LOCUS       NM_144848              21627 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus epiplakin 1 (Eppk1), mRNA.
ACCESSION   NM_144848 NM_173025 XM_910512
VERSION     NM_144848.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 21627)
  AUTHORS   Ueo,D., Furuhashi,M., Sasaki,T., Kudoh,J., Parry,D.A.D.,
            Winter,D.J., Sasaki,T., Hashimoto,T., Tsuruta,D. and Fujiwara,S.
  TITLE     Intragenic copy number variation in mouse epiplakin 1 (Eppk1) and
            the conservation of the repeat structures in the lower vertebrates
  JOURNAL   J Dermatol Sci 103 (3), 186-189 (2021)
   PUBMED   34275721
  REMARK    GeneRIF: Intragenic copy number variation in mouse epiplakin 1
            (Eppk1) and the conservation of the repeat structures in the lower
            vertebrates.
REFERENCE   2  (bases 1 to 21627)
  AUTHORS   Szabo,S., Wogenstein,K.L., Osterreicher,C.H., Guldiken,N., Chen,Y.,
            Doler,C., Wiche,G., Boor,P., Haybaeck,J., Strnad,P. and Fuchs,P.
  TITLE     Epiplakin attenuates experimental mouse liver injury by chaperoning
            keratin reorganization
  JOURNAL   J Hepatol 62 (6), 1357-1366 (2015)
   PUBMED   25617501
  REMARK    GeneRIF: In several liver stress models epiplakin and K8 genes
            displayed identical expression patterns and transgenic K8
            overexpression resulted in elevated hepatic epiplakin levels.
REFERENCE   3  (bases 1 to 21627)
  AUTHORS   Wogenstein,K.L., Szabo,S., Lunova,M., Wiche,G., Haybaeck,J.,
            Strnad,P., Boor,P., Wagner,M. and Fuchs,P.
  TITLE     Epiplakin deficiency aggravates murine caerulein-induced acute
            pancreatitis and favors the formation of acinar keratin granules
  JOURNAL   PLoS One 9 (9), e108323 (2014)
   PUBMED   25232867
  REMARK    GeneRIF: Epiplakin is a protective protein during acute
            pancreatitis, and that its loss causes impaired disease-associated
            keratin reorganization.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 21627)
  AUTHORS   Kokado,M., Okada,Y., Goto,M., Ishikawa,K., Miyamoto,T.,
            Yamanaka,O., Fujiwara,S. and Saika,S.
  TITLE     Increased fragility, impaired differentiation, and acceleration of
            migration of corneal epithelium of epiplakin-null mice
  JOURNAL   Invest Ophthalmol Vis Sci 54 (5), 3780-3789 (2013)
   PUBMED   23599337
  REMARK    GeneRIF: Lacking epiplakin affects cell differentiation of the
            corneal epithelium, as well as its proliferation activity and its
            structural integrity.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 21627)
  AUTHORS   Matsuo,A., Yoshida,T., Yasukawa,T., Miki,R., Kume,K. and Kume,S.
  TITLE     Epiplakin1 is expressed in the cholangiocyte lineage cells in
            normal liver and adult progenitor cells in injured liver
  JOURNAL   Gene Expr Patterns 11 (3-4), 255-262 (2011)
   PUBMED   21216305
  REMARK    GeneRIF: Eppk1 serves as a useful marker for detecting the hepatic
            progenitor population in the developing and adult liver
REFERENCE   6  (bases 1 to 21627)
  AUTHORS   Yoshida,T., Shiraki,N., Baba,H., Goto,M., Fujiwara,S., Kume,K. and
            Kume,S.
  TITLE     Expression patterns of epiplakin1 in pancreas, pancreatic cancer
            and regenerating pancreas
  JOURNAL   Genes Cells 13 (7), 667-678 (2008)
   PUBMED   18498355
  REMARK    GeneRIF: Serves as a useful marker for detecting pancreatic
            progenitor cells in developing and regenerating pancreas.
REFERENCE   7  (bases 1 to 21627)
  AUTHORS   Spazierer,D., Raberger,J., Gross,K., Fuchs,P. and Wiche,G.
  TITLE     Stress-induced recruitment of epiplakin to keratin networks
            increases their resistance to hyperphosphorylation-induced
            disruption
  JOURNAL   J Cell Sci 121 (Pt 6), 825-833 (2008)
   PUBMED   18285451
REFERENCE   8  (bases 1 to 21627)
  AUTHORS   Spazierer,D., Fuchs,P., Reipert,S., Fischer,I., Schmuth,M.,
            Lassmann,H. and Wiche,G.
  TITLE     Epiplakin is dispensable for skin barrier function and for
            integrity of keratin network cytoarchitecture in simple and
            stratified epithelia
  JOURNAL   Mol Cell Biol 26 (2), 559-568 (2006)
   PUBMED   16382147
REFERENCE   9  (bases 1 to 21627)
  AUTHORS   Goto,M., Sumiyoshi,H., Sakai,T., Fassler,R., Ohashi,S., Adachi,E.,
            Yoshioka,H. and Fujiwara,S.
  TITLE     Elimination of epiplakin by gene targeting results in acceleration
            of keratinocyte migration in mice
  JOURNAL   Mol Cell Biol 26 (2), 548-558 (2006)
   PUBMED   16382146
  REMARK    GeneRIF: EPPK might be linked functionally with keratin 6.
REFERENCE   10 (bases 1 to 21627)
  AUTHORS   Spazierer,D., Fuchs,P., Proll,V., Janda,L., Oehler,S., Fischer,I.,
            Hauptmann,R. and Wiche,G.
  TITLE     Epiplakin gene analysis in mouse reveals a single exon encoding a
            725-kDa protein with expression restricted to epithelial tissues
  JOURNAL   J Biol Chem 278 (34), 31657-31666 (2003)
   PUBMED   12791695
  REMARK    GeneRIF: characterization of the epiplakin gene locus and the
            isolation of full-length epiplakin cDNA using BAC vectors;
            expression is restricted to epithelial tissues and its gene maps to
            mouse chromosome 15
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AY312170.1.
            
            [WARNING] On Aug 28, 2024 this sequence was replaced by
            NM_144848.3.
