LOCUS       NM_001362585            5782 bp    mRNA    linear   ROD 06-JUN-2024
DEFINITION  Mus musculus epsin 2 (Epn2), transcript variant 4, mRNA.
ACCESSION   NM_001362585 XM_006532163
VERSION     NM_001362585.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5782)
  AUTHORS   Wang,B., Tang,X., Yao,L., Wang,Y., Chen,Z., Li,M., Wu,N., Wu,D.,
            Dai,X., Jiang,H. and Ai,D.
  TITLE     Disruption of USP9X in macrophages promotes foam cell formation and
            atherosclerosis
  JOURNAL   J Clin Invest 132 (10) (2022)
   PUBMED   35389885
REFERENCE   2  (bases 1 to 5782)
  AUTHORS   Dong,Y., Wang,B., Cui,K., Cai,X., Bhattacharjee,S., Wong,S.,
            Cowan,D.B. and Chen,H.
  TITLE     Epsins Negatively Regulate Aortic Endothelial Cell Function by
            Augmenting Inflammatory Signaling
  JOURNAL   Cells 10 (8), 1918 (2021)
   PUBMED   34440686
  REMARK    GeneRIF: Epsins Negatively Regulate Aortic Endothelial Cell
            Function by Augmenting Inflammatory Signaling.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5782)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5782)
  AUTHORS   Song,K., Cai,X., Dong,Y., Wu,H., Wei,Y., Shankavaram,U.T., Cui,K.,
            Lee,Y., Zhu,B., Bhattacharjee,S., Wang,B., Zhang,K., Wen,A.,
            Wong,S., Yu,L., Xia,L., Welm,A.L., Bielenberg,D.R.,
            Camphausen,K.A., Kang,Y. and Chen,H.
  TITLE     Epsins 1 and 2 promote NEMO linear ubiquitination via LUBAC to
            drive breast cancer development
  JOURNAL   J Clin Invest 131 (1) (2021)
   PUBMED   32960814
  REMARK    GeneRIF: Epsins 1 and 2 promote NEMO linear ubiquitination via
            LUBAC to drive breast cancer development.
REFERENCE   5  (bases 1 to 5782)
  AUTHORS   Dong,Y., Lee,Y., Cui,K., He,M., Wang,B., Bhattacharjee,S., Zhu,B.,
            Yago,T., Zhang,K., Deng,L., Ouyang,K., Wen,A., Cowan,D.B., Song,K.,
            Yu,L., Brophy,M.L., Liu,X., Wylie-Sears,J., Wu,H., Wong,S., Cui,G.,
            Kawashima,Y., Matsumoto,H., Kodera,Y., Wojcikiewicz,R.J.H.,
            Srivastava,S., Bischoff,J., Wang,D.Z., Ley,K. and Chen,H.
  TITLE     Epsin-mediated degradation of IP3R1 fuels atherosclerosis
  JOURNAL   Nat Commun 11 (1), 3984 (2020)
   PUBMED   32770009
  REMARK    GeneRIF: Epsin-mediated degradation of IP3R1 fuels atherosclerosis.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5782)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   7  (bases 1 to 5782)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
REFERENCE   8  (bases 1 to 5782)
  AUTHORS   Hussain,N.K., Yamabhai,M., Ramjaun,A.R., Guy,A.M., Baranes,D.,
            O'Bryan,J.P., Der,C.J., Kay,B.K. and McPherson,P.S.
  TITLE     Splice variants of intersectin are components of the endocytic
            machinery in neurons and nonneuronal cells
  JOURNAL   J Biol Chem 274 (22), 15671-15677 (1999)
   PUBMED   10336464
REFERENCE   9  (bases 1 to 5782)
  AUTHORS   Kay,B.K., Yamabhai,M., Wendland,B. and Emr,S.D.
  TITLE     Identification of a novel domain shared by putative components of
            the endocytic and cytoskeletal machinery
  JOURNAL   Protein Sci 8 (2), 435-438 (1999)
   PUBMED   10048338
REFERENCE   10 (bases 1 to 5782)
  AUTHORS   Yamabhai,M., Hoffman,N.G., Hardison,N.L., McPherson,P.S.,
            Castagnoli,L., Cesareni,G. and Kay,B.K.
