LOCUS       NM_007942                715 bp    mRNA    linear   ROD 24-OCT-2024
DEFINITION  Mus musculus erythropoietin (Epo), transcript variant 1, mRNA.
ACCESSION   NM_007942
VERSION     NM_007942.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 715)
  AUTHORS   Bessoles,S., Chiron,A., Sarrabayrouse,G., De La Grange,P.,
            Abina,A.M. and Hacein-Bey-Abina,S.
  TITLE     Erythropoietin induces tumour progression and CD39 expression on
            immune cells in a preclinical model of triple-negative breast
            cancer
  JOURNAL   Immunology 173 (2), 360-380 (2024)
   PUBMED   38953295
  REMARK    GeneRIF: Erythropoietin induces tumour progression and CD39
            expression on immune cells in a preclinical model of
            triple-negative breast cancer.
REFERENCE   2  (bases 1 to 715)
  AUTHORS   Marrow,J.P., Alshamali,R., Edgett,B.A., Allwood,M.A.,
            Cochrane,K.L.S., Al-Sabbag,S., Ayoub,A., Ask,K., Hare,G.M.T.,
            Brunt,K.R. and Simpson,J.A.
  TITLE     Cardiomyocyte crosstalk with endothelium modulates cardiac
            structure, function, and ischemia-reperfusion injury susceptibility
            through erythropoietin
  JOURNAL   Front Physiol 15, 1397049 (2024)
   PUBMED   39011088
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 715)
  AUTHORS   Wu,G., Cao,B., Zhai,H., Liu,B., Huang,Y., Chen,X., Ling,H.,
            Ling,S., Jin,S., Yang,X. and Wang,J.
  TITLE     EPO promotes the progression of rheumatoid arthritis by inducing
            desialylation via increasing the expression of neuraminidase 3
  JOURNAL   Ann Rheum Dis 83 (5), 564-575 (2024)
   PUBMED   38272667
  REMARK    GeneRIF: EPO promotes the progression of rheumatoid arthritis by
            inducing desialylation via increasing the expression of
            neuraminidase 3.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 715)
  AUTHORS   Allwood,M.A., Edgett,B.A., Platt,M.J., Marrow,J.P., Coyle-Asbil,B.,
            Holjak,E.J.B., Nelson,V.L., Bangali,S., Alshamali,R., Jacyniak,K.,
            Klein,J.M., Farquharson,L., Romanova,N., Northrup,V., Ogilvie,L.M.,
            Ayoub,A., Ask,K., Vickaryous,M.K., Hare,G.M.T., Brunt,K.R. and
            Simpson,J.A.
  TITLE     Novel roles of cardiac-derived erythropoietin in cardiac
            development and function
  JOURNAL   J Mol Cell Cardiol 188, 90-104 (2024)
   PUBMED   38382296
  REMARK    GeneRIF: Novel roles of cardiac-derived erythropoietin in cardiac
            development and function.
REFERENCE   5  (bases 1 to 715)
  AUTHORS   Chowdhury,K., Goulding,M., Walther,C., Imai,K. and Fickenscher,H.
  TITLE     The ubiquitous transactivator Zfp-38 is upregulated during
            spermatogenesis with differential transcription
  JOURNAL   Mech Dev 39 (3), 129-142 (1992)
   PUBMED   1284028
REFERENCE   6  (bases 1 to 715)
  AUTHORS   Sakata,S. and Enoki,Y.
  TITLE     Developmental changes in plasma erythroid colony-stimulating
            activity in mice: cyclic erythropoiesis associated with rapid
            growth
  JOURNAL   J Dev Physiol 18 (5), 211-216 (1992)
   PUBMED   1307096
REFERENCE   7  (bases 1 to 715)
  AUTHORS   Rachinsky,T.L., Crenshaw,E.B. 3rd and Taylor,P.
  TITLE     Assignment of the gene for acetylcholinesterase to distal mouse
            chromosome 5
  JOURNAL   Genomics 14 (2), 511-514 (1992)
   PUBMED   1358806
REFERENCE   8  (bases 1 to 715)
  AUTHORS   Wilkie,T.M., Gilbert,D.J., Olsen,A.S., Chen,X.N., Amatruda,T.T.,
            Korenberg,J.R., Trask,B.J., de Jong,P., Reed,R.R., Simon,M.I. et
            al.
