LOCUS       NM_181548               1077 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus ES cell-expressed Ras (Eras), mRNA.
ACCESSION   NM_181548
VERSION     NM_181548.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1077)
  AUTHORS   Zhu,Z., Zou,Q., Wang,C., Li,D., Yang,Y., Xiao,Y., Jin,Y., Yan,J.,
            Luo,L., Sun,Y. and Liang,X.
  TITLE     Isl Identifies the Extraembryonic Mesodermal/Allantois Progenitors
            and is Required for Placenta Morphogenesis and Vasculature
            Formation
  JOURNAL   Adv Sci (Weinh) 11 (32), e2400238 (2024)
   PUBMED   38923264
REFERENCE   2  (bases 1 to 1077)
  AUTHORS   Gordeeva,O., Gordeev,A. and Khaydukov,S.
  TITLE     Expression dynamics of Mage family genes during self-renewal and
            differentiation of mouse pluripotent stem and teratocarcinoma cells
  JOURNAL   Oncotarget 10 (35), 3248-3266 (2019)
   PUBMED   31143371
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1077)
  AUTHORS   Suarez-Cabrera,C., de la Pena,B., Gonzalez,L.L., Page,A.,
            Martinez-Fernandez,M., Casanova,M.L., Paramio,J.M.,
            Rojo-Sebastian,A., Moreno-Bueno,G., Maroto,A., Ramirez,A. and
            Navarro,M.
  TITLE     The Ras-related gene ERAS is involved in human and murine breast
            cancer
  JOURNAL   Sci Rep 8 (1), 13038 (2018)
   PUBMED   30158566
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1077)
  AUTHORS   Newlaczyl,A.U., Coulson,J.M. and Prior,I.A.
  TITLE     Quantification of spatiotemporal patterns of Ras isoform expression
            during development
  JOURNAL   Sci Rep 7, 41297 (2017)
   PUBMED   28117393
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1077)
  AUTHORS   Zhao,Z.A., Yu,Y., Ma,H.X., Wang,X.X., Lu,X., Zhai,Y., Zhang,X.,
            Wang,H. and Li,L.
  TITLE     The roles of ERAS during cell lineage specification of mouse early
            embryonic development
  JOURNAL   Open Biol 5 (8) (2015)
   PUBMED   26269429
  REMARK    GeneRIF: ERAS may also play important roles in cell lineage
            specification during mouse early embryonic development.
REFERENCE   6  (bases 1 to 1077)
  AUTHORS   Lee,M.Y., Lee,S.H., Park,J.H. and Han,H.J.
  TITLE     Interaction of galectin-1 with caveolae induces mouse embryonic
            stem cell proliferation through the Src, ERas, Akt and mTOR
            signaling pathways
  JOURNAL   Cell Mol Life Sci 66 (8), 1467-1478 (2009)
   PUBMED   19266163
  REMARK    GeneRIF: galectin-1 increased DNA synthesis in mouse ES cells via
            Src, caveolin-1 Akt, and mTOR signaling pathways
REFERENCE   7  (bases 1 to 1077)
  AUTHORS   Miyamoto,S., Yasui,Y., Kim,M., Sugie,S., Murakami,A.,
            Ishigamori-Suzuki,R. and Tanaka,T.
  TITLE     A novel rasH2 mouse carcinogenesis model that is highly susceptible
            to 4-NQO-induced tongue and esophageal carcinogenesis is useful for
            preclinical chemoprevention studies
  JOURNAL   Carcinogenesis 29 (2), 418-426 (2008)
   PUBMED   18174262
  REMARK    GeneRIF: rasH2 may have a role in susceptibility to
            chemically-induced tongue and esophageal neoplasms
REFERENCE   8  (bases 1 to 1077)
  AUTHORS   Takahashi,K., Nakagawa,M., Young,S.G. and Yamanaka,S.
  TITLE     Differential membrane localization of ERas and Rheb, two
            Ras-related proteins involved in the phosphatidylinositol
            3-kinase/mTOR pathway
  JOURNAL   J Biol Chem 280 (38), 32768-32774 (2005)
   PUBMED   16046393
  REMARK    GeneRIF: ERas and Rheb are two Ras-related proteins involved in the
            phosphatidylinositol 3-kinase/mTOR pathway; ERas is localized at
            the plasma membrane, while Rheb is on endomembranes.
REFERENCE   9  (bases 1 to 1077)
  AUTHORS   Mitsui,K., Tokuzawa,Y., Itoh,H., Segawa,K., Murakami,M.,
            Takahashi,K., Maruyama,M., Maeda,M. and Yamanaka,S.
