LOCUS       NM_007944               3159 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus epidermal growth factor receptor pathway substrate
            15-like 1 (Eps15l1), transcript variant 1, mRNA.
ACCESSION   NM_007944
VERSION     NM_007944.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3159)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3159)
  AUTHORS   Milesi,C., Alberici,P., Pozzi,B., Oldani,A., Beznoussenko,G.V.,
            Raimondi,A., Soppo,B.E., Amodio,S., Caldieri,G., Malabarba,M.G.,
            Bertalot,G., Confalonieri,S., Parazzoli,D., Mironov,A.A.,
            Tacchetti,C., Di Fiore,P.P., Sigismund,S. and Offenhauser,N.
  TITLE     Redundant and nonredundant organismal functions of EPS15 and
            EPS15L1
  JOURNAL   Life Sci Alliance 2 (1), e201800273 (2019)
   PUBMED   30692166
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3159)
  AUTHORS   Evergren,E., Cobbe,N. and McMahon,H.T.
  TITLE     Eps15R and clathrin regulate EphB2-mediated cell repulsion
  JOURNAL   Traffic 19 (1), 44-57 (2018)
   PUBMED   28972287
  REMARK    GeneRIF: A novel interaction motif in Eps15R, DPFxxLDPF, is shown
            to bind directly to the clathrin terminal domain in vitro.
            Interaction between Eps15R and clathrin is required for
            EphB2-mediated cell repulsion.
REFERENCE   4  (bases 1 to 3159)
  AUTHORS   Teckchandani,A., Mulkearns,E.E., Randolph,T.W., Toida,N. and
            Cooper,J.A.
  TITLE     The clathrin adaptor Dab2 recruits EH domain scaffold proteins to
            regulate integrin beta1 endocytosis
  JOURNAL   Mol Biol Cell 23 (15), 2905-2916 (2012)
   PUBMED   22648170
REFERENCE   5  (bases 1 to 3159)
  AUTHORS   Lee,D.W., Zhao,X., Yim,Y.I., Eisenberg,E. and Greene,L.E.
  TITLE     Essential role of cyclin-G-associated kinase (Auxilin-2) in
            developing and mature mice
  JOURNAL   Mol Biol Cell 19 (7), 2766-2776 (2008)
   PUBMED   18434600
REFERENCE   6  (bases 1 to 3159)
  AUTHORS   Polo,S., Sigismund,S., Faretta,M., Guidi,M., Capua,M.R., Bossi,G.,
            Chen,H., De Camilli,P. and Di Fiore,P.P.
  TITLE     A single motif responsible for ubiquitin recognition and
            monoubiquitination in endocytic proteins
  JOURNAL   Nature 416 (6879), 451-455 (2002)
   PUBMED   11919637
  REMARK    GeneRIF: a short amino-acid stretch at the carboxy-termini of the
            monoubiquitinated endocytic proteins Eps15 and eps15R is
            indispensable for their monoubiquitination
REFERENCE   7  (bases 1 to 3159)
  AUTHORS   Offenhauser,N., Santolini,E., Simeone,A. and Di Fiore,P.P.
  TITLE     Differential patterns of expression of Eps15 and Eps15R during
            mouse embryogenesis
  JOURNAL   Mech Dev 95 (1-2), 309-312 (2000)
   PUBMED   10906484
REFERENCE   8  (bases 1 to 3159)
  AUTHORS   Coda,L., Salcini,A.E., Confalonieri,S., Pelicci,G., Sorkina,T.,
            Sorkin,A., Pelicci,P.G. and Di Fiore,P.P.
  TITLE     Eps15R is a tyrosine kinase substrate with characteristics of a
            docking protein possibly involved in coated pits-mediated
            internalization
  JOURNAL   J Biol Chem 273 (5), 3003-3012 (1998)
   PUBMED   9446614
REFERENCE   9  (bases 1 to 3159)
  AUTHORS   Wong,W.T., Schumacher,C., Salcini,A.E., Romano,A., Castagnino,P.,
            Pelicci,P.G. and Di Fiore,P.P.
