LOCUS       NM_001379456            1979 bp    mRNA    linear   ROD 09-JUN-2024
DEFINITION  Mus musculus epiphycan (Epyc), transcript variant 2, mRNA.
ACCESSION   NM_001379456 XM_030244868
VERSION     NM_001379456.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1979)
  AUTHORS   Xie,Z., Ma,X.H., Bai,Q.F., Tang,J., Sun,J.H., Jiang,F., Guo,W.,
            Wang,C.M., Yang,R., Wen,Y.C., Wang,F.Y., Chen,Y.X., Zhang,H.,
            He,D.Z., Kelley,M.W., Yang,S. and Zhang,W.J.
  TITLE     ZBTB20 is essential for cochlear maturation and hearing in mice
  JOURNAL   Proc Natl Acad Sci U S A 120 (24), e2220867120 (2023)
   PUBMED   37279265
REFERENCE   2  (bases 1 to 1979)
  AUTHORS   Yang,L.M., Stout,L., Rauchman,M. and Ornitz,D.M.
  TITLE     Analysis of FGF20-regulated genes in organ of Corti progenitors by
            translating ribosome affinity purification
  JOURNAL   Dev Dyn 249 (10), 1217-1242 (2020)
   PUBMED   32492250
REFERENCE   3  (bases 1 to 1979)
  AUTHORS   Wu,J., Li,H., Han,L., Sun,T., Tian,Y. and Wang,X.
  TITLE     The spatiotemporal expression pattern of Syndecans in murine
            embryonic teeth
  JOURNAL   Gene Expr Patterns 36, 119109 (2020)
   PUBMED   32220631
REFERENCE   4  (bases 1 to 1979)
  AUTHORS   Besse,L., Sheeba,C.J., Holt,M., Labuhn,M., Wilde,S., Feneck,E.,
            Bell,D., Kucharska,A. and Logan,M.P.O.
  TITLE     Individual Limb Muscle Bundles Are Formed through Progressive Steps
            Orchestrated by Adjacent Connective Tissue Cells during Primary
            Myogenesis
  JOURNAL   Cell Rep 30 (10), 3552-3565 (2020)
   PUBMED   32160556
REFERENCE   5  (bases 1 to 1979)
  AUTHORS   Aydogdu,N., Rudat,C., Trowe,M.O., Kaiser,M., Ludtke,T.H.,
            Taketo,M.M., Christoffels,V.M., Moon,A. and Kispert,A.
  TITLE     TBX2 and TBX3 act downstream of canonical WNT signaling in
            patterning and differentiation of the mouse ureteric mesenchyme
  JOURNAL   Development 145 (23) (2018)
   PUBMED   30478225
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1979)
  AUTHORS   Soto-Suazo,M., San Martin,S., Ferro,E.S. and Zorn,T.M.
  TITLE     Differential expression of glycosaminoglycans and proteoglycans in
            the migratory pathway of the primordial germ cells of the mouse
  JOURNAL   Histochem Cell Biol 118 (1), 69-78 (2002)
   PUBMED   12122449
REFERENCE   7  (bases 1 to 1979)
  AUTHORS   Johnson,J., Shinomura,T., Eberspaecher,H., Pinero,G.,
            Decrombrugghe,B. and Hook,M.
  TITLE     Expression and localization of PG-Lb/epiphycan during mouse
            development
  JOURNAL   Dev Dyn 216 (4-5), 499-510 (1999)
   PUBMED   10633869
REFERENCE   8  (bases 1 to 1979)
  AUTHORS   Danielson,K.G., Siracusa,L.D., Donovan,P.J. and Iozzo,R.V.
  TITLE     Decorin, epiphycan, and lumican genes are closely linked on murine
            Chromosome 10 and are deleted in lethal steel mutants
  JOURNAL   Mamm Genome 10 (2), 201-203 (1999)
   PUBMED   9922406
REFERENCE   9  (bases 1 to 1979)
  AUTHORS   Iwata,Y., Shinomura,T., Kurita,K., Zako,M. and Kimata,K.
