LOCUS       NM_175332               2349 bp    mRNA    linear   ROD 03-SEP-2024
DEFINITION  Mus musculus elongin BC and polycomb repressive complex 2
            associated protein (Epop), mRNA.
ACCESSION   NM_175332
VERSION     NM_175332.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2349)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2349)
  AUTHORS   Malaiya,S., Cortes-Gutierrez,M., Herb,B.R., Coffey,S.R.,
            Legg,S.R.W., Cantle,J.P., Colantuoni,C., Carroll,J.B. and
            Ament,S.A.
  TITLE     Single-Nucleus RNA-Seq Reveals Dysregulation of Striatal Cell
            Identity Due to Huntington's Disease Mutations
  JOURNAL   J Neurosci 41 (25), 5534-5552 (2021)
   PUBMED   34011527
  REMARK    GeneRIF: Single-Nucleus RNA-Seq Reveals Dysregulation of Striatal
            Cell Identity Due to Huntington's Disease Mutations.
REFERENCE   3  (bases 1 to 2349)
  AUTHORS   Miller,S.A., Damle,M., Kim,J. and Kingston,R.E.
  TITLE     Full methylation of H3K27 by PRC2 is dispensable for initial
            embryoid body formation but required to maintain differentiated
            cell identity
  JOURNAL   Development 148 (7) (2021)
   PUBMED   33688077
  REMARK    GeneRIF: Full methylation of H3K27 by PRC2 is dispensable for
            initial embryoid body formation but required to maintain
            differentiated cell identity.
REFERENCE   4  (bases 1 to 2349)
  AUTHORS   Meng,T.G., Zhou,Q., Ma,X.S., Liu,X.Y., Meng,Q.R., Huang,X.J.,
            Liu,H.L., Lei,W.L., Zhao,Z.H., Ouyang,Y.C., Hou,Y., Schatten,H.,
            Ou,X.H., Wang,Z.B., Gao,S.R. and Sun,Q.Y.
  TITLE     PRC2 and EHMT1 regulate H3K27me2 and H3K27me3 establishment across
            the zygote genome
  JOURNAL   Nat Commun 11 (1), 6354 (2020)
   PUBMED   33311485
  REMARK    GeneRIF: PRC2 and EHMT1 regulate H3K27me2 and H3K27me3
            establishment across the zygote genome.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2349)
  AUTHORS   Elsen,G.E., Bedogni,F., Hodge,R.D., Bammler,T.K., MacDonald,J.W.,
            Lindtner,S., Rubenstein,J.L.R. and Hevner,R.F.
  TITLE     The Epigenetic Factor Landscape of Developing Neocortex Is
            Regulated by Transcription Factors Pax6--> Tbr2--> Tbr1
  JOURNAL   Front Neurosci 12, 571 (2018)
   PUBMED   30186101
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2349)
  AUTHORS   Beringer,M., Pisano,P., Di Carlo,V., Blanco,E., Chammas,P.,
            Vizan,P., Gutierrez,A., Aranda,S., Payer,B., Wierer,M. and Di
            Croce,L.
  TITLE     EPOP Functionally Links Elongin and Polycomb in Pluripotent Stem
            Cells
  JOURNAL   Mol Cell 64 (4), 645-658 (2016)
   PUBMED   27863225
  REMARK    GeneRIF: EPOP (E130012A19Rik) functionally links elongin B, elongin
            C, and polycomb in pluripotent stem cells.
REFERENCE   7  (bases 1 to 2349)
  AUTHORS   De Cegli,R., Iacobacci,S., Flore,G., Gambardella,G., Mao,L.,
            Cutillo,L., Lauria,M., Klose,J., Illingworth,E., Banfi,S. and di
            Bernardo,D.
  TITLE     Reverse engineering a mouse embryonic stem cell-specific
            transcriptional network reveals a new modulator of neuronal
            differentiation
  JOURNAL   Nucleic Acids Res 41 (2), 711-726 (2013)
   PUBMED   23180766
  REMARK    GeneRIF: Results demonstrated that E130012A19Rik (E13), is a
            protein-coding gene implicated in regulating the commitment towards
            the different neuronal subtypes and glia cells.
