LOCUS       NP_001349514             652 aa            linear   ROD 28-APR-2025
DEFINITION  epsin-2 isoform 4 [Mus musculus].
ACCESSION   NP_001349514 XP_006532226
VERSION     NP_001349514.1
DBSOURCE    REFSEQ: accession NM_001362585.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 652)
  AUTHORS   Wang,B., Tang,X., Yao,L., Wang,Y., Chen,Z., Li,M., Wu,N., Wu,D.,
            Dai,X., Jiang,H. and Ai,D.
  TITLE     Disruption of USP9X in macrophages promotes foam cell formation and
            atherosclerosis
  JOURNAL   J Clin Invest 132 (10) (2022)
   PUBMED   35389885
REFERENCE   2  (residues 1 to 652)
  AUTHORS   Dong,Y., Wang,B., Cui,K., Cai,X., Bhattacharjee,S., Wong,S.,
            Cowan,D.B. and Chen,H.
  TITLE     Epsins Negatively Regulate Aortic Endothelial Cell Function by
            Augmenting Inflammatory Signaling
  JOURNAL   Cells 10 (8), 1918 (2021)
   PUBMED   34440686
  REMARK    GeneRIF: Epsins Negatively Regulate Aortic Endothelial Cell
            Function by Augmenting Inflammatory Signaling.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 652)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 652)
  AUTHORS   Song,K., Cai,X., Dong,Y., Wu,H., Wei,Y., Shankavaram,U.T., Cui,K.,
            Lee,Y., Zhu,B., Bhattacharjee,S., Wang,B., Zhang,K., Wen,A.,
            Wong,S., Yu,L., Xia,L., Welm,A.L., Bielenberg,D.R.,
            Camphausen,K.A., Kang,Y. and Chen,H.
  TITLE     Epsins 1 and 2 promote NEMO linear ubiquitination via LUBAC to
            drive breast cancer development
  JOURNAL   J Clin Invest 131 (1) (2021)
   PUBMED   32960814
  REMARK    GeneRIF: Epsins 1 and 2 promote NEMO linear ubiquitination via
            LUBAC to drive breast cancer development.
REFERENCE   5  (residues 1 to 652)
  AUTHORS   Dong,Y., Lee,Y., Cui,K., He,M., Wang,B., Bhattacharjee,S., Zhu,B.,
            Yago,T., Zhang,K., Deng,L., Ouyang,K., Wen,A., Cowan,D.B., Song,K.,
            Yu,L., Brophy,M.L., Liu,X., Wylie-Sears,J., Wu,H., Wong,S., Cui,G.,
            Kawashima,Y., Matsumoto,H., Kodera,Y., Wojcikiewicz,R.J.H.,
            Srivastava,S., Bischoff,J., Wang,D.Z., Ley,K. and Chen,H.
  TITLE     Epsin-mediated degradation of IP3R1 fuels atherosclerosis
  JOURNAL   Nat Commun 11 (1), 3984 (2020)
   PUBMED   32770009
  REMARK    GeneRIF: Epsin-mediated degradation of IP3R1 fuels atherosclerosis.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 652)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   7  (residues 1 to 652)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
REFERENCE   8  (residues 1 to 652)
  AUTHORS   Hussain,N.K., Yamabhai,M., Ramjaun,A.R., Guy,A.M., Baranes,D.,
            O'Bryan,J.P., Der,C.J., Kay,B.K. and McPherson,P.S.
  TITLE     Splice variants of intersectin are components of the endocytic
            machinery in neurons and nonneuronal cells
  JOURNAL   J Biol Chem 274 (22), 15671-15677 (1999)
   PUBMED   10336464
REFERENCE   9  (residues 1 to 652)
  AUTHORS   Kay,B.K., Yamabhai,M., Wendland,B. and Emr,S.D.
  TITLE     Identification of a novel domain shared by putative components of
            the endocytic and cytoskeletal machinery
  JOURNAL   Protein Sci 8 (2), 435-438 (1999)
   PUBMED   10048338
REFERENCE   10 (residues 1 to 652)
  AUTHORS   Yamabhai,M., Hoffman,N.G., Hardison,N.L., McPherson,P.S.,
            Castagnoli,L., Cesareni,G. and Kay,B.K.
  TITLE     Intersectin, a novel adaptor protein with two Eps15 homology and
            five Src homology 3 domains
  JOURNAL   J Biol Chem 273 (47), 31401-31407 (1998)
   PUBMED   9813051
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL604029.12.
            
            On Apr 20, 2018 this sequence version replaced XP_006532226.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK139793.1, SRR1660817.76934.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..652
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 37.96 cM"
     Protein         1..652
                     /product="epsin-2 isoform 4"
                     /note="EPS-15-interacting protein 2;
                     intersectin-EH-binding protein 2"
                     /calculated_mol_wt=69478
     Region          19..141
                     /region_name="ENTH_Epsin"
                     /note="Epsin N-Terminal Homology (ENTH) domain of Epsin
                     family; cd16990"
                     /db_xref="CDD:340787"
     Site            order(25,29..30,63,69,73)
                     /site_type="other"
                     /note="phosphoinositide binding site [chemical binding]"
                     /db_xref="CDD:340787"
     CDS             1..652
                     /gene="Epn2"
                     /gene_synonym="9530051D10Rik; Ibp2"
                     /coded_by="NM_001362585.1:289..2247"
                     /note="isoform 4 is encoded by transcript variant 4"
                     /db_xref="GeneID:13855"
                     /db_xref="MGI:MGI:1333766"
ORIGIN      
        1 mttssirrqm knivnnysea eikvreatsn dpwgpssslm teiadltynv vafseimsmv
       61 wkrlndhgkn wrhvykaltl ldyliktgse rvaqqcreni faiqtlkdfq yidrdgkdqg
      121 invrekskql vallkdeerl kvervqalkt kermaqvatg vgsnqitfgr gssqpnlsts
      181 yseqeygkag gspasyhgsp easlcpqhrt gamlgqseel qplsqrhpcl phlglashpn
      241 gdwaqpcltc draaratspr vsseleqarp qtsgeeelql qlalamsrev aeqssesvqt
      301 argskeerlr rgddlrlqma leesrrdtvk vpkkkeakac ckpgshsqqt tlldlmdalp
      361 ssgpvtqkte pwsagasanq tnpwggtvap snitdpwpsf gtkpaasvdp wgvpttastq
      421 svpknsdpwa asqqpasnag kttdawgaak pssasgsfel fsnfngtvkd dfsefdnlrt
      481 skkpaesgas vppqdsrtts pdlfesqslt sasskpssar ktpesflgpn aalvnldslv
      541 tkpappaqsl npflapgaaa papvnpfqvn qpqpltlnql rgspvlgssa sfgsgpgvet
      601 vapmtsvaph ssvgasgssl tplgptamnm vgsvgippsa aqstgttnpf ll
//