  TITLE     The gene structure and organization of mouse PG-Lb, a small
            chondroitin/dermatan sulphate proteoglycan
  JOURNAL   Biochem J 331 (Pt 3) (Pt 3), 959-964 (1998)
   PUBMED   9560328
REFERENCE   10 (bases 1 to 1979)
  AUTHORS   Kurita,K., Shinomura,T., Ujita,M., Zako,M., Kida,D., Iwata,H. and
            Kimata,K.
  TITLE     Occurrence of PG-Lb, a leucine-rich small chondroitin/dermatan
            sulphate proteoglycan in mammalian epiphyseal cartilage: molecular
            cloning and sequence analysis of the mouse cDNA
  JOURNAL   Biochem J 318 (Pt 3) (Pt 3), 909-914 (1996)
   PUBMED   8836137
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC159710.9 and AC099715.9.
            
            On Apr 3, 2020 this sequence version replaced XM_030244868.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK157900.1, AK157901.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-360               AC159710.9         181877-182236
            361-537             AC159710.9         184462-184638
            538-712             AC099715.9         45821-45995
            713-871             AC099715.9         50000-50158
            872-1074            AC099715.9         50969-51171
            1075-1170           AC099715.9         52311-52406
            1171-1979           AC099715.9         56423-57231
FEATURES             Location/Qualifiers
     source          1..1979
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 50.35 cM"
     gene            1..1979
                     /gene="Epyc"
                     /gene_synonym="Dspg3; PG-Lb; SLRR3B"
                     /note="epiphycan"
                     /db_xref="GeneID:13516"
                     /db_xref="MGI:MGI:107942"
     exon            1..360
                     /gene="Epyc"
                     /gene_synonym="Dspg3; PG-Lb; SLRR3B"
                     /inference="alignment:Splign:2.1.0"
     exon            361..537
                     /gene="Epyc"
                     /gene_synonym="Dspg3; PG-Lb; SLRR3B"
                     /inference="alignment:Splign:2.1.0"
     CDS             373..1341
                     /gene="Epyc"
                     /gene_synonym="Dspg3; PG-Lb; SLRR3B"
                     /note="proteoglycan-Lb; dermatan sulfate proteoglycan 3;
                     small chondroitin/dermatan sulfate proteoglycan; dermatan
                     sulphate proteoglycan 3"
                     /codon_start=1
                     /product="epiphycan precursor"
                     /protein_id="NP_001366385.1"
                     /db_xref="GeneID:13516"
                     /db_xref="MGI:MGI:107942"
                     /translation="MGMLARVALGLIIIDAVLAAPTTELFNYDSEVYDAILEDTGTFY
                     NYEHIPDNHVENEKVSERLSGNRELLTPGPQLGDNQDEDKDEESTPRLIDGSSPQEPE
                     FPGLLGPHTNEDFPTCLLCTCISTTVYCDDHELDAIPPLPKKTTYFYSRFNRIKKINK
                     NDFASLNDLKRIDLTSNLISEIDEDAFRKLPHLQELVLRDNKIKQLPELPNTLTFIDI
                     SNNRLGRKGIKQEAFKDMYDLHHLYITDNSLDHIPLPLPESLRALHLQNNDILEMHED
                     TFCNVKNLTYVRKALEDIRLDGNPINLSRTPQAYMCLPRLPIGSFI"
     exon            538..712
                     /gene="Epyc"
                     /gene_synonym="Dspg3; PG-Lb; SLRR3B"
                     /inference="alignment:Splign:2.1.0"
     exon            713..871
                     /gene="Epyc"
                     /gene_synonym="Dspg3; PG-Lb; SLRR3B"
                     /inference="alignment:Splign:2.1.0"
     exon            872..1074
                     /gene="Epyc"
                     /gene_synonym="Dspg3; PG-Lb; SLRR3B"
