LOCUS       NM_030711               5363 bp    mRNA    linear   ROD 12-NOV-2023
DEFINITION  Mus musculus endoplasmic reticulum aminopeptidase 1 (Erap1), mRNA.
ACCESSION   NM_030711
VERSION     NM_030711.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5363)
  AUTHORS   Ryu HM, Islam SMS, Sayeed HM, Babita R, Seong JK, Lee H and Sohn S.
  TITLE     Characterization of immune responses associated with ERAP-1
            expression in HSV-induced Behcet's disease mouse model
  JOURNAL   Clin Immunol 250, 109305 (2023)
   PUBMED   37003592
  REMARK    GeneRIF: Characterization of immune responses associated with
            ERAP-1 expression in HSV-induced Behcet's disease mouse model.
REFERENCE   2  (bases 1 to 5363)
  AUTHORS   Geiger KM, Manoharan M, Coombs R, Arana K, Park CS, Lee AY, Shastri
            N, Robey EA and Coscoy L.
  TITLE     Murine cytomegalovirus downregulates ERAAP and induces an
            unconventional T cell response to self
  JOURNAL   Cell Rep 42 (4), 112317 (2023)
   PUBMED   36995940
  REMARK    GeneRIF: Murine cytomegalovirus downregulates ERAAP and induces an
            unconventional T cell response to self.
REFERENCE   3  (bases 1 to 5363)
  AUTHORS   Niu Y, Jiang H, Yin H, Wang F, Hu R, Hu X, Peng B, Shu Y, Li Z,
            Chen S and Guo F.
  TITLE     Hepatokine ERAP1 Disturbs Skeletal Muscle Insulin Sensitivity Via
            Inhibiting USP33-Mediated ADRB2 Deubiquitination
  JOURNAL   Diabetes 71 (5), 921-933 (2022)
   PUBMED   35192681
REFERENCE   4  (bases 1 to 5363)
  AUTHORS   Blake MK, O'Connell P, Pepelyayeva Y, Godbehere S, Aldhamen YA and
            Amalfitano A.
  TITLE     ERAP1 is a critical regulator of inflammasome-mediated
            proinflammatory and ER stress responses
  JOURNAL   BMC Immunol 23 (1), 9 (2022)
   PUBMED   35246034
  REMARK    GeneRIF: ERAP1 is a critical regulator of inflammasome-mediated
            proinflammatory and ER stress responses.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5363)
  AUTHORS   O'Connell P, Blake MK, Godbehere S, Aldhamen YA and Amalfitano A.
  TITLE     Absence of ERAP1 in B Cells Increases Susceptibility to Central
            Nervous System Autoimmunity, Alters B Cell Biology, and
            Mechanistically Explains Genetic Associations between ERAP1 and
            Multiple Sclerosis
  JOURNAL   J Immunol 207 (12), 2952-2965 (2021)
   PUBMED   34810226
  REMARK    GeneRIF: Absence of ERAP1 in B Cells Increases Susceptibility to
            Central Nervous System Autoimmunity, Alters B Cell Biology, and
            Mechanistically Explains Genetic Associations between ERAP1 and
            Multiple Sclerosis.
REFERENCE   6  (bases 1 to 5363)
  AUTHORS   Yan J, Parekh VV, Mendez-Fernandez Y, Olivares-Villagomez D,
            Dragovic S, Hill T, Roopenian DC, Joyce S and Van Kaer L.
  TITLE     In vivo role of ER-associated peptidase activity in tailoring
            peptides for presentation by MHC class Ia and class Ib molecules
  JOURNAL   J Exp Med 203 (3), 647-659 (2006)
   PUBMED   16505142
REFERENCE   7  (bases 1 to 5363)
  AUTHORS   Hammer GE, Gonzalez F, Champsaur M, Cado D and Shastri N.