            
            On or before Dec 7, 2005 this sequence version replaced
            XM_910512.1, NM_173025.1, NM_144848.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY312170.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
FEATURES             Location/Qualifiers
     source          1..21627
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 35.37 cM"
     gene            1..21627
                     /gene="Eppk1"
                     /gene_synonym="6230424I18Rik; EPIPL; EPIPL1; EPPK"
                     /note="epiplakin 1"
                     /db_xref="GeneID:223650"
                     /db_xref="MGI:MGI:2386306"
     exon            1..1087
                     /gene="Eppk1"
                     /gene_synonym="6230424I18Rik; EPIPL; EPIPL1; EPPK"
                     /inference="alignment:Splign:2.1.0"
     exon            1088..9032
                     /gene="Eppk1"
                     /gene_synonym="6230424I18Rik; EPIPL; EPIPL1; EPPK"
                     /inference="alignment:Splign:2.1.0"
     CDS             1134..20780
                     /gene="Eppk1"
                     /gene_synonym="6230424I18Rik; EPIPL; EPIPL1; EPPK"
                     /codon_start=1
                     /product="epiplakin"
                     /protein_id="NP_659097.2"
                     /db_xref="GeneID:223650"
                     /db_xref="MGI:MGI:2386306"
                     /translation="MNGQAPPHDVVVANGTEKFIVPKIKKNQLGASTPSRPQAEAALP
                     TTARSIAGVYVEASGQTQSIYAAIKQGLLPTGLGLTLLEAQAATGGLVDLAQGQLLPV
                     SEALRRGLVGLELKEKLLAAERAVTGYPDPYGGEKLSLFQAIKKEVVDRTLGWRLLEA
                     QLATGGLVDPTQGVQVAPELACQQGLLDKETWLSLVESEPSMGTPGFSDPNTLEQLPY
                     SVLLGRCVQDPSSGLPLLPLKTTFHTLAGAASASMLLEAGVLNEEMVRDLQEGMLVVS
                     DVGTRPEVRRYLEGTGGLAGVVLLPGGHKKSFFQATVEHLVSKGIALQLLEAQAATRT
                     LVHPTTGQRLWVEEAVKAGLVGPELHEQLLVAEQAVTGYYDPFSSSRIPVFQAMKKGL
                     VDQPLALRLLDAQLATGGLICPARRFRLPLEAALRFGCLDEETRQRLSQAMGFSDPTT
                     HDRLGYEQLLALSVTDPETGLAFLPLPGMSHANEPQGPTFIDHCTRQALSKATTSISV
                     GRYQGRPVSLWELLFSESVPVKKRAMLAQRHQEGALSVEELAAELKNIVEQAAATAKV
                     TFAGLRDTVTPGELLKAEIINQDLFEQLERGQTSAQDVGSLDSVQRYLQGTGSIAGLL
                     LPDSQERLSIYEARSKGLLRPGTALILLEAQAATGFIIDPKENKRYSVEEALRAGVIG
                     PDVYAKLLSAEHAVTGYTDPYSGEQISLFQAMQRDLIVRDHGIRLLEAQIATGGVIDP
                     VHSHRVPVDVAYQRGYFDQILNSILLDPSDDTKGFFDPNTHENLTYLQLLERCVHDSE
                     TGLHLLPLSSTRPQLVDSSTRQAFQKLLLSVKYGRFRGQRVSAWELVNSEYFTEDRRR
                     QLLQRYRQRKITLEQVTQLLEKEMRRWTDITLPALQGQVTAYQLLEAHIINQELLDQV
                     LTGTISPDALLQVGDVHRYLRGSGTVGGVLLKPSNQRISLYQAMKQKLLPPSTALALL
                     EAQAATGTITDPCSMETLSVDEAVCRGVVGAEVYGKLKRAEHSITGYRDPFSGKKVSL
                     FRAMKKGLVPVEQATRLLEAQVSTGGVVDPTTHLHLPMPVAVQRGCIDREMEAALSRS
                     PETFPTPDGRGHTSYAQLLEHCLQDKASGLHLLPLTEDAPNVPTDTQIQETLQASAGT
                     EDGLSLWDLLTSCHFTEEQRRGYLEDVKVGKISVPQLQNTVRSWVHSAKLLARARITV
                     PGPRGEVPATWLRDAGIITQETLEALAQGMQSPDEVAKQPTVKVCLWGTGCVAGVLLQ
                     PSGTKLSIAQAVRDGLLPTGLGQQLLEAQVASGFLVNPLTNQRLSVEGAVKAGLVGME
                     QSEHLRQVEKAVTGYSDPFSGGSLSLWQAMEKGLVTQSEAFPLLQVQLATGGVVDPVH
                     GVHLPQEVAYKLGLLDEQTSRVLTATGKENKLFFDPNSREKVTYQQLRELCVLDADTG
                     LWLLPLPQGTVLEVDDHTAVALRAMKVPINMGRFQGHSVSLWDLLHSEYVGAEKRREL
                     VALCCSGRAAALRQVIGMLTTLVEAAEKQPSQATFKGLRKQVSAGDLFRSQLITKQTL
                     DELNQGKRTVQEVTEMDSVRRSLEGGNFIAGVLIQDTKEKMSIPEALRRHILRPGTAL
                     VLLEAQAATGFIIDPVENRKLTVEQAFQAGMFGKETYMKLLSAERAVTGYTDPYTGEQ
                     ISLFQAMQRDLIVRDHGIRLLEAQIATGGIIDPVHSHRVPVDVAYQRGYFNEEMNRIL
                     SDPSDDTKGFFDPNTHENLTYLQLLERCVEDPETGLYMLEIVKKGETYTYIDEATRQA
                     LTSRTVKMYVGKFAGQTVSVWDLLSSQYFTEGRRRKLLREYRAQNIGLENLLEVITST
                     VEETEKQSQIFKVPGIHGDVTAAELFNSGILNKKTLDALRSGDRGFQDLRWLEDVRVY
                     LEGSNYIAGVIAPLTQKVMSFYEASREELIPAGFAAQMLEAQAATGYLMDPCTNQRLC
                     VDEAIAAGLVGEDLRERLVNAEMAAKGYKDPATGETIPLYQAMERKLVGREEALRLLE
                     VQVATGGVIDPRHHHRVPLDTACQRGCMCDDSLVLIADQKHMRKRFVDPNTQEKVTYQ
                     ELQDRCQREEKSGWALFPVVKDKKDIEYVDEATKRALEAEQVEVTVGRYRGQRRSVWE
                     LLNSEYVSEEKKMELVRLYKEDTTRALQKVVELILQMIADKERRSRQLWFRGLRTQVT
                     AEELLRSEVITKQTLEDLEEGRTTVDQIERKEDVKRYLKGTSCIAGVLVPVQGEPGRQ
                     EKMSIYQAMWKGVLRPGTALVLLEAQAATGFIIDPVNNRRLSVEEAVAAGVVGGEIQE
                     KLLSAERAVTGYTDPYTGDQISLFQAMQRDLIVRDHGIRLLEAQIATGGVIDPVHSHR
                     VPVDVAYQRGYFDEDMNSILADPGDDTKGFFDPNTHENLTYLQLLRRCVRDPETGFYM
                     LQLAGKGSSVHHLSEELRRALREARVTPGTGDFQGQSISVWELLFYREVPESLRQDLL
                     RCYQAGGLTVHDVTTTLTSLLARAKDGSPRGDPQGALGKATMEVKRGHLRGHEVPVWD
                     ILTSNYVSRDTRKELLAQFSSGSLTLPMLKRRLTTIIEEAEETQESKPKPRDASLKQQ
                     DTGARGSGTSPDEGDAQDSSESARQQQEQTLRATTMQVHRGQFRDQQVSVWKVLFSSY
                     LSETRREELLAQHLAGKLGVMELVSLLTQIIEETEERLSKVSFPGLRRQVSASELCTS
                     GILDRDTMRELAQGTKTIHEVTEMDSVKRYLGGSSCIAGVLVPVQGEPGRQEKMSIYQ
                     AMWKGVLRPGTALVLLEAQAATGFIIDPVNNRRLSVEEAVAAGVVGGEIQEKLLSAER
                     AVTGYTDPYTGDQISLFQAMQRDLIVRDHGIRLLEAQIATGGVIDPVHSHRVPVDVAY
                     QRGYFDEDMNSILADPGDDTKGFFDPNTHENLTYLQLLRRCVRDPETGFYMLQLAGKG
