LOCUS       NM_027984               3884 bp    mRNA    linear   ROD 30-JUL-2024
DEFINITION  Mus musculus epsin 3 (Epn3), transcript variant 1, mRNA.
ACCESSION   NM_027984
VERSION     NM_027984.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3884)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3884)
  AUTHORS   Mohan,R.A., Bosada,F.M., van Weerd,J.H., van Duijvenboden,K.,
            Wang,J., Mommersteeg,M.T.M., Hooijkaas,I.B., Wakker,V., de Gier-de
            Vries,C., Coronel,R., Boink,G.J.J., Bakkers,J., Barnett,P.,
            Boukens,B.J. and Christoffels,V.M.
  TITLE     T-box transcription factor 3 governs a transcriptional program for
            the function of the mouse atrioventricular conduction system
  JOURNAL   Proc Natl Acad Sci U S A 117 (31), 18617-18626 (2020)
   PUBMED   32675240
REFERENCE   3  (bases 1 to 3884)
  AUTHORS   Mori,J., Tanikawa,C., Ohnishi,N., Funauchi,Y., Toyoshima,O.,
            Ueda,K. and Matsuda,K.
  TITLE     EPSIN 3, A Novel p53 Target, Regulates the Apoptotic Pathway and
            Gastric Carcinogenesis
  JOURNAL   Neoplasia 19 (3), 185-195 (2017)
   PUBMED   28152424
REFERENCE   4  (bases 1 to 3884)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643. PMID: 29144450]
REFERENCE   5  (bases 1 to 3884)
  AUTHORS   Messa,M., Fernandez-Busnadiego,R., Sun,E.W., Chen,H., Czapla,H.,
            Wrasman,K., Wu,Y., Ko,G., Ross,T., Wendland,B. and De Camilli,P.
  TITLE     Epsin deficiency impairs endocytosis by stalling the
            actin-dependent invagination of endocytic clathrin-coated pits
  JOURNAL   Elife 3, e03311 (2014)
   PUBMED   25122462
  REMARK    GeneRIF: Epsin deficiency impairs endocytosis by stalling the
            actin-dependent invagination of endocytic clathrin-coated pits.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3884)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   7  (bases 1 to 3884)
  AUTHORS   Ko,G., Paradise,S., Chen,H., Graham,M., Vecchi,M., Bianchi,F.,
            Cremona,O., Di Fiore,P.P. and De Camilli,P.
  TITLE     Selective high-level expression of epsin 3 in gastric parietal
            cells, where it is localized at endocytic sites of apical
            canaliculi
  JOURNAL   Proc Natl Acad Sci U S A 107 (50), 21511-21516 (2010)
   PUBMED   21115825
  REMARK    GeneRIF: data suggest that epsin 3 cooperates with other bilayer
            binding proteins with curvature sensing/generating properties in
            the specialized traffic and membrane remodeling processes typical
            of gastric parietal cells
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL645809.8 and AK009469.1.