  TITLE     The aminopeptidase ERAAP shapes the peptide repertoire displayed by
            major histocompatibility complex class I molecules
  JOURNAL   Nat Immunol 7 (1), 103-112 (2006)
   PUBMED   16299505
REFERENCE   8  (bases 1 to 5363)
  AUTHORS   Yamazaki T, Akada T, Niizeki O, Suzuki T, Miyashita H and Sato Y.
  TITLE     Puromycin-insensitive leucyl-specific aminopeptidase (PILSAP) binds
            and catalyzes PDK1, allowing VEGF-stimulated activation of S6K for
            endothelial cell proliferation and angiogenesis
  JOURNAL   Blood 104 (8), 2345-2352 (2004)
   PUBMED   15187024
REFERENCE   9  (bases 1 to 5363)
  AUTHORS   Serwold T, Gonzalez F, Kim J, Jacob R and Shastri N.
  TITLE     ERAAP customizes peptides for MHC class I molecules in the
            endoplasmic reticulum
  JOURNAL   Nature 419 (6906), 480-483 (2002)
   PUBMED   12368856
  REMARK    GeneRIF: identification of ERAAP, the aminopeptidase associated
            with antigen processing in the endoplasmic reticulum (ERAAP)
REFERENCE   10 (bases 1 to 5363)
  AUTHORS   Miyashita H, Yamazaki T, Akada T, Niizeki O, Ogawa M, Nishikawa S
            and Sato Y.
  TITLE     A mouse orthologue of puromycin-insensitive leucyl-specific
            aminopeptidase is expressed in endothelial cells and plays an
            important role in angiogenesis
  JOURNAL   Blood 99 (9), 3241-3249 (2002)
   PUBMED   11964289
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC138120.3.
            
            [WARNING] On Dec 20, 2023 this sequence was replaced by
            NM_030711.6.
            
            On Apr 14, 2018 this sequence version replaced NM_030711.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK036559.1, AK030329.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-41                AC138120.3         113836-113876
            42-585              AC138120.3         120154-120697
            586-724             AC138120.3         131616-131754
            725-859             AC138120.3         134253-134387
            860-980             AC138120.3         136292-136412
            981-1135            AC138120.3         137392-137546
            1136-1249           AC138120.3         138092-138205
            1250-1381           AC138120.3         140082-140213
            1382-1513           AC138120.3         140427-140558
            1514-1585           AC138120.3         140701-140772
            1586-1740           AC138120.3         141941-142095
            1741-1820           AC138120.3         143383-143462
            1821-2004           AC138120.3         145291-145474
            2005-2161           AC138120.3         146727-146883
            2162-2346           AC138120.3         147578-147762
            2347-2508           AC138120.3         148605-148766
            2509-2649           AC138120.3         149246-149386
            2650-2731           AC138120.3         149808-149889
            2732-5363           AC138120.3         164557-167188
FEATURES             Location/Qualifiers
     source          1..5363
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 40.48 cM"
     gene            1..5363
                     /gene="Erap1"