                     SSVHHLSEELRRALREARVTPGTGDFQGQSISVWELLFYREVPESLRQDLLRRYQAGG
                     LTVHDVTTTLTSLLARAKDGSPRXDPQGALGKATMEVKRGHLRGHXVPVWDILTSNYV
                     SRDTRKELLAQFSSGSLTLPMLKRRLTTIIEEAEETQESKPKPRDASLKQQDTGARGS
                     GTSPDEGDAQDSSESARQQQEQTLRATTMQVHRGQFRDQQVSVWKVLFSSYLSETRRE
                     ELLAQHLAGKLGVMELVSLLTQIIEETEERLSKVSFPGLRRQVSASELCTSGILDRDT
                     MRELAQGTKTIHEVTEMDSVKRYLGGSSCIAGVLVPVQGEPGRQEKMSIYQAMWKGVL
                     RPGTALVLLEAQAATGFIIDPVNNRRLSVEEAVAAGVVGGEIQEKLLSAERAVTGYTD
                     PYTGDQISLFQAMQRDLIVRDHGIRLLEAQIATGGVIDPVHSHRVPVDVAYQRGYFDE
                     DMNSILADPGDDTKGFFDPNTHENLTYLQLLRRCVRDPETGFYMLQLAGKGSSVHHLS
                     EELRRALREARVTPGTGDFQGQSISVWELLFYREVPESLRQDLLRRYQAGGLTVHDVT
                     TTLTSLLARAKDGSPRXDPQGALGKATMEVKRGHLRGHXVPVWDILTSNYVSRDTRKE
                     LLAQFSSGSLTLPMLKRRLTTIIEEAEETQESKPKPRDASLKQQDTGARGSGTSPDEG
                     DAQDSSESARQQQEQTLRATTMQVHRGQFRDQQVSVWKVLFSSYLSETRREELLAQHL
                     AGKLGVMELVSLLTQIIEETEERLSKVSFPGLRRQVSASELCTSGILDRDTMRELAQG
                     TKTIHEVTEMDSVKRYLGGSSCIAGVLVPVQGEPGRQEKMSIYQAMWKGVLRPGTALV
                     LLEAQAATGFIIDPVNNRRLSVEEAVAAGVVGGEIQEKLLSAERAVTGYTDPYTGDQI
                     SLFQAMQRDLIVRDHGIRLLEAQIATGGVIDPVHSHRVPVDVAYQRGYFDEDMNSILA
                     DPGDDTKGFFDPNTHENLTYLQLLRRCVRDPETGFYMLQLAGKGSSVHHLSEELRRAL
                     REARVTPGTGDFQGQSISVWELLFYREVPESLRQDLLRRYQAGGLTVHDVTTTLTSLL
                     ARAKDGSPRXDPQGALGKATMEVKRGHLRGHXVPVWDILTSNYVSRDTRKELLAQFSS
                     GSLTLPMLKRRLTTIIEEAEETQESKPKPRDASLKQQDTGARGSGTSPDEGDAQDSSE
                     SARQQQEQTLRATTMQVHRGQFRDQQVSVWKVLFSSYLSETRREELLAQHLAGKLGVM
                     ELVSLLTQIIEETEERLSKVSFPGLRRQVSASELCTSGILDRDTMRELAQGTKTIHEV
                     TEMDSVKRYLGGSSCIAGVLVPVQGEPGRQEKMSIYQAMWKGVLRPGTALVLLEAQAA
                     TGFIIDPVNNRRLSVEEAVAAGVVGGEIQEKLLSAERAVTGYTDPYTGDQISLFQAMQ
                     RDLIVRDHGIRLLEAQIATGGVIDPVHSHRVPVDVAYQRGYFDEDMNSILADPGDDTK
                     GFFDPNTHENLTYLQLLRRCVRDPETGFYMLQLAGKGSSVHHLSEELRRALREARVTP
                     GTGDFQGQSISVWELLFYREVPESLRQDLLRRYQAGGLTVHDVTTTLTSLLARAKDGS
                     PRXDPQGALGKATMEVKRGHLRGHXVPVWDILTSNYVSRDTRKELLAQFSSGSLTLPM
                     LKRRLTTIIEEAEETQESKPKPRDASLKQQDTGARGSGTSPDEGDAQDSSESARQQQE
                     QTLRATTMQVHRGQFRDQQVSVWKVLFSSYLSETRREELLAQHLAGKLGVMELVSLLT
                     QIIEETEERLSKVSFPGLRRQVSASELCTSGILDRDTMRELAQGTKTIHEVTEMDSVK
                     RYLGGSSCIAGVLVPVQGEPGRQEKMSIYQAMWKGVLRPGTALVLLEAQAATGFIIDP
                     VNNRRLSVEEAVAAGVVGGEIQEKLLSAERAVTGYTDPYTGDQISLFQAMQRDLIVRD
                     HGIRLLEAQIATGGVIDPVHSHRVPVDVAYQRGYFDEDMNSILADPGDDTKGFFDPNT
                     HENLTYLQLLRRCVRDPETGFYMLQLAGKGSSVHHLSEELRRALREARVTPGTGDFQG
                     QSISVWELLFYREVPESLRQDLLRRYQAGGLTVHDVTTTLTSLLARAKDGSPRXDPQG
                     ALGKATMEVKRGHLRGHXVPVWDILTSNYVSRDTRKELLAQFSSGSLTLPMLKRRLTT
                     IIEEAEETQESKPKPRDASLKQQDTGARGSGTSPDEGDAQDSSESARQQQEQTLRATT
                     MQVHRGQFRDQQVSVWKVLFSSYLSETRREELLAQHLAGKLGVMELVSLLTQIIEETE
                     ERLSKVSFPGLRRQVSASELCTSGILDRDTMRELAQGTKTIHEVTEMDSVKRYLGGSS
                     CIAGVLVPVQGEPGRQEKMSIYQAMWKGVLRPGTALVLLEAQAATGFIIDPVNNRRLS
                     VEEAVAAGVVGGEIQEKLLSAERAVTGYTDPYTGDQISLFQAMQRDLIVRDHGIRLLE
                     AQIATGGVIDPVHSHRVPVDVAYQRGYFDEDMNSILADPGDDTKGFFDPNTHENLTYL
                     QLLRRCVRDPETGFYMLQLAGKGSSVHHLSEELRRALREARVTPGTGDFQGQSISVWE
                     LLFYREVPESLRQDLLRRYQAGGLTVHDVTTTLTSLLARAKDGSPRXDPQGALGKATM
                     EVKRGHLRGHXVPVWDILTSNYVSRDTRKELLAQFSSGSLTLPMLKRRLTTIIEEAEE
                     TQESKPKPRDASLKQQDTGARGSGTSPDEGDAQDSSESARQQQEQTLRATTMQVHRGQ
                     FRDQQVSVWKVLFSSYLSETRREELLAQHLAGKLGVMELVSLLTQIIEETEERLSKVS
                     FPGLRRQVSASELCTSGILDRDTMRELAQGTKTIHEVTEMDSVKRYLGGSSCIAGVLV
                     PVQGEPGRQEKMSIYQAMWKGVLRPGTALVLLEAQAATGFIIDPVNNRRLSVEEAVAA
                     GVVGGEIQEKLLSAERAVTGYTDPYTGDQISLFQAMQRDLIVRDHGIRLLEAQIATGG
                     VIDPVHSHRVPVDVAYQRGYFDEDMNSILADPGDDTKGFFDPNTHENLTYLQLLRRCV
                     RDPETGFYMLQLAGKGSSVHHLSEELRRALREARVTPGTGDFQGQSISVWELLFYREV
                     PESLRQDLLRRYQAGGLTVHDVTTTLTSLLARAKDGSPREDPQGALGKATMEVKRGHL
                     RGHVVPVWDILTSNYVSRDTRKELLAQFSSGSLTLPMLKRRLTTIIEEAEETQESKPK
                     PRDASLKQQDTGARGSGTSPDEGDAQDSSESARQQQEQTLRATTMQVHRGQFRDQQVS
                     VWKVLFSSYLSETRREELLAQHLAGKLGVMELVSLLTQIIEETEERLSKVSFPGLRRQ
                     VSASELCTSGILDRDTMRELAQGTKTIHEVTEMDSVKRYLGGSSCIAGVLVPVQGEPG
                     RQEKMSIYQAMWKGVLRPGTALVLLEAQAATGFIIDPVNNRRLSVEEAVAAGVVGGEI
                     QEKLLSAERAVTGYTDPYTGDQISLFQAMQRDLIVKNHGIRLLEAQIATGGVIDPVHS
                     HRVPVDVAYQRGYFDQEMNSILADPGDDTKGFFDPNTHENLTYLQLLQRATIDPETGL
                     LFLSLSKG"
     exon            9033..21595
                     /gene="Eppk1"
                     /gene_synonym="6230424I18Rik; EPIPL; EPIPL1; EPPK"
                     /inference="alignment:Splign:2.1.0"
     regulatory      21574..21579
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Eppk1"
                     /gene_synonym="6230424I18Rik; EPIPL; EPIPL1; EPPK"
                     /note="hexamer: AATAAA"
     polyA_site      21595
                     /gene="Eppk1"
                     /gene_synonym="6230424I18Rik; EPIPL; EPIPL1; EPPK"