  TITLE     Intersectin, a novel adaptor protein with two Eps15 homology and
            five Src homology 3 domains
  JOURNAL   J Biol Chem 273 (47), 31401-31407 (1998)
   PUBMED   9813051
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL604029.12.
            
            On Apr 20, 2018 this sequence version replaced XM_006532163.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK139793.1, SRR1660817.76934.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-121               AL604029.12        166634-166754       c
            122-883             AL604029.12        133217-133978       c
            884-1054            AL604029.12        131225-131395       c
            1055-1167           AL604029.12        122338-122450       c
            1168-1203           AL604029.12        121645-121680       c
            1204-1314           AL604029.12        120638-120748       c
            1315-1489           AL604029.12        119585-119759       c
            1490-1654           AL604029.12        110096-110260       c
            1655-1741           AL604029.12        109473-109559       c
            1742-1957           AL604029.12        108726-108941       c
            1958-5782           AL604029.12        102950-106774       c
FEATURES             Location/Qualifiers
     source          1..5782
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 37.96 cM"
     gene            1..5782
                     /gene="Epn2"
                     /gene_synonym="9530051D10Rik; Ibp2"
                     /note="epsin 2"
                     /db_xref="GeneID:13855"
                     /db_xref="MGI:MGI:1333766"
     exon            1..121
                     /gene="Epn2"
                     /gene_synonym="9530051D10Rik; Ibp2"
                     /inference="alignment:Splign:2.1.0"
     exon            122..883
                     /gene="Epn2"
                     /gene_synonym="9530051D10Rik; Ibp2"
                     /inference="alignment:Splign:2.1.0"
     CDS             289..2247
                     /gene="Epn2"
                     /gene_synonym="9530051D10Rik; Ibp2"
                     /note="isoform 4 is encoded by transcript variant 4;
                     EPS-15-interacting protein 2; intersectin-EH-binding
                     protein 2"
                     /codon_start=1
                     /product="epsin-2 isoform 4"
                     /protein_id="NP_001349514.1"
                     /db_xref="GeneID:13855"
                     /db_xref="MGI:MGI:1333766"
                     /translation="MTTSSIRRQMKNIVNNYSEAEIKVREATSNDPWGPSSSLMTEIA
                     DLTYNVVAFSEIMSMVWKRLNDHGKNWRHVYKALTLLDYLIKTGSERVAQQCRENIFA
                     IQTLKDFQYIDRDGKDQGINVREKSKQLVALLKDEERLKVERVQALKTKERMAQVATG
                     VGSNQITFGRGSSQPNLSTSYSEQEYGKAGGSPASYHGSPEASLCPQHRTGAMLGQSE
                     ELQPLSQRHPCLPHLGLASHPNGDWAQPCLTCDRAARATSPRVSSELEQARPQTSGEE
                     ELQLQLALAMSREVAEQSSESVQTARGSKEERLRRGDDLRLQMALEESRRDTVKVPKK
                     KEAKACCKPGSHSQQTTLLDLMDALPSSGPVTQKTEPWSAGASANQTNPWGGTVAPSN
                     ITDPWPSFGTKPAASVDPWGVPTTASTQSVPKNSDPWAASQQPASNAGKTTDAWGAAK