                     /gene_synonym="A-LAP; ARTS-1; Arts1; ERAAP; PILSA; PILSAP"
                     /note="endoplasmic reticulum aminopeptidase 1"
                     /db_xref="GeneID:80898"
                     /db_xref="MGI:MGI:1933403"
     exon            1..41
                     /gene="Erap1"
                     /gene_synonym="A-LAP; ARTS-1; Arts1; ERAAP; PILSA; PILSAP"
                     /inference="alignment:Splign:2.1.0"
     exon            42..585
                     /gene="Erap1"
                     /gene_synonym="A-LAP; ARTS-1; Arts1; ERAAP; PILSA; PILSAP"
                     /inference="alignment:Splign:2.1.0"
     CDS             95..2887
                     /gene="Erap1"
                     /gene_synonym="A-LAP; ARTS-1; Arts1; ERAAP; PILSA; PILSAP"
                     /note="type 1 tumor necrosis factor receptor shedding
                     aminopeptidase regulator; adipocyte-derived leucine
                     aminopeptidase; aminopeptidase PILS; VEGF-induced
                     aminopeptidase; puromycin-insensitive leucyl-specific
                     aminopeptidase"
                     /codon_start=1
                     /product="endoplasmic reticulum aminopeptidase 1
                     precursor"
                     /protein_id="NP_109636.1"
                     /db_xref="CCDS:CCDS26647.1"
                     /db_xref="GeneID:80898"
                     /db_xref="MGI:MGI:1933403"
                     /translation="MPSLLPLVLTFLSVSSPSWCQNSDIESLKASNGDSFPWNNMRLP
                     EYMTPIHYDLMIHANLSTLTFWGKTEVEIIASRPTSTIIMHSHHLQISKATLRRGAGE
                     MLSEEPLKVLEYPAHEQVALLAAQPLLAGSLYTVIIDYAANLSESFHGFYKSTYRTQE
                     GEMRILAATQFEPTAARMAFPCFDEPALKASFSIKIKRDPRHLAISNMPLVKSVNVAE
                     GLIEDHFDITVKMSTYLVAFIISDFKSVSKMTKSGVKVSVYAVPDKINQADYALDAAV
                     TLLEFYEDYFNIPYPLPKQDLAAIPDFQSGAMENWGLTTYRESSLLYDKEKSSASSKL
                     GITMIVSHELAHQWFGNLVTMEWWNDLWLNEGFAKFMEFVSVTVTHPELKVEDYFFGK
                     CFNAMEVDALNSSHPVSTPVENPAQIREMFDDVSYEKGACILNMLRDYLSADTFKRGI
                     VQYLQKYSYKNTKNEDLWNSMMHICPTDGTQTMDGFCSRSQHSSSTSHWRQEVVDVKT
                     MMNTWTLQKGFPLITITVSGRNVHMKQEHYMKGSERFPETGYLWHVPLTFITSKSDSV
                     QRFLLKTKTDVLILPEAVQWIKFNVGMNGYYIVHYADDGWASLSGLLKEAHTTISSND
                     RASLINNAFQLVSIEKLSIEKALDLTLYLKNETEIMPIFQALNELIPMYKLMEKRDMI
                     EVETQFKDFLLKLLKDLIDKQTWTDEGSVSERMLRSQLLLLACVRNYQPCVQRAERYF
                     REWKSSNGNMSIPIDVTLAVFAVGAQNTEGWDFLYSKYQSSLSSTEKSQIEFSLCTSK
                     DPEKLQWLLDQSFKGEIIKTQEFPHILTLIGRNPVGYPLAWKFLRENWNKLVQKFELG
                     SSSIAHMVMGTTDQFSTRARLEEVKGFFSSLKENGSQLRCVQQTIETIEENIRWMDKN
                     FDKIRLWLQKEKPELL"
     exon            586..724
                     /gene="Erap1"
                     /gene_synonym="A-LAP; ARTS-1; Arts1; ERAAP; PILSA; PILSAP"
                     /inference="alignment:Splign:2.1.0"
     exon            725..859
                     /gene="Erap1"
                     /gene_synonym="A-LAP; ARTS-1; Arts1; ERAAP; PILSA; PILSAP"
                     /inference="alignment:Splign:2.1.0"
     exon            860..980