                     /note="major polyA site"
ORIGIN      
        1 ggatgggcag gagaggtgtg ccatctgctt tggcctagcg acatgggatc tctgagcagc
       61 aaaggggaga accagccaga agatccacga aaggttcctg tgctggactc ctagtgtgcc
      121 agcccctgag gtcatcaccc tgaggctctg gacctccaac caaatgggca ctaacagacc
      181 cctgtctctg aaggtgagag ctgggatggg cttcagagct aggtcctcct gatgctaggt
      241 cctcctgatg ctaggttctc ctgatgctgg gtccttcaga tggactgagg aacttatttg
      301 agccccaggg gggtgggaaa tgtcagggag ctgaatggtg agatgaagcc tggccacccc
      361 ttgcagacag ggctgccaat tgtcaaagac cgcagagact ccagctccta caaggtcaaa
      421 acctcagagc agtccactga ggagctgtga agactccaag atccagaaga tagggacagg
      481 aaaccgtggc agagcatgct cagggactga gcaggagctt ggagcacaca gagtggggtt
      541 gggtctctca ccaggctggc ctcgaactca gaaatctgcc tgcctctgtc tcccaggtgc
      601 tgggattaaa ggcgtgcacc gccactgtcc cggcatgtct ctcactctca gcaataaaga
      661 ggagtttggg gaactgaaac tctctttggt gggtcttcat ttcccttgca aacttcattc
      721 aaaagccaca gagcccatgt tgctctccac tcccaaccca gagcaggccc gcattctttt
      781 tcaatgactt gtagtaggga gggagggagg gagggaggaa aggagggact ttgcaactca
      841 acagcctctc ccagcttgag ttgctcagag gtagccctgc cccatgcttt agtttgtgtt
      901 cacctgccca ctccacctgt cctgtggggt gcccaacctg gctttcagcc ccgcctaccg
      961 ccctcaatgg ggaagggact tgggtcaaca tagggagggg ccatgccgat ttaaatgctt
     1021 gtggcgcggg gctcccggcg tggagggagc ggagagacag aggaccgcgc cagccttgtc
     1081 acgacaggac acaagcagac cttaagcaag ttctgtgcca ccagctgtcc acgatgaacg
     1141 gccaggcccc tcctcatgat gtcgtagttg ccaatggaac tgagaagttc attgtcccta
     1201 aaatcaagaa gaaccaattg ggagccagca ctccttcaag gccccaagca gaagctgccc
     1261 tacctaccac agccagaagt attgctgggg tatatgtgga ggcctcgggg cagacccaga
     1321 gcatctatgc tgctataaag cagggcctcc tgcccactgg gcttggactg actttgcttg
     1381 aggcccaggc agccactggg ggcctcgtgg accttgccca gggccagctt cttcctgtgt
     1441 ctgaggccct aaggcggggt ctagtgggat tggagcttaa ggagaaatta ctggctgctg
     1501 aacgtgcagt tactggctat cccgacccct atgggggtga aaagctgtcc ctcttccagg
     1561 ccatcaagaa agaagttgta gacaggaccc tggggtggag attgctagag gcccagctag
     1621 ctactggggg cctggtggac ccaacccagg gtgtgcaagt agccccagag ctagcctgcc
     1681 agcagggcct tttggataag gagacatggc tcagcctggt ggagtcagag cccagtatgg
     1741 gtacccctgg tttttctgac cccaacacgc tggagcagct gccatactct gtgctgttgg
     1801 gtaggtgtgt gcaagacccc agctcagggc tgcccctatt gcccttaaag accactttcc
     1861 acaccctggc tggagcagcc agtgcgtcaa tgctgctgga ggcgggagta ctaaatgaag
     1921 agatggtccg agacctgcag gagggcatgc tggtggtgtc agacgtgggc acacgtcccg
     1981 aggtgcgacg ttatctggaa ggcactggag ggttagcggg ggttgtcctg ttgcctggag
     2041 gtcacaagaa gagctttttc caggctacag ttgaacactt ggtctcaaag ggtattgcac
     2101 tacaactctt agaggctcag gctgccaccc gcacccttgt gcacccaacc acaggccagc
     2161 gtctttgggt ggaagaggca gtcaaggctg gcctggttgg cccagaactt catgagcagc
     2221 tcctggttgc agaacaggca gtaactgggt attatgaccc ctttagcagc tcccgaatcc
     2281 ccgttttcca ggctatgaag aagggacttg tggaccagcc actggctctg cgtctcctag
     2341 atgcccagct agctacaggt gggcttatat gcccagctcg cagattccgg ctgcccctgg
     2401 aggctgccct gcgctttggc tgtctggacg aagagactcg gcaacgtctc tctcaggcaa
     2461 tgggcttttc agatcctacc acacacgatc gtcttggcta tgaacagctg ctggccctct
     2521 ctgttactga cccagagaca gggcttgcct tcctgcctct ccctggaatg tcccacgcaa
     2581 atgagcccca gggacccaca tttattgatc actgtactcg acaggccttg agcaaggcta
     2641 caacctccat ctctgtaggg aggtaccagg gcaggcctgt ctccctctgg gaactgctct
     2701 tttctgagtc agtgcccgtt aagaagaggg caatgcttgc ccagcggcac caggaagggg
     2761 ctctgtccgt ggaggagctg gcagctgagc tgaagaacat tgttgagcag gctgccgcaa
     2821 ctgccaaagt cacctttgct gggttgaggg acaccgtgac accaggagag ttgttgaaag
     2881 ctgagataat caatcaggac ctgtttgagc agttggaacg tggacagacc tcagcccaag
     2941 atgtgggcag cctggactcc gtgcagaggt acctgcaggg cacaggcagt attgcaggcc
     3001 ttttgcttcc tgactcccag gaacgactca gtatctatga ggcccgtagc aaggggctcc
     3061 tcaggcctgg tactgccctg atcttgcttg aggcccaggc tgccacaggc tttatcattg
     3121 acccaaaaga gaacaagaga tactctgtgg aggaggcact gagggctggt gtcattgggc
     3181 ccgatgtata tgccaagttg ctctctgcag aacatgccgt gactggctac acggacccct
     3241 actctgggga gcagatctcc ctcttccagg ccatgcagag ggacctcatt gtgagagacc
     3301 acggcattcg cctgctggag gcccagatcg ccacaggtgg tgtcattgac cccgtgcaca
     3361 gccaccgtgt gcccgtggac gtggcctacc aacgtggcta ctttgatcag attctgaact
     3421 ctatcctgct ggacccttct gatgacacca agggcttctt tgaccccaac acgcatgaaa
     3481 atctcactta cctgcagctc ctggagcgct gtgtacatga ctccgagaca ggcctgcacc
     3541 tcctgcccct cagtagtaca cgaccccagc tggtggatag ctccactcgg caggccttcc
     3601 agaagctact gctctccgtg aaatatggac ggttccgggg gcagagagtt tctgcgtggg
     3661 agctggttaa ctctgaatat ttcacagagg accggaggag gcagctcctg caacgttatc
     3721 ggcagcgcaa gatcacactg gagcaggtca ctcagctgct ggagaaagag atgaggaggt
     3781 ggacagacat cacactgcct gccctacagg gccaggtcac tgcctaccag cttctagagg
     3841 cccacatcat caaccaggag ctcctggacc aggtgctgac agggacgatc agcccagatg
     3901 ccctccttca ggtgggtgat gttcacaggt accttcgggg ctcaggcact gtgggtggtg
     3961 tgctgctaaa gccctccaac cagcgaatca gtctctacca ggccatgaag cagaagctgc
     4021 tgccacctag tacagctttg gccttgctgg aggcccaggc agccactgga actatcactg
     4081 acccctgcag tatggagacc ctgtcagtag atgaggccgt gtgccgggga gttgtgggag
     4141 cagaagtata tggcaagttg aagcgagcag aacattctat cactggctac agagacccct
     4201 tttctggaaa aaaggtgtcc ctgttcaggg ccatgaagaa gggcctcgtc cccgtggagc
