LOCUS       NM_133867               2313 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus EPS8-like 3 (Eps8l3), mRNA.
ACCESSION   NM_133867
VERSION     NM_133867.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2313)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2313)
  AUTHORS   Bell,S.M., Zhang,L., Xu,Y., Besnard,V., Wert,S.E., Shroyer,N. and
            Whitsett,J.A.
  TITLE     Kruppel-like factor 5 controls villus formation and initiation of
            cytodifferentiation in the embryonic intestinal epithelium
  JOURNAL   Dev Biol 375 (2), 128-139 (2013)
   PUBMED   23266329
REFERENCE   3  (bases 1 to 2313)
  AUTHORS   Disanza,A., Carlier,M.F., Stradal,T.E., Didry,D., Frittoli,E.,
            Confalonieri,S., Croce,A., Wehland,J., Di Fiore,P.P. and Scita,G.
  TITLE     Eps8 controls actin-based motility by capping the barbed ends of
            actin filaments
  JOURNAL   Nat Cell Biol 6 (12), 1180-1188 (2004)
   PUBMED   15558031
REFERENCE   4  (bases 1 to 2313)
  AUTHORS   Offenhauser,N., Borgonovo,A., Disanza,A., Romano,P., Ponzanelli,I.,
            Iannolo,G., Di Fiore,P.P. and Scita,G.
  TITLE     The eps8 family of proteins links growth factor stimulation to
            actin reorganization generating functional redundancy in the
            Ras/Rac pathway
  JOURNAL   Mol Biol Cell 15 (1), 91-98 (2004)
   PUBMED   14565974
  REMARK    Erratum:[Mol Biol Cell. 2019 Sep 1;30(19):2535. doi:
            10.1091/mbc.E03-06-0427-corr.. PMID: 31465253]
REFERENCE   5  (bases 1 to 2313)
  AUTHORS   Tocchetti,A., Confalonieri,S., Scita,G., Di Fiore,P.P. and
            Betsholtz,C.
  TITLE     In silico analysis of the EPS8 gene family: genomic organization,
            expression profile, and protein structure
  JOURNAL   Genomics 81 (2), 234-244 (2003)
   PUBMED   12620401
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC079042.31 and AY074932.1.
            
            On Jul 17, 2009 this sequence version replaced NM_133867.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY074932.1, BC014734.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849377, SAMN00849378
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-8                 AC079042.31        139915-139922       c
            9-2313              AY074932.1         25-2329
FEATURES             Location/Qualifiers
     source          1..2313
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 46.83 cM"
     gene            1..2313
                     /gene="Eps8l3"
                     /gene_synonym="Eps8r3"
                     /note="EPS8-like 3"
                     /db_xref="GeneID:99662"
                     /db_xref="MGI:MGI:2139743"
     exon            1..137
                     /gene="Eps8l3"
                     /gene_synonym="Eps8r3"
                     /inference="alignment:Splign:2.1.0"
     exon            138..192
                     /gene="Eps8l3"
                     /gene_synonym="Eps8r3"
                     /inference="alignment:Splign:2.1.0"
     CDS             162..1964
                     /gene="Eps8l3"
                     /gene_synonym="Eps8r3"
                     /note="epidermal growth factor receptor pathway substrate
                     8 related protein 3; ESP8-like 3; EPS8-like protein 3;
                     EPS8-related protein 3"
                     /codon_start=1
                     /product="epidermal growth factor receptor kinase
                     substrate 8-like protein 3"
                     /protein_id="NP_598628.1"
                     /db_xref="CCDS:CCDS38594.1"