                     /gene="Erap1"
                     /gene_synonym="A-LAP; ARTS-1; Arts1; ERAAP; PILSA; PILSAP"
                     /inference="alignment:Splign:2.1.0"
     exon            981..1135
                     /gene="Erap1"
                     /gene_synonym="A-LAP; ARTS-1; Arts1; ERAAP; PILSA; PILSAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1136..1249
                     /gene="Erap1"
                     /gene_synonym="A-LAP; ARTS-1; Arts1; ERAAP; PILSA; PILSAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1250..1381
                     /gene="Erap1"
                     /gene_synonym="A-LAP; ARTS-1; Arts1; ERAAP; PILSA; PILSAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1382..1513
                     /gene="Erap1"
                     /gene_synonym="A-LAP; ARTS-1; Arts1; ERAAP; PILSA; PILSAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1514..1585
                     /gene="Erap1"
                     /gene_synonym="A-LAP; ARTS-1; Arts1; ERAAP; PILSA; PILSAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1586..1740
                     /gene="Erap1"
                     /gene_synonym="A-LAP; ARTS-1; Arts1; ERAAP; PILSA; PILSAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1741..1820
                     /gene="Erap1"
                     /gene_synonym="A-LAP; ARTS-1; Arts1; ERAAP; PILSA; PILSAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1821..2004
                     /gene="Erap1"
                     /gene_synonym="A-LAP; ARTS-1; Arts1; ERAAP; PILSA; PILSAP"
                     /inference="alignment:Splign:2.1.0"
     exon            2005..2161
                     /gene="Erap1"
                     /gene_synonym="A-LAP; ARTS-1; Arts1; ERAAP; PILSA; PILSAP"
                     /inference="alignment:Splign:2.1.0"
     exon            2162..2346
                     /gene="Erap1"
                     /gene_synonym="A-LAP; ARTS-1; Arts1; ERAAP; PILSA; PILSAP"
                     /inference="alignment:Splign:2.1.0"
     exon            2347..2508
                     /gene="Erap1"
                     /gene_synonym="A-LAP; ARTS-1; Arts1; ERAAP; PILSA; PILSAP"
                     /inference="alignment:Splign:2.1.0"
     exon            2509..2649
                     /gene="Erap1"
                     /gene_synonym="A-LAP; ARTS-1; Arts1; ERAAP; PILSA; PILSAP"
                     /inference="alignment:Splign:2.1.0"
     exon            2650..2731
                     /gene="Erap1"
                     /gene_synonym="A-LAP; ARTS-1; Arts1; ERAAP; PILSA; PILSAP"
                     /inference="alignment:Splign:2.1.0"
     exon            2732..5363
                     /gene="Erap1"
                     /gene_synonym="A-LAP; ARTS-1; Arts1; ERAAP; PILSA; PILSAP"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 actttcggtc ccgggcggcc agactggcgg ctgtgatgaa ggtaatttga gcaagaagat
       61 agtgtctctg ctcctcaaat agccacttgc aagcatgccc tctcttcttc ccctagtatt
      121 gacattttta tctgtgtcat ctccttcttg gtgtcagaac agtgatatag aatctctaaa
      181 agctagtaat ggagactcat tcccttggaa taatatgcga cttcctgagt atatgacccc
      241 gattcattat gatctcatga tccatgcaaa cctcagcact ctgactttct ggggaaaaac