                     PSSASGSFELFSNFNGTVKDDFSEFDNLRTSKKPAESGASVPPQDSRTTSPDLFESQS
                     LTSASSKPSSARKTPESFLGPNAALVNLDSLVTKPAPPAQSLNPFLAPGAAAPAPVNP
                     FQVNQPQPLTLNQLRGSPVLGSSASFGSGPGVETVAPMTSVAPHSSVGASGSSLTPLG
                     PTAMNMVGSVGIPPSAAQSTGTTNPFLL"
     exon            884..1054
                     /gene="Epn2"
                     /gene_synonym="9530051D10Rik; Ibp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1055..1167
                     /gene="Epn2"
                     /gene_synonym="9530051D10Rik; Ibp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1168..1203
                     /gene="Epn2"
                     /gene_synonym="9530051D10Rik; Ibp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1204..1314
                     /gene="Epn2"
                     /gene_synonym="9530051D10Rik; Ibp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1315..1489
                     /gene="Epn2"
                     /gene_synonym="9530051D10Rik; Ibp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1490..1654
                     /gene="Epn2"
                     /gene_synonym="9530051D10Rik; Ibp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1655..1741
                     /gene="Epn2"
                     /gene_synonym="9530051D10Rik; Ibp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1742..1957
                     /gene="Epn2"
                     /gene_synonym="9530051D10Rik; Ibp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1958..5782
                     /gene="Epn2"
                     /gene_synonym="9530051D10Rik; Ibp2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4391..4396
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Epn2"
                     /gene_synonym="9530051D10Rik; Ibp2"
                     /note="hexamer: AATATA"
     polyA_site      4416
                     /gene="Epn2"
                     /gene_synonym="9530051D10Rik; Ibp2"
                     /note="major polyA site"
     regulatory      5763..5768
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Epn2"
                     /gene_synonym="9530051D10Rik; Ibp2"
                     /note="hexamer: ATTAAA"
     polyA_site      5782
                     /gene="Epn2"
                     /gene_synonym="9530051D10Rik; Ibp2"
ORIGIN      
        1 cctctcggcc gccatgttgg ctggcgtgtg ggtgtcaaac gctgcacagg ctcgggtcgc
       61 tcccgcttct cccgcgtcgc cggcggctgc agccttgcac tcgcgctggc caggaacgga
      121 gggcatggct gccagcttct gggacctgag gctttggagg aggaaatgac tgtggagggc
      181 cattttgttc catctgcatt tctgacacgg aaacttccta gggtgcaggc ttaggggaca
      241 ggaaagtttc tcttgaaggg cttcacattt gtaacaaaga agataaaaat gacaacttca
      301 tctatcagac ggcagatgaa aaacattgtg aacaattact cagaggctga aatcaaagtc
      361 cgggaggcca cctccaatga cccgtggggc ccatccagct ctctgatgac tgagattgct
      421 gacctgacct acaatgtggt agcgttctcg gagatcatga gcatggtttg gaagcgactt
      481 aatgaccatg gcaagaactg gcggcatgta tacaaggcac tgacactgct ggactacctt
      541 atcaagacag gttctgagcg ggtggcccag cagtgccgtg agaacatctt tgccatacag
      601 actctgaagg actttcagta cattgaccgt gatggcaaag accagggtat taacgttcga
      661 gagaaatcaa agcaactggt tgcgctcctc aaggatgagg agcggctgaa ggttgagaga