            
            On May 1, 2010 this sequence version replaced NM_027984.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC016454.1, SRR14995047.697485.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-282               AL645809.8         22073-22354         c
            283-962             AL645809.8         18382-19061         c
            963-2003            AK009469.1         343-1383
            2004-3884           AL645809.8         11979-13859         c
FEATURES             Location/Qualifiers
     source          1..3884
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 58.9 cM"
     gene            1..3884
                     /gene="Epn3"
                     /gene_synonym="2310022G12Rik"
                     /note="epsin 3"
                     /db_xref="GeneID:71889"
                     /db_xref="MGI:MGI:1919139"
     exon            1..282
                     /gene="Epn3"
                     /gene_synonym="2310022G12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            283..962
                     /gene="Epn3"
                     /gene_synonym="2310022G12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            963..1081
                     /gene="Epn3"
                     /gene_synonym="2310022G12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1082..1162
                     /gene="Epn3"
                     /gene_synonym="2310022G12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1163..1294
                     /gene="Epn3"
                     /gene_synonym="2310022G12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1295..1382
                     /gene="Epn3"
                     /gene_synonym="2310022G12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1383..1652
                     /gene="Epn3"
                     /gene_synonym="2310022G12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1653..1769
                     /gene="Epn3"
                     /gene_synonym="2310022G12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1770..2003
                     /gene="Epn3"
                     /gene_synonym="2310022G12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2004..3884
                     /gene="Epn3"
                     /gene_synonym="2310022G12Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2475..2480
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Epn3"
                     /gene_synonym="2310022G12Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2500
                     /gene="Epn3"
                     /gene_synonym="2310022G12Rik"
                     /note="major polyA site"
     regulatory      3036..3041
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Epn3"
                     /gene_synonym="2310022G12Rik"
                     /note="hexamer: ACTAAA"
     polyA_site      3057
                     /gene="Epn3"
                     /gene_synonym="2310022G12Rik"
     regulatory      3861..3866
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Epn3"
                     /gene_synonym="2310022G12Rik"
                     /note="hexamer: AGTAAA"
     polyA_site      3882
                     /gene="Epn3"
                     /gene_synonym="2310022G12Rik"
ORIGIN      
        1 tgaggcagac ctgcctggcc agctgaacaa ctttcctccc gagagtgctg gccggcagga
       61 gtcgaggagg cagccgcgag agtctgagcg gccacccgct ggggggaccc tgcggtcctt
      121 ccgagagaga gctctgtgcc tttcggtcca aggtagagct cccgcgacca gggtttatgg
      181 tggatggctc tggggctgct cctgaagctg tgccatcccc atacaagtca gagggtcact
      241 gcagaggctg cgggggctgg ggcgagggag cccactctgg agccccatgt ggaacccaag
      301 gacacagccg ccctgctgaa agcaaggcgg cccatccttc aagaccgtga cctcgagacg
      361 gtggcgctcg gccctctacc tccgacgggg gcgggggccg cccacctcca agtccccaac
      421 tatgacaacc tctgcactcc gccgccaggt gaagaacatt gttcacaact actctgaggc
      481 cgagatcaag gtgcgtgagg ccaccagcaa tgacccctgg ggcccaccca gttctctcat
      541 gtcagagatt gctgacctga ccttcaacac ggtggccttt gctgaggtta tggggatggt
      601 gtggcggagg ctcaatgaca gcggtaagaa ctggcgacac gtatacaagg ctctgacact