      301 agaagtagaa atcatagcta gccggcccac cagcaccatt attatgcata gtcaccacct
      361 gcaaatatct aaggccaccc tcagaagagg agctggagag atgctgtctg aagaaccact
      421 gaaggtcctg gaatatcctg ctcatgagca agttgcactg ctggctgccc agccgcttct
      481 tgctgggtcc ctgtacacag ttatcatcga ctatgctgcc aacctgtctg agagtttcca
      541 tggattctat aagagcacct acagaacaca ggaaggtgaa atgagaatac ttgcagcaac
      601 acagtttgaa cccacagctg ctagaatggc ttttccctgc tttgatgaac ctgccctcaa
      661 ggcaagtttt tccatcaaga taaagaggga tccaaggcac ctggccatct ccaacatgcc
      721 cctggtgaaa tctgtgaatg ttgctgaagg actcatagaa gaccattttg acatcactgt
      781 gaagatgagt acctacctag tggccttcat catttctgat tttaagtctg tgagcaagat
      841 gactaagagt ggagtcaagg tttctgtgta tgctgtgcca gacaagataa atcaagccga
      901 ttatgctctg gatgctgcag tgactcttct agagttttat gaggattatt tcaacattcc
      961 atatccttta cccaagcaag atcttgctgc aatcccagac tttcagtctg gtgctatgga
     1021 aaactgggga ctgaccacat acagagagtc ctctctgtta tacgataaag aaaagtcttc
     1081 tgcatctagt aagcttggca tcacaatgat tgtgtcccat gaactggctc accagtggtt
     1141 cgggaacctg gtcaccatgg aatggtggaa tgacctttgg ctcaatgaag gatttgccaa
     1201 atttatggag tttgtgtctg tcactgtgac ccatcctgaa ctaaaagttg aagactattt
     1261 ctttggcaag tgttttaatg caatggaagt tgatgcatta aactcctctc accctgtatc
     1321 cacacctgtg gagaatcctg cgcagattcg ggagatgttt gatgatgttt cttatgaaaa
     1381 gggagcttgt attctgaata tgctaagaga ttatctgagt gcagatacat ttaaaagagg
     1441 aattgtacag tatctccaaa agtatagtta taaaaacaca aaaaacgagg acctgtggaa
     1501 tagcatgatg catatttgcc ctacagatgg cacacaaaca atggatggct tctgctctag
     1561 aagccaacac tcatcatcaa cctcacactg gcgtcaggag gttgtagatg taaagaccat
     1621 gatgaacaca tggacactgc agaagggctt tcctctgata accatcactg tgagtgggcg
     1681 gaatgtgcac atgaagcaag aacactacat gaagggttca gaacgcttcc cagagactgg
     1741 gtatttgtgg catgttccac tgacattcat taccagcaaa tcagactcag tccagagatt
     1801 tttgctgaag acaaagacag atgtgctcat cctcccagaa gcagtgcagt ggatcaaatt
     1861 taacgtggga atgaatggct attacattgt gcattacgcg gatgatggat gggcttctct
     1921 gagtggcctt ttaaaagaag cgcacacaac aatcagcagt aatgatcggg caagtctcat
     1981 caacaatgca tttcagctgg tcagcattga aaagttatca atagaaaaag ccctggattt
     2041 aaccctgtac ttgaaaaatg aaactgaaat tatgcccata ttccaagctt tgaatgaact
     2101 catacctatg tataagttaa tggagaaaag agatatgatt gaggtggaaa ctcaatttaa
     2161 ggacttcctt ctcaagttgc tgaaggacct tattgataag cagacttgga cagatgaagg
     2221 ctctgtctca gagaggatgc tcaggagcca gctcctcctc ctcgcatgtg tgcgcaatta
     2281 tcagccctgt gtgcagaggg cagagcgcta tttcagagag tggaagtcat ctaatggaaa
     2341 catgagcatc cctattgatg tgaccttggc tgtgtttgct gtcggggccc aaaacacaga
     2401 aggctgggat tttctttata gtaaatatca gtcttctttg tctagtactg agaaaagcca
     2461 aattgaattt tccctctgta caagcaaaga tccagaaaaa cttcagtggc ttctagatca
     2521 aagttttaag ggagagataa taaaaactca ggaatttcca catattctca cactcattgg
     2581 cagaaaccca gtgggttatc cattggcctg gaagtttctg agggaaaatt ggaataagct
     2641 tgtacagaaa tttgaacttg gctcatcgtc catagctcac atggtaatgg gaacaacaga
     2701 ccagttttcc accagagcac gtcttgaaga ggtaaaagga ttcttcagtt ccttgaaaga
     2761 aaacggttct cagctccgtt gtgttcaaca aaccattgag accattgaag aaaacatacg