                     /db_xref="GeneID:99662"
                     /db_xref="MGI:MGI:2139743"
                     /translation="MSRPSSRAIYLHRKEYSQSMASEPTLLQHRVEHLMTCKLGTQRV
                     REPKDALQKLQEMDAQGRVWSQDLFLQVRDGWLHLLDIETKEELDSYRLDNIKAIDVA
                     LNTCSYNSILSVTVQESGLPGISTLLFQCQEVGAEQLRTSLQKALEEELEERPRFGVH
                     HPSQDRWKGPPLERPLPIQQAPPLEQRFSPEHRFPPEQPHNMTSERSISPSSRSLTHY
                     PSAREPNGFTLPPPPRRAPSPEDPERDEEVLNHVLRDIELFAGKLKEVQARNSHKKTK
                     LGRKKKKSKNGITQAEYIDCFQKIKLSFNLLGKLALRMQETSAPEFVGLIFQTLKFIL
                     SQCPEAGLPAKVISPLLTPKAIDLLQSCLSPPEDTLWKSLGTSWTTSWADWTGSEPPP
                     YQPTFYDGWQIPQPRSMMPITNQDSISLRGSRMRSSLHFPRDEPYNHNPEYEDSNLPL
                     SSPSPGRAALKMQVLYEFEARNAQELTVAQGEILEVLDQSKRWWLVKNEAGLTGYIPS
                     NILEPLPAGAPRGHRQPSFRAPMLRLSSKPEEVTAWLQAENFSTVTVRTLGSLMGSQL
                     LHMRPGELQMLCPQEAPRIQARLDAVRRMLGMTH"
     exon            193..257
                     /gene="Eps8l3"
                     /gene_synonym="Eps8r3"
                     /inference="alignment:Splign:2.1.0"
     exon            258..416
                     /gene="Eps8l3"
                     /gene_synonym="Eps8r3"
                     /inference="alignment:Splign:2.1.0"
     exon            417..566
                     /gene="Eps8l3"
                     /gene_synonym="Eps8r3"
                     /inference="alignment:Splign:2.1.0"
     exon            567..622
                     /gene="Eps8l3"
                     /gene_synonym="Eps8r3"
                     /inference="alignment:Splign:2.1.0"
     exon            623..780
                     /gene="Eps8l3"
                     /gene_synonym="Eps8r3"
                     /inference="alignment:Splign:2.1.0"
     exon            781..899
                     /gene="Eps8l3"
                     /gene_synonym="Eps8r3"
                     /inference="alignment:Splign:2.1.0"
     exon            900..1020
                     /gene="Eps8l3"
                     /gene_synonym="Eps8r3"
                     /inference="alignment:Splign:2.1.0"
     exon            1021..1082
                     /gene="Eps8l3"
                     /gene_synonym="Eps8r3"
                     /inference="alignment:Splign:2.1.0"
     exon            1083..1157
                     /gene="Eps8l3"
                     /gene_synonym="Eps8r3"
                     /inference="alignment:Splign:2.1.0"
     exon            1158..1306
                     /gene="Eps8l3"
                     /gene_synonym="Eps8r3"
                     /inference="alignment:Splign:2.1.0"
     exon            1307..1388
                     /gene="Eps8l3"
                     /gene_synonym="Eps8r3"
                     /inference="alignment:Splign:2.1.0"
     exon            1389..1423
                     /gene="Eps8l3"
                     /gene_synonym="Eps8r3"
                     /inference="alignment:Splign:2.1.0"
     exon            1424..1616
                     /gene="Eps8l3"
                     /gene_synonym="Eps8r3"
                     /inference="alignment:Splign:2.1.0"
     exon            1617..1745
                     /gene="Eps8l3"
                     /gene_synonym="Eps8r3"
                     /inference="alignment:Splign:2.1.0"
     exon            1746..1819
                     /gene="Eps8l3"
                     /gene_synonym="Eps8r3"
                     /inference="alignment:Splign:2.1.0"
     exon            1820..1952
                     /gene="Eps8l3"
