LOCUS       NM_001374622            4070 bp    mRNA    linear   ROD 09-JUN-2024
DEFINITION  Mus musculus EPS8-like 1 (Eps8l1), transcript variant 3, mRNA.
ACCESSION   NM_001374622 XM_006540323
VERSION     NM_001374622.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4070)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4070)
  AUTHORS   Jung,H., Park,H., Choi,Y., Kang,H., Lee,E., Kweon,H., Roh,J.D.,
            Ellegood,J., Choi,W., Kang,J., Rhim,I., Choi,S.Y., Bae,M.,
            Kim,S.G., Lee,J., Chung,C., Yoo,T., Park,H., Kim,Y., Ha,S.,
            Um,S.M., Mo,S., Kwon,Y., Mah,W., Bae,Y.C., Kim,H., Lerch,J.P.,
            Paik,S.B. and Kim,E.
  TITLE     Sexually dimorphic behavior, neuronal activity, and gene expression
            in Chd8-mutant mice
  JOURNAL   Nat Neurosci 21 (9), 1218-1228 (2018)
   PUBMED   30104731
REFERENCE   3  (bases 1 to 4070)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643. PMID: 29144450]
REFERENCE   4  (bases 1 to 4070)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   5  (bases 1 to 4070)
  AUTHORS   Disanza,A., Carlier,M.F., Stradal,T.E., Didry,D., Frittoli,E.,
            Confalonieri,S., Croce,A., Wehland,J., Di Fiore,P.P. and Scita,G.
  TITLE     Eps8 controls actin-based motility by capping the barbed ends of
            actin filaments
  JOURNAL   Nat Cell Biol 6 (12), 1180-1188 (2004)
   PUBMED   15558031
REFERENCE   6  (bases 1 to 4070)
  AUTHORS   Offenhauser,N., Borgonovo,A., Disanza,A., Romano,P., Ponzanelli,I.,
            Iannolo,G., Di Fiore,P.P. and Scita,G.
  TITLE     The eps8 family of proteins links growth factor stimulation to
            actin reorganization generating functional redundancy in the
            Ras/Rac pathway
  JOURNAL   Mol Biol Cell 15 (1), 91-98 (2004)
   PUBMED   14565974
  REMARK    Erratum:[Mol Biol Cell. 2019 Sep 1;30(19):2535. doi:
            10.1091/mbc.E03-06-0427-corr. PMID: 31465253]
REFERENCE   7  (bases 1 to 4070)
  AUTHORS   Tocchetti,A., Confalonieri,S., Scita,G., Di Fiore,P.P. and
            Betsholtz,C.
  TITLE     In silico analysis of the EPS8 gene family: genomic organization,
            expression profile, and protein structure
  JOURNAL   Genomics 81 (2), 234-244 (2003)
   PUBMED   12620401
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC161218.10.
            
            On Oct 7, 2019 this sequence version replaced XM_006540323.3.
            
            Transcript Variant: This variant (3) encodes the longer isoform
            (2).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13422600.1218463.1,
                                           SRR7345562.1486769.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-328               AC161218.10        76053-76380
            329-382             AC161218.10        80715-80768
            383-423             AC161218.10        84210-84250
            424-482             AC161218.10        84552-84610
            483-644             AC161218.10        85237-85398
            645-794             AC161218.10        85639-85788
            795-877             AC161218.10        86164-86246
            878-1139            AC161218.10        86583-86844
            1140-1266           AC161218.10        87152-87278
            1267-1355           AC161218.10        87469-87557
            1356-1430           AC161218.10        87655-87729
            1431-1579           AC161218.10        87831-87979
            1580-1721           AC161218.10        89287-89428
            1722-1750           AC161218.10        89541-89569
            1751-1880           AC161218.10        92686-92815