     4261 aggcgacccg cctactagag gcacaggtgt ccacaggagg ggtcgttgat cccacaaccc
     4321 acctccacct ccccatgcct gtggcagtcc agcgtggctg cattgatcga gagatggagg
     4381 cggccttgtc cagatctcct gagacctttc ccacacccga tggccggggg cacaccagct
     4441 atgcccagct tctggaacac tgtctccagg acaaagcctc tgggcttcac ctcctgcccc
     4501 tgacagaaga tgcccccaac gtccccactg acacacagat ccaggagacc ctgcaagcat
     4561 cagctggcac tgaagacggt ttgtcgctct gggacttgct cacctcttgc cactttaccg
     4621 aggaacagcg ccgcggctac ctcgaggatg tgaaggttgg gaagatttct gtgccacagc
     4681 tacagaacac tgtgcgcagc tgggtgcact cagcgaaact cctggcccgg gcccgcatca
     4741 ctgtgccagg cccacggggc gaggtccctg ccacttggct acgagatgct ggtattatca
     4801 cccaagagac gctggaagca ctggcacagg gcatgcagtc tcccgatgag gtagccaaac
     4861 agcctacggt gaaggtctgc ctctggggta cgggctgtgt ggccggggtg ctgctccagc
     4921 cctcggggac caagttgagc attgcccagg ctgtaagaga tggcctcctg cccacaggtc
     4981 tgggccagca gctgctggag gcccaggtgg catctggctt cctcgtcaat ccgctaacca
     5041 accagagatt gtcagtggag ggtgcagtga aggctggcct ggtgggcatg gagcagagtg
     5101 aacatctgag gcaggttgaa aaggctgtga cagggtactc agaccccttt tcaggaggtt
     5161 ccctttctct gtggcaggcc atggagaagg ggcttgtaac ccaaagtgag gcctttcctc
     5221 tcctgcaagt ccagctggcc acagggggtg ttgtggaccc cgtccatgga gtgcacctgc
     5281 cccaggaagt ggcctacaag cttggtctcc tggacgagca gacaagccga gtgctgaccg
     5341 ccactgggaa ggaaaacaaa ctcttttttg accccaactc ccgtgagaag gtgacatacc
     5401 agcagctcag ggaactctgt gtgctggatg ccgacactgg cttgtggctg ctgcccctgc
     5461 cccagggcac tgtgcttgaa gtggatgacc atactgcggt ggcactgagg gctatgaagg
     5521 tgcccatcaa catggggagg ttccaagggc acagtgtgtc actctgggac ctgctacact
     5581 ctgagtatgt tggggctgag aagcggaggg agctggtggc actttgttgt tccgggaggg
     5641 ctgccgctct gcgacaggtc atcggtatgc tcaccaccct ggtggaagct gcagagaagc
     5701 agccctcgca ggccaccttc aaagggctcc ggaagcaggt ttcagctggg gacttgttta
     5761 ggtcccagct gatcaccaag cagacactgg atgagctcaa tcaggggaag aggacggtcc
     5821 aggaagtgac agagatggat agtgtgagga ggtccctgga aggaggcaac ttcattgctg
     5881 gggtccttat tcaggataca aaagagaaga tgagtatccc agaggccttg agaaggcaca
     5941 ttctgaggcc aggcacagcc ctggtgctgc tggaggcaca ggcagccact ggtttcatca
     6001 ttgaccccgt ggaaaaccgg aagctaactg tagagcaagc gttccaggca gggatgtttg
     6061 ggaaggaaac ctacatgaag ctgttatcag ccgagcgggc tgtcaccggc tatacagacc
     6121 cttacacggg agaacagatc tccctctttc aggccatgca gagggacctt attgtcaggg
     6181 accatggcat ccgtctactg gaggcccaga tcgccacagg tggtatcatt gaccctgtgc
     6241 acagccaccg tgtgcctgtg gacgtggcct accaacgtgg ctacttcaat gaggagatga
     6301 accgcatctt gtctgaccca agcgatgaca ccaagggctt ctttgacccc aacacccatg
     6361 agaacctcac ttacctgcag ctgctagagc gctgtgtgga ggaccctgag actggcctgt
     6421 atatgttgga aattgtaaag aaaggagaaa cctacacata cattgatgaa gccacaaggc
     6481 aagctctgac atccagaact gtgaaaatgt atgtagggaa gtttgcaggc cagacggtgt
     6541 ctgtgtggga cctgttatct tcccagtatt ttaccgaagg aaggaggaga aagcttttgc
     6601 gggagtacag agcccagaac ataggcctgg agaatctgct ggaggtgatt acctcgaccg
     6661 tggaagaaac agagaagcaa agtcaaatat tcaaggtgcc gggtatccat ggcgacgtga
     6721 cagctgcaga actgttcaac tccgggatcc ttaacaagaa gaccctggat gcactccgca
     6781 gtggggatag agggttccag gacctccgct ggctggagga tgtacgtgtc tacctggagg
     6841 gcagcaatta catcgctgga gtgatagcac ccctaaccca gaaggtcatg agcttctacg
     6901 aggccagcag ggaagagctc atccccgcag ggtttgcagc tcagatgctg gaggcacagg
     6961 ctgccactgg gtacctaatg gacccttgca ccaaccagag gctgtgtgtg gatgaggcca
     7021 tagcagctgg gctggtgggt gaagacctga gagagagact tgtgaatgca gagatggcag
     7081 caaagggcta caaagaccca gccacagggg agactatccc actctaccag gccatggaga
     7141 ggaagttagt cggaagggag gaggcactga ggttgctgga ggtgcaggtg gccacgggtg
     7201 gggtcattga ccctcggcac caccatcggg tccctctgga tacagcctgc cagcggggct
     7261 gtatgtgtga cgacagcctt gttctcattg ctgaccaaaa gcacatgagg aaaaggtttg
     7321 tggatcccaa cacacaagaa aaggtcacat accaggagct gcaggaccgg tgccagcggg
     7381 aagagaagtc aggctgggct ctgttcccag tggtcaagga caaaaaggac atagaatatg
     7441 ttgatgaggc caccaaaagg gccctggagg cagaacaggt ggaagtgact gtggggaggt
     7501 acagaggcca gaggcgatct gtgtgggaac tgctgaactc agagtatgtg tctgaagaga
     7561 agaagatgga actagttaga ctatacaaag aggacacaac ccgggcactg cagaaggtgg
     7621 tagagctcat cctacaaatg attgcagaca aggaaaggag aagcaggcaa ctctggttcc
     7681 gaggattaag aactcaggtc acagctgagg aactgctgag gtcagaggtc atcacaaaac
     7741 agactctgga ggacctggaa gaagggagaa ccacagtaga tcagattgaa cgaaaggaag
     7801 acgtgaagag atacctcaag ggaaccagct gcatagcggg ggtcctggtg cccgtccagg
     7861 gagagcctgg gcgccaggag aagatgagca tctatcaggc catgtggaag ggagtcctga
     7921 ggccaggcac agccctggtg ctgctggagg ctcaggcagc cacaggcttc atcatcgacc
     7981 cagtgaacaa ccgcagactg tctgtggagg aggccgtggc tgcaggcgtg gtgggaggcg
     8041 agatccaaga gaagctgctg tctgctgagc gtgcggtcac cgggtacacg gacccctaca
     8101 ccggggacca gatctccctc ttccaggcca tgcagaggga cctcattgtg agagaccatg
     8161 gcattcgttt gttggaagcc cagattgcca cgggtggcgt catcgatcct gtgcacagcc
     8221 accgtgtgcc cgtggacgtg gcctaccagc gtggctactt tgatgaagac atgaacagca
     8281 ttttggcgga ccctggtgac gacaccaagg gcttctttga ccccaacact cacgagaacc
     8341 tcacttacct acagctgctg cgccgctgtg tgcgcgaccc agagactggc ttctacatgc
     8401 tgcagctggc tggaaagggc tccagtgtgc accacctgag cgaggagctg agacgggccc
     8461 tgcgtgaagc ccgtgtgacc ccaggcacgg gcgacttcca gggccagagc atctctgtct
     8521 gggagcttct cttctaccga gaggtgcctg agagtctgcg ccaggacctg ctgcgttgct
     8581 accaggcagg tgggctcacc gttcatgacg tgaccaccac actcacctca ctgctggccc