  TITLE     A protein-binding domain, EH, identified in the receptor tyrosine
            kinase substrate Eps15 and conserved in evolution
  JOURNAL   Proc Natl Acad Sci U S A 92 (21), 9530-9534 (1995)
   PUBMED   7568168
REFERENCE   10 (bases 1 to 3159)
  AUTHORS   Schumacher,C., Knudsen,B.S., Ohuchi,T., Di Fiore,P.P.,
            Glassman,R.H. and Hanafusa,H.
  TITLE     The SH3 domain of Crk binds specifically to a conserved
            proline-rich motif in Eps15 and Eps15R
  JOURNAL   J Biol Chem 270 (25), 15341-15347 (1995)
   PUBMED   7797522
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY270130.1, AK146781.1 and CD774936.1.
            
            On Mar 26, 2008 this sequence version replaced NM_007944.2.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK146781.1, U29156.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-23                BY270130.1         1-23
            24-3141             AK146781.1         2-3119
            3142-3159           CD774936.1         1-18                c
FEATURES             Location/Qualifiers
     source          1..3159
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 35.02 cM"
     gene            1..3159
                     /gene="Eps15l1"
                     /gene_synonym="9830147J04Rik; Eps15-rs; Eps15R"
                     /note="epidermal growth factor receptor pathway substrate
                     15-like 1"
                     /db_xref="GeneID:13859"
                     /db_xref="MGI:MGI:104582"
     exon            1..70
                     /gene="Eps15l1"
                     /gene_synonym="9830147J04Rik; Eps15-rs; Eps15R"
                     /inference="alignment:Splign:2.1.0"
     exon            71..112
                     /gene="Eps15l1"
                     /gene_synonym="9830147J04Rik; Eps15-rs; Eps15R"
                     /inference="alignment:Splign:2.1.0"
     exon            113..202
                     /gene="Eps15l1"
                     /gene_synonym="9830147J04Rik; Eps15-rs; Eps15R"
                     /inference="alignment:Splign:2.1.0"
     exon            203..250
                     /gene="Eps15l1"
                     /gene_synonym="9830147J04Rik; Eps15-rs; Eps15R"
                     /inference="alignment:Splign:2.1.0"
     exon            251..346
                     /gene="Eps15l1"
                     /gene_synonym="9830147J04Rik; Eps15-rs; Eps15R"
                     /inference="alignment:Splign:2.1.0"
     exon            347..409
                     /gene="Eps15l1"
                     /gene_synonym="9830147J04Rik; Eps15-rs; Eps15R"
                     /inference="alignment:Splign:2.1.0"
     exon            410..535
                     /gene="Eps15l1"
                     /gene_synonym="9830147J04Rik; Eps15-rs; Eps15R"
                     /inference="alignment:Splign:2.1.0"
     exon            536..595
                     /gene="Eps15l1"
                     /gene_synonym="9830147J04Rik; Eps15-rs; Eps15R"
                     /inference="alignment:Splign:2.1.0"
     exon            596..823
                     /gene="Eps15l1"
                     /gene_synonym="9830147J04Rik; Eps15-rs; Eps15R"
                     /inference="alignment:Splign:2.1.0"
     exon            824..981
                     /gene="Eps15l1"
                     /gene_synonym="9830147J04Rik; Eps15-rs; Eps15R"
                     /inference="alignment:Splign:2.1.0"
     exon            982..1138
                     /gene="Eps15l1"
