LOCUS       NM_022313               2055 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus Era like 12S mitochondrial rRNA chaperone 1 (Eral1),
            mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_022313
VERSION     NM_022313.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2055)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2055)
  AUTHORS   de Bournonville,C., Lemoine,P., Foidart,J.M., Arnal,J.F.,
            Lenfant,F. and Cornil,C.A.
  TITLE     Role of membrane estrogen receptor alpha (ERalpha) in the rapid
            regulation of male sexual behavior
  JOURNAL   J Neuroendocrinol 35 (10), e13341 (2023)
   PUBMED   37806316
  REMARK    GeneRIF: Role of membrane estrogen receptor alpha (ERalpha) in the
            rapid regulation of male sexual behavior.
REFERENCE   3  (bases 1 to 2055)
  AUTHORS   Li,S., Kuang,M., Chen,L., Li,Y., Liu,S., Du,H., Cao,L. and You,F.
  TITLE     The mitochondrial protein ERAL1 suppresses RNA virus infection by
            facilitating RIG-I-like receptor signaling
  JOURNAL   Cell Rep 34 (3), 108631 (2021)
   PUBMED   33472079
  REMARK    GeneRIF: The mitochondrial protein ERAL1 suppresses RNA virus
            infection by facilitating RIG-I-like receptor signaling.
REFERENCE   4  (bases 1 to 2055)
  AUTHORS   Key,J., Kohli,A., Barcena,C., Lopez-Otin,C., Heidler,J., Wittig,I.
            and Auburger,G.
  TITLE     Global Proteome of LonP1+/- Mouse Embryonal Fibroblasts Reveals
            Impact on Respiratory Chain, but No Interdependence between Eral1
            and Mitoribosomes
  JOURNAL   Int J Mol Sci 20 (18), 4523 (2019)
   PUBMED   31547314
  REMARK    GeneRIF: LonP1(+/-) mouse embryonal fibroblasts also showed Eral1
            accumulation, but no systematic effect on mitoribosomal subunits.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2055)
  AUTHORS   Szczepanowska,K., Maiti,P., Kukat,A., Hofsetz,E., Nolte,H.,
            Senft,K., Becker,C., Ruzzenente,B., Hornig-Do,H.T., Wibom,R.,
            Wiesner,R.J., Kruger,M. and Trifunovic,A.
  TITLE     CLPP coordinates mitoribosomal assembly through the regulation of
            ERAL1 levels
  JOURNAL   EMBO J 35 (23), 2566-2583 (2016)
   PUBMED   27797820
  REMARK    GeneRIF: The authors show that the defect in mitoribosomal assembly
            is a consequence of the accumulation of ERAL1, a putative 12S rRNA
            chaperone, and novel ClpXP substrate.
REFERENCE   6  (bases 1 to 2055)
  AUTHORS   Thiagarajan,R.D., Georgas,K.M., Rumballe,B.A., Lesieur,E.,
            Chiu,H.S., Taylor,D., Tang,D.T., Grimmond,S.M. and Little,M.H.
  TITLE     Identification of anchor genes during kidney development defines
            ontological relationships, molecular subcompartments and regulatory
            pathways
  JOURNAL   PLoS One 6 (2), e17286 (2011)
   PUBMED   21386911
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 2055)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   8  (bases 1 to 2055)
  AUTHORS   Britton,R.A., Chen,S.M., Wallis,D., Koeuth,T., Powell,B.S.,
            Shaffer,L.G., Largaespada,D., Jenkins,N.A., Copeland,N.G.,
            Court,D.L. and Lupski,J.R.
  TITLE     Isolation and preliminary characterization of the human and mouse
            homologues of the bacterial cell cycle gene era
  JOURNAL   Genomics 67 (1), 78-82 (2000)
   PUBMED   10945472
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY158323.1, AK012155.1 and AF190730.1.