     8641 gagccaagga tgggagccca cgtggggatc cacaaggagc cctgggcaag gccaccatgg
     8701 aagtaaaacg gggtcatctc cggggccacg aggtcccagt gtgggacatt ctgacatcca
     8761 actatgtgag cagggacacc cggaaggagc tgctggccca gttcagctct gggtcgctga
     8821 ctctgcccat gctgaagagg agactgacca ccattattga ggaggctgag gagacacagg
     8881 agtccaagcc aaagccgaga gacgcctctc ttaagcaaca ggacactggg gccagaggct
     8941 cagggacctc cccagacgag ggagatgctc aggacagctc cgagagtgcc aggcagcaac
     9001 aggagcagac tctgcgtgcc accaccatgc aggtacaccg tgggcagttc cgggaccagc
     9061 aagtttctgt gtggaaagtc ctgttctcct cctacctgag tgagacccgc cgggaggagc
     9121 tccttgccca gcacttggct ggcaagctgg gggtaatgga actcgtttcc ctcctcaccc
     9181 aaatcatcga ggagacagaa gaacggctca gcaaggtgtc tttccccggc ctgaggcgac
     9241 aggtgtccgc atctgagttg tgtacctctg gcatcctgga ccgggacacc atgcgagaac
     9301 tggcacaggg caccaagacc attcatgagg tgacagagat ggactccgtc aagcgctacc
     9361 tggggggctc cagctgcata gcgggcgtcc tggtgcccgt ccagggagag cctgggcgcc
     9421 aggagaagat gagcatctat caggccatgt ggaagggagt cctgaggcca ggcacagccc
     9481 tggtgctgct ggaggctcag gcagccacag gcttcatcat cgacccagtg aacaaccgca
     9541 gactgtctgt ggaggaggcc gtggctgcag gcgtggtggg aggcgagatc caagagaagc
     9601 tgctgtctgc tgagcgtgcg gtcaccgggt acacggaccc ctacaccggg gaccagatct
     9661 ccctcttcca ggccatgcag agggacctca ttgtgagaga ccatggcatt cgtttgttgg
     9721 aagcccagat tgccacgggt ggcgtcatcg accctgtgca cagccaccgt gtgcccgtgg
     9781 acgtggccta ccagcgtggc tactttgatg aagacatgaa cagcattttg gcggaccctg
     9841 gtgacgacac caagggcttc tttgacccca acactcacga gaacctcact tacctacagc
     9901 tgctgcgccg ctgtgtgcgc gacccagaga ctggcttcta catgctgcag ctggctggaa
     9961 agggctccag tgtgcaccac ctgagcgagg agctgagacg ggccctgcgt gaagcccgtg
    10021 tgaccccagg cacgggcgac ttccagggcc agagcatctc tgtctgggag cttctcttct
    10081 accgagaggt gcctgagagt ctgcgccagg acctgctgcg tcgctaccag gcaggtgggc
    10141 tcaccgttca tgacgtgacc accacactca cctcactgct ggcccgagcc aaggatggga
    10201 gcccacgtgr ggatccacaa ggagccctgg gcaaggccac catggaagta aaacggggtc
    10261 atctccgggg ccacgwggtc ccagtgtggg acattctgac atccaactat gtgagcaggg
    10321 acacccggaa ggagctgctg gcccagttca gctctgggtc gctgactctg cccatgctga
    10381 agaggagact gaccaccatt attgaggagg ctgaggagac acaggagtcc aagccaaagc
    10441 cgagagacgc ctctcttaag caacaggaca ctggggccag aggctcaggg acctccccag
    10501 acgagggaga tgctcaggac agctccgaga gtgccaggca gcaacaggag cagactctgc
    10561 gtgccaccac catgcaggta caccgtgggc agttccggga ccagcaagtt tctgtgtgga
    10621 aagtcctgtt ctcctcctac ctgagtgaga cccgccggga ggagctcctt gcccagcact
    10681 tggctggcaa gctgggggta atggaactcg tttccctcct cacccaaatc atcgaggaga
    10741 cagaagaacg gctcagcaag gtgtctttcc ccggcctgag gcgacaggtg tccgcatctg
    10801 agttgtgtac ctctggcatc ctggaccggg acaccatgcg agaactggca cagggcacca
    10861 agaccattca tgaggtgaca gagatggact ccgtcaagcg ctacctgggg ggctccagct
    10921 gcatagcggg cgtcctggtg cccgtccagg gagagcctgg gcgccaggag aagatgagca
    10981 tctatcaggc catgtggaag ggagtcctga ggccaggcac agccctggtg ctgctggagg
    11041 ctcaggcagc cacaggcttc atcatcgacc cagtgaacaa ccgcagactg tctgtggagg
    11101 aggccgtggc tgcaggcgtg gtgggaggcg agatccaaga gaagctgytg tctgctgagc
    11161 gtgcggtcac cgggtacacg gacccctaca ccggggacca gatctccctc ttccaggcca
    11221 tgcagaggga cctcattgtg agagaccatg gcattcgttt gttggaagcc cagattgcca
    11281 cgggtggcgt catcgaccct gtgcacagcc accgtgtgcc cgtggacgtg gcctaccagc
    11341 gtggctactt tgatgaagac atgaacagca ttttggcgga ccctggtgac gacaccaagg
    11401 gcttctttga ccccaacact cacgagaacc tcacttacct acagctgctg cgccgctgtg
    11461 tgcgcgaccc agagactggc ttctacatgc tgcagctggc tggaaagggc tccagtgtgc
    11521 accacctgag cgaggagctg agacgggccc tgcgtgaagc ccgtgtgacc ccaggcacgg
    11581 gcgacttcca gggccagagc atctctgtct gggagcttct cttctaccga gaggtgcctg
    11641 agagtctgcg ccaggacctg ctgcgtcgct accaggcagg tgggctcacc gttcatgacg
    11701 tgaccaccac actcacctca ctgctggccc gagccaagga tgggagccca cgtgrggatc
    11761 cacaaggagc cctgggcaag gccaccatgg aagtaaaacg gggtcatctc cggggccacg
    11821 wggtcccagt gtgggacatt ctgacatcca actatgtgag cagggacacc cggaaggagc
    11881 tgctggccca gttcagctct gggtcgctga ctctgcccat gctgaagagg agactgacca
    11941 ccattattga ggaggctgag gagacacagg agtccaagcc aaagccgaga gacgcctctc
    12001 ttaagcaaca ggacactggg gccagaggct cagggacctc cccagacgag ggagatgctc
    12061 aggacagctc cgagagtgcc aggcagcaac aggagcagac tctgcgtgcc accaccatgc
    12121 aggtacaccg tgggcagttc cgggaccagc aagtttctgt gtggaaagtc ctgttctcct
    12181 cctacctgag tgagacccgc cgggaggagc tccttgccca gcacttggct ggcaagctgg
    12241 gggtaatgga actcgtttcc ctcctcaccc aaatcatcga ggagacagaa gaacggctca
    12301 gcaaggtgtc tttccccggc ctgaggcgac aggtgtccgc atctgagttg tgtacctctg
    12361 gcatcctgga ccgggacacc atgcgagaac tggcacaggg caccaagacc attcatgagg
    12421 tgacagagat ggactccgtc aagcgctacc tggggggctc cagctgcata gcgggcgtcc
    12481 tggtgcccgt ccagggagag cctgggcgcc aggagaagat gagcatctat caggccatgt
    12541 ggaagggagt cctgaggcca ggcacagccc tggtgctgct ggaggctcag gcagccacag
    12601 gcttcatcat cgacccagtg aacaaccgca gactgtctgt ggaggaggcc gtggctgcag
    12661 gcgtggtggg aggcgagatc caagagaagc tgytgtctgc tgagcgtgcg gtcaccgggt
    12721 acacggaccc ctacaccggg gaccagatct ccctcttcca ggccatgcag agggacctca
    12781 ttgtgagaga ccatggcatt cgtttgttgg aagcccagat tgccacgggt ggcgtcatcg
    12841 accctgtgca cagccaccgt gtgcccgtgg acgtggccta ccagcgtggc tactttgatg
    12901 aagacatgaa cagcattttg gcggaccctg gtgacgacac caagggcttc tttgacccca