  TITLE     Evolution of the mammalian G protein alpha subunit multigene family
  JOURNAL   Nat Genet 1 (2), 85-91 (1992)
   PUBMED   1302014
  REMARK    Review article
REFERENCE   9  (bases 1 to 715)
  AUTHORS   Shoemaker,C.B. and Mitsock,L.D.
  TITLE     Murine erythropoietin gene: cloning, expression, and human gene
            homology
  JOURNAL   Mol Cell Biol 6 (3), 849-858 (1986)
   PUBMED   3773894
REFERENCE   10 (bases 1 to 715)
  AUTHORS   McDonald,J.D., Lin,F.K. and Goldwasser,E.
  TITLE     Cloning, sequencing, and evolutionary analysis of the mouse
            erythropoietin gene
  JOURNAL   Mol Cell Biol 6 (3), 842-848 (1986)
   PUBMED   3022133
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC119265.1.
            
            On Sep 3, 2006 this sequence version replaced NM_007942.1.
            
            Summary: This gene encodes the glycoprotein hormone erythropoietin
            that regulates the production of red blood cells and biosynthesis
            of hemoglobin. The predominant expression of this gene shifts from
            the liver during fetal development to kidney in adults. A complete
            lack of the encoded protein causes embryonic lethal anemia in mice.
            The conditional inactivation of this gene in adult mice results in
            a chronic, normocytic and normochromic anemia. Transgenic mice
            expressing the human ortholog of this gene exhibit polycythemia.
            Alternative splicing results in multiple transcript variants
            encoding different isoforms. [provided by RefSeq, Aug 2015].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer protein (isoform 1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC144883.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135, SAMN01164137
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..715
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 76.5 cM"
     gene            1..715
                     /gene="Epo"
                     /note="erythropoietin"
                     /db_xref="GeneID:13856"
                     /db_xref="MGI:MGI:95407"
     exon            1..84
                     /gene="Epo"
                     /inference="alignment:Splign:2.1.0"
     CDS             72..650
                     /gene="Epo"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1"
                     /codon_start=1
                     /product="erythropoietin isoform 1 precursor"
                     /protein_id="NP_031968.1"
                     /db_xref="CCDS:CCDS39332.1"
                     /db_xref="GeneID:13856"
                     /db_xref="MGI:MGI:95407"
                     /translation="MGVPERPTLLLLLSLLLIPLGLPVLCAPPRLICDSRVLERYILE
                     AKEAENVTMGCAEGPRLSENITVPDTKVNFYAWKRMEVEEQAIEVWQGLSLLSEAILQ
                     AQALLANSSQPPETLQLHIDKAISGLRSLTSLLRVLGAQKELMSPPDTTPPAPLRTLT
                     VDTFCKLFRVYANFLRGKLKLYTGEVCRRGDR"
     exon            85..227
                     /gene="Epo"
                     /inference="alignment:Splign:2.1.0"
     exon            228..314
                     /gene="Epo"
                     /inference="alignment:Splign:2.1.0"
     exon            315..494
                     /gene="Epo"
                     /inference="alignment:Splign:2.1.0"
     exon            495..715
                     /gene="Epo"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gatgaagact tgcagcgtgg acactggccc agccccgggt cgctaaggag ctccggcagc
       61 taggcgcgga gatgggggtg cccgaacgtc ccaccctgct gcttttactc tccttgctac
      121 tgattcctct gggcctccca gtcctctgtg ctcccccacg cctcatctgc gacagtcgag
      181 ttctggagag gtacatctta gaggccaagg aggcagaaaa tgtcacgatg ggttgtgcag
      241 aaggtcccag actgagtgaa aatattacag tcccagatac caaagtcaac ttctatgctt
      301 ggaaaagaat ggaggtggaa gaacaggcca tagaagtttg gcaaggcctg tccctgctct
      361 cagaagccat cctgcaggcc caggccctgc tagccaattc ctcccagcca ccagagaccc
      421 ttcagcttca tatagacaaa gccatcagtg gtctacgtag cctcacttca ctgcttcggg
      481 tactgggagc tcagaaggaa ttgatgtcgc ctccagatac caccccacct gctccactcc
      541 gaacactcac agtggatact ttctgcaagc tcttccgggt ctacgccaac ttcctccggg
      601 ggaaactgaa gctgtacacg ggagaggtct gcaggagagg ggacaggtga catgctgctg
      661 ccaccgtggt ggaccgacga acttgctccc cgtcactgtg tcatgccaac cctcc
//