  TITLE     The homeoprotein Nanog is required for maintenance of pluripotency
            in mouse epiblast and ES cells
  JOURNAL   Cell 113 (5), 631-642 (2003)
   PUBMED   12787504
REFERENCE   10 (bases 1 to 1077)
  AUTHORS   Takahashi,K., Mitsui,K. and Yamanaka,S.
  TITLE     Role of ERas in promoting tumour-like properties in mouse embryonic
            stem cells
  JOURNAL   Nature 423 (6939), 541-545 (2003)
   PUBMED   12774123
  REMARK    GeneRIF: transforming oncogene ERas is important in the tumour-like
            growth properties of embryonic stem cells
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AB093573.1.
            
            On Jun 11, 2003 this sequence version replaced NM_181548.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB093573.1, BC119277.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1077
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 3.58 cM"
     gene            1..1077
                     /gene="Eras"
                     /gene_synonym="ecat5; Ha-Ras2; HRAS2; HRasp"
                     /note="ES cell-expressed Ras"
                     /db_xref="GeneID:353283"
                     /db_xref="MGI:MGI:2665023"
     exon            1..139
                     /gene="Eras"
                     /gene_synonym="ecat5; Ha-Ras2; HRAS2; HRasp"
                     /inference="alignment:Splign:2.1.0"
     exon            140..1077
                     /gene="Eras"
                     /gene_synonym="ecat5; Ha-Ras2; HRAS2; HRasp"
                     /inference="alignment:Splign:2.1.0"
     CDS             178..861
                     /gene="Eras"
                     /gene_synonym="ecat5; Ha-Ras2; HRAS2; HRasp"
                     /EC_number="3.6.5.2"
                     /note="small GTPase E-Ras; embryonic stem cell-expressed
                     Ras"
                     /codon_start=1
                     /product="GTPase ERas"
                     /protein_id="NP_853526.1"
                     /db_xref="CCDS:CCDS29980.1"
                     /db_xref="GeneID:353283"
                     /db_xref="MGI:MGI:2665023"
                     /translation="MALPTKSSILDLSSGTPCTRSPEESHEAWAQCKDAGRQLPEYKA
                     VVVGASGVGKSALTIQMTHQCFVKDHDPTIQDSYWKEVARDNGGYILNVLDTSGQDIH
                     RALRDQCLASGDGVLGVFALDDPSSLDQLQQIWSTWTPHHKQPLVLVGNKCDLVTTAG
                     DAHAAAALLAHKLGAPLVKTSAKTRQGVEEAFALLVHEIQRAQEAVAESSKKTRHQKA
                     VCSCGCSVA"
ORIGIN      
        1 caggggtcgg gcaggtggga gggggaagct cacatctccg ccctctgctg cctctggggg
       61 tagggagcat cctaaccccc aactgtccgg tcagatccgc ctactgcccc tcatcagact
      121 gctactcctg ggagcacagc acctgctctt tacacctctt ccttgagctg ctggggaatg
      181 gctttgccta caaagtctag catcttggac ctgagctccg gcaccccatg caccagatct
      241 ccagaggaaa gtcacgaggc ttgggcacag tgcaaagatg ctggcaggca gctacccgag
      301 tacaaggcag tggtggtggg tgcaagtggt gttggtaaaa gtgctctcac catccagatg
      361 actcaccaat gcttcgtgaa agaccatgac cccactatcc aagattccta ctggaaggaa
      421 gtggccaggg acaacggagg ctacattcta aatgttctgg atacatctgg gcaggatatt
      481 caccgggctc tgcgtgacca gtgcttggca tctggtgatg gtgtgctggg cgtctttgct
      541 cttgacgacc cctcgtctct ggaccagttg cagcagatat ggtccacctg gacccctcac
      601 cacaagcagc ctctggtact agtgggcaac aagtgtgacc tggtgaccac tgctggagat
      661 gctcatgctg ccgcagccct ccttgctcac aagttggggg cccccttggt gaagacctca
      721 gccaagacgc ggcaaggtgt ggaggaagcc tttgccctgc ttgtccatga gattcagagg
      781 gcccaggagg ctgtggccga atcaagcaag aagacccgac accagaaagc cgtgtgtagc
      841 tgtggctgct ctgtagcctg aagatctttg tctagcaaat tgacccttgt ctcatgtcaa
      901 ggtgacaatt ctcttgtaat aagatttccc tctccgacca agttaccaca gacatctttt
      961 tattgtcatt tggtgagaag ttacgtggta acatgggaca tccctcattg actgtgtttt
     1021 atgaaactct atgcaaaatt aaataaatgt tctcaggatt caaagcttcc tttatac
//
