LOCUS       NM_010149               1825 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus erythropoietin receptor (Epor), transcript variant 1,
            mRNA.
ACCESSION   NM_010149 XM_978769
VERSION     NM_010149.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1825)
  AUTHORS   Lyu,J., Gu,Z., Zhang,Y., Vu,H.S., Lechauve,C., Cai,F., Cao,H.,
            Keith,J., Brancaleoni,V., Granata,F., Motta,I., Cappellini,M.D.,
            Huang,L.J., DeBerardinis,R.J., Weiss,M.J., Ni,M. and Xu,J.
  TITLE     A glutamine metabolic switch supports erythropoiesis
  JOURNAL   Science 386 (6723), eadh9215 (2024)
   PUBMED   39541460
REFERENCE   2  (bases 1 to 1825)
  AUTHORS   Yin,W., Rajvanshi,P.K., Rogers,H.M., Yoshida,T., Kopp,J.B., An,X.,
            Gassmann,M. and Noguchi,C.T.
  TITLE     Erythropoietin regulates energy metabolism through EPO-EpoR-RUNX1
            axis
  JOURNAL   Nat Commun 15 (1), 8114 (2024)
   PUBMED   39284834
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1825)
  AUTHORS   Zakaria,M.F., Sonoda,S., Kato,H., Ma,L., Uehara,N.,
            Kyumoto-Nakamura,Y., Sharifa,M.M., Yu,L., Dai,L.,
            Yamauchi-Tomoda,E., Aijima,R., Yamaza,H., Nishimura,F. and
            Yamaza,T.
  TITLE     Erythropoietin receptor signal is crucial for periodontal ligament
            stem cell-based tissue reconstruction in periodontal disease
  JOURNAL   Sci Rep 14 (1), 6719 (2024)
   PUBMED   38509204
  REMARK    GeneRIF: Erythropoietin receptor signal is crucial for periodontal
            ligament stem cell-based tissue reconstruction in periodontal
            disease.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1825)
  AUTHORS   Han,Y., Gao,C., Liu,Y., Zhang,H., Wang,S., Zhao,H., Bao,W., Guo,X.,
            Vinchi,F., Lobo,C., Shi,P., Mendelson,A., Luchsinger,L., Zhong,H.,
            Yazdanbakhsh,K. and An,X.
  TITLE     Hemolysis-driven IFNalpha production impairs erythropoiesis by
            negatively regulating EPO signaling in sickle cell disease
  JOURNAL   Blood 143 (11), 1018-1031 (2024)
   PUBMED   38127913
  REMARK    GeneRIF: Hemolysis-driven IFNalpha production impairs
            erythropoiesis by negatively regulating EPO signaling in sickle
            cell disease.
REFERENCE   5  (bases 1 to 1825)
  AUTHORS   Cardarelli,S., Biglietto,M., Orsini,T., Fustaino,V., Monaco,L., de
            Oliveira do Rego,A.G., Liccardo,F., Masciarelli,S., Fazi,F.,
            Naro,F., De Angelis,L. and Pellegrini,M.
  TITLE     Modulation of cAMP/cGMP signaling as prevention of congenital heart
            defects in Pde2A deficient embryos: a matter of oxidative stress
  JOURNAL   Cell Death Dis 15 (2), 169 (2024)
   PUBMED   38395995
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1825)
  AUTHORS   Nett,M.A., Cerretti,D.P., Berson,D.R., Seavitt,J., Gilbert,D.J.,
            Jenkins,N.A., Copeland,N.G., Black,R.A. and Chaplin,D.D.
  TITLE     Molecular cloning of the murine IL-1 beta converting enzyme cDNA
  JOURNAL   J Immunol 149 (10), 3254-3259 (1992)
   PUBMED   1431103
REFERENCE   7  (bases 1 to 1825)
  AUTHORS   Heberlein,C., Fischer,K.D., Stoffel,M., Nowock,J., Ford,A.,
            Tessmer,U. and Stocking,C.
  TITLE     The gene for erythropoietin receptor is expressed in multipotential
            hematopoietic and embryonal stem cells: evidence for
            differentiation stage-specific regulation
  JOURNAL   Mol Cell Biol 12 (4), 1815-1826 (1992)
   PUBMED   1312671
REFERENCE   8  (bases 1 to 1825)
  AUTHORS   Shapiro,S.D., Griffin,G.L., Gilbert,D.J., Jenkins,N.A.,
            Copeland,N.G., Welgus,H.G., Senior,R.M. and Ley,T.J.
  TITLE     Molecular cloning, chromosomal localization, and bacterial
            expression of a murine macrophage metalloelastase
  JOURNAL   J Biol Chem 267 (7), 4664-4671 (1992)
   PUBMED   1537850
REFERENCE   9  (bases 1 to 1825)
  AUTHORS   Longmore,G.D., Pharr,P. and Lodish,H.F.
  TITLE     Mutation in murine erythropoietin receptor induces
            erythropoietin-independent erythroid proliferation in vitro,
            polycythemia in vivo
  JOURNAL   Leukemia 6 Suppl 3, 130S-134S (1992)
   PUBMED   1318465
REFERENCE   10 (bases 1 to 1825)
  AUTHORS   Hino,M., Tojo,A., Misawa,Y., Morii,H., Takaku,F. and Shibuya,M.