      721 gttcaggctc tcaaaaccaa agagcgcatg gctcaggtgg ccactggcgt gggcagcaac
      781 caaatcacct ttggccgtgg ctccagccag cccaaccttt ctaccagcta ctcagagcag
      841 gagtatggca aggctggggg ctcgccggca tcctaccacg gctcgccaga ggcctcgctg
      901 tgcccccagc accgcacagg ggccatgctg ggtcagagtg aggagctgca gccactgagc
      961 cagcgccacc cctgcctgcc gcacctgggc ctagcctccc accctaatgg cgactgggcc
     1021 cagccctgcc tcacttgtga ccgcgcagcc cgagctactt ccccacgagt atcctctgag
     1081 ttagagcagg cccggccaca gacaagcgga gaagaggagc tgcagctaca actggcactt
     1141 gccatgagca gagaggttgc tgagcagtca tcagaaagcg tgcagacagc cagaggcagc
     1201 aaggaagaac gcctcaggcg gggtgatgac ctcagattgc agatggctct ggaagaaagc
     1261 cggagagaca cagtaaaagt tccaaaaaag aaagaggcga aagcttgttg caagccaggc
     1321 tcccactccc agcagactac cttgttggat ttaatggatg ccctccccag ctcaggccct
     1381 gttacacaga aaactgagcc ctggagtgca ggagcctctg ctaaccagac caacccctgg
     1441 ggtggaacag tggctccttc gaacattact gacccgtggc catcgtttgg taccaagcca
     1501 gctgcctctg tggacccctg gggagtacct accacagcca gcacacagtc tgtccctaag
     1561 aactcagacc cttgggcagc ctcacagcag cctgcctcca atgctggaaa gacaacagat
     1621 gcctggggag ctgctaagcc cagttctgcc tcagggtcct ttgagctctt cagtaatttc
     1681 aacggtacag ttaaagatga tttttctgaa tttgacaacc ttcgaacttc aaaaaaacca
     1741 gctgagtcag gggcctcagt gccaccccag gacagcagaa ccacgagccc tgacctcttt
     1801 gagtctcaat ccttgacttc tgcgtcaagc aagcctagca gtgccaggaa aacacctgag
     1861 tccttcctgg gccccaatgc agccctggtg aacctggact cattggtgac taagcctgct
     1921 ccaccagctc agtcccttaa tcccttcctg gcaccaggtg ctgctgctcc agcccctgtc
     1981 aaccccttcc aggtcaacca gccccagccg ctgacactga accagctccg gggaagccct
     2041 gtcctgggaa gcagtgcatc ctttgggtct ggtccagggg tggagactgt ggctcccatg
     2101 acctcagtag ctccacactc atcagtgggg gccagtggct cctccttgac accactgggc
     2161 cctacagcaa tgaacatggt aggcagtgtg ggcattcccc catcagcagc tcagtcaaca
     2221 ggcacaacaa accctttcct tctctagtga ccaggtggga acttgcccga gtgaacaccc
     2281 agagtgccga gccaaggatg tcaagtgggg actcactctg ttttgtgtag tggctgagaa
     2341 tacggtggta ggggtattag agcttcaggt ccagcttcct ggtgaaagag tggttgttac
     2401 aatccagacc ttcaggctgt gggtagggtg gcctcactgt cctagtcggg cccctgtgtc
     2461 tcttcctaag tgctcagcac tactgaggtc tggaaaggag gtgttaccag tgttgctcaa
     2521 gattctggga tgctgtctag cccagaactt ggacagtcac attgtgtgtg ccccaccccc
     2581 agttatcttc agggtgtgga caaggtaaag ctctggcccc acttgacact gactgttggg
     2641 aagtggttgt gcatttttta ttttcctttg actcaatgtg agtccaaggt gaacactcct
     2701 accagtgtgg agctttaagc tgactgagcg caaccctgcc ctgtggctct gtgcttgtgc
     2761 acgtttgcac agtttgttga gtacagtttc atatttgagt ttgcaaaatt atctaatagt
     2821 ctttttttgg ctaatatttt tataacgtgg ttcttattta actgtctagt tttgatagaa
     2881 ttgaccaagt ctggctgaat taaggtcttg gcatgtatta ttttagtggt ctaatttctc
     2941 ttatttatgg ttttaactgt aagaaaactt taaaagaaga gatatttgga tgacaaaaat
     3001 atgccttatg gaaaactaag caaattcttt ataggaaaaa aaaaaacgga atttgattac
     3061 acaaaaaaga attttattaa aacaaaacaa aaacttccaa caataacaaa ccccgcagcc
     3121 tctagttgcc tttttccttt cttcaactct tttgatgaat tatcagtcag ttgactctgc
     3181 agcatttttg ccgagattgg agaggctttt tgctactagt atattggcat cttaaggtta
