LOCUS       NM_029495               1869 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus epithelial stromal interaction 1 (Epsti1), transcript
            variant a, mRNA.
ACCESSION   NM_029495
VERSION     NM_029495.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1869)
  AUTHORS   Bei,Y.R., Zhang,S.C., Song,Y., Tang,M.L., Zhang,K.L., Jiang,M.,
            He,R.C., Wu,S.G., Liu,X.H., Wu,L.M., Dai,X.Y. and Hu,Y.W.
  TITLE     EPSTI1 promotes monocyte adhesion to endothelial cells in vitro via
            upregulating VCAM-1 and ICAM-1 expression
  JOURNAL   Acta Pharmacol Sin 44 (1), 71-80 (2023)
   PUBMED   35778487
  REMARK    GeneRIF: EPSTI1 promotes monocyte adhesion to endothelial cells in
            vitro via upregulating VCAM-1 and ICAM-1 expression.
REFERENCE   2  (bases 1 to 1869)
  AUTHORS   Kim,Y.H., Lee,J.R. and Hahn,M.J.
  TITLE     Regulation of inflammatory gene expression in macrophages by
            epithelial-stromal interaction 1 (Epsti1)
  JOURNAL   Biochem Biophys Res Commun 496 (2), 778-783 (2018)
   PUBMED   29217193
  REMARK    GeneRIF: These findings identify Epsti1 as a modulator of
            macrophage activation and polarization via the Stat1 and p65
            pathways, and suggest a potentially important role of Epsti1 in
            immunotherapies against inflammatory diseases.
REFERENCE   3  (bases 1 to 1869)
  AUTHORS   Ghazalpour,A., Doss,S., Zhang,B., Wang,S., Plaisier,C.,
            Castellanos,R., Brozell,A., Schadt,E.E., Drake,T.A., Lusis,A.J. and
            Horvath,S.
  TITLE     Integrating genetic and network analysis to characterize genes
            related to mouse weight
  JOURNAL   PLoS Genet 2 (8), e130 (2006)
   PUBMED   16934000
REFERENCE   4  (bases 1 to 1869)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY719992.1, AK077223.1 and AK135710.1.
            
            On Feb 3, 2010 this sequence version replaced NM_029495.1.
            
            Transcript Variant: This variant (a) represents the longer
            transcript and encodes the longer isoform (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK135710.1, AK136055.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-195               BY719992.1         2-196
            196-1717            AK077223.1         2-1523
            1718-1869           AK135710.1         1709-1860
FEATURES             Location/Qualifiers
     source          1..1869
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 41.08 cM"
     gene            1..1869
                     /gene="Epsti1"
                     /gene_synonym="2310046K10Rik; 5033415K03Rik; BRESI1"
                     /note="epithelial stromal interaction 1"
                     /db_xref="GeneID:108670"
                     /db_xref="MGI:MGI:1915168"
     exon            1..426
                     /gene="Epsti1"
                     /gene_synonym="2310046K10Rik; 5033415K03Rik; BRESI1"
                     /inference="alignment:Splign:2.1.0"
     CDS             248..1192
                     /gene="Epsti1"
                     /gene_synonym="2310046K10Rik; 5033415K03Rik; BRESI1"
                     /note="isoform a is encoded by transcript variant a;
                     epithelial-stromal interaction protein 1; epithelial
                     stromal interaction 1 (breast)"
                     /codon_start=1
                     /product="epithelial-stromal interaction protein 1 isoform
                     a"
                     /protein_id="NP_083771.1"
                     /db_xref="CCDS:CCDS56971.1"
                     /db_xref="GeneID:108670"
                     /db_xref="MGI:MGI:1915168"
                     /translation="MYTRSKVVGPGLGTSSISRDHAGAGQRRELGLQQNRRQSLEVAA
                     PEGPKMERQGHADQGSAGTYTLIAPNESRRQKIQRIAEQELADLERWKQQNRAKPVYL
                     VPQRLGGSQSEAEVRQKQQLQQMRSKYQQKLKRDESIRIRKEAEEAKFQKMKAIQREK
                     SNKLEEKKQLQEDIRRATFREHHQSKTAELLSRLDTERRNRSACLIAPPATQSSRWKL
                     PVLLRDPSWAGSQAHRDSPQKEDNPRLQKTRDGHQKNKLLETKGQHQEEERAQIHQAE
                     HWRVNNAFLDRLQGKSQPGGLEQSGGCCNMNSTDSWGI"
     exon            427..485
                     /gene="Epsti1"
                     /gene_synonym="2310046K10Rik; 5033415K03Rik; BRESI1"
                     /inference="alignment:Splign:2.1.0"
     exon            486..569
                     /gene="Epsti1"
                     /gene_synonym="2310046K10Rik; 5033415K03Rik; BRESI1"
                     /inference="alignment:Splign:2.1.0"
     exon            570..643
                     /gene="Epsti1"
                     /gene_synonym="2310046K10Rik; 5033415K03Rik; BRESI1"
                     /inference="alignment:Splign:2.1.0"