                     /inference="alignment:Splign:2.1.0"
     exon            1075..1170
                     /gene="Epyc"
                     /gene_synonym="Dspg3; PG-Lb; SLRR3B"
                     /inference="alignment:Splign:2.1.0"
     exon            1171..1979
                     /gene="Epyc"
                     /gene_synonym="Dspg3; PG-Lb; SLRR3B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1763..1768
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Epyc"
                     /gene_synonym="Dspg3; PG-Lb; SLRR3B"
                     /note="hexamer: ATTAAA"
     polyA_site      1783
                     /gene="Epyc"
                     /gene_synonym="Dspg3; PG-Lb; SLRR3B"
                     /note="major polyA site"
     regulatory      1950..1955
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Epyc"
                     /gene_synonym="Dspg3; PG-Lb; SLRR3B"
                     /note="hexamer: AATAAA"
     polyA_site      1979
                     /gene="Epyc"
                     /gene_synonym="Dspg3; PG-Lb; SLRR3B"
ORIGIN      
        1 gtgttaattc ccttcctttc ttaactggtg aatttgttag agaagagacc tacgaaaact
       61 agcctttttc tacttaaata ttttaaggtg acattttggc aattacagct aattagcatc
      121 gctgcaagct ttgtgtactg tgaaattcgg attatttagc ttagcttgtg tgactataat
      181 ataatgaacg gtttttaaag acagagaagc attctccagg ttaggttttt caaacagaaa
      241 gttgagtgtt acaaattaca cctcccacag accagaattc ctatccattg gtcaggggca
      301 aataccaagg actctgtatg ctcagtcact ctgtgcgact tcatcaagtc ggagccaaag
      361 aaatcttgaa agatgggaat gctagcaaga gttgccctgg gacttatcat cattgatgct
      421 gtattggctg caccaactac agagctcttt aactatgact cagaagtgta tgatgccatc
      481 ttggaggaca cagggacctt ttataactat gaacacattc ctgacaacca tgtagagaac
      541 gagaaagtgt ctgagaggct ttctgggaac agagagctcc tgaccccagg cccacagcta
      601 ggggacaacc aggatgaaga caaggatgaa gaatctactc ccaggctgat cgatggctct
      661 tccccacagg agccagaatt cccggggctt ctgggtccac acaccaacga agactttcca
      721 acttgtctcc tgtgtacttg tataagtacc actgtatact gtgatgacca tgaactggac
      781 gctattcctc cactgcccaa gaagactaca tatttctatt cacgttttaa cagaattaaa
      841 aagatcaaca aaaatgactt tgcaagctta aatgatttaa aaaggatcga tctgacatca
      901 aatttaatat cggagattga tgaagatgca ttccgaaagc tgcctcacct ccaagagctg
      961 gttctgcgtg acaataagat aaagcagctt ccagaattgc caaacacttt gacatttatt
     1021 gatatcagca acaatagact gggaagaaaa ggcattaaac aagaagcttt taaagatatg
     1081 tatgatctcc accatctcta tatcaccgat aacagcttgg accacatccc tctaccactc
     1141 ccagaaagtc tgcgggctct tcacctccag aataatgaca ttctggagat gcatgaagat
     1201 actttctgca atgttaaaaa tttaacttat gttcgtaagg cattagagga tattcgactg
     1261 gatggaaacc ctatcaacct cagcagaact cctcaagcct acatgtgtct acctcgtttg
     1321 cccattggga gttttatcta atgttaggat gctaggcaaa tatcagaatt gtgatgcttt
     1381 ctgtagccaa gagaagcata tatctcttca gaagcaaact cagtatattt gagatgcgtt
     1441 taaaacatgt ggcacaatga tataaacaat aagctaaagg tgttgagata aaataagagt
     1501 tcaataattt aattaaacat gattaggtat aaattaacaa aatatataga cagtaagtta
     1561 aataaaatgt atgccaacta gtcatcaaat ctcatcaaga attgtaggtg ttcatgtcaa
     1621 gttaaatatg taagaaataa aatattggta atgaatactt tagatacgtt gctaagatgt
     1681 agacatttta attaaacttc tctagtcttt attttcactc atgtatgttt cccacctgat
     1741 tcagttaaga gcagaaaaaa atattaaatg tgtttgaaag atatatggtc ttgtgaaaaa
     1801 gtatttctta taattgtagt gtgcaaataa ctatgtaata gcagtataca ttccttcagt
     1861 ttctaatgac atctatcatc tataagaaca tcaactcatt ttgcaaactt ggttagttga
     1921 cagctacctg tattcctcta catacaaaaa ataaaatatg agatatagag catattaaa
//