      661 attggactac ctgctcaaga cgggctcaga acgtgtggcc caccagtgcc gcgagaacct
      721 ctacactatc cagactctca aggacttcca gtatattgac cgagatggca aggatcaggg
      781 cgtcaatgtt cgtgagaagg tcaaacaggt gatggccctt ctcaaggatg aggagcgcct
      841 gcggcaagag cgaacccatg ctctcaagac caaagagcga atggccctgg aaggcatggg
      901 tattggcagc gggcagctgg gctacagccg cagatctcgg ggctccccct cttcttacac
      961 gtccgcatct tcgtccccgc gctatgcctc agacctggag caggcgcggc ctcagacttc
     1021 tggagaagaa gagctgcagc tgcagctggc cttggccatg agtcgcgaag aggctgaaag
     1081 gccagtcccc ccagcctccc acagggatga ggacctgcag ctgcagctgg ctctgagcct
     1141 gagccggcaa gagcatgaga agggggtgag atcctggaag ggagatgact ctccagtggc
     1201 caacggcgca gaacctgctg gccaacgtcg tcaacgggac agggagcctg agagagaaga
     1261 gagaaaggag gaggagaagc tgaaaactag tcagtcctcc atcctggact tggctgacat
     1321 cttcgcacct gccccggccc tgccttccac acactgctct gctgacccat gggacatccc
     1381 aggtctcagg ccgaacacag agccaagtgg ctcctcttgg ggaccttctg cagacccctg
     1441 gtctccagtt ccctctggaa atgccctgtc ccgaagccag ccttgggatt tgcttcctac
     1501 tctttcttcc tctgagccct ggggcaggac cccagtgcta ccttctggac cccccatcgc
     1561 agacccctgg gcaccaagct cccctacccg caaactcccc agcactggag cagacccttg
     1621 gggggcctct atggagacct ctgacacctc tgctctaggt ggtgcctcgc ccttcgaccc
     1681 atttgccaaa cctctagaat ccacagaacc caaggagagc cgggacagtg cccaggccct
     1741 gcccacgggg aagtccccca gcactgtgga gctagaccca tttggagact ccagccccag
     1801 ttgcaagcag aatggcatga aggaacctga agcccttgac ctgggtgtgc taggagaggc
     1861 gctaccgcag cagccaggaa aggaagcgcg cccctgccgg actccggagt ccttcctggg
     1921 cccctctgcc tcttctttgg tcaacttgga ctcactagtc aaggcacccc tggctgcaag
     1981 gacccggaat cccttcctga caggtctggg tgttccgtcc ccaaccaacc cgtttggcgc
     2041 gggcgatcag ggcaggccga ccctaaacca gatgcgtacc ggctcccctg ctctgggcct
     2101 gccgccgggg ggacccgtcg gggcgcccgt gggctctatg acctacagcg cctctctgcc
     2161 ccttccgctc agcagcgtgc cggtaggcgc gaccctcccc gcctcggtca gcgtcttccc
     2221 gcaagcggga gccttcgccc cgccgccggc gagcttgcct cagccactgc tgcccacgtc
     2281 cggcccaatg gggccgctgc ccccgcaggc tggcactaat cccttcctct gagacgcttt
     2341 agcgcctgcg cgcgaagccc cgcctcctcg agggcggatc gtgcaggttg agcactgatc
     2401 tgtggacccc ctgacacatc ctgaaaccca actagggact gaccgcgtct tggggacgaa
     2461 gactacaccc gcctaataaa gactggaatc tacgtcctca gctcttacca agtggacttt
     2521 ttgaggggtg tggcagctgg atcaggaccc ccgcacccat tacctgctga ggcagaaact
     2581 ccttgacaat ctgaatgtcc tcatagccct ctcaaccccc attccccttt cctcttggcc
     2641 tggtgcctcc ctttcatgct gtctcaatca ttcaggcatt agtccatcac acacaggata
     2701 ctcctaaagt aaggggcgac agcatttgct cattctttga tgtgctatgc accttaggca
     2761 gagaatttca cctaatcgta ttgcaaggag cctcggcgtt acttcagagt ttgtaaggcc
     2821 ctacctaagc tggatatgca gtactctctg tccaaaactg ggttaagaat ttcaaaacag
     2881 agttgataaa catggtgaca catacgagta atcccagcac ttaagggggt ggaggtaaga
     2941 ggatcctgag ttcaaggcca gcctgggctt aacattatta ttattattat tattattatt
     3001 attattatta ttattacaag gcaggagaag aataaactaa aggtccaaac ttcccaagag
     3061 aggtagcaca ggtctttctt actagtctta tttaatagcc aacagaagct ttcgagaagt
     3121 acagtgacat gttctaaatc acaaagctgg agtgacgtgg ggctaggatt cagagtcaga
     3181 cagtctggct ccctggggag gatcaggttt aatacagcaa acactgactg tcttggatga
     3241 aatgctgggc tcatccagga ggaacccagg atggctgaac ccccatcttc caggagctag
     3301 gaggacagaa aggtagtcga caagccagta gcactggata tagctgcagt acagccagtc
     3361 acaggaaaca acttctctta tgtctgactt ggtcatccaa aattcaactc tgccccagct
     3421 cctttcacca gggctgaaga gagccacctt gactatctga ggtctggacc tctgcaaggt
     3481 tgttgcaggg cttaggaaac caaacacagc cagcacctgg acttctgcct tgagggttac
     3541 catggctacc cacgtgcgct caggacccag ggtctgacct ggcaggcagc ttgagtctgg
     3601 ctttgttctc tttgggggtc accgagagca cgtggacttc ctcagcctga agcaccatag
     3661 tcagaggtgg cccattgtca ctgtccttct taggaacatg ggcaggagct gttctggttg
     3721 taagggaggg caggcagcca cagggctgct gcaggcagga gggggcaaga gcagctgctt
     3781 agaagccgag cctagcaaac tctgctccag ggctgaactt aatgataatc gcctagtaat
     3841 gagtggttaa gtcgctcttg agtaaatgac ttcacctctc tgtg
//