REFERENCE   8  (bases 1 to 2349)
  AUTHORS   Hunkapiller,J., Shen,Y., Diaz,A., Cagney,G., McCleary,D.,
            Ramalho-Santos,M., Krogan,N., Ren,B., Song,J.S. and Reiter,J.F.
  TITLE     Polycomb-like 3 promotes polycomb repressive complex 2 binding to
            CpG islands and embryonic stem cell self-renewal
  JOURNAL   PLoS Genet 8 (3), e1002576 (2012)
   PUBMED   22438827
REFERENCE   9  (bases 1 to 2349)
  AUTHORS   Zhang,Z., Jones,A., Sun,C.W., Li,C., Chang,C.W., Joo,H.Y., Dai,Q.,
            Mysliwiec,M.R., Wu,L.C., Guo,Y., Yang,W., Liu,K., Pawlik,K.M.,
            Erdjument-Bromage,H., Tempst,P., Lee,Y., Min,J., Townes,T.M. and
            Wang,H.
  TITLE     PRC2 complexes with JARID2, MTF2, and esPRC2p48 in ES cells to
            modulate ES cell pluripotency and somatic cell reprogramming
  JOURNAL   Stem Cells 29 (2), 229-240 (2011)
   PUBMED   21732481
  REMARK    GeneRIF: these studies identify JARID2, MTF2, and esPRC2p48 as
            important regulatory subunits of PRC2 in ES cells and reveal
            critical functions of these subunits.
REFERENCE   10 (bases 1 to 2349)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC055770.1.
            
            On Aug 5, 2006 this sequence version replaced NM_175332.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC055770.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
FEATURES             Location/Qualifiers
     source          1..2349
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 61.03 cM"
     gene            1..2349
                     /gene="Epop"
                     /gene_synonym="E13; E130012A19Rik; esPRC2p48"
                     /note="elongin BC and polycomb repressive complex 2
                     associated protein"
                     /db_xref="GeneID:103551"
                     /db_xref="MGI:MGI:2143991"
     exon            1..2330
                     /gene="Epop"
                     /gene_synonym="E13; E130012A19Rik; esPRC2p48"
                     /inference="alignment:Splign:2.1.0"
     CDS             436..1545
                     /gene="Epop"
                     /gene_synonym="E13; E130012A19Rik; esPRC2p48"
                     /note="ES cell-specific PRC2 subunit p48; elongin and
                     polycomb associated protein; uncharacterized protein
                     C17orf96 homolog; embryonic stem cell-specific PRC2
                     subunit p48"
                     /codon_start=1
                     /product="elongin BC and Polycomb repressive complex
                     2-associated protein"
                     /protein_id="NP_780541.2"
                     /db_xref="CCDS:CCDS25322.1"
                     /db_xref="GeneID:103551"
                     /db_xref="MGI:MGI:2143991"
                     /translation="METLCPPPRLAVPASPRGSPCSPTPLKPRRGTPEFSPLCLRALA
                     FCALAKPRPSSLGLGPGELAPRTPVLLGPPASPCTGGWAADGLKHLGGQAGRPSDVSS
                     PAREDADVAVCPGGGEEEEGGGGFPHFGAGSCAPPGRCPAPLRPQDSPTNPAWSPPRP
                     ARGLDAASSPPLEPGSPPPSPPAGLSPEPAPSEQPVPASEAPGGGDPAPTAPEAPALS
                     PSTADAAPDPPRDLRQEHFNRLIRRSKLWCYAKGFALDTPSLRRGPERPAAKARGAAK
