LOCUS       NM_029735               4922 bp    mRNA    linear   ROD 24-DEC-2024
DEFINITION  Mus musculus glutamyl-prolyl-tRNA synthetase 1 (Eprs1), transcript
            variant 1, mRNA.
ACCESSION   NM_029735 XM_129647 XM_899627 XM_899630 XM_899635 XM_899640
            XM_899642 XM_899647 XM_899651 XM_899655 XM_899659 XM_899665
            XM_916645
VERSION     NM_029735.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4922)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4922)
  AUTHORS   Wu,J., Hollinger,J., Bonanno,E., Jiang,F. and Yao,P.
  TITLE     Cardiomyocyte-Specific Loss of Glutamyl-prolyl-tRNA Synthetase
            Leads to Disturbed Protein Homeostasis and Dilated Cardiomyopathy
  JOURNAL   Cells 13 (1), 35 (2023)
   PUBMED   38201239
  REMARK    GeneRIF: Cardiomyocyte-Specific Loss of Glutamyl-prolyl-tRNA
            Synthetase Leads to Disturbed Protein Homeostasis and Dilated
            Cardiomyopathy.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4922)
  AUTHORS   Lee,E.Y., Kim,S.M., Hwang,J.H., Jang,S.Y., Park,S., Choi,S.,
            Lee,G.S., Hwang,J., Moon,J.H., Fox,P.L., Kim,S., Lee,C.H. and
            Kim,M.H.
  TITLE     Glutamyl-prolyl-tRNA synthetase 1 coordinates early endosomal
            anti-inflammatory AKT signaling
  JOURNAL   Nat Commun 13 (1), 6455 (2022)
   PUBMED   36309524
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4922)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4922)
  AUTHORS   Vasu,K., Ramachandiran,I., Terenzi,F., Khan,D., China,A., Khan,K.,
            Chechi,A., Baleanu-Gogonea,C., Gogonea,V. and Fox,P.L.
  TITLE     The zinc-binding domain of mammalian prolyl-tRNA synthetase is
            indispensable for catalytic activity and organism viability
  JOURNAL   iScience 24 (3), 102215 (2021)
   PUBMED   33748704
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4922)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   7  (bases 1 to 4922)
  AUTHORS   Kim,J.Y., Kang,Y.S., Lee,J.W., Kim,H.J., Ahn,Y.H., Park,H., Ko,Y.G.
            and Kim,S.
  TITLE     p38 is essential for the assembly and stability of macromolecular
            tRNA synthetase complex: implications for its physiological
            significance
  JOURNAL   Proc Natl Acad Sci U S A 99 (12), 7912-7916 (2002)
   PUBMED   12060739
REFERENCE   8  (bases 1 to 4922)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   9  (bases 1 to 4922)
  AUTHORS   Kaiser,E., Hu,B., Becher,S., Eberhard,D., Schray,B., Baack,M.,
            Hameister,H. and Knippers,R.
  TITLE     The human EPRS locus (formerly the QARS locus): a gene encoding a
            class I and a class II aminoacyl-tRNA synthetase
  JOURNAL   Genomics 19 (2), 280-290 (1994)
   PUBMED   8188258
REFERENCE   10 (bases 1 to 4922)
  AUTHORS   Fett,R. and Knippers,R.
  TITLE     The primary structure of human glutaminyl-tRNA synthetase. A highly
            conserved core, amino acid repeat regions, and homologies with
            translation elongation factors
  JOURNAL   J Biol Chem 266 (3), 1448-1455 (1991)
   PUBMED   1988429
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK141072.1, CF537682.1, CB520692.1, BC094679.1, BC058337.1,
            CK635189.1 and AI845980.1.
