LOCUS       NM_001411820            1621 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus erythropoietin receptor (Epor), transcript variant 2,
            mRNA.
ACCESSION   NM_001411820 XM_017313130
VERSION     NM_001411820.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1621)
  AUTHORS   Lyu,J., Gu,Z., Zhang,Y., Vu,H.S., Lechauve,C., Cai,F., Cao,H.,
            Keith,J., Brancaleoni,V., Granata,F., Motta,I., Cappellini,M.D.,
            Huang,L.J., DeBerardinis,R.J., Weiss,M.J., Ni,M. and Xu,J.
  TITLE     A glutamine metabolic switch supports erythropoiesis
  JOURNAL   Science 386 (6723), eadh9215 (2024)
   PUBMED   39541460
REFERENCE   2  (bases 1 to 1621)
  AUTHORS   Yin,W., Rajvanshi,P.K., Rogers,H.M., Yoshida,T., Kopp,J.B., An,X.,
            Gassmann,M. and Noguchi,C.T.
  TITLE     Erythropoietin regulates energy metabolism through EPO-EpoR-RUNX1
            axis
  JOURNAL   Nat Commun 15 (1), 8114 (2024)
   PUBMED   39284834
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1621)
  AUTHORS   Zakaria,M.F., Sonoda,S., Kato,H., Ma,L., Uehara,N.,
            Kyumoto-Nakamura,Y., Sharifa,M.M., Yu,L., Dai,L.,
            Yamauchi-Tomoda,E., Aijima,R., Yamaza,H., Nishimura,F. and
            Yamaza,T.
  TITLE     Erythropoietin receptor signal is crucial for periodontal ligament
            stem cell-based tissue reconstruction in periodontal disease
  JOURNAL   Sci Rep 14 (1), 6719 (2024)
   PUBMED   38509204
  REMARK    GeneRIF: Erythropoietin receptor signal is crucial for periodontal
            ligament stem cell-based tissue reconstruction in periodontal
            disease.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1621)
  AUTHORS   Han,Y., Gao,C., Liu,Y., Zhang,H., Wang,S., Zhao,H., Bao,W., Guo,X.,
            Vinchi,F., Lobo,C., Shi,P., Mendelson,A., Luchsinger,L., Zhong,H.,
            Yazdanbakhsh,K. and An,X.
  TITLE     Hemolysis-driven IFNalpha production impairs erythropoiesis by
            negatively regulating EPO signaling in sickle cell disease
  JOURNAL   Blood 143 (11), 1018-1031 (2024)
   PUBMED   38127913
  REMARK    GeneRIF: Hemolysis-driven IFNalpha production impairs
            erythropoiesis by negatively regulating EPO signaling in sickle
            cell disease.
REFERENCE   5  (bases 1 to 1621)
  AUTHORS   Cardarelli,S., Biglietto,M., Orsini,T., Fustaino,V., Monaco,L., de
            Oliveira do Rego,A.G., Liccardo,F., Masciarelli,S., Fazi,F.,
            Naro,F., De Angelis,L. and Pellegrini,M.
  TITLE     Modulation of cAMP/cGMP signaling as prevention of congenital heart
            defects in Pde2A deficient embryos: a matter of oxidative stress
  JOURNAL   Cell Death Dis 15 (2), 169 (2024)
   PUBMED   38395995
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1621)
  AUTHORS   Nett,M.A., Cerretti,D.P., Berson,D.R., Seavitt,J., Gilbert,D.J.,
            Jenkins,N.A., Copeland,N.G., Black,R.A. and Chaplin,D.D.
  TITLE     Molecular cloning of the murine IL-1 beta converting enzyme cDNA
  JOURNAL   J Immunol 149 (10), 3254-3259 (1992)
   PUBMED   1431103
REFERENCE   7  (bases 1 to 1621)
  AUTHORS   Heberlein,C., Fischer,K.D., Stoffel,M., Nowock,J., Ford,A.,
            Tessmer,U. and Stocking,C.