                     KRRRPAPPPPSVQPRRPVPTLPTSSTFSLLDCFPCPPALVVEENGDLGPASSLRLQGD
                     AKPPPAHPLWKWQMGGPAVPEPPGLKSWWVNLEEL"
ORIGIN      
        1 ggagccagcg gggaagaaag aagctgagag ggcggaaggc gccctccccg ccgctgggcc
       61 cgggcaccgg gcgccgggcc ggggtccttc ccgccggcgg cgagcgccgg ctgctttgtt
      121 tgcccccgcc tcggcgttga ggggtgatcg tgccgggcat tgcgccggga acgcggcggc
      181 aggaagcgcg accgatcgca ccggggacgc gcggggaccc aggagtccgg ccgcggcgag
      241 ggccgcgtga cgataccgag gagagagccg gagcgccgcc gcgggctctt ggtggtgggc
      301 cccggacgcc cgtgagcaca gacctccccg tcgacggggg gcgatgttcc cctggcccgc
      361 aggctcttcg ggccgccggg gtatcccgcc gttgggacca gggcccccgc agtgggcgac
      421 ccccaaggct gctccatgga gactctgtgt cctcctcccc gcctggcagt gcccgcttcc
      481 ccgcgggggt ctccctgctc gcctacgccc ctgaagccgc gtcgggggac cccagagttc
      541 tccccactgt gcctgcgtgc cctcgccttc tgcgcccttg ccaaaccccg gccgtcctcc
      601 ctgggcctgg ggcctggaga gctggcgccg cggaccccgg tgctgctggg ccccccggcc
      661 tcgccatgca caggaggctg ggccgcggac ggcctgaagc acctcggggg acaggccggg
      721 cggccgagcg acgtgagctc cccggcccgc gaggatgcag acgtcgcggt gtgcccaggc
      781 ggtggagagg aggaagaggg cggaggcggc ttcccgcact tcggcgctgg ttcctgcgca
      841 cctccgggcc gctgccctgc tcccctgcgt cctcaggact ctccgaccaa ccccgcctgg
      901 tccccgccca ggccagcccg gggtcttgat gcagctagca gtccgcccct tgagcccggc
      961 tccccgcctc cgtcgccacc tgcgggcctc tccccggagc ctgcgccttc cgagcagcct
     1021 gtgccggcct ccgaggctcc agggggtgga gaccctgcgc cgaccgcgcc tgaggcaccc
     1081 gcgctcagcc cctcgacggc agacgcagca ccggacccgc cccgcgatct ccgccaggaa
     1141 catttcaacc gcctgatccg ccgctcgaaa ctttggtgtt acgcgaaggg gttcgccctg
     1201 gacactccaa gtttgcgccg agggcccgaa cggcccgcgg ccaaagcccg tggagcagcc
     1261 aagaaacgac ggcggccagc gccgcccccg cccagtgtgc agccacggcg gcccgtcccg
     1321 acgcttccta catcgagcac cttcagcctc cttgactgct tcccctgtcc cccagctctg
     1381 gtggtggaag agaacggaga cctagggccg gcttcctcgc ttcgcctcca gggagacgcc
     1441 aagccgccgc ctgcccaccc gctgtggaag tggcagatgg gaggacccgc tgtccctgag
     1501 cccccgggtc tcaaatcctg gtgggtcaac ttggaagaac tatgagcgtc ggacctcttc
     1561 tacccggggg caagttgggt tccccggaca gactgagggc tccaggaggg agcatcgatt
     1621 ctgaaatttg gctgatcttt gctttgcatt ttatgggctg tggcccgcgg gacctcaaat
     1681 gacagtgatc ttcaagcacc cgagaggtcc ggctgatgct ctttctactc atctttgtgg
     1741 aagatccaag gactggcgtc cgggaaagcc tgcagaaagc ttagtgacca tctccgtcct
     1801 ccctgcgggc gggcagagcc ttcaccgcag gggagcacag cggctaaggc ccgaagacca
     1861 aaagaaaggg acagagggac ggaccttggt gatggacaaa ccggttgttt ccatgtttga
     1921 atgagggtca gtttagcggt gtgggggctg tggttggggt ttgaaggtga ttgacagctc
     1981 cctgggggca tcccccaccc cccactgccc agacctttaa ccctttacac ctccctcttt
     2041 tctctccgta gtcctccccc tccccaagtt caggtgattt tcccttgtca agatcttcag
     2101 tcccagccag cagactttac ccttttgtcc agttttggag tttccctttg ccggaaggtt
     2161 ggatgaagga aagagacctc cagcctcagc gttctcctca cattctgaga ggaaaggagg
     2221 aagagggcca tgctgtgtgg cccaaggctg gctttgcccg gggaaggagc caaaaactcc
     2281 cggggaaaat gatggaagat ggaataaatc aataaaatca gaccaaacaa aaaaaaaaaa
     2341 aaaaaaaaa
//