            
            On Oct 28, 2017 this sequence version replaced NM_029735.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660817.46524.1, BC141049.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-51                AK141072.1         2-52
            52-239              CF537682.1         1-188
            240-257             CB520692.1         1-18
            258-672             BC094679.1         1-415
            673-1648            BC058337.1         575-1550
            1649-4022           BC094679.1         1392-3765
            4023-4398           CK635189.1         213-588
            4399-4896           BC094679.1         4142-4639
            4897-4922           AI845980.1         1-26                c
FEATURES             Location/Qualifiers
     source          1..4922
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 89.5 cM"
     gene            1..4922
                     /gene="Eprs1"
                     /gene_synonym="2410081F06Rik; 3010002K18Rik; Eprs; Qprs"
                     /note="glutamyl-prolyl-tRNA synthetase 1"
                     /db_xref="GeneID:107508"
                     /db_xref="MGI:MGI:97838"
     exon            1..200
                     /gene="Eprs1"
                     /gene_synonym="2410081F06Rik; 3010002K18Rik; Eprs; Qprs"
                     /inference="alignment:Splign:2.1.0"
     CDS             155..4693
                     /gene="Eprs1"
                     /gene_synonym="2410081F06Rik; 3010002K18Rik; Eprs; Qprs"
                     /EC_number="6.1.1.15"
                     /EC_number="6.1.1.17"
                     /note="isoform 1 is encoded by transcript variant 1;
                     bifunctional aminoacyl-tRNA synthetase;
                     glutamine-proline-tRNA synthetase; bifunctional
                     glutamate/proline--tRNA ligase"
                     /codon_start=1
                     /product="bifunctional glutamate/proline--tRNA ligase
                     isoform 1"
                     /protein_id="NP_084011.1"
                     /db_xref="CCDS:CCDS35818.1"
                     /db_xref="GeneID:107508"
                     /db_xref="MGI:MGI:97838"
                     /translation="MAALCLTVNAGNPPLEALLAVEHVKGDVSISVEEGKENLLRVSE
                     TVAFTDVNSILRYLARIATTSGLYGTNLMEHTEIDHWLEFSATKLSSCDRLTSAINEL
                     NHCLSLRTYLVGNSLTLADLCVWATLKGSAAWQEHLKQNKTLVHVKRWFGFLEAQQAF
                     RSVGTKWDVSGNRATVAPDKKQDVGKFVELPGAEMGKVTVRFPPEASGYLHIGHAKAA
                     LLNQHYQVNFKGKLIMRFDDTNPEKEKEDFEKVILEDVAMLHIKPDQFTYTSDHFETI
                     MKYAEKLIQEGKAYVDDTPAEQMKAEREQRTESKHRKNSVEKNLQMWEEMKKGSQFGQ
                     SCCLRAKIDMSSNNGCMRDPTLYRCKIQPHPRTGNKYNVYPTYDFACPIVDSIEGVTH
                     ALRTTEYHDRDEQFYWIIEALGIRKPYIWEYSRLNLNNTVLSKRKLTWFVNEGLVDGW
                     DDPRFPTVRGVLRRGMTVEGLKQFIAAQGSSRSVVNMEWDKIWAFNKKVIDPVAPRYV
                     ALLKKEVVPVNVLDAQEEMKEVARHPKNPDVGLKPVWYSPKVFIEGADAETFSEGEMV
                     TFINWGNINITKIHKNADGKITSLDAKLNLENKDYKKTTKITWLAESTHALSIPAVCV
                     TYEHLITKPVLGKDEDFKQYINKDSKHEELMLGDPCLKDLKKGDIIQLQRRGFFICDQ
                     PYEPVSPYSCREAPCILIYIPDGHTKEMPTSGSKEKTKVEISKKETSSAPKERPAPAV
                     SSTCATAEDSSVLYSRVAVQGDVVRELKAKKAPKEDIDAAVKQLLTLKAEYKEKTGQE
                     YKPGNPSAAAVQTVSTKSSSNTVESTSLYNKVAAQGEVVRKLKAEKAPKAKVTEAVEC
                     LLSLKAEYKEKTGKDYVPGQPPASQNSHSNPVSNAQPAGAEKPEAKVLFDRVACQGEV