    12961 acactcacga gaacctcact tacctacagc tgctgcgccg ctgtgtgcgc gacccagaga
    13021 ctggcttcta catgctgcag ctggctggaa agggctccag tgtgcaccac ctgagcgagg
    13081 agctgagacg ggccctgcgt gaagcccgtg tgaccccagg cacgggcgac ttccagggcc
    13141 agagcatctc tgtctgggag cttctcttct accgagaggt gcctgagagt ctgcgccagg
    13201 acctgctgcg tcgctaccag gcaggtgggc tcaccgttca tgacgtgacc accacactca
    13261 cctcactgct ggcccgagcc aaggatggga gcccacgtgr ggatccacaa ggagccctgg
    13321 gcaaggccac catggaagta aaacggggtc atctccgggg ccacgwggtc ccagtgtggg
    13381 acattctgac atccaactat gtgagcaggg acacccggaa ggagctgctg gcccagttca
    13441 gctctgggtc gctgactctg cccatgctga agaggagact gaccaccatt attgaggagg
    13501 ctgaggagac acaggagtcc aagccaaagc cgagagacgc ctctcttaag caacaggaca
    13561 ctggggccag aggctcaggg acctccccag acgagggaga tgctcaggac agctccgaga
    13621 gtgccaggca gcaacaggag cagactctgc gtgccaccac catgcaggta caccgtgggc
    13681 agttccggga ccagcaagtt tctgtgtgga aagtcctgtt ctcctcctac ctgagtgaga
    13741 cccgccggga ggagctcctt gcccagcact tggctggcaa gctgggggta atggaactcg
    13801 tttccctcct cacccaaatc atcgaggaga cagaagaacg gctcagcaag gtgtctttcc
    13861 ccggcctgag gcgacaggtg tccgcatctg agttgtgtac ctctggcatc ctggaccggg
    13921 acaccatgcg agaactggca cagggcacca agaccattca tgaggtgaca gagatggact
    13981 ccgtcaagcg ctacctgggg ggctccagct gcatagcggg cgtcctggtg cccgtccagg
    14041 gagagcctgg gcgccaggag aagatgagca tctatcaggc catgtggaag ggagtcctga
    14101 ggccaggcac agccctggtg ctgctggagg ctcaggcagc cacaggcttc atcatcgacc
    14161 cagtgaacaa ccgcagactg tctgtggagg aggccgtggc tgcaggcgtg gtgggaggcg
    14221 agatccaaga gaagctgytg tctgctgagc gtgcggtcac cgggtacacg gacccctaca
    14281 ccggggacca gatctccctc ttccaggcca tgcagaggga cctcattgtg agagaccatg
    14341 gcattcgttt gttggaagcc cagattgcca cgggtggcgt catcgaccct gtgcacagcc
    14401 accgtgtgcc cgtggacgtg gcctaccagc gtggctactt tgatgaagac atgaacagca
    14461 ttttggcgga ccctggtgac gacaccaagg gcttctttga ccccaacact cacgagaacc
    14521 tcacttacct acagctgctg cgccgctgtg tgcgcgaccc agagactggc ttctacatgc
    14581 tgcagctggc tggaaagggc tccagtgtgc accacctgag cgaggagctg agacgggccc
    14641 tgcgtgaagc ccgtgtgacc ccaggcacgg gcgacttcca gggccagagc atctctgtct
    14701 gggagcttct cttctaccga gaggtgcctg agagtctgcg ccaggacctg ctgcgtcgct
    14761 accaggcagg tgggctcacc gttcatgacg tgaccaccac actcacctca ctgctggccc
    14821 gagccaagga tgggagccca cgtgrggatc cacaaggagc cctgggcaag gccaccatgg
    14881 aagtaaaacg gggtcatctc cggggccacg wggtcccagt gtgggacatt ctgacatcca
    14941 actatgtgag cagggacacc cggaaggagc tgctggccca gttcagctct gggtcgctga
    15001 ctctgcccat gctgaagagg agactgacca ccattattga ggaggctgag gagacacagg
    15061 agtccaagcc aaagccgaga gacgcctctc ttaagcaaca ggacactggg gccagaggct
    15121 cagggacctc cccagacgag ggagatgctc aggacagctc cgagagtgcc aggcagcaac
    15181 aggagcagac tctgcgtgcc accaccatgc aggtacaccg tgggcagttc cgggaccagc
    15241 aagtttctgt gtggaaagtc ctgttctcct cctacctgag tgagacccgc cgggaggagc
    15301 tccttgccca gcacttggct ggcaagctgg gggtaatgga actcgtttcc ctcctcaccc
    15361 aaatcatcga ggagacagaa gaacggctca gcaaggtgtc tttccccggc ctgaggcgac
    15421 aggtgtccgc atctgagttg tgtacctctg gcatcctgga ccgggacacc atgcgagaac
    15481 tggcacaggg caccaagacc attcatgagg tgacagagat ggactccgtc aagcgctacc
    15541 tggggggctc cagctgcata gcgggcgtcc tggtgcccgt ccagggagag cctgggcgcc
    15601 aggagaagat gagcatctat caggccatgt ggaagggagt cctgaggcca ggcacagccc
    15661 tggtgctgct ggaggctcag gcagccacag gcttcatcat cgacccagtg aacaaccgca
    15721 gactgtctgt ggaggaggcc gtggctgcag gcgtggtggg aggcgagatc caagagaagc
    15781 tgytgtctgc tgagcgtgcg gtcaccgggt acacggaccc ctacaccggg gaccagatct
    15841 ccctcttcca ggccatgcag agggacctca ttgtgagaga ccatggcatt cgtttgttgg
    15901 aagcccagat tgccacgggt ggcgtcatcg accctgtgca cagccaccgt gtgcccgtgg
    15961 acgtggccta ccagcgtggc tactttgatg aagacatgaa cagcattttg gcggaccctg
    16021 gtgacgacac caagggcttc tttgacccca acactcacga gaacctcact tacctacagc
    16081 tgctgcgccg ctgtgtgcgc gacccagaga ctggcttcta catgctgcag ctggctggaa
    16141 agggctccag tgtgcaccac ctgagcgagg agctgagacg ggccctgcgt gaagcccgtg
    16201 tgaccccagg cacgggcgac ttccagggcc agagcatctc tgtctgggag cttctcttct
    16261 accgagaggt gcctgagagt ctgcgccagg acctgctgcg tcgctaccag gcaggtgggc
    16321 tcaccgttca tgacgtgacc accacactca cctcactgct ggcccgagcc aaggatggga
    16381 gcccacgtgr ggatccacaa ggagccctgg gcaaggccac catggaagta aaacggggtc
    16441 atctccgggg ccacgwggtc ccagtgtggg acattctgac atccaactat gtgagcaggg
    16501 acacccggaa ggagctgctg gcccagttca gctctgggtc gctgactctg cccatgctga
    16561 agaggagact gaccaccatt attgaggagg ctgaggagac acaggagtcc aagccaaagc
    16621 cgagagacgc ctctcttaag caacaggaca ctggggccag aggctcaggg acctccccag
    16681 acgagggaga tgctcaggac agctccgaga gtgccaggca gcaacaggag cagactctgc
    16741 gtgccaccac catgcaggta caccgtgggc agttccggga ccagcaagtt tctgtgtgga
    16801 aagtcctgtt ctcctcctac ctgagtgaga cccgccggga ggagctcctt gcccagcact
    16861 tggctggcaa gctgggggta atggaactcg tttccctcct cacccaaatc atcgaggaga
    16921 cagaagaacg gctcagcaag gtgtctttcc ccggcctgag gcgacaggtg tccgcatctg
    16981 agttgtgtac ctctggcatc ctggaccggg acaccatgcg agaactggca cagggcacca
    17041 agaccattca tgaggtgaca gagatggact ccgtcaagcg ctacctgggg ggctccagct
    17101 gcatagcggg cgtcctggtg cccgtccagg gagagcctgg gcgccaggag aagatgagca
    17161 tctatcaggc catgtggaag ggagtcctga ggccaggcac agccctggtg ctgctggagg
    17221 ctcaggcagc cacaggcttc atcatcgacc cagtgaacaa ccgcagactg tctgtggagg