                     /gene_synonym="Eps8r3"
                     /inference="alignment:Splign:2.1.0"
     exon            1953..2270
                     /gene="Eps8l3"
                     /gene_synonym="Eps8r3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2240..2245
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Eps8l3"
                     /gene_synonym="Eps8r3"
                     /note="hexamer: AATAAA"
     polyA_site      2263
                     /gene="Eps8l3"
                     /gene_synonym="Eps8r3"
                     /note="major polyA site"
ORIGIN      
        1 gccacctgat caccagtagg tctctgcctg aggcgctggc agagaagcca aacagagctc
       61 cctccaacat tagtggacca ctggctcaag catcagactc cttgggggac caaacaccag
      121 gcggcactgg caaccaggaa gctgccctca gcagtgtcac catgtcccgg cccagcagca
      181 gagccatcta cttgcaccgg aaggaatatt cccagagtat ggcctcagaa cctaccctcc
      241 tacagcacag ggtggagcat ctgatgacat gtaagctggg gacacagaga gtccgggagc
      301 caaaggatgc cctacagaag cttcaggaga tggatgccca gggccgagtg tggagtcaag
      361 acctgttcct gcaggtcaga gatggctggc tccatctgct ggacattgag actaaggagg
      421 aactggattc ttaccgcctg gacaacatca aggccataga cgtagccctt aacacctgct
      481 cctataactc catcttatct gtcactgtgc aggagtctgg cttgccaggc atcagcactt
      541 tgctgttcca atgccaggaa gtgggggcag agcagctgag gacaagcctg cagaaggccc
      601 tggaagaaga gctagaagaa agacctcgat ttggagtcca tcatccaagc caggacagat
      661 ggaaggggcc tcctctggaa aggccactcc ctatacaaca ggcaccccct ctggagcaga
      721 ggttctctcc agagcatagg tttcctccag aacagccaca taacatgacc tcagaacgca
      781 gcatctcgcc atcctcaagg tctctgacac actacccaag tgcccgagaa cccaatggct
      841 tcactctgcc tcctcctccg aggcgtgctc cctctcccga ggacccagag agggatgagg
      901 aggtgctgaa ccacgtccta agagacattg agctgtttgc tggaaagctg aaggaggtcc
      961 aggcaagaaa cagtcataag aagacaaaac ttgggagaaa aaagaaaaag tctaaaaatg
     1021 ggataacaca agcagagtac attgactgct tccagaagat caagttgagc ttcaacctct
     1081 tggggaagct ggctttgcgg atgcaggaaa caagcgcccc tgagttcgtg ggcctcatct
     1141 tccaaaccct gaaatttatc ctatctcagt gccctgaggc tggccttcca gccaaagtga
     1201 tttcccccct cctcaccccc aaagcaatag acctgctgca gtcctgtcta agcccacccg
     1261 aggacacact ctggaagtca ctaggcacat cctggaccac cagctgggct gactggacag
     1321 gcagtgaacc gccaccctac caacccacat tctacgatgg ctggcagatt ccacagcccc
     1381 gctccatgat gcccataaca aaccaggatt cgatttccct ccgaggttct aggatgagga
     1441 gcagcctaca tttccctcgg gatgagccat acaaccataa ccctgaatac gaggactcaa
     1501 acctcccact ctccagcccc agccctggca gagcagccct gaaaatgcaa gtcctgtacg
     1561 agtttgaagc aaggaatgcc caggaactga ctgtggcaca gggggagatt ctggaggttc
     1621 tggatcagag caagcgatgg tggctggtga agaacgaagc aggactgact ggttacattc
     1681 ccagcaatat cctggagccc ctgccagctg gagccccgag aggccaccga caaccatcct
     1741 ttagggcccc aatgcttcgc ctgagctcaa agcctgagga ggtcacagcc tggctacaag
     1801 cagagaactt ctccactgtc actgtaagga ccctcgggtc cctaatggga agccagctac
     1861 ttcacatgag acctggggag ctgcagatgc tgtgtccaca ggaggctcca cggatccagg
     1921 cccggctgga cgctgtcaga aggatgctgg ggatgactca ttagagacca gctcgaatac
     1981 ctctaagacc aaggacctct catgtgcaag atggagtatt tggtacccag ttagagcccc
     2041 tggaagtcct ctttcagtta gtggcaagcc acatatcctg gatcacaaag caaagaagat
     2101 gaacaggtcc agacactgag gcaaatggta cctcattggg ttggagaccc tcaccggtta
     2161 ctatttattt taccccacac cctaagttgg catacttatt cccagtctta ctcctgatct
     2221 ctttagtccc aatcctgcca ataaaaagca tcgtttaact tgttctatga aaaaaaaaaa
     2281 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaa
//