                     VRKLKAEKASKDQVDSAVQELLQLKAQYKSLTGIEYKPVSATGAEDKDKKKKEKENKS
                     EKQNKPQKQNDGQGKDSSKSQGSGLSSGGAGEGQGPKKQTRLGLEAKKEENLAEWYSQ
                     VITKSEMIEYYDVSGCYILRPWSYSIWESIKDFFDAEIKKLGVENCYFPIFVSQAALE
                     KEKNHIEDFAPEVAWVTRSGKTELAEPIAIRPTSETVMYPAYAKWVQSHRDLPVRLNQ
                     WCNVVRWEFKHPQPFLRTREFLWQEGHSAFATFEEAADEVLQILELYARVYEELLAIP
                     VVRGRKTEKEKFAGGDYTTTIEAFISASGRAIQGATSHHLGQNFSKMCEIVFEDPKTP
                     GEKQFAYQCSWGLTTRTIGVMVMVHGDNMGLVLPPRVASVQVVVIPCGITNALSEEDR
                     EALMAKCNEYRRRLLGANIRVRVDLRDNYSPGWKFNHWELKGVPVRLEVGPRDMKSCQ
                     FVAVRRDTGEKLTIAEKEAEAKLEKVLEDIQLNLFTRASEDLKTHMVVSNTLEDFQKV
                     LDAGKVAQIPFCGEIDCEDWIKKMTARDQDVEPGAPSMGAKSLCIPFNPLCELQPGAM
                     CVCGKNPAKFYTLFGRSY"
     exon            201..285
                     /gene="Eprs1"
                     /gene_synonym="2410081F06Rik; 3010002K18Rik; Eprs; Qprs"
                     /inference="alignment:Splign:2.1.0"
     exon            286..385
                     /gene="Eprs1"
                     /gene_synonym="2410081F06Rik; 3010002K18Rik; Eprs; Qprs"
                     /inference="alignment:Splign:2.1.0"
     exon            386..542
                     /gene="Eprs1"
                     /gene_synonym="2410081F06Rik; 3010002K18Rik; Eprs; Qprs"
                     /inference="alignment:Splign:2.1.0"
     exon            543..682
                     /gene="Eprs1"
                     /gene_synonym="2410081F06Rik; 3010002K18Rik; Eprs; Qprs"
                     /inference="alignment:Splign:2.1.0"
     exon            683..777
                     /gene="Eprs1"
                     /gene_synonym="2410081F06Rik; 3010002K18Rik; Eprs; Qprs"
                     /inference="alignment:Splign:2.1.0"
     exon            778..904
                     /gene="Eprs1"
                     /gene_synonym="2410081F06Rik; 3010002K18Rik; Eprs; Qprs"
                     /inference="alignment:Splign:2.1.0"
     exon            905..1097
                     /gene="Eprs1"
                     /gene_synonym="2410081F06Rik; 3010002K18Rik; Eprs; Qprs"
                     /inference="alignment:Splign:2.1.0"
     exon            1098..1269
                     /gene="Eprs1"
                     /gene_synonym="2410081F06Rik; 3010002K18Rik; Eprs; Qprs"
                     /inference="alignment:Splign:2.1.0"
     exon            1270..1503
                     /gene="Eprs1"
                     /gene_synonym="2410081F06Rik; 3010002K18Rik; Eprs; Qprs"
                     /inference="alignment:Splign:2.1.0"
     exon            1504..1588
                     /gene="Eprs1"
                     /gene_synonym="2410081F06Rik; 3010002K18Rik; Eprs; Qprs"
                     /inference="alignment:Splign:2.1.0"
     exon            1589..1648
                     /gene="Eprs1"
                     /gene_synonym="2410081F06Rik; 3010002K18Rik; Eprs; Qprs"
                     /inference="alignment:Splign:2.1.0"
     exon            1649..1759
                     /gene="Eprs1"
                     /gene_synonym="2410081F06Rik; 3010002K18Rik; Eprs; Qprs"
                     /inference="alignment:Splign:2.1.0"
     exon            1760..1896
                     /gene="Eprs1"
                     /gene_synonym="2410081F06Rik; 3010002K18Rik; Eprs; Qprs"