            1881-2012           AC161218.10        92920-93051
            2013-2121           AC161218.10        93246-93354
            2122-2296           AC161218.10        93496-93670
            2297-2429           AC161218.10        93975-94107
            2430-4070           AC161218.10        94197-95837
FEATURES             Location/Qualifiers
     source          1..4070
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 2.58 cM"
     gene            1..4070
                     /gene="Eps8l1"
                     /gene_synonym="2310051G19Rik; 4632407K17Rik; DRC3; EPS8R1"
                     /note="EPS8-like 1"
                     /db_xref="GeneID:67425"
                     /db_xref="MGI:MGI:1914675"
     exon            1..328
                     /gene="Eps8l1"
                     /gene_synonym="2310051G19Rik; 4632407K17Rik; DRC3; EPS8R1"
                     /inference="alignment:Splign:2.1.0"
     exon            329..382
                     /gene="Eps8l1"
                     /gene_synonym="2310051G19Rik; 4632407K17Rik; DRC3; EPS8R1"
                     /inference="alignment:Splign:2.1.0"
     exon            383..423
                     /gene="Eps8l1"
                     /gene_synonym="2310051G19Rik; 4632407K17Rik; DRC3; EPS8R1"
                     /inference="alignment:Splign:2.1.0"
     exon            424..482
                     /gene="Eps8l1"
                     /gene_synonym="2310051G19Rik; 4632407K17Rik; DRC3; EPS8R1"
                     /inference="alignment:Splign:2.1.0"
     exon            483..644
                     /gene="Eps8l1"
                     /gene_synonym="2310051G19Rik; 4632407K17Rik; DRC3; EPS8R1"
                     /inference="alignment:Splign:2.1.0"
     exon            645..794
                     /gene="Eps8l1"
                     /gene_synonym="2310051G19Rik; 4632407K17Rik; DRC3; EPS8R1"
                     /inference="alignment:Splign:2.1.0"
     exon            795..877
                     /gene="Eps8l1"
                     /gene_synonym="2310051G19Rik; 4632407K17Rik; DRC3; EPS8R1"
                     /inference="alignment:Splign:2.1.0"
     exon            878..1139
                     /gene="Eps8l1"
                     /gene_synonym="2310051G19Rik; 4632407K17Rik; DRC3; EPS8R1"
                     /inference="alignment:Splign:2.1.0"
     exon            1140..1266
                     /gene="Eps8l1"
                     /gene_synonym="2310051G19Rik; 4632407K17Rik; DRC3; EPS8R1"
                     /inference="alignment:Splign:2.1.0"
     exon            1267..1355
                     /gene="Eps8l1"
                     /gene_synonym="2310051G19Rik; 4632407K17Rik; DRC3; EPS8R1"
                     /inference="alignment:Splign:2.1.0"
     exon            1356..1430
                     /gene="Eps8l1"
                     /gene_synonym="2310051G19Rik; 4632407K17Rik; DRC3; EPS8R1"
                     /inference="alignment:Splign:2.1.0"
     exon            1431..1579
                     /gene="Eps8l1"
                     /gene_synonym="2310051G19Rik; 4632407K17Rik; DRC3; EPS8R1"
                     /inference="alignment:Splign:2.1.0"
     exon            1580..1721
                     /gene="Eps8l1"
                     /gene_synonym="2310051G19Rik; 4632407K17Rik; DRC3; EPS8R1"
                     /inference="alignment:Splign:2.1.0"
     exon            1722..1750
                     /gene="Eps8l1"
                     /gene_synonym="2310051G19Rik; 4632407K17Rik; DRC3; EPS8R1"
                     /inference="alignment:Splign:2.1.0"
     exon            1751..1880
                     /gene="Eps8l1"