  TITLE     The gene for erythropoietin receptor is expressed in multipotential
            hematopoietic and embryonal stem cells: evidence for
            differentiation stage-specific regulation
  JOURNAL   Mol Cell Biol 12 (4), 1815-1826 (1992)
   PUBMED   1312671
REFERENCE   8  (bases 1 to 1621)
  AUTHORS   Shapiro,S.D., Griffin,G.L., Gilbert,D.J., Jenkins,N.A.,
            Copeland,N.G., Welgus,H.G., Senior,R.M. and Ley,T.J.
  TITLE     Molecular cloning, chromosomal localization, and bacterial
            expression of a murine macrophage metalloelastase
  JOURNAL   J Biol Chem 267 (7), 4664-4671 (1992)
   PUBMED   1537850
REFERENCE   9  (bases 1 to 1621)
  AUTHORS   Longmore,G.D., Pharr,P. and Lodish,H.F.
  TITLE     Mutation in murine erythropoietin receptor induces
            erythropoietin-independent erythroid proliferation in vitro,
            polycythemia in vivo
  JOURNAL   Leukemia 6 Suppl 3, 130S-134S (1992)
   PUBMED   1318465
REFERENCE   10 (bases 1 to 1621)
  AUTHORS   Hino,M., Tojo,A., Misawa,Y., Morii,H., Takaku,F. and Shibuya,M.
  TITLE     Unregulated expression of the erythropoietin receptor gene caused
            by insertion of spleen focus-forming virus long terminal repeat in
            a murine erythroleukemia cell line
  JOURNAL   Mol Cell Biol 11 (11), 5527-5533 (1991)
   PUBMED   1656233
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC163623.5.
            
            On Sep 6, 2022 this sequence version replaced XM_017313130.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK010968.1, SRR13422601.826414.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164140 [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-189               AC163623.5         28346-28534         c
            190-365             AC163623.5         27833-28008         c
            366-523             AC163623.5         27590-27747         c
            524-677             AC163623.5         26832-26985         c
            678-765             AC163623.5         26666-26753         c
            766-853             AC163623.5         25903-25990         c
            854-1621            AC163623.5         25045-25812         c
FEATURES             Location/Qualifiers
     source          1..1621
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 7.93 cM"
     gene            1..1621
                     /gene="Epor"
                     /note="erythropoietin receptor"
                     /db_xref="GeneID:13857"
                     /db_xref="MGI:MGI:95408"
     exon            1..189
                     /gene="Epor"
                     /inference="alignment:Splign:2.1.0"
     CDS             155..1465
                     /gene="Epor"
                     /note="isoform 2 is encoded by transcript variant 2;
                     EPO-R"
                     /codon_start=1
                     /product="erythropoietin receptor isoform 2"
                     /protein_id="NP_001398749.1"
                     /db_xref="GeneID:13857"
                     /db_xref="MGI:MGI:95408"
                     /translation="MDFNYSFSYQLEGESRKSCSLHQAPTVRGSVRFWCSLPTADTSS
                     FVPLELQVTEASGSPRYHRIIHINEVVLLDAPAGLLARRAEEGSHVVLRWLPPPGAPM
                     TTHIRYEVDVSAGNRAGGTQRVEVLEGRTECVLSNLRGGTRYTFAVRARMAEPSFSGF
                     WSAWSEPASLLTASDLDPLILTLSLILVLISLLLTVLALLSHRRTLQQKIWPGIPSPE
