LOCUS       NP_780541                369 aa            linear   ROD 27-APR-2025
DEFINITION  elongin BC and Polycomb repressive complex 2-associated protein
            [Mus musculus].
ACCESSION   NP_780541
VERSION     NP_780541.2
DBSOURCE    REFSEQ: accession NM_175332.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 369)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 369)
  AUTHORS   Malaiya,S., Cortes-Gutierrez,M., Herb,B.R., Coffey,S.R.,
            Legg,S.R.W., Cantle,J.P., Colantuoni,C., Carroll,J.B. and
            Ament,S.A.
  TITLE     Single-Nucleus RNA-Seq Reveals Dysregulation of Striatal Cell
            Identity Due to Huntington's Disease Mutations
  JOURNAL   J Neurosci 41 (25), 5534-5552 (2021)
   PUBMED   34011527
  REMARK    GeneRIF: Single-Nucleus RNA-Seq Reveals Dysregulation of Striatal
            Cell Identity Due to Huntington's Disease Mutations.
REFERENCE   3  (residues 1 to 369)
  AUTHORS   Miller,S.A., Damle,M., Kim,J. and Kingston,R.E.
  TITLE     Full methylation of H3K27 by PRC2 is dispensable for initial
            embryoid body formation but required to maintain differentiated
            cell identity
  JOURNAL   Development 148 (7) (2021)
   PUBMED   33688077
  REMARK    GeneRIF: Full methylation of H3K27 by PRC2 is dispensable for
            initial embryoid body formation but required to maintain
            differentiated cell identity.
REFERENCE   4  (residues 1 to 369)
  AUTHORS   Meng,T.G., Zhou,Q., Ma,X.S., Liu,X.Y., Meng,Q.R., Huang,X.J.,
            Liu,H.L., Lei,W.L., Zhao,Z.H., Ouyang,Y.C., Hou,Y., Schatten,H.,
            Ou,X.H., Wang,Z.B., Gao,S.R. and Sun,Q.Y.
  TITLE     PRC2 and EHMT1 regulate H3K27me2 and H3K27me3 establishment across
            the zygote genome
  JOURNAL   Nat Commun 11 (1), 6354 (2020)
   PUBMED   33311485
  REMARK    GeneRIF: PRC2 and EHMT1 regulate H3K27me2 and H3K27me3
            establishment across the zygote genome.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 369)
  AUTHORS   Elsen,G.E., Bedogni,F., Hodge,R.D., Bammler,T.K., MacDonald,J.W.,
            Lindtner,S., Rubenstein,J.L.R. and Hevner,R.F.
  TITLE     The Epigenetic Factor Landscape of Developing Neocortex Is
            Regulated by Transcription Factors Pax6--> Tbr2--> Tbr1
  JOURNAL   Front Neurosci 12, 571 (2018)
   PUBMED   30186101
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 369)
  AUTHORS   Beringer,M., Pisano,P., Di Carlo,V., Blanco,E., Chammas,P.,
            Vizan,P., Gutierrez,A., Aranda,S., Payer,B., Wierer,M. and Di
            Croce,L.
  TITLE     EPOP Functionally Links Elongin and Polycomb in Pluripotent Stem
            Cells
  JOURNAL   Mol Cell 64 (4), 645-658 (2016)
   PUBMED   27863225
  REMARK    GeneRIF: EPOP (E130012A19Rik) functionally links elongin B, elongin
            C, and polycomb in pluripotent stem cells.
REFERENCE   7  (residues 1 to 369)
  AUTHORS   De Cegli,R., Iacobacci,S., Flore,G., Gambardella,G., Mao,L.,
            Cutillo,L., Lauria,M., Klose,J., Illingworth,E., Banfi,S. and di
            Bernardo,D.
  TITLE     Reverse engineering a mouse embryonic stem cell-specific
            transcriptional network reveals a new modulator of neuronal
            differentiation
  JOURNAL   Nucleic Acids Res 41 (2), 711-726 (2013)
   PUBMED   23180766
  REMARK    GeneRIF: Results demonstrated that E130012A19Rik (E13), is a
            protein-coding gene implicated in regulating the commitment towards
            the different neuronal subtypes and glia cells.