     exon            644..727
                     /gene="Epsti1"
                     /gene_synonym="2310046K10Rik; 5033415K03Rik; BRESI1"
                     /inference="alignment:Splign:2.1.0"
     exon            728..801
                     /gene="Epsti1"
                     /gene_synonym="2310046K10Rik; 5033415K03Rik; BRESI1"
                     /inference="alignment:Splign:2.1.0"
     exon            802..895
                     /gene="Epsti1"
                     /gene_synonym="2310046K10Rik; 5033415K03Rik; BRESI1"
                     /inference="alignment:Splign:2.1.0"
     exon            896..928
                     /gene="Epsti1"
                     /gene_synonym="2310046K10Rik; 5033415K03Rik; BRESI1"
                     /inference="alignment:Splign:2.1.0"
     exon            929..1009
                     /gene="Epsti1"
                     /gene_synonym="2310046K10Rik; 5033415K03Rik; BRESI1"
                     /inference="alignment:Splign:2.1.0"
     exon            1010..1083
                     /gene="Epsti1"
                     /gene_synonym="2310046K10Rik; 5033415K03Rik; BRESI1"
                     /inference="alignment:Splign:2.1.0"
     exon            1084..1183
                     /gene="Epsti1"
                     /gene_synonym="2310046K10Rik; 5033415K03Rik; BRESI1"
                     /inference="alignment:Splign:2.1.0"
     exon            1184..1869
                     /gene="Epsti1"
                     /gene_synonym="2310046K10Rik; 5033415K03Rik; BRESI1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1696..1701
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Epsti1"
                     /gene_synonym="2310046K10Rik; 5033415K03Rik; BRESI1"
                     /note="hexamer: AATAAA"
     polyA_site      1718
                     /gene="Epsti1"
                     /gene_synonym="2310046K10Rik; 5033415K03Rik; BRESI1"
                     /note="major polyA site"
     regulatory      1848..1853
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Epsti1"
                     /gene_synonym="2310046K10Rik; 5033415K03Rik; BRESI1"
                     /note="hexamer: AATAAA"
     polyA_site      1866
                     /gene="Epsti1"
                     /gene_synonym="2310046K10Rik; 5033415K03Rik; BRESI1"
ORIGIN      
        1 agttcttcag ccttgctaga ggcaggctca gcccaggaag ctaacctgtg agaaagtcca
       61 agggtgtccg ggtagagaat gaatgaggaa gttctctgaa cccagcgggt ggttaaagag
      121 aaatcgaaac tcagctgtta aaaccgctct ccttgctctt cagaacccct tcctcgagcc
      181 tccttagaag cccttaccag catccgtccc tcaaaggctg tggccaggac cccacgggct
      241 gtggaccatg tacacccgca gtaaggtggt gggcccaggc ttgggcactt cctccatctc
      301 tcgggaccac gctggagctg ggcagcgcag ggagctgggc ttgcagcaaa accggagaca
      361 gagtttggag gtggcagctc ccgagggccc caagatggag aggcaggggc atgctgacca
      421 gggaagcgca ggcacataca ccctgatagc accaaacgag agcagaaggc agaagataca
      481 gagaattgct gagcaagaac tggcagacct ggagagatgg aagcaacaga acagggcaaa
      541 accagtctac ttggtgccac aacggctggg tggaagccag tctgaggctg aagtcagaca
      601 gaaacaacag ctgcaacaga tgcgttctaa ataccagcaa aagctcaaga gggatgaatc
      661 tattcgaatc aggaaggaag ctgaggaagc caagttccaa aaaatgaaag caatccagag
      721 ggagaagagt aataaactag aggagaaaaa gcaacttcaa gaagacatca gaagagccac
      781 atttcgagag catcatcagt ccaaaacggc tgagctcttg agcagactgg acacagagcg
      841 gagaaacaga agtgcctgtc tgattgctcc tcctgccacc cagtcctcga gatggaaact
      901 tccagtcctg cttagagatc ccagctgggc cggcagccaa gcacacaggg attctccgca
      961 gaaggaagac aaccccaggc tgcaaaagac gagggatgga catcagaaga ataaattact
     1021 ggaaactaaa ggacagcacc aggaggaaga aagagcccaa atccatcaag ctgaacactg
     1081 gagggtaaat aatgcttttc tggaccgact ccaaggcaaa agtcaaccag gtggcctcga
     1141 gcagtctgga ggctgttgca atatgaatag tactgacagc tggggtatat gagaaatcgt
     1201 cacttctatc tggccttcat cagctgactt ttgaaaatcc tcatgagatg tgtttcctta
     1261 atgcggttct atttggcatc tgtcttaatt ccttaatttc aactgcccac ccactcaacc
     1321 aagctgttgt gggtggccag tttctctcca tcattagtga tgtgtagtct ctcagagact
     1381 gattactgac tcctgtttaa cctctactgc cagaaaaatg ttaccttatc ttttcttaat
     1441 ttgccttgcc ttttattaaa tgaataagta gagaaatgtt agtaaaatgg taaaagggaa
     1501 tcacgtgaca ttcagggtag gaagagcttg gatgctgtag atgtatgtct ctctaattaa
     1561 cttttttttt tctgtactga ttcttacagc aggtttaggt atactttggg gtcttttaaa
     1621 attcctactt tttaaaatct aggatacaaa tgtgaccaaa agaagatctc ttatactttc
     1681 atagacaaat ttataaataa attctgaact acttcttata taaatgggtc atttttaaca
     1741 tgctgttttt attaataaat tggtaatttc acataataca tcccaacccc tcttacttct
     1801 cagtctttgc aggtctgccc cactatcctt gtggccttcc ctcaaaaaat aaaaagatga
     1861 aacaaagtt
//