                     SEFEGLFTTHKGNFQLWLLQRDGCLWWSPGSSFPEDPPAHLEVLSEPRWAVTQAGDPG
                     ADDEGPLLEPVGSEHAQDTYLVLDKWLLPRTPCSENLSGPGGSVDPVTMDEASETSSC
                     PSDLASKPRPEGTSPSSFEYTILDPSSQLLCPRALPPELPPTPPHLKYLYLVVSDSGI
                     STDYSSGGSQGVHGDSSDGPYSHPYENSLVPDSEPLHPGYVACS"
     exon            190..365
                     /gene="Epor"
                     /inference="alignment:Splign:2.1.0"
     exon            366..523
                     /gene="Epor"
                     /inference="alignment:Splign:2.1.0"
     exon            524..677
                     /gene="Epor"
                     /inference="alignment:Splign:2.1.0"
     exon            678..765
                     /gene="Epor"
                     /inference="alignment:Splign:2.1.0"
     exon            766..853
                     /gene="Epor"
                     /inference="alignment:Splign:2.1.0"
     exon            854..1621
                     /gene="Epor"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1596..1601
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Epor"
                     /note="hexamer: AATATA"
     polyA_site      1621
                     /gene="Epor"
                     /note="major polyA site"
ORIGIN      
        1 agacctgggc ttccctgatc tccccctccc cccgccatgg ctatcccctt ttctagcggc
       61 cctgctggca tcccggggct ccgaagaact tctgtgcttc acccaacgct tggaagactt
      121 ggtgtgtttc tgggaggaag cggcgagctc cgggatggac ttcaactaca gcttctcata
      181 ccagctcgag ggtgagtcac gaaagtcatg tagcctgcac caggctccca ccgtccgcgg
      241 ctccgtgcgt ttctggtgtt cactgccaac agcggacaca tcgagttttg tgccgctgga
      301 gctgcaggtg acggaggcgt ccggttctcc tcgctatcac cgcatcatcc atatcaatga
      361 agtagtgctc ctggacgccc ccgcggggct gctggcgcgc cgggcagaag agggcagcca
      421 cgtggtgctg cgctggctgc cacctcctgg agcacctatg accacccaca tccgatatga
      481 agtggacgtg tcggcaggca accgggcagg agggacacaa agggtggagg tcctggaagg
      541 ccgcactgag tgtgttctga gcaacctgcg gggcgggacg cgctacacct tcgctgttcg
      601 agcgcgcatg gccgagccga gcttcagcgg attctggagt gcctggtctg agcccgcgtc
      661 actactgacc gctagcgacc tggaccctct catcttgacg ctgtctctca ttctggtcct
      721 catctcgctg ttgctgacgg ttctggccct gctgtcccac cgccggactc tgcagcagaa
      781 gatctggcct ggcatcccaa gcccagagag cgagtttgag ggtctcttca ccacccacaa
      841 gggtaacttc cagctgtggc tgctgcagcg tgatggttgt ctgtggtgga gcccgggcag
      901 ctccttccct gaggatccac ctgcccacct agaggtcctc tcagagccac gctgggcagt
      961 gactcaggct ggggacccag gggcagatga tgaggggccc ttactggagc cggtgggcag
     1021 tgagcatgcc caggacacct acttggtatt ggataagtgg ttgctgcccc ggaccccatg
     1081 cagtgagaac ctctcagggc ctgggggcag tgtggaccct gtgactatgg atgaagcttc
     1141 agaaacatct tcctgcccgt ctgacttggc ctcaaagccc aggccagagg gcacctcacc
     1201 ttccagcttt gagtacacca tcctggaccc cagctctcag ctcctgtgcc ctcgggcact
     1261 gcctcccgag ctacctccca ctccacctca cttgaagtac ctataccttg tggtgtccga
     1321 ttctggcatc tcaacagatt acagttcggg gggctctcag ggagtccacg gggactcatc
     1381 tgatggcccc tactcccacc cctatgagaa cagccttgtc ccagactcag agcctctgca
     1441 tcccggctat gtggcctgct cctaggactc cagcctacaa cgtcttgaac gggattggtg
     1501 aagccatact taaagtcaga gctgaccttg gccctctgag caggaagaga cagccttgca
     1561 atgttaagat taagagttat ctgtctgtat atagaaatat atatatatat cgatttttct
     1621 a
//