REFERENCE   8  (residues 1 to 369)
  AUTHORS   Hunkapiller,J., Shen,Y., Diaz,A., Cagney,G., McCleary,D.,
            Ramalho-Santos,M., Krogan,N., Ren,B., Song,J.S. and Reiter,J.F.
  TITLE     Polycomb-like 3 promotes polycomb repressive complex 2 binding to
            CpG islands and embryonic stem cell self-renewal
  JOURNAL   PLoS Genet 8 (3), e1002576 (2012)
   PUBMED   22438827
REFERENCE   9  (residues 1 to 369)
  AUTHORS   Zhang,Z., Jones,A., Sun,C.W., Li,C., Chang,C.W., Joo,H.Y., Dai,Q.,
            Mysliwiec,M.R., Wu,L.C., Guo,Y., Yang,W., Liu,K., Pawlik,K.M.,
            Erdjument-Bromage,H., Tempst,P., Lee,Y., Min,J., Townes,T.M. and
            Wang,H.
  TITLE     PRC2 complexes with JARID2, MTF2, and esPRC2p48 in ES cells to
            modulate ES cell pluripotency and somatic cell reprogramming
  JOURNAL   Stem Cells 29 (2), 229-240 (2011)
   PUBMED   21732481
  REMARK    GeneRIF: these studies identify JARID2, MTF2, and esPRC2p48 as
            important regulatory subunits of PRC2 in ES cells and reveal
            critical functions of these subunits.
REFERENCE   10 (residues 1 to 369)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC055770.1.
            
            On Aug 5, 2006 this sequence version replaced NP_780541.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC055770.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..369
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 61.03 cM"
     Protein         1..369
                     /product="elongin BC and Polycomb repressive complex
                     2-associated protein"
                     /note="ES cell-specific PRC2 subunit p48; elongin and
                     polycomb associated protein; uncharacterized protein
                     C17orf96 homolog; embryonic stem cell-specific PRC2
                     subunit p48"
                     /calculated_mol_wt=37964
     Region          1..33
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TNS8.1)"
     Site            15
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:A6NHQ4; propagated from
                     UniProtKB/Swiss-Prot (Q7TNS8.1)"
     Site            19
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:A6NHQ4; propagated from
                     UniProtKB/Swiss-Prot (Q7TNS8.1)"
     Region          39..48
                     /region_name="BC-box.
                     /evidence=ECO:0000269|PubMed:27863225,
                     ECO:0000269|PubMed:27863226"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TNS8.1)"
     Site            52
                     /site_type="methylation"
                     /note="Asymmetric dimethylarginine.
                     /evidence=ECO:0000250|UniProtKB:A6NHQ4; propagated from
                     UniProtKB/Swiss-Prot (Q7TNS8.1)"
     Region          89..237
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TNS8.1)"
     Region          256..299
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TNS8.1)"
     Region          <295..360
                     /region_name="EPOP"
                     /note="Elongin BC and Polycomb repressive complex
                     2-associated protein; pfam15223"
                     /db_xref="CDD:434546"
     Region          301..349
                     /region_name="Interaction with SUZ12.
                     /evidence=ECO:0000250|UniProtKB:A6NHQ4"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TNS8.1)"
     CDS             1..369
                     /gene="Epop"
                     /gene_synonym="E13; E130012A19Rik; esPRC2p48"
                     /coded_by="NM_175332.3:436..1545"
                     /db_xref="CCDS:CCDS25322.1"
                     /db_xref="GeneID:103551"
                     /db_xref="MGI:MGI:2143991"
ORIGIN      
        1 metlcppprl avpasprgsp csptplkprr gtpefsplcl ralafcalak prpsslglgp
       61 gelaprtpvl lgppaspctg gwaadglkhl ggqagrpsdv ssparedadv avcpgggeee
      121 eggggfphfg agscappgrc paplrpqdsp tnpawspprp argldaassp plepgsppps
      181 ppaglspepa pseqpvpase apgggdpapt apeapalsps tadaapdppr dlrqehfnrl
      241 irrsklwcya kgfaldtpsl rrgperpaak argaakkrrr pappppsvqp rrpvptlpts
      301 stfslldcfp cppalvveen gdlgpasslr lqgdakpppa hplwkwqmgg pavpeppglk
      361 swwvnleel
//