                     /gene_synonym="2310051G19Rik; 4632407K17Rik; DRC3; EPS8R1"
                     /inference="alignment:Splign:2.1.0"
     exon            1881..2012
                     /gene="Eps8l1"
                     /gene_synonym="2310051G19Rik; 4632407K17Rik; DRC3; EPS8R1"
                     /inference="alignment:Splign:2.1.0"
     exon            2013..2121
                     /gene="Eps8l1"
                     /gene_synonym="2310051G19Rik; 4632407K17Rik; DRC3; EPS8R1"
                     /inference="alignment:Splign:2.1.0"
     exon            2122..2296
                     /gene="Eps8l1"
                     /gene_synonym="2310051G19Rik; 4632407K17Rik; DRC3; EPS8R1"
                     /inference="alignment:Splign:2.1.0"
     exon            2297..2429
                     /gene="Eps8l1"
                     /gene_synonym="2310051G19Rik; 4632407K17Rik; DRC3; EPS8R1"
                     /inference="alignment:Splign:2.1.0"
     exon            2430..4070
                     /gene="Eps8l1"
                     /gene_synonym="2310051G19Rik; 4632407K17Rik; DRC3; EPS8R1"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      2993
                     /gene="Eps8l1"
                     /gene_synonym="2310051G19Rik; 4632407K17Rik; DRC3; EPS8R1"
                     /note="major polyA site"
     polyA_site      3774
                     /gene="Eps8l1"
                     /gene_synonym="2310051G19Rik; 4632407K17Rik; DRC3; EPS8R1"
     regulatory      3925..3930
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Eps8l1"
                     /gene_synonym="2310051G19Rik; 4632407K17Rik; DRC3; EPS8R1"
                     /note="hexamer: ACTAAA"
     polyA_site      3937
                     /gene="Eps8l1"
                     /gene_synonym="2310051G19Rik; 4632407K17Rik; DRC3; EPS8R1"
     polyA_site      3951
                     /gene="Eps8l1"
                     /gene_synonym="2310051G19Rik; 4632407K17Rik; DRC3; EPS8R1"
     polyA_site      4070
                     /gene="Eps8l1"
                     /gene_synonym="2310051G19Rik; 4632407K17Rik; DRC3; EPS8R1"
ORIGIN      
        1 cccacaccca ccctccctga taaccagcca cagtccccct taactgtgag cttgattttt
       61 ctcccctgga aggatttcct cgttggaggg gtatgagttc ggagtcggga gggtagagat
      121 aagaaaggtg acaagggtca gtacatcaag gccctacatt tgatacttca gaaggactct
      181 caatgcaaaa gaggaaaatt ccacctcctg aactacagcg agccagggcg gacacagggt
      241 ggggaattat cagcttcgct ggaggcccag catggctgaa tgagcaggca tggggctgga
      301 aagacttctt cagggagaga gtcctcaggc acctccaagt ggacagagca cctcatcttg
      361 ccaccatgag caccaccaca gggcctgaag ctgcacccaa accaagtgca aagtctatct
      421 atgaacagag aaaacgttac tccaccgtgg ttatggctga cgtgtcccag tatcatgtca
      481 atcacctggt caccttctgc ttgggggaag aagatggcgt gcacactgtg gaagatgctt
      541 ccagaaagct ggcagtcatg gacagccagg ggcgtgtctg ggcacaggag atgctactga
      601 gagtgtcacc tagtcaagtc actctgcttg atccagtctc caaggaagaa ctagagtcat
      661 atcctctcga tgccatcgta cgctgcgacg cggtgatgcc ccgaggacgg agccgttcat
      721 tgctgctcct ggtgtgccag gagccagagc gtgcacagcc ggatgttcat ttcttccagg
      781 gcctgctcct cggagcggag ctgatccgtg aggacatcca aggggctctg cagaactacc
      841 gctccggacg tggagaacgc agggcagcag cgctcagggc gacgcaggag gagctgcgac
      901 gcggcgcctc tccagcagcg gagaccccgc ccttacagcg tcgcccgtct gtccgcctgg
      961 tgatcaacac cgtggaacca tccgcagtcc gcgggcgacc ccaagtggag tcaattccag
     1021 agactgagga agcaaggaaa cccgaccaag ctcgcacgac tagcagtgct gaccctacct
     1081 ccccagactt gggcccaaga ggacctgagc tggcgggtct gcaggcagag cgggatgtgg
     1141 atattctgaa ccacgtgttt gacgacgtgg agagttttgt atccagactg caaaaatcag