                     /inference="alignment:Splign:2.1.0"
     exon            1897..2104
                     /gene="Eprs1"
                     /gene_synonym="2410081F06Rik; 3010002K18Rik; Eprs; Qprs"
                     /inference="alignment:Splign:2.1.0"
     exon            2105..2217
                     /gene="Eprs1"
                     /gene_synonym="2410081F06Rik; 3010002K18Rik; Eprs; Qprs"
                     /inference="alignment:Splign:2.1.0"
     exon            2218..2335
                     /gene="Eprs1"
                     /gene_synonym="2410081F06Rik; 3010002K18Rik; Eprs; Qprs"
                     /inference="alignment:Splign:2.1.0"
     exon            2336..2695
                     /gene="Eprs1"
                     /gene_synonym="2410081F06Rik; 3010002K18Rik; Eprs; Qprs"
                     /inference="alignment:Splign:2.1.0"
     exon            2696..2929
                     /gene="Eprs1"
                     /gene_synonym="2410081F06Rik; 3010002K18Rik; Eprs; Qprs"
                     /inference="alignment:Splign:2.1.0"
     exon            2930..3192
                     /gene="Eprs1"
                     /gene_synonym="2410081F06Rik; 3010002K18Rik; Eprs; Qprs"
                     /inference="alignment:Splign:2.1.0"
     exon            3193..3244
                     /gene="Eprs1"
                     /gene_synonym="2410081F06Rik; 3010002K18Rik; Eprs; Qprs"
                     /inference="alignment:Splign:2.1.0"
     exon            3245..3454
                     /gene="Eprs1"
                     /gene_synonym="2410081F06Rik; 3010002K18Rik; Eprs; Qprs"
                     /inference="alignment:Splign:2.1.0"
     exon            3455..3527
                     /gene="Eprs1"
                     /gene_synonym="2410081F06Rik; 3010002K18Rik; Eprs; Qprs"
                     /inference="alignment:Splign:2.1.0"
     exon            3528..3607
                     /gene="Eprs1"
                     /gene_synonym="2410081F06Rik; 3010002K18Rik; Eprs; Qprs"
                     /inference="alignment:Splign:2.1.0"
     exon            3608..3709
                     /gene="Eprs1"
                     /gene_synonym="2410081F06Rik; 3010002K18Rik; Eprs; Qprs"
                     /inference="alignment:Splign:2.1.0"
     exon            3710..3865
                     /gene="Eprs1"
                     /gene_synonym="2410081F06Rik; 3010002K18Rik; Eprs; Qprs"
                     /inference="alignment:Splign:2.1.0"
     exon            3866..4063
                     /gene="Eprs1"
                     /gene_synonym="2410081F06Rik; 3010002K18Rik; Eprs; Qprs"
                     /inference="alignment:Splign:2.1.0"
     exon            4064..4237
                     /gene="Eprs1"
                     /gene_synonym="2410081F06Rik; 3010002K18Rik; Eprs; Qprs"
                     /inference="alignment:Splign:2.1.0"
     exon            4238..4398
                     /gene="Eprs1"
                     /gene_synonym="2410081F06Rik; 3010002K18Rik; Eprs; Qprs"
                     /inference="alignment:Splign:2.1.0"
     exon            4399..4477
                     /gene="Eprs1"
                     /gene_synonym="2410081F06Rik; 3010002K18Rik; Eprs; Qprs"
                     /inference="alignment:Splign:2.1.0"
     exon            4478..4542
                     /gene="Eprs1"
                     /gene_synonym="2410081F06Rik; 3010002K18Rik; Eprs; Qprs"