     3241 aaaggaaaaa caacgcatga ttgtgacttg ccagttttta tcaactaatc cctttttgta
     3301 cctggaatgc agggattgcc agggacttcc atttactgca ggccagaaat gtggctggct
     3361 gccccaccat catgctcagg ttaatgagat tgtgtgaaaa tgggggtgat tctatacatg
     3421 tgggctcaga ggtcatcagg gatggtcccc tagctgagtc atggcagaga ctggcccaga
     3481 tttgtctgtc tgccagctcc aactcaggct gctgaccagg aagtaaccac atcctatttt
     3541 ggagatgaaa aagtcctcac atggcataga tttaacatac gtgcactgat actatccttt
     3601 ctctcccaac ctcctgatgt cctcactact cactgttaag aaaagtatta aatcttgagt
     3661 taagagacca cagacttgca ttcttcagag aaaggactgc cccttcttgg tcctggcagt
     3721 ttgtgtcctt cctgcaatat ggacttctct aaccttaagc tccaaggaca cccagccacc
     3781 tgccagctcc tctctgcatc cagagaaact tttggccccc agcacgcaca gagttgactc
     3841 agtgattcct gtttgagaga ggactgcact taagcccctc ctgggtctga gtctacatgc
     3901 tgctcctagg ccccacaagc caagggccct tcctaactac ccattccacc caggaccaga
     3961 ggccgaggga aaggtttggg ctctgctatt caggaaggct gatggctggg ctcctacctg
     4021 ggagagatgg agacatcaca ggatggaggc cagtcaccag tccagattgt gcttccttca
     4081 gattgtacat gctagggcca gaactgcctg ctgtgggcct gggattctac tccagaagac
     4141 aagagcccat ctgactgggg ccccatccca gtagccactg ggctcctcct tcaacaggcc
     4201 atccagcgca tgtccctgtt acccgctgca ctgatcatga agccgctggc cactgccatg
     4261 tgtgttgcac acgtgccacc atgcccttct tgatgaatac cctgaaggaa gtcacccagc
     4321 tatttctcag tcccagggct ggtgggtggt tttggatttg tgttgactgt tgatacttat
     4381 ttactgtata aatataattt atcatttgta tcatgatgtg ggttttggct gtgtcctttc
     4441 actatcctgt ctttaacaat ccagtgggac aagatgtggc agggctggct agggaagcag
     4501 cttggtctgc agtcaggctc aaggacaggc tcaggtctgc ttttgatgga cattgccatg
     4561 gtctgtgtga aggttgtgct gggcagatgt tagcccagac ggctatcagt tctgaggcca
     4621 gttctcagca tgctttagtg gtttcacatt cacttcctgt cttagggtta ctactaagta
     4681 ccctatgatg aagcaccatg accaaagcaa cttgggaagg ctagggttta tttatgcttc
     4741 cacatcactg ttcatcagca cctgcacctc tccacagacc ggatttctct gtcagttgag
     4801 cacttatctt ctgtgtcctg gatagtagaa ggtaggtttg attagcaggt taccagctac
     4861 tgttacaggt agccctctgg gcaccaaggc cttcagtttt acctctcaga ccaaaaggtc
     4921 tgattggttt tttctgtgtt cagctaagag ttgagggctt atggaggcag agcagcaggg
     4981 caagtgacac tgctataaat aaacagtgtg agggtggcac tggggcccga ggaagccttc
     5041 cagcaccaga aagggtctag gatagcctca agctcagctc tgtaggaaac ccaccctttg
     5101 agtgagcagt cgggagccag ctttttgcct gcacagatat tgccagccag gacttgctct
     5161 gataccaagg ttttgtgctg gctaaatttt atgtcaactt gtcacaagct agagtcactg
     5221 ggagataagg aagcttcaac tgagagaatg tcttcatagg attaggcagg cctgtagggc
     5281 attttcttat ttggtaatta gtagggaagt gcccagccca ttgtagatgg tgccatccct
     5341 aggctgatgg ttcaggttgc tataacaaag caggcagagc aagccatgtg gagaaagcca
     5401 gtaagcagca ctcttccatg gcccagactt acttcagtga tggtctgtga tatagaactg
     5461 taagccacta agccctttct tctccaactt gattttggtc acggtgttta ttaagcaaca
     5521 gaaaccctta caggaggctg cttccctcag aacttgagca ggctgtgagc tctttacttc
     5581 tgtaagctcc attgacacat actgcttttt ttgtttgttt gggttttttt tttttgtttt
     5641 gttttgtttt ttgagacagg ctttctcttt gtaacagcgc tggctatcct ggaactctct
     5701 tcgtagacca ggttggcctt gaactcagag atctgcctgc ctgcctgcct ccaggtgctg
     5761 gaattaaagg cacatgccac ca
//