     1201 cagaggctac ccgggttttg gagcaccgcg agagaggccg caggacacga cgccgagctg
     1261 cgggagaggg tctgctgaca ctgagggcca agccacccac tgaggctgag tacaccgacg
     1321 tgcttcagaa aatcaaatac gccttcagtc tgctggcccg gttgcgaggc aacatcgcca
     1381 acccctcctc tccagagctg ttgcactttc tgtttggacc tctgcagatg attgtgaaca
     1441 cttcaggcgg ccctgagttc gcgaagagtg tgcgacgacc gcatttgacg ttggaggctg
     1501 tgactctgct ccgcgacaat gtcactcctg gtgaaaatga actatggacc tcgctgggag
     1561 actcctggac ctgcccaggg gtggagctgc ccccggaaga agggtctcca tacagtccgg
     1621 aattctacaa tggctgggag cctccggcca ctgatccaca gggccgcccc tgggaggacc
     1681 cagtggaaaa acagctacaa cacgagaagc ggcgcaggca gcaaagcgcc ccccaggtcg
     1741 cggtcaatgg tcagcaagat ccagaactgg aaactgagtc ccagctagaa gagaaagcca
     1801 gaaaatgggt tctgtgtaat tatgacttcc aggcccgaaa tggcagcgag ctatctgtca
     1861 agcaccgaga tgtgttggag gtcctggatg acaggcgcaa atggtggaag gttcgggacc
     1921 atcagggaca agagggctat gtaccctata atatcctgac accccaccct ggacctcagg
     1981 tgcaccgcag ccaaagcccc gcaagacacc tagagactag cacacctcct cccccacctg
     2041 ccccagctcc agccccaact caggtgcggc cccagtggga cagttgcgac agtctaaaca
     2101 gtttggatcc cagcgagaag gagaaattct cccagatgct ttgtgtcaat gaggagctgc
     2161 agtcgcgcct ggcgcagggc cgttcgggtc ccagccgggt aaccccgggg ccccgagccc
     2221 aagagcccca gctcagcccg cgctctgagg cctcggtggt ccgtgcctgg ctgcagacca
     2281 agggctttag ctccgggact gtggaggcgc tcggtgtgct gaccggcgca cagctcttct
     2341 cgctgcaaaa ggaagagttg cgggcggtgt gccccgagga aggggcgcga gtgtacagcc
     2401 aagtcactgt gcagcgcgcg ctgctggagg acagagaaaa agtatcagag ctggaggccg
     2461 tgatggagaa gcaaaagaaa aaagtggaag gcgagaccaa aacagaagtc atttgatccc
     2521 ggctcgatca caaaaagtga tgagacgatg gggttcccag cgccccgtag gacaacagtc
     2581 gccagacttc cccccaccca ctcacccatc gccagtggca gtagatgcca taaaggatct
     2641 cccagcctgg gttctccgct atcctggcgg gcagactgca ctgacagtac tgacgggaac
     2701 tcttccagag ggactgatgg gaatggggaa agggacagag catagacact accagagagg
     2761 cacgttcaag aggcgcaatg gtggccctgt gcgttgtgat gcgctataaa cagcctcctt
     2821 ataggctaag tccacctgct gtccccctct tgccagctac caaggaggca gaaatctggg
     2881 agacacccca tatattctct ccatgaaagc ctggagattc caacccaggc ttcctcttaa
     2941 gcaccagtct atcctcactc tagcactacc tacaatctct ggttcaaaac ccattcctgg
     3001 ctcctcgctc ttcttggtcc agttacctag catgaggcct gggatttttc tttcaaacgc
     3061 tgagggcgtc tcctcccacc ctccattttg ggccaacccc ttcaatcaga agcatttcgc
     3121 acttactgct tctgctggtt ggaacagcct ccatcattct ggctcagctc acctgcatgc
     3181 catagatgcc tgcgccagcc agccacccag gatccagcta tggagatctg gatttttcct
     3241 gggcatgcta taggctcttg ggtcttccag tcccctcgag aactttctcc ctgccaagcc
     3301 ctgcaagttg tccggtttat ttaggtggct aataagggct ggttttctca ttcagactag
     3361 gtatccctaa ggtctttctt ttcctgctgt ggcgcttctc tttgcatcct taagacactt
     3421 ccgagagtcc catcactgca gtctgcctct gctcctgaag cagttcagtt cttacctaag
     3481 ccagcaggtg gcacacctca aatgcaacct agaaaagcca gcctttgggc tgacagcttc
     3541 actgttcgca caaccttcta gagcatttaa accactgcgg atgtcccttg tccctgtcta
     3601 cccctcaagc atgtcccttg gcttctcctg acatgtggga taaaacctaa ctccagcatg
     3661 agagttgatg cacatgactg ctccaggttc agggccaccc ttcctcactt ttcaggactc
     3721 tggacattga ttcacgctgt ttgcactgcc aggaacagac ccttcagaac ctaatcactg
     3781 cctgtcatac cttatgtcag ggttgggtgg ttggttttgt tggagatagt ctggatatag
     3841 cctcaaagtc tcatttctcc cgttttagtt tccttgaacg ctgggattcc tggcaaatac
     3901 cctgtagcct tttttctaag agaaactaaa aacacgagca gtttgcccaa actgttttag
     3961 tgagctccca ggctgcaggc tgaaatgcag gcagggacca gctgacttgt tggaacatca
     4021 gatgcctgta ggtctctctg gtctggaatc tgatcacttc tatctgatta
//