                     /inference="alignment:Splign:2.1.0"
     exon            4543..4906
                     /gene="Eprs1"
                     /gene_synonym="2410081F06Rik; 3010002K18Rik; Eprs; Qprs"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4878..4883
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Eprs1"
                     /gene_synonym="2410081F06Rik; 3010002K18Rik; Eprs; Qprs"
                     /note="hexamer: AATAAA"
     polyA_site      4901
                     /gene="Eprs1"
                     /gene_synonym="2410081F06Rik; 3010002K18Rik; Eprs; Qprs"
                     /note="major polyA site"
ORIGIN      
        1 gtagcgtgcg caccgactcc ggcggtggcg gcccgtgggg aggagtcagg gctgcggtgc
       61 cttcggtcgc gcgcacacgt tgcatctcct tgcttccacc tgaaccctcg ccgccaggaa
      121 ggcagcccga cgagtagacc gcagctcctg ggagatggcg gcgctgtgcc tcacggtgaa
      181 cgccggaaac cctccgctgg aagctctgct ggcggtggaa catgtgaaag gtgatgtcag
      241 catttctgtg gaagaaggga aagagaatct tcttcgggtt tctgagactg tggcattcac
      301 tgacgtgaat tcaatcctgc gctacctggc tagaattgca actacgtctg ggctgtatgg
      361 gactaacctg atggagcaca ctgagattga tcattggttg gagtttagtg ctacaaagtt
      421 gtcttcgtgt gataggctga cttctgcaat caacgagctt aatcattgcc tgtctctgag
      481 aacataccta gttgggaact ccttgacctt agcagatcta tgtgtttggg ccaccctaaa
      541 aggaagtgct gcatggcagg aacacttgaa acagaacaaa actctagtcc acgttaaacg
      601 ctggtttggc tttcttgagg cccagcaggc cttccgctca gttggcacca agtgggatgt
      661 ttcaggaaac agagctacag tggcacctga caaaaaacaa gatgttggga aattcgtgga
      721 gcttccaggt gcagagatgg gaaaggtgac agtcagattc cccccagagg ctagtggtta
      781 cttacacatt gggcatgcga aagctgctct tctgaaccag cactaccagg ttaactttaa
      841 agggaaactg atcatgagat ttgatgacac aaacccagaa aaggaaaagg aagattttga
      901 gaaggtcatc ttggaagatg ttgcaatgct gcatattaaa ccagatcagt ttacttacac
      961 ttcagatcat tttgaaacta taatgaagta tgcagagaaa ttaattcaag aagggaaggc
     1021 ttatgtggat gacactcctg cagaacagat gaaggcggaa cgtgaacaga ggacagaatc
     1081 caaacacagg aagaactctg ttgagaagaa tctacagatg tgggaagaaa tgaaaaaagg
     1141 aagccagttt ggtcagtcct gttgcctgcg agcaaaaatt gacatgagta gtaacaatgg
     1201 gtgtatgaga gacccgaccc tttaccgatg caaaatccag ccccacccaa ggactgggaa
     1261 taaatacaat gtttatccaa catatgactt tgcctgccct atagtggaca gcattgaagg
     1321 tgttactcat gccttgagga caacagagta ccacgaccga gatgaacaat tttattggat
     1381 cattgaagct ttaggcataa ggaaaccata catctgggag tacagtcgct taaatctcaa
     1441 caacaccgtg ctgtccaaaa gaaagctcac gtggtttgtc aatgaaggac tggtagatgg
     1501 atgggatgac ccacggtttc ctacagttcg tggagttctg agaagaggga tgacagttga
     1561 ggggctgaag cagttcattg ctgctcaggg ctcctcaagg tctgttgtga acatggaatg
     1621 ggacaaaatc tgggcgttca acaaaaaggt tattgaccca gtggctccac ggtacgttgc
     1681 attgctgaag aaggaagtcg tcccagtgaa tgtcctggat gcgcaggagg agatgaagga
     1741 agtagccaga caccccaaga atcctgatgt tggtttgaag cctgtgtggt acagtcccaa
     1801 ggttttcata gaaggggccg atgcagagac tttctcagag ggtgagatgg tcacatttat
     1861 aaactggggc aacatcaaca ttactaaaat acacaaaaat gcagatggaa aaattacatc
     1921 tctagatgca aaattgaatt tggaaaacaa agactacaag aaaaccacca agatcacttg
     1981 gcttgctgag agcacacacg ctctctcgat cccagccgtc tgtgtcactt atgagcactt
     2041 gatcacaaag ccagtgctgg gaaaagatga ggacttcaag cagtacatca acaaagacag
     2101 taagcatgaa gagctaatgc taggagatcc ttgccttaaa gatctgaaaa aaggagacat
     2161 catacaactg cagaggagag ggttcttcat atgcgaccag ccatacgaac ctgtcagccc