            
            On Jan 16, 2008 this sequence version replaced NM_022313.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF190730.1, BC068271.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-11                BY158323.1         2-12
            12-2010             AK012155.1         2-2000
            2011-2055           AF190730.1         1979-2023
FEATURES             Location/Qualifiers
     source          1..2055
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 46.74 cM"
     gene            1..2055
                     /gene="Eral1"
                     /gene_synonym="2610524P08Rik; 9130407C09Rik; Era; M-ERA;
                     MERA-S; MERA-W"
                     /note="Era like 12S mitochondrial rRNA chaperone 1"
                     /db_xref="GeneID:57837"
                     /db_xref="MGI:MGI:1889295"
     exon            1..307
                     /gene="Eral1"
                     /gene_synonym="2610524P08Rik; 9130407C09Rik; Era; M-ERA;
                     MERA-S; MERA-W"
                     /inference="alignment:Splign:2.1.0"
     CDS             25..1338
                     /gene="Eral1"
                     /gene_synonym="2610524P08Rik; 9130407C09Rik; Era; M-ERA;
                     MERA-S; MERA-W"
                     /note="GTP-binding protein era homolog; ERA-like GTPase;
                     ERA-like protein 1; CEGA; ERA-W; conserved ERA-like
                     GTPase"
                     /codon_start=1
                     /product="GTPase Era, mitochondrial"
                     /protein_id="NP_071708.2"
                     /db_xref="CCDS:CCDS48856.1"
                     /db_xref="GeneID:57837"
                     /db_xref="MGI:MGI:1889295"
                     /translation="MAAPRRYCAGLVRALLGARQVGSHAGREWLAPPGCLLGNQARCV
                     SCVVGSTFSGPLLASASSRYGQDSALDRILGFSQPDSSLVPSVPAVSVHRDEQNLLLV
                     HTPDMPENPRVLRVVLLGAPNAGKSTLSNQLLGRKVFPVSKKVHTTRCQALGVITEKE
                     TQVILLDTPGIISPVKQKRHHLERSLLEDPWTSMESADLVVVLVDVSDKWTRSRLNPQ
                     VLQCLTKFSQVPSILVLNKVDCLKQKSVLLELTAALTEGVVNGKKLNIKQALRSRSST
                     HCPGPETEGPNAHSVRNPQRIGWPYFQEIFMLSALNNKDVNTLKQYLLTQAQPGPWEF
                     HSGVLTSQTPEEICANKIREKLLEYLPEEVPYGVQQKTVIWEEGPSGELVIQQNLLVP
                     KESHVRILIGQKGLLISQIAQEVGRDLMDIFHCDVLIRLSVKLLK"
     exon            308..435
                     /gene="Eral1"
                     /gene_synonym="2610524P08Rik; 9130407C09Rik; Era; M-ERA;
                     MERA-S; MERA-W"
                     /inference="alignment:Splign:2.1.0"
     exon            436..513
                     /gene="Eral1"
                     /gene_synonym="2610524P08Rik; 9130407C09Rik; Era; M-ERA;
                     MERA-S; MERA-W"
                     /inference="alignment:Splign:2.1.0"
     exon            514..560
                     /gene="Eral1"
                     /gene_synonym="2610524P08Rik; 9130407C09Rik; Era; M-ERA;
                     MERA-S; MERA-W"
                     /inference="alignment:Splign:2.1.0"
     exon            561..622
                     /gene="Eral1"
                     /gene_synonym="2610524P08Rik; 9130407C09Rik; Era; M-ERA;
                     MERA-S; MERA-W"
                     /inference="alignment:Splign:2.1.0"
     exon            623..735
                     /gene="Eral1"
                     /gene_synonym="2610524P08Rik; 9130407C09Rik; Era; M-ERA;
                     MERA-S; MERA-W"
                     /inference="alignment:Splign:2.1.0"
     exon            736..984
                     /gene="Eral1"
                     /gene_synonym="2610524P08Rik; 9130407C09Rik; Era; M-ERA;
                     MERA-S; MERA-W"
                     /inference="alignment:Splign:2.1.0"