     2821 atggatggat aagaattttg ataaaataag actgtggctg caaaaagaaa agccagagtt
     2881 gctgtgacaa tatgtttctt gccaagttcc agaatttatg atgagcaaaa ttttgttcaa
     2941 tttgagtatt tttaaactaa agatagttgt tttggctact actgaagata ttttcttatt
     3001 tcatttcact tgattatgtc tgagaaaagc ttcaatgact gtgattgaca ggtttaaacc
     3061 caagtgccca gctccttgcc acagaaaaac ccagggggct tcttctcagt ttatacttca
     3121 gcttctgtgt cggccattca tcagtatttt tgtaagactg aatagtgagg cataactgtg
     3181 cagtgaatgc ttggctcctt agccatgctg ggaagtggct gtgcagcagc cctcctgttg
     3241 acctctctgg ctctacagtc ctgcagtctc tcttcctggg ttcacttatg ggtgctgcct
     3301 tgcaggatcc acttaatcag acacttttgc cctctggatt ttgttaatag tgtttggtag
     3361 ttgttatcca tgagggattg catagaggtg tttattttct tgtacttgcc tctggctggc
     3421 tttcaaccac cgtaagtctt actcctaaga ggtggccttt cccccccccc cccccccgca
     3481 ctctgataac tacttccttt tcatcctttg gggcatgggg caacagtgga aacctgctga
     3541 taccagtcat ggtagtactt gtcattttca ctgaacctac gtgcacattt gtttttaaaa
     3601 atattgtata tctataaccc tcgttggata agtcaaatat gagagccact tactttcttt
     3661 ggaaggttat ttttaaaaat gcagagtgca ttcagatctg tatcagaaat atctcgtttt
     3721 aagatatact tgtgagtcac tgatccctta agtagggagt agggttgtaa attcctaaat
     3781 aactcataat agcacttact gaaaataaat cattgaggac tcactaacaa aggacaatat
     3841 taataatatg tttatattag tataaggaaa gattctttaa atcttaaaaa gatttttttg
     3901 atgtatggca taaatgatag gaaaaatatc aacatatggt gctgtaatat actatgaaat
     3961 aaagcgattt taggggttca attatatttt cactggccta ccaaaatact tgagattaaa
     4021 tgaggaaaga ttttagttga tggcttgttg gctctgttat taaaggcctg tggtgagaca
     4081 ctatggctac cataacaggt atcagggaag aatgtttatc cagtattggc cagaaaacaa
     4141 aacaagagcc agatagaagt ctggggacac agtgtactgg tcaaagccat actcccacag
     4201 actgggtcta cttcttcaat tacacctacc caccattcaa gcatgaatca tcagtgaatt
     4261 ggtgacagca aatggattaa tccactaagg agctcagccc ttatggtcag tctcctctgt
     4321 tactattacc accaggtggg agccaagact tcaacacacg agctcgcttg gggggggggg
     4381 gcactttata tctaatcccc aacagatgtg tttatagttc catttttata ttaacttcat
     4441 ctgacagctt gaaaatagaa aatgattcac tggtaatttt ttttccccag actacatata
     4501 aaataaaaca catagccaag aacttcatgt aaaatatttt cctttaattg aattttatat
     4561 cttaattaat gaaacacaaa tactgatttt tgttttggtc accttcactt ttggaaaagc
     4621 ccattttcta aacagataaa atattacata tgcagcaact ttttgtaata aaaaccatct
     4681 gttctttact tctaaggcaa tatctgcaat tgttttcacc tgactaggat tttaaaagta
     4741 aacaatagaa aagaataaaa aggattcctt tagatcctat ggcatatgca agtcactgtg
     4801 agttaccagc aaacactgaa gtcttgagaa tattcctaat taaaaaaata tttttgatac
     4861 cttaagtata tgtgtgattt tatagccact cttaaattta tttagtcaca tcacttaagt
     4921 atattcctat gtgtacatgg aagtttgtat attagagcca tagccttgga agcatatgtg
     4981 ccaatgccaa aggtttcagc atgcttttag aaacgaaaag agtaaacaga cacctacact
     5041 gccaagatac aaggattaga caataatgaa ttcaaaactc agggagtgtg atggtttgac
     5101 tatgctcggc gcatgcagta ccattgttgg aatagaagtg gccttgttag aggaagtatg
     5161 tcattgtggg tatggggttt acgacactca tcccagtccc ctggaagcca gttttctcct
     5221 gtttacctta ggaacacgat gtagaactct tagcttctcc taaaccatgc ctacctggat
     5281 gctgctatgt tcctgccttg ataataatgg accaaacctc tgaacctgta agccagcccc
     5341 aattaaatgt ccttataaga gtt
//