                     /gene_synonym="9830147J04Rik; Eps15-rs; Eps15R"
                     /inference="alignment:Splign:2.1.0"
     exon            1139..1224
                     /gene="Eps15l1"
                     /gene_synonym="9830147J04Rik; Eps15-rs; Eps15R"
                     /inference="alignment:Splign:2.1.0"
     exon            1225..1297
                     /gene="Eps15l1"
                     /gene_synonym="9830147J04Rik; Eps15-rs; Eps15R"
                     /inference="alignment:Splign:2.1.0"
     exon            1298..1459
                     /gene="Eps15l1"
                     /gene_synonym="9830147J04Rik; Eps15-rs; Eps15R"
                     /inference="alignment:Splign:2.1.0"
     exon            1460..1657
                     /gene="Eps15l1"
                     /gene_synonym="9830147J04Rik; Eps15-rs; Eps15R"
                     /inference="alignment:Splign:2.1.0"
     exon            1658..1822
                     /gene="Eps15l1"
                     /gene_synonym="9830147J04Rik; Eps15-rs; Eps15R"
                     /inference="alignment:Splign:2.1.0"
     exon            1823..1946
                     /gene="Eps15l1"
                     /gene_synonym="9830147J04Rik; Eps15-rs; Eps15R"
                     /inference="alignment:Splign:2.1.0"
     exon            1947..1997
                     /gene="Eps15l1"
                     /gene_synonym="9830147J04Rik; Eps15-rs; Eps15R"
                     /inference="alignment:Splign:2.1.0"
     exon            1998..2134
                     /gene="Eps15l1"
                     /gene_synonym="9830147J04Rik; Eps15-rs; Eps15R"
                     /inference="alignment:Splign:2.1.0"
     exon            2135..2195
                     /gene="Eps15l1"
                     /gene_synonym="9830147J04Rik; Eps15-rs; Eps15R"
                     /inference="alignment:Splign:2.1.0"
     exon            2196..2278
                     /gene="Eps15l1"
                     /gene_synonym="9830147J04Rik; Eps15-rs; Eps15R"
                     /inference="alignment:Splign:2.1.0"
     exon            2279..2411
                     /gene="Eps15l1"
                     /gene_synonym="9830147J04Rik; Eps15-rs; Eps15R"
                     /inference="alignment:Splign:2.1.0"
     exon            2412..2617
                     /gene="Eps15l1"
                     /gene_synonym="9830147J04Rik; Eps15-rs; Eps15R"
                     /inference="alignment:Splign:2.1.0"
     exon            2618..3147
                     /gene="Eps15l1"
                     /gene_synonym="9830147J04Rik; Eps15-rs; Eps15R"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3126..3131
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Eps15l1"
                     /gene_synonym="9830147J04Rik; Eps15-rs; Eps15R"
                     /note="hexamer: TATAAA"
     polyA_site      3147
                     /gene="Eps15l1"
                     /gene_synonym="9830147J04Rik; Eps15-rs; Eps15R"
                     /note="major polyA site"
ORIGIN      
        1 gttccttcgg cgctccggag gccgagtccg cacgaagatg gcggcgccgc ttgtacccct
       61 ctcgcagcag attcccggtg gaaatccgtt atacgagtct tattacaagc aggtggaccc
      121 tgcctacaca gggagagttg gggcaagcga ggctgcgctg tttctgaaga aatcggggct
      181 ctcagacatc atcctgggga agatatggga cttggcagac cccgaaggta aagggttctt
      241 ggacaaacag ggtttctatg ttgcactgcg actggtggcc tgtgcacaga gtggccatga
      301 agtcaccttg agcagtctga gcctcaccat gccaccacca aaatttcatg ataccagcag
      361 cccactgatg gccacacagt catctgcaga gacccactgg gctgtgcggg tggaggagaa