     exon            985..1134
                     /gene="Eral1"
                     /gene_synonym="2610524P08Rik; 9130407C09Rik; Era; M-ERA;
                     MERA-S; MERA-W"
                     /inference="alignment:Splign:2.1.0"
     exon            1135..1215
                     /gene="Eral1"
                     /gene_synonym="2610524P08Rik; 9130407C09Rik; Era; M-ERA;
                     MERA-S; MERA-W"
                     /inference="alignment:Splign:2.1.0"
     exon            1216..2014
                     /gene="Eral1"
                     /gene_synonym="2610524P08Rik; 9130407C09Rik; Era; M-ERA;
                     MERA-S; MERA-W"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1988..1993
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Eral1"
                     /gene_synonym="2610524P08Rik; 9130407C09Rik; Era; M-ERA;
                     MERA-S; MERA-W"
                     /note="hexamer: AATAAA"
     polyA_site      2014
                     /gene="Eral1"
                     /gene_synonym="2610524P08Rik; 9130407C09Rik; Era; M-ERA;
                     MERA-S; MERA-W"
                     /note="major polyA site"
ORIGIN      
        1 ggtaccaggg tgcattgcgg caaaatggct gcccccaggc ggtactgcgc tgggctcgtt
       61 cgggccttgt taggggcccg acaggtgggt tcgcatgcag ggagggaatg gcttgctccg
      121 cccggctgtc ttctaggtaa ccaggcgagg tgcgtgtcct gtgtcgtggg ctccactttc
      181 tctggtcccc tcctggcctc ggcctctagt cgttatggtc aggactccgc cttggaccgt
      241 atccttggat tttctcagcc tgacagttcg ttggttccga gcgtccccgc ggtgtcggtg
      301 cacagagatg agcagaatct actcttggtg cacactcccg acatgcctga gaatccacgg
      361 gtcctccgcg tggtcctcct gggagcccca aatgcaggga agtcaacact ttccaatcag
      421 ctgctgggcc gtaaagtgtt tcctgtttca aagaaggtgc acaccactcg atgtcaagct
      481 ctgggggtca tcacagagaa ggagacccaa gtgattctgc ttgacacacc tggcatcatc
      541 agtcctgtta aacagaagag gcaccatctg gagcgctctt tgctggaaga tccatggacg
      601 agcatggaat ctgctgatct tgttgtagtt cttgtggatg tgtcagacaa gtggaccagg
      661 agtcggctca acccccaggt gctgcagtgc ttgaccaagt tctctcaggt ccctagcatc
      721 ctcgtcttaa acaaggtaga ttgcctgaag cagaagtcag ttctcctgga gctgacagca
      781 gccctcactg aaggtgttgt caatggcaag aagcttaata tcaagcaggc cttgcgctca
      841 cgctccagca cccactgccc tggccctgaa actgagggcc caaatgcaca ctcagtgagg
      901 aaccctcaga gaattggctg gccctacttc caggagatct tcatgttatc agcactaaac
      961 aacaaggatg tgaacacatt gaagcaatac cttctgacac aggcccagcc aggaccctgg
     1021 gagttccaca gtggtgtgct cactagccag acacccgaag agatctgtgc caataaaatc
     1081 agagagaagc tcttagagta cctgcctgag gaggtgccct acggtgtgca gcagaagaca
     1141 gtgatatggg aggaaggacc aagtggagag ctagtgatcc aacagaacct tctggtgccc
     1201 aaagaatctc atgtgaggat cctgattggt cagaagggcc tcttgatctc ccagattgca
     1261 caggaggtgg gccgggacct catggacatc ttccactgtg acgttctcat ccgcctctct
     1321 gtgaaactcc tcaaatgacc atcctctgtt gcttctccca gtggatccct gctcaagctg
     1381 ctggcagagt cactgactag aactacccct gtcagagggg tctacaggac tgggaagggc
     1441 catggacact gactggtttc cattgtgagg gacccatagc tacagctgca tatgtagcag
     1501 aggatggcct agtcggtcgg tcatcaatgg gaggagaggc ccttggtcct gtgaaggtcc
     1561 tgtgccagcc agcctggcat tgccgagtct gcacagtgct tgcccaacca tgtttccact
     1621 tagctcagtt ctcggggcgt tcctctgcct agggtctcag tcagttgtat aggatacatg
     1681 ctgaaccaca ccctagaacc catggttcta agtcatgtcc accccgctag cattggaacc
     1741 aaactcttgc cctgagtttc cagttgttgg taggaacaca atttttctct tctcccccaa
     1801 gttcctcacc ttgaagttgc ataaggaccc gtgtttcctt tttcttttat tattattatt
     1861 attttttttt ttgagaccgg gttcttaccc tacaactctg actggctggc tatctctaca
     1921 tagatcaggc tagctttaaa ctcacaaagg tcctcccatc ccatccaacc acccagcctc
     1981 ggatgctaat aaagttaaat gacaagtgct cttaaaaaaa aaaaaaaaaa aaaaaaaaaa
     2041 aaaaaaaaaa aaaaa
//