    17281 aggccgtggc tgcaggcgtg gtgggaggcg agatccaaga gaagctgytg tctgctgagc
    17341 gtgcggtcac cgggtacacg gacccctaca ccggggacca gatctccctc ttccaggcca
    17401 tgcagaggga cctcattgtg agagaccatg gcattcgttt gttggaagcc cagattgcca
    17461 cgggtggcgt catcgaccct gtgcacagcc accgtgtgcc cgtggacgtg gcctaccagc
    17521 gtggctactt tgatgaagac atgaacagca ttttggcgga ccctggtgac gacaccaagg
    17581 gcttctttga ccccaacact cacgagaacc tcacttacct acagctgctg cgccgctgtg
    17641 tgcgcgaccc agagactggc ttctacatgc tgcagctggc tggaaagggc tccagtgtgc
    17701 accacctgag cgaggagctg agacgggccc tgcgtgaagc ccgtgtgacc ccaggcacgg
    17761 gcgacttcca gggccagagc atctctgtct gggagcttct cttctaccga gaggtgcctg
    17821 agagtctgcg ccaggacctg ctgcgtcgct accaggcagg tgggctcacc gttcatgacg
    17881 tgaccaccac actcacctca ctgctggccc gagccaagga tgggagccca cgtgrggatc
    17941 cacaaggagc cctgggcaag gccaccatgg aagtaaaacg gggtcatctc cggggccacg
    18001 wggtcccagt gtgggacatt ctgacatcca actatgtgag cagggacacc cggaaggagc
    18061 tgctggccca gttcagctct gggtcgctga ctctgcccat gctgaagagg agactgacca
    18121 ccattattga ggaggctgag gagacacagg agtccaagcc aaagccgaga gacgcctctc
    18181 ttaagcaaca ggacactggg gccagaggct cagggacctc cccagacgag ggagatgctc
    18241 aggacagctc cgagagtgcc aggcagcaac aggagcagac tctgcgtgcc accaccatgc
    18301 aggtacaccg tgggcagttc cgggaccagc aagtttctgt gtggaaagtc ctgttctcct
    18361 cctacctgag tgagacccgc cgggaggagc tccttgccca gcacttggct ggcaagctgg
    18421 gggtaatgga actcgtttcc ctcctcaccc aaatcatcga ggagacagaa gaacggctca
    18481 gcaaggtgtc tttccccggc ctgaggcgac aggtgtccgc atctgagttg tgtacctctg
    18541 gcatcctgga ccgggacacc atgcgagaac tggcacaggg caccaagacc attcatgagg
    18601 tgacagagat ggactccgtc aagcgctacc tggggggctc cagctgcata gcgggcgtcc
    18661 tggtgcccgt ccagggagag cctgggcgcc aggagaagat gagcatctat caggccatgt
    18721 ggaagggagt cctgaggcca ggcacagccc tggtgctgct ggaggctcag gcagccacag
    18781 gcttcatcat cgacccagtg aacaaccgca gactgtctgt ggaggaggcc gtggctgcag
    18841 gcgtggtggg aggcgagatc caagagaagc tgytgtctgc tgagcgtgcg gtcaccgggt
    18901 acacggaccc ctacaccggg gaccagatct ccctcttcca ggccatgcag agggacctca
    18961 ttgtgagaga ccatggcatt cgtttgttgg aagcccagat tgccacgggt ggcgtcatcg
    19021 accctgtgca cagccaccgt gtgcccgtgg acgtggccta ccagcgtggc tactttgatg
    19081 aagacatgaa cagcattttg gcggaccctg gtgacgacac caagggcttc tttgacccca
    19141 acactcacga gaacctcact tacctacagc tgctgcgccg ctgtgtgcgc gacccagaga
    19201 ctggcttcta catgctgcag ctggctggaa agggctccag tgtgcaccac ctgagcgagg
    19261 agctgagacg ggccctgcgt gaagcccgtg tgaccccagg cacgggcgac ttccagggcc
    19321 agagcatctc tgtctgggag cttctcttct accgagaggt gcctgagagt ctgcgccagg
    19381 acctgctgcg tcgctaccag gcaggtgggc tcaccgttca tgacgtgacc accacactca
    19441 cctcactgct ggcccgagcc aaggatggga gcccacgtga ggatccacaa ggagccctgg
    19501 gcaaggccac catggaagta aaacggggtc atctccgggg ccacgtggtc ccagtgtggg
    19561 acattctgac atccaactat gtgagcaggg acacccggaa ggagctgctg gcccagttca
    19621 gctctgggtc gctgactctg cccatgctga agaggagact gaccaccatt attgaggagg
    19681 ctgaggagac acaggagtcc aagccaaagc cgagagacgc ctctcttaag caacaggaca
    19741 ctggggccag aggctcaggg acctccccag acgagggaga tgctcaggac agctccgaga
    19801 gtgccaggca gcaacaggag cagactctgc gtgccaccac catgcaggta caccgtgggc
    19861 agttccggga ccagcaagtt tctgtgtgga aagtcctgtt ctcctcctac ctgagtgaga
    19921 cccgccggga ggagctcctt gcccagcact tggctggcaa gctgggggta atggaactcg
    19981 tttccctcct cacccaaatc atcgaggaga cagaagaacg gctcagcaag gtgtctttcc
    20041 ccggcctgag gcgacaggtg tccgcatctg agttgtgtac ctctggcatc ctggaccggg
    20101 acaccatgcg agaactggca cagggcacca agaccattca tgaggtgaca gagatggact
    20161 ccgtcaagcg ctacctgggg ggctccagct gcatagcggg cgtcctggtg cccgtccagg
    20221 gagagcctgg gcgccaggag aagatgagca tctatcaggc catgtggaag ggagtcctga
    20281 ggccaggcac agccctggtg ctgctggagg ctcaggcagc cacaggcttc atcatcgacc
    20341 cagtgaacaa ccgcagactg tctgtggagg aggccgtggc tgcaggcgtg gtgggaggcg
    20401 agatccaaga gaagctgctg tctgctgagc gtgcggtcac cgggtacacg gacccctaca
    20461 ccggggacca gatctccctc ttccaggcca tgcagaggga cctcattgtt aagaaccatg
    20521 gtattcgact gctggaagcc cagattgcca caggtggcgt catcgatcct gtgcacagcc
    20581 accgtgtgcc cgtggacgtg gcctaccagc gtggctactt tgatcaagag atgaacagca
    20641 ttttggcaga ccctggtgac gacaccaagg gcttctttga tcccaacact catgagaacc
    20701 tcacttacct acagcttctg cagagagcta caattgaccc tgagacggga ttattgtttc
    20761 tctccctctc taagggctga ttttcttttt gtaaggttct gagactttat ggaaggtacc
    20821 tctgcattct cataaaccct gactctgatc cttaaattcc ctctctcctt tcagctcctg
    20881 tttttcaggg taggttatgt tcttttccct ttccctgcct gcttctgatt ggtaattttg
    20941 tgtcctgtac ctgttctccc gcttttctcc ttgttttttt ttttttttcc tcctctaaaa
    21001 ttttcttatg ttgattctta tgactgtttt ctgttcttgc aacatgaggt cagagggagc
    21061 cttttgtttt tgttttgttg gttttttttt gttttttgtt ttttttgttt tttgtttttt
    21121 gttttttctg agacagggtt tctctgctac agctttgatt gtcctggtac tcactctgtt
    21181 gaacagtctg gtgtcattct cagagattca tctgcttcct cctctggagg actgggatta
    21241 agggcatgtg ccatcgctgc tcagccaagg aagtggtctt tgaattgagc acagcaatcc
    21301 ttcaccttgt agtgtacacc agtctcagag tgaatggcaa tcttttctat tggtttccca
    21361 agcactggga ttgcaagcat aaagcaccat gcttggccaa gatcttcaaa gattttcaat
    21421 tcatggccac tttgtacatg gtgtgtcttg atttgccctc tgtgttagga ataatgtcgc
    21481 tcatcttttc tccatgtacc tctgagacat cccacaggtc ggtgtattac aactcagggt
    21541 attacaactt ttcgtgtctt catgtctttt gataataaat gaattttccg ctcttaaaaa
    21601 aaaaaaaaaa aaaaaaaaaa aaaaaaa
//