  TITLE     Unregulated expression of the erythropoietin receptor gene caused
            by insertion of spleen focus-forming virus long terminal repeat in
            a murine erythroleukemia cell line
  JOURNAL   Mol Cell Biol 11 (11), 5527-5533 (1991)
   PUBMED   1656233
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC163623.5.
            
            On Sep 6, 2022 this sequence version replaced NM_010149.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC046282.1, J04843.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164140 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-260               AC163623.5         29459-29718         c
            261-393             AC163623.5         28346-28478         c
            394-569             AC163623.5         27833-28008         c
            570-727             AC163623.5         27590-27747         c
            728-881             AC163623.5         26832-26985         c
            882-969             AC163623.5         26666-26753         c
            970-1057            AC163623.5         25903-25990         c
            1058-1825           AC163623.5         25045-25812         c
FEATURES             Location/Qualifiers
     source          1..1825
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 7.93 cM"
     gene            1..1825
                     /gene="Epor"
                     /note="erythropoietin receptor"
                     /db_xref="GeneID:13857"
                     /db_xref="MGI:MGI:95408"
     exon            1..260
                     /gene="Epor"
                     /inference="alignment:Splign:2.1.0"
     exon            261..393
                     /gene="Epor"
                     /inference="alignment:Splign:2.1.0"
     exon            394..569
                     /gene="Epor"
                     /inference="alignment:Splign:2.1.0"
     exon            570..727
                     /gene="Epor"
                     /inference="alignment:Splign:2.1.0"
     exon            728..881
                     /gene="Epor"
                     /inference="alignment:Splign:2.1.0"
     exon            882..969
                     /gene="Epor"
                     /inference="alignment:Splign:2.1.0"
     exon            970..1057
                     /gene="Epor"
                     /inference="alignment:Splign:2.1.0"
     exon            1058..1825
                     /gene="Epor"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1800..1805
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Epor"
                     /note="hexamer: AATATA"
     polyA_site      1825
                     /gene="Epor"
                     /note="major polyA site"
ORIGIN      
        1 agaagctcct ggtcagctgt gtccggcagc tgctgctgac ccagctgtgg actaggggaa
       61 aggggaaaga ggaaagggaa ggagaggtgg gggggacgaa acaggggcgc tggagccctg
      121 agcttcctga agctagggct gcatcatgga caaactcagg gtgcccctct ggcctcgggt
      181 aggccccctc tgtctcctac ttgctggggc agcctgggca ccttcaccca gcctcccgga
      241 ccccaagttt gagagcaaag cggccctgct ggcatcccgg ggctccgaag aacttctgtg
      301 cttcacccaa cgcttggaag acttggtgtg tttctgggag gaagcggcga gctccgggat
      361 ggacttcaac tacagcttct cataccagct cgagggtgag tcacgaaagt catgtagcct
      421 gcaccaggct cccaccgtcc gcggctccgt gcgtttctgg tgttcactgc caacagcgga
      481 cacatcgagt tttgtgccgc tggagctgca ggtgacggag gcgtccggtt ctcctcgcta
      541 tcaccgcatc atccatatca atgaagtagt gctcctggac gcccccgcgg ggctgctggc
      601 gcgccgggca gaagagggca gccacgtggt gctgcgctgg ctgccacctc ctggagcacc
      661 tatgaccacc cacatccgat atgaagtgga cgtgtcggca ggcaaccggg caggagggac
      721 acaaagggtg gaggtcctgg aaggccgcac tgagtgtgtt ctgagcaacc tgcggggcgg
      781 gacgcgctac accttcgctg ttcgagcgcg catggccgag ccgagcttca gcggattctg
      841 gagtgcctgg tctgagcccg cgtcactact gaccgctagc gacctggacc ctctcatctt
      901 gacgctgtct ctcattctgg tcctcatctc gctgttgctg acggttctgg ccctgctgtc
      961 ccaccgccgg actctgcagc agaagatctg gcctggcatc ccaagcccag agagcgagtt
     1021 tgagggtctc ttcaccaccc acaagggtaa cttccagctg tggctgctgc agcgtgatgg
     1081 ttgtctgtgg tggagcccgg gcagctcctt ccctgaggat ccacctgccc acctagaggt
     1141 cctctcagag ccacgctggg cagtgactca ggctggggac ccaggggcag atgatgaggg
     1201 gcccttactg gagccggtgg gcagtgagca tgcccaggac acctacttgg tattggataa
     1261 gtggttgctg ccccggaccc catgcagtga gaacctctca gggcctgggg gcagtgtgga
     1321 ccctgtgact atggatgaag cttcagaaac atcttcctgc ccgtctgact tggcctcaaa
     1381 gcccaggcca gagggcacct caccttccag ctttgagtac accatcctgg accccagctc
     1441 tcagctcctg tgccctcggg cactgcctcc cgagctacct cccactccac ctcacttgaa
     1501 gtacctatac cttgtggtgt ccgattctgg catctcaaca gattacagtt cggggggctc
     1561 tcagggagtc cacggggact catctgatgg cccctactcc cacccctatg agaacagcct
     1621 tgtcccagac tcagagcctc tgcatcccgg ctatgtggcc tgctcctagg actccagcct
     1681 acaacgtctt gaacgggatt ggtgaagcca tacttaaagt cagagctgac cttggccctc
     1741 tgagcaggaa gagacagcct tgcaatgtta agattaagag ttatctgtct gtatatagaa
     1801 atatatatat atatcgattt ttcta
//