      421 ggcaaagttt gatggcatct ttgaaagcct tctaccagtc aatgggctac tctctggaga
      481 caaggtcaag ccggtcctca tgaactcgaa actacctctg gatgtgctgg gcagggtctg
      541 ggacctcagt gacatagaca aggatggaca tttggaccga gatgagtttg ctgtggctat
      601 gcacttggtg taccgcgccc tggagaagga accagtgccc tccatcctgc ccccgcccct
      661 catcccaccc tctaagagga agaagactgt gtttgcagga gctgtgcctg tcctgcctgc
      721 tagtccccca cccaaagaca gcctccgctc cacaccatcc cacggcagcg taagcagcct
      781 caacagcaca ggcagcctgt ccccgaagca cagcgtcaag cagccaccag tggcctgggt
      841 tgtgcctgtg gcagataaga tgcgctttga tgagatcttt ttgaagacag acctggacct
      901 tgatggctat gtgagtggcc aggaagttaa ggagatcttc atgcactcag gcctcactca
      961 gaaccttctg gcacacatct gggccctggc tgatacaaga caaacgggca agttaagcaa
     1021 agagcagttc gcactagcta tgtatttcat tcagcagaag gtcagtaaag gcatcgaccc
     1081 tcctcaagtc ctctcgcctg acatggtgcc accctctgag agaggcactc ccattccaga
     1141 cagttcaagt actctggcat caggagagtt cactggtgtt aaagagctgg atgacattag
     1201 ccaggagatc gcacagttgc agagagagaa atactcattg gaacaagaca tcagagaaaa
     1261 ggaagaggca atcagacaga aaaccagcga agtacaggaa ttacaaaatg acctagaccg
     1321 ggaaactagt agtctgcagg agcttgaggc tcagaaacag gatgcccagg accgcctgga
     1381 tgagatggac cagcagaagg ctaagctgcg ggacatgctg agtgacgtgc ggcagaaatg
     1441 ccaggatgag acccagacaa tctcatcatt gaaaacccag attcagtctc aggagtcaga
     1501 cttgaagtcc caggaggatg acctgaacag ggccaagtca gagctgaatc ggctgcagca
     1561 agaggagaca cagctggagc agagcatcca ggctggacgt gcacagctgg agaccatcct
     1621 caggtccctg aagtgcacac aggatgacat caaccaggca agaagcaagc tgtcccagct
     1681 acaggagagc cacctagaag ctcaccggag cctggaacag tatgaccagg tgcctgatgg
     1741 ggtctctggt accagcctgc ctgacctggc caccttgaac gaaggcatct tgctggcaga
     1801 gaggggcggc tttggagcta tggatgatcc tttcaaaaac aaagccttat tgtttagcaa
     1861 caactcccag gaacttcatc cagacccctt ccaggctgag gaccccttca agtccgaccc
     1921 atttaaagga gctgacccct tcaaaggtga tcctttccaa agtgatccct tctcagagca
     1981 gcagacagca gctacagacc catttggagg ggatcctttc aaagaaagtg acccattcca
     2041 cagctcaagc agtgatgact tcttcaagaa acagacaaag aatgacccat ttacctcaga
     2101 ccccttcaca aagaaccctt ccttaccttc aaagctcgac ccatttgagt ccagtgatcc
     2161 tttttcatcc tccagcatct cctcgaaagg ttcagatccc tttggaaccc tagacccctt
     2221 tggaagcagc tccttcagca gtgccgaggg cttcgctgac ttcagtcaga tgtccaagcc
     2281 cccaccttct ggccccttct cctcctcctt gggaggcaca ggattctcag atgacccctt
     2341 taaaagtaaa caggacactc ctgctctgcc tccgaagaag cccgctcctc cacggcccaa
     2401 accgcccagc ggtcagagta cacctgtaag ccagctgggt tcttcagact tccctgagtc
     2461 ccctgatcca ttccagccac tcggggctga cagcggcgac ccgttccaaa ataaaaaggg
     2521 gtttggggac ccatttagtg gcaaagatcc atttgcccct tcctcttcag ctaaacctcc
     2581 taagacctct tcctccggct ttgccgactt cacctctttt ggcaatgagg agcagcaatt
     2641 ggcttgggcc aagcgggaga gtgaaaaagc ggagcaagag cggctggcga ggctgcggcg
     2701 acaggaacag gaggacctgg aactggccat cgccctcagc aaggctgata tgccagccta
     2761 ggtgacacag gggaagccgc agctgtatgt acacatccct tcaagttgtg ccatgccaca
     2821 gccaaggaca gctggccaca gggcctcagg ctacagggac cttgttgaga ggcctcagac
     2881 actgctcacc cctgtgggtg ggccaggaag gcagctatag gtaaaagtcc tggaacctgc
     2941 cagtctctga ggtatgatgg tgatcagtta ggctcttcct tccaatcatt cagtggctga
     3001 cagagaaggc ctccagtctc ctagctgcag acaagctcca cccccagccc ttccttgcat
     3061 ccacaagaca ccccacacac atgatgtatg cattcgttgt ataaaaatga agtttgaatg
     3121 attaatataa aatattttaa tacaaaaaaa aaaaaaaaa
//
