaacccctcc tccggcgttg ccccactgaa gccagagcat ctccaagtgt
     1381 tcgaaaccct ggaggagatc acaggttacc tatacatttc agcatggcca gagagcttcc
     1441 aagacctcag tgtcttccag aaccttcggg tcattcgggg acggattctc catgatggtg
     1501 cttactcatt gacgttgcaa ggcctgggga ttcactcact ggggctacgc tcactgcggg
     1561 agctgggcag tggattggct ctcattcacc gcaacaccca tctctgcttt gtaaacactg
     1621 taccttggga ccagctcttc cggaacccgc accaggccct actccacagt gggaaccggc
     1681 cagaagaggc atgtggtctt gagggcttgg tctgtaactc actgtgtgcc cgtgggcact
     1741 gctgggggcc agggcccacc cagtgtgtca actgcagtca gttcctccgg ggccaggagt
     1801 gtgtggagga gtgccgagta tggaaggggc tccccaggga gtatgtgagg ggcaagcact
     1861 gtctgccatg ccaccccgag tgtcagcctc aaaacagctc ggagacctgc tatggatcgg
     1921 aggctgacca gtgtgaggct tgtgcccact acaaggactc atcttcctgt gtggctcgct
     1981 gccccagtgg tgtgaagcca gacctctcct acatgcctat ctggaagtac ccggatgagg
     2041 agggcatatg tcagccatgc cccatcaact gcacccactc atgtgtggac ctggacgaac
     2101 gaggctgccc agcagagcag agagccagcc cagtgacatt catcattgca actgtggtgg
     2161 gcgtcctgtt gttcctgatc atagtggtgg tcattggaat cctaatcaaa cgaaggcgac
     2221 agaagatccg gaagtatacc atgcgtaggc tgctgcagga gaccgagctg gtggagccgc
     2281 tgacgcccag tggagctgtg cccaaccagg ctcagatgcg gatcctaaag gagacagagc
     2341 taaggaagct gaaggtgctt gggtcaggag ccttcggcac tgtctacaag ggcatctgga
     2401 tcccagatgg ggagaacgtg aaaatccccg tggccatcaa ggtgttgagg gaaaacacat
     2461 ctcctaaagc taacaaagaa atcctagatg aagcgtacgt catggctggt gtgggttctc
     2521 catatgtgtc ccgcctcctg ggcatctgcc tgacatccac agtgcagctg gtgacacagc
     2581 ttatgcccta tggctgcctt ctggaccatg tccgagaaca ccgaggtcgc ttaggctccc
     2641 aggacctgct caactggtgt gttcagattg ccaaggggat gagctacctg gaggaagttc
     2701 ggcttgttca cagggaccta gctgcccgaa acgtgctagt caagagtccc aaccacgtca
     2761 agattaccga cttcgggctg gcacggctgc tggacattga tgagactgaa taccatgcag
     2821 atgggggcaa ggtgcccatc aagtggatgg cattggaatc tattctcaga cgccggttca
     2881 cccatcagag tgatgtgtgg agctatggtg tgactgtgtg ggagctgatg acctttgggg
     2941 ccaaacctta cgatgggatc ccagctcggg agatccctga tttgctggag aagggagaac
     3001 gcctacctca gcctccaatc tgcaccatcg acgtctacat gatcatggtc aaatgttgga
     3061 tgattgactc cgaatgtcgc ccgagattcc gggagttggt atcagaattc tcccgtatgg
     3121 caagggaccc ccagcgcttt gtggtcatcc agaacgagga cttaggcccc tccagcccca
     3181 tggacagcac cttctaccgt tcactgctgg aggatgatga catgggggag ctggtcgatg
     3241 ctgaagagta cctggtaccc cagcagggat tcttctcccc agaccctgcc ctaggtactg
     3301 ggagcacagc ccaccgcaga caccgcagct cgtcggccag gagtggcggt ggtgagctga
     3361 cactgggcct ggagccctcg gaagaagagc cccccagatc tccactggct ccctccgaag
     3421 gggctggctc cgatgtgttt gatggtgacc tggcagtggg ggtaaccaaa ggactgcaga
     3481 gcctctctcc acatgacctc agccctctac agcggtacag tgaggatccc acattacctc
     3541 tgccccccga gactgatggc tacgttgctc ccctggcctg cagcccccag cccgagtatg
     3601 tgaaccagcc agaggttcgg cctcagtctc ccttgacccc agagggtcct ccgcctccca
     3661 tccgacctgc tggtgctact ctagaaagac ccaagactct ctctcctggg aaaaatgggg
     3721 ttgtcaaaga cgtttttgcc tttgggggtg ctgtggagaa ccctgaatac ttagcaccca
     3781 gagcaggcac tgcctctcag ccccaccctt ctcctgcctt cagcccagcc tttgacaacc
     3841 tctattactg ggaccagaac tcatcggagc agggtcctcc accaagtacc tttgaaggga
     3901 cccccactgc agagaaccct gagtacctag gcctggatgt gccagtatga ggtcacatgt
     3961 gcagacatcc tctgtcttca gagtggggaa ggaaggccta acttgtggtc tccatcgccc
     4021 gccacaaagc agggagaagg tcctctggcc acatgacatc cagggcagcc ggctatgcca
     4081 ggaacgtgcc ctgaggaacc tcgctcgatg cttcaatcct gagtggttaa gagggccccg
     4141 cctggccgga agagacagca cactgttcag ccccagagga ttacagaccc tgactgccct
     4201 gacagactgt agggtccagt gggtattcct tacctggcct ggctctcttg gttctgaaga
     4261 ctgagggaag ctcagcctgc aagggaggag gccccaggtg aatatcctgg gagcaggaca
     4321 ccccactagg actgaggcac gtgcatccca agagggggac agcacttgca cccagactgg
     4381 tctttgtaca gagtttattt tgttctgttt ttacttttgt tttttgtttt ttttttaaag
     4441 atgaaataag gatacagtgg gagagtgggt gttatatgaa agtcgggggg tgctgtcccc
     4501 tttctccatt tgcaatgaga tttgtaaaat aactggaccc cagcctatgt ctgagagtgg
     4561 tcccgggccg ggtcaaaccg tattgctcat ctgacacaca gctcctcctg gagtgagtgt
     4621 gtagagatct tccaaaagtt tgagacaatt tggctttggg cttgagggac tggggagtta
     4681 ggattccttc tgaaggccct ttggcaacag ggtcattctc cgttggacac actcatacca
     4741 aggctacccc cagaatactc cgttggacac actcattcca aggctacccc cagaatgaag
     4801 tcctgtcctc ccagtgggag aggggagctt gtggagagca ttgccatgtg acttgttttc
     4861 cttgccttag aaagaagtat ccatccagga aaaccccacc cactaggtgt tagtcccacc
     4921 cactaggtgt tagcagggcc agactgacct gtgtgccccc cgcacaggct ggacataaac
     4981 acacgccagt tgacacaa
//