     2221 atatagttgc agagaagctc catgcatcct gatatacata cctgatgggc acacaaagga
     2281 aatgccaaca tccggatcaa aggaaaagac caaagtggaa atctcaaaaa aggagacaag
     2341 ctctgctcct aaagaaagac cagcacctgc tgtgagttct acttgtgcta cagctgagga
     2401 ttcctccgtc ctctacagca gagtggcggt gcagggggat gtggttcgtg aattgaaagc
     2461 caagaaagcg ccaaaggaag atatagacgc agctgtgaag cagcttttga ctttgaaagc
     2521 tgaatataaa gagaaaactg ggcaggagta taaacctggg aacccctctg ctgcagcagt
     2581 acagactgtt tctacaaagt catcatcaaa cactgtggaa agtacatctt tatacaataa
     2641 agtcgctgcc caaggggagg tggtccgaaa gctgaaagcg gaaaaggctc ctaaggctaa
     2701 agtaactgaa gctgtggaat gtttgctgtc cctgaaagct gagtataaag aaaagactgg
     2761 gaaggactat gtacctggcc agcccccagc atcgcagaac tcacattcaa accctgtcag
     2821 taatgctcag cctgctggag cggagaaacc agaagccaaa gtgctatttg acagagtggc
     2881 ttgtcaagga gaagtagttc gaaaacttaa agctgaaaag gcctctaagg atcaagtgga
     2941 ttcggcggta caagaacttc ttcagctgaa ggcacagtac aagtcgctga caggaatcga
     3001 gtataagcct gtgtctgcta ctggggcaga agacaaagat aaaaagaaga aagaaaaaga
     3061 aaataaatct gaaaagcaga acaagcctca gaaacaaaat gatggccaag ggaaagactc
     3121 ttccaaaagc caaggcagtg gcctgtcatc aggtggagca ggagaagggc aggggcctaa
     3181 gaaacagacc agattgggtc ttgaagcaaa aaaagaagaa aatcttgccg aatggtactc
     3241 tcaagtcatc acaaagtccg agatgattga atactacgat gtgagtggct gctatatcct
     3301 ccgtccctgg tcgtactcca tctgggagtc cattaaggac ttctttgacg ctgagatcaa
     3361 gaagctcggt gttgagaact gctacttccc catatttgtg tctcaggctg cgttagagaa
     3421 agagaagaat cacatcgaag actttgctcc tgaggttgct tgggttacaa gatcaggaaa
     3481 aacagagttg gcagagccaa ttgccattcg tcctactagt gaaacagtga tgtatccggc
     3541 atatgctaaa tgggtgcagt cccacagaga cctgcccgtc aggctcaacc agtggtgcaa
     3601 tgtggtgcgc tgggagttca aacacccaca gcctttcctc cgaactcggg agttcctgtg
     3661 gcaggagggg cacagcgcct ttgccacctt tgaggaagca gctgatgagg ttttacagat
     3721 ccttgagtta tatgctcgag tatatgaaga gctcttagcc attcctgttg tgagaggaag
     3781 gaagactgaa aaggagaagt ttgcaggagg agactacaca accacaatag aagccttcat
     3841 atctgccagc ggacgcgcca ttcagggagc aacatcacac catttaggcc agaatttctc
     3901 caaaatgtgt gaaatagttt ttgaagatcc caagacacca ggagaaaagc agtttgcata
     3961 ccagtgctcc tggggcctga caacacgaac catcggtgtg atggtcatgg tccatgggga
     4021 caacatgggc ctagtgcttc caccccgagt agcatctgtc caggtggtag tcattccctg
     4081 tggaatcaca aatgccctgt ctgaagaaga cagagaggca ctgatggcaa aatgcaacga
     4141 gtacagaagg cggctgcttg gtgctaacat ccgagtccga gtcgatctac gagacaacta
     4201 ctccccaggc tggaagttca accactggga actcaaggga gttccagtca gacttgaggt
     4261 ggggccacgt gatatgaaga gctgtcagtt tgtagcagtc agacgagata ctggagagaa
     4321 actgacaatt gctgagaagg aggctgaggc taagctggaa aaggttttgg aagacatcca
     4381 gctgaacctt ttcacaaggg cttctgaaga ccttaaaacc cacatggttg tgtctaatac
     4441 actggaggac ttccagaagg tgctagatgc tggaaaggtt gcacagattc cattttgtgg
     4501 ggaaattgac tgtgaggact ggatcaaaaa gatgactgcc agggatcaag atgtggaacc
     4561 tggtgctcca tccatgggag ccaaaagcct ttgcattcct ttcaaccctc tgtgtgagct
     4621 gcagcccgga gccatgtgtg tctgtggcaa gaatcctgcc aagttctaca ccttgtttgg
     4681 tcggagttac tgatggacaa aacagaagcc actctctctc tcgctcatct ttttttaaaa
     4741 ccactgatac gaagatcttc tcagatgcaa tttttctttt tcatttttta aaacttctaa
     4801 aaaaggtcat gagataaaac agctattctt atgcctaaat taacagtgga aaatactttt
     4861 ctgtaaacag ccagggtaat aaaaaccatg aactaattgt attttaaaaa aaaaaaaaaa
     4921 aa
//
